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<description>Sciences Indexed Since 1998</description>
<title>Pharmacology - Sciences Indexed Since 1998</title>
<atom:link href="http://scienceindex.com/xmlfeeds.php?cmd=popular&amp;id=56" rel="self" type="application/rss+xml" /><link>http://scienceindex.com/view/56/Pharmacology/1.html</link>
<item>
<title>Solid-state amorphization of linaprazan by mechanical milling and evidence of polymorphism</title>
<link>http://scienceindex.com/stories/3123978/Solidstate_amorphization_of_linaprazan_by_mechanical_milling_and_evidence_of_polymorphism.html</link>
<guid>http://scienceindex.com/stories/3123978/Solidstate_amorphization_of_linaprazan_by_mechanical_milling_and_evidence_of_polymorphism.html</guid><description><![CDATA[In this paper, we study the thermodynamic and structural changes of crystalline linaprazan (a proton pump inhibitor) upon high-energy ball milling at room temperature. The investigations have been ...]]></description>
<pubDate>Sun, 19 May 2013 21:13:00 +0100</pubDate>
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<item>
<title>Human skin is permselective for the small, monovalent cations sodium and potassium but not for nickel and chromium</title>
<link>http://scienceindex.com/stories/3123977/Human_skin_is_permselective_for_the_small_monovalent_cations_sodium_and_potassium_but_not_for_nickel_and_chromium.html</link>
<guid>http://scienceindex.com/stories/3123977/Human_skin_is_permselective_for_the_small_monovalent_cations_sodium_and_potassium_but_not_for_nickel_and_chromium.html</guid><description><![CDATA[The molar conductance of excised human skin (Λ skin) immersed in electrolyte solutions comprising four cationic (Na+, K+, Ni2+, and Cr3+) and five anionic (Cl−, NO3−, SO42−, CrO42−, and Cr...]]></description>
<pubDate>Sun, 19 May 2013 21:13:00 +0100</pubDate>
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<title>Stereoselectivity in pharmacokinetics of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys: Model-based pharmacokinetic analysis and in vitro–in vivo extrapolation approach</title>
<link>http://scienceindex.com/stories/3123976/Stereoselectivity_in_pharmacokinetics_of_rivoglitazone_a_novel_peroxisome_proliferatoractivated_receptor__agonist_in_rats_and_monkeys_Modelbased_pharmacokinetic_analysis_and_in_vitroin_vivo_extrapolation_approach.html</link>
<guid>http://scienceindex.com/stories/3123976/Stereoselectivity_in_pharmacokinetics_of_rivoglitazone_a_novel_peroxisome_proliferatoractivated_receptor__agonist_in_rats_and_monkeys_Modelbased_pharmacokinetic_analysis_and_in_vitroin_vivo_extrapolation_approach.html</guid><description><![CDATA[Stereoselectivity in pharmacokinetics of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys was examined. The pharmacokinetic model involving chiral i...]]></description>
<pubDate>Sun, 19 May 2013 21:12:59 +0100</pubDate>
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<item>
<title>In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice</title>
<link>http://scienceindex.com/stories/3123975/In_vivo_evidence_of_organic_cation_transportermediated_tracheal_accumulation_of_the_anticholinergic_agent_ipratropium_in_mice.html</link>
<guid>http://scienceindex.com/stories/3123975/In_vivo_evidence_of_organic_cation_transportermediated_tracheal_accumulation_of_the_anticholinergic_agent_ipratropium_in_mice.html</guid><description><![CDATA[Ipratropium bromide (IPR) is an anticholinergic used to treat chronic obstructive pulmonary disease (COPD), and is a substrate of organic cation transporters. The present study aimed to assess the ...]]></description>
<pubDate>Sun, 19 May 2013 21:12:59 +0100</pubDate>
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<title>Evaluation of monooleine aqueous dispersions as tools for topical administration of curcumin: Characterization, in vitro and ex-vivo studies</title>
<link>http://scienceindex.com/stories/3123974/Evaluation_of_monooleine_aqueous_dispersions_as_tools_for_topical_administration_of_curcumin_Characterization_in_vitro_and_exvivo_studies.html</link>
<guid>http://scienceindex.com/stories/3123974/Evaluation_of_monooleine_aqueous_dispersions_as_tools_for_topical_administration_of_curcumin_Characterization_in_vitro_and_exvivo_studies.html</guid><description><![CDATA[Curcumin (CUR) is a well-known natural compound showing antioxidant, anti-inflammatory, and antitumor abilities but characterized by poor bioavailability and chemical instability, which drastically...]]></description>
<pubDate>Sun, 19 May 2013 21:12:59 +0100</pubDate>
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<title>Application of permeability-limited physiologically-based pharmacokinetic models: Part II - prediction of P-glycoprotein mediated drug–drug interactions with digoxin</title>
<link>http://scienceindex.com/stories/3123973/Application_of_permeabilitylimited_physiologicallybased_pharmacokinetic_models_Part_II__prediction_of_Pglycoprotein_mediated_drugdrug_interactions_with_digoxin.html</link>
<guid>http://scienceindex.com/stories/3123973/Application_of_permeabilitylimited_physiologicallybased_pharmacokinetic_models_Part_II__prediction_of_Pglycoprotein_mediated_drugdrug_interactions_with_digoxin.html</guid><description><![CDATA[Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug–drug interactions (DDIs) in vivo. The overall aim of our study was to investigate the inhibitory potenti...]]></description>
<pubDate>Sun, 19 May 2013 21:12:59 +0100</pubDate>
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<title>Association between waking electroencephalography and cognitive event-related potentials in patients with obstructive sleep apnea</title>
<link>http://scienceindex.com/stories/3123958/Association_between_waking_electroencephalography_and_cognitive_eventrelated_potentials_in_patients_with_obstructive_sleep_apnea.html</link>
<guid>http://scienceindex.com/stories/3123958/Association_between_waking_electroencephalography_and_cognitive_eventrelated_potentials_in_patients_with_obstructive_sleep_apnea.html</guid><description><![CDATA[Sleepiness, cognitive deficits, abnormal event-related potentials (ERP), and slowing of the waking electroencephalography (EEG) activity have been reported in patients with obstructive sleep apnea ...]]></description>
<pubDate>Sun, 19 May 2013 19:13:14 +0100</pubDate>
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<item>
<title>Impact of Heat Treatment on Miscibility of Proteins and Disaccharides in Frozen Solutions</title>
<link>http://scienceindex.com/stories/3123943/Impact_of_Heat_Treatment_on_Miscibility_of_Proteins_and_Disaccharides_in_Frozen_Solutions.html</link>
<guid>http://scienceindex.com/stories/3123943/Impact_of_Heat_Treatment_on_Miscibility_of_Proteins_and_Disaccharides_in_Frozen_Solutions.html</guid><description><![CDATA[The purpose of this study was to elucidate the effect of heat treatment (annealing) on the miscibility of concentrated protein and disaccharide mixtures in the freezing segment of lyophilization. F...]]></description>
<pubDate>Sun, 19 May 2013 18:21:37 +0100</pubDate>
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<title>Structural meta-analysis of regular human insulin in pharmaceutical formulations</title>
<link>http://scienceindex.com/stories/3123942/Structural_metaanalysis_of_regular_human_insulin_in_pharmaceutical_formulations.html</link>
<guid>http://scienceindex.com/stories/3123942/Structural_metaanalysis_of_regular_human_insulin_in_pharmaceutical_formulations.html</guid><description><![CDATA[We have studied regular acting, wild-type human insulin at potency of 100 U/mL from four different pharmaceutical products directly from their final finished formulation by the combined use of mass...]]></description>
<pubDate>Sun, 19 May 2013 18:21:36 +0100</pubDate>
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<title>Design and evaluation of theranostic perfluorocarbon particles for simultaneous antigen-loading and 19F-MRI tracking of dendritic cells</title>
<link>http://scienceindex.com/stories/3123926/Design_and_evaluation_of_theranostic_perfluorocarbon_particles_for_simultaneous_antigenloading_and_19FMRI_tracking_of_dendritic_cells.html</link>
<guid>http://scienceindex.com/stories/3123926/Design_and_evaluation_of_theranostic_perfluorocarbon_particles_for_simultaneous_antigenloading_and_19FMRI_tracking_of_dendritic_cells.html</guid><description><![CDATA[Perfluorocarbon (PFC) particles are currently on the rise as cell labeling agents for 19F-MRI tracking of dendritic cell (DC)-based vaccines. In this work, we design theranostic PFC particles for s...]]></description>
<pubDate>Sun, 19 May 2013 17:29:54 +0100</pubDate>
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<title>Development and evaluation of novel solid nanodispersion system for oral delivery of poorly water-soluble drugs</title>
<link>http://scienceindex.com/stories/3123925/Development_and_evaluation_of_novel_solid_nanodispersion_system_for_oral_delivery_of_poorly_watersoluble_drugs.html</link>
<guid>http://scienceindex.com/stories/3123925/Development_and_evaluation_of_novel_solid_nanodispersion_system_for_oral_delivery_of_poorly_watersoluble_drugs.html</guid><description><![CDATA[The aim of the present study was to develop and evaluate a novel drug solubilization platform (so-called solid nanodispersion) prepared by a simple co-grinding and solvent-free process. Using struc...]]></description>
<pubDate>Sun, 19 May 2013 17:29:53 +0100</pubDate>
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<title>Omega 3 Fatty Acids as Pharmacotherapeutics in Psoriasis: Current Status and Scope of Nanomedicine in its Effective Delivery</title>
<link>http://scienceindex.com/stories/3123910/Omega_3_Fatty_Acids_as_Pharmacotherapeutics_in_Psoriasis_Current_Status_and_Scope_of_Nanomedicine_in_its_Effective_Delivery.html</link>
<guid>http://scienceindex.com/stories/3123910/Omega_3_Fatty_Acids_as_Pharmacotherapeutics_in_Psoriasis_Current_Status_and_Scope_of_Nanomedicine_in_its_Effective_Delivery.html</guid><description><![CDATA[Psoriasis is a multifactorial autoimmune skin disorder based on irregularities of the T- cell function. The abnormal keratinocyte hyper proliferation in psoriasis arises due to the activation of T-...]]></description>
<pubDate>Sun, 19 May 2013 16:53:23 +0100</pubDate>
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<title>Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis</title>
<link>http://scienceindex.com/stories/3123909/HypoxiaInducible_Factor_A_Potential_Therapeutic_Target_for_Rheumatoid_Arthritis.html</link>
<guid>http://scienceindex.com/stories/3123909/HypoxiaInducible_Factor_A_Potential_Therapeutic_Target_for_Rheumatoid_Arthritis.html</guid><description><![CDATA[The hypoxic microenvironment is a clinicopathological characteristic of many diseases, such as rheumatoid arthritis (RA). As a transcription factor activating the gene expression involved in proces...]]></description>
<pubDate>Sun, 19 May 2013 16:53:21 +0100</pubDate>
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<title>Sirtuins Family- Recent Development as a Drug Target for Aging, Metabolism, and Age Related Diseases</title>
<link>http://scienceindex.com/stories/3123908/Sirtuins_Family_Recent_Development_as_a_Drug_Target_for_Aging_Metabolism_and_Age_Related_Diseases.html</link>
<guid>http://scienceindex.com/stories/3123908/Sirtuins_Family_Recent_Development_as_a_Drug_Target_for_Aging_Metabolism_and_Age_Related_Diseases.html</guid><description><![CDATA[Silent information regulator 2 (Sir2) proteins, or sirtuins, are a family of proteins which influence several physiological responses and have implications for treating diseases of ageing. In this ...]]></description>
<pubDate>Sun, 19 May 2013 16:53:18 +0100</pubDate>
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<title>Structure and Evolution of Human Sirtuins</title>
<link>http://scienceindex.com/stories/3123907/Structure_and_Evolution_of_Human_Sirtuins.html</link>
<guid>http://scienceindex.com/stories/3123907/Structure_and_Evolution_of_Human_Sirtuins.html</guid><description><![CDATA[Sirtuins form a large homology family of enzymes found almost ubiquitously in living organisms and involved in numerous biological processes. The human genome encodes for seven paralog sirtuins, id...]]></description>
<pubDate>Sun, 19 May 2013 16:53:16 +0100</pubDate>
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<title>Human Sirtuins: An Overview of an Emerging Drug Target in Age-Related Diseases and Cancer</title>
<link>http://scienceindex.com/stories/3123906/Human_Sirtuins_An_Overview_of_an_Emerging_Drug_Target_in_AgeRelated_Diseases_and_Cancer.html</link>
<guid>http://scienceindex.com/stories/3123906/Human_Sirtuins_An_Overview_of_an_Emerging_Drug_Target_in_AgeRelated_Diseases_and_Cancer.html</guid><description><![CDATA[Sir2-like proteins (Sirtuins) are a class of enzymes conserved throughout the kingdoms of life. In fact, from Archaea to Mammals, these (class III) NAD+-dependent deacetylases catalyse the removal ...]]></description>
<pubDate>Sun, 19 May 2013 16:53:15 +0100</pubDate>
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<title>Sirtuin-1 and HIV-1: An Overview</title>
<link>http://scienceindex.com/stories/3123905/Sirtuin1_and_HIV1_An_Overview.html</link>
<guid>http://scienceindex.com/stories/3123905/Sirtuin1_and_HIV1_An_Overview.html</guid><description><![CDATA[Sirtuins are a family of NAD+-dependent protein deacetylases, which regulate cell survival and energy metabolism, inflammation and cancer. Recent studies have shown that sirtuin-1 (SIRT1) modulates...]]></description>
<pubDate>Sun, 19 May 2013 16:53:13 +0100</pubDate>
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<title>Sirtuins as Possible Targets in Neurodegenerative Diseases</title>
<link>http://scienceindex.com/stories/3123904/Sirtuins_as_Possible_Targets_in_Neurodegenerative_Diseases.html</link>
<guid>http://scienceindex.com/stories/3123904/Sirtuins_as_Possible_Targets_in_Neurodegenerative_Diseases.html</guid><description><![CDATA[Age-related diseases pose as an enormous problem on aging populations of the world. Despite the fact that many advances have been made on understanding of the neurodegeneration, there is still no c...]]></description>
<pubDate>Sun, 19 May 2013 16:53:11 +0100</pubDate>
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<title>Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience</title>
<link>http://scienceindex.com/stories/3123903/Nicotinamide_Phosphoribosyltransferase_NAMPT_Inhibitors_as_Therapeutics_Rationales_Controversies_Clinical_Experience.html</link>
<guid>http://scienceindex.com/stories/3123903/Nicotinamide_Phosphoribosyltransferase_NAMPT_Inhibitors_as_Therapeutics_Rationales_Controversies_Clinical_Experience.html</guid><description><![CDATA[Nicotinamide adenine dinucleotide (NAD+) biosynthesis from nicotinamide is used by mammalian cells to replenish their NAD&amp;#43; stores and to avoid unwanted nicotinamide accumulation. Pharmacologica...]]></description>
<pubDate>Sun, 19 May 2013 16:53:10 +0100</pubDate>
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<title>Sirtuins as Possible Drug Targets in Type 2 Diabetes</title>
<link>http://scienceindex.com/stories/3123902/Sirtuins_as_Possible_Drug_Targets_in_Type_2_Diabetes.html</link>
<guid>http://scienceindex.com/stories/3123902/Sirtuins_as_Possible_Drug_Targets_in_Type_2_Diabetes.html</guid><description><![CDATA[The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem in industrialized countries, and new therapeutic strategies to prevent T2DM are urgently needed worldwide. I...]]></description>
<pubDate>Sun, 19 May 2013 16:53:02 +0100</pubDate>
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<title>Plasma Proteins Interaction with Curcumin Nanoparticles: Implications in Cancer Therapeutics</title>
<link>http://scienceindex.com/stories/3123799/Plasma_Proteins_Interaction_with_Curcumin_Nanoparticles_Implications_in_Cancer_Therapeutics.html</link>
<guid>http://scienceindex.com/stories/3123799/Plasma_Proteins_Interaction_with_Curcumin_Nanoparticles_Implications_in_Cancer_Therapeutics.html</guid><description><![CDATA[Curcumin, a natural bioactive polyphenol, has been widely investigated as a conventional medicine for centuries. Over the past two decades, major pre-clinical and clinical trials have demonstrated ...]]></description>
<pubDate>Sun, 19 May 2013 11:44:19 +0100</pubDate>
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<title>Interactions of Dietary Flavonoids with Proteins: Insights from Fluorescence Spectroscopy and Other Related Biophysical Studies</title>
<link>http://scienceindex.com/stories/3123798/Interactions_of_Dietary_Flavonoids_with_Proteins_Insights_from_Fluorescence_Spectroscopy_and_Other_Related_Biophysical_Studies.html</link>
<guid>http://scienceindex.com/stories/3123798/Interactions_of_Dietary_Flavonoids_with_Proteins_Insights_from_Fluorescence_Spectroscopy_and_Other_Related_Biophysical_Studies.html</guid><description><![CDATA[In 1936, Rusznyak and Szent-Gyorgyi first drew attention to the therapeutically beneficial role of dietary flavonoids, which are the most common group of polyphenols ubiquitously present in plant b...]]></description>
<pubDate>Sun, 19 May 2013 11:44:17 +0100</pubDate>
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<title>New Insights on Flavonoid-Serum Albumin Interactions from Concerted Spectroscopic Methods and Molecular Modeling</title>
<link>http://scienceindex.com/stories/3123797/New_Insights_on_FlavonoidSerum_Albumin_Interactions_from_Concerted_Spectroscopic_Methods_and_Molecular_Modeling.html</link>
<guid>http://scienceindex.com/stories/3123797/New_Insights_on_FlavonoidSerum_Albumin_Interactions_from_Concerted_Spectroscopic_Methods_and_Molecular_Modeling.html</guid><description><![CDATA[The paper offers a survey on literature data on the very wide subject concerning the interaction of a particular class of polyphenols, flavonoids, with plasma proteins. Recent developments in apply...]]></description>
<pubDate>Sun, 19 May 2013 11:44:15 +0100</pubDate>
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<title>Interactions of Polyphenols with Plasma Proteins: Insights from Analytical Techniques</title>
<link>http://scienceindex.com/stories/3123796/Interactions_of_Polyphenols_with_Plasma_Proteins_Insights_from_Analytical_Techniques.html</link>
<guid>http://scienceindex.com/stories/3123796/Interactions_of_Polyphenols_with_Plasma_Proteins_Insights_from_Analytical_Techniques.html</guid><description><![CDATA[Phenolic compounds are commonly found in natural sources like plant-based foods and beverages. These compounds have received much attention due to their unique biological properties. Polyphenols po...]]></description>
<pubDate>Sun, 19 May 2013 11:44:13 +0100</pubDate>
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<title>Influence of Polyphenol-plasma Protein Interaction on the Antioxidant Properties of Polyphenols</title>
<link>http://scienceindex.com/stories/3123795/Influence_of_Polyphenolplasma_Protein_Interaction_on_the_Antioxidant_Properties_of_Polyphenols.html</link>
<guid>http://scienceindex.com/stories/3123795/Influence_of_Polyphenolplasma_Protein_Interaction_on_the_Antioxidant_Properties_of_Polyphenols.html</guid><description><![CDATA[Polyphenols are the most abundant antioxidants. Polyphenols are known to non-covalent interact with plasma proteins in blood through hydrophobic or hydrophilic interactions. It was found that the e...]]></description>
<pubDate>Sun, 19 May 2013 11:44:11 +0100</pubDate>
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<title>Advances on the Interaction between Tea Catechins and Plasma Proteins: Structure- Affinity Relationship, Influence on Antioxidant Activity, and Molecular Docking Aspects</title>
<link>http://scienceindex.com/stories/3123794/Advances_on_the_Interaction_between_Tea_Catechins_and_Plasma_Proteins_Structure_Affinity_Relationship_Influence_on_Antioxidant_Activity_and_Molecular_Docking_Aspects.html</link>
<guid>http://scienceindex.com/stories/3123794/Advances_on_the_Interaction_between_Tea_Catechins_and_Plasma_Proteins_Structure_Affinity_Relationship_Influence_on_Antioxidant_Activity_and_Molecular_Docking_Aspects.html</guid><description><![CDATA[Tea materials are widely consumed beverages in the world and are a rich source of dietary polyphenols. Catechins found in tea show excellent antioxidant potential, which is beneficial for many dise...]]></description>
<pubDate>Sun, 19 May 2013 11:44:09 +0100</pubDate>
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<title>Interactions Between Plasma Proteins and Naturally Occurring Polyphenols</title>
<link>http://scienceindex.com/stories/3123793/Interactions_Between_Plasma_Proteins_and_Naturally_Occurring_Polyphenols.html</link>
<guid>http://scienceindex.com/stories/3123793/Interactions_Between_Plasma_Proteins_and_Naturally_Occurring_Polyphenols.html</guid><description><![CDATA[The plant natural products known as polyphenols are found at micronutrient levels in fruits, vegetables, and plant-based beverages such as wine, tea, coffee and cocoa. Consumption of a fruit- and v...]]></description>
<pubDate>Sun, 19 May 2013 11:44:07 +0100</pubDate>
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<title>Structures Required of Polyphenols for Inhibiting Advanced Glycation end Products Formation</title>
<link>http://scienceindex.com/stories/3123792/Structures_Required_of_Polyphenols_for_Inhibiting_Advanced_Glycation_end_Products_Formation.html</link>
<guid>http://scienceindex.com/stories/3123792/Structures_Required_of_Polyphenols_for_Inhibiting_Advanced_Glycation_end_Products_Formation.html</guid><description><![CDATA[The properties of polyphenols as AGEs formation inhibitors have attracted great interest among researchers. This review discusses the antiglycation activities of polyphenols and focuses on the rela...]]></description>
<pubDate>Sun, 19 May 2013 11:44:05 +0100</pubDate>
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<title>Polyphenols: A Diverse Class of Multi-Target Anti-HIV-1 Agents</title>
<link>http://scienceindex.com/stories/3123791/Polyphenols_A_Diverse_Class_of_MultiTarget_AntiHIV1_Agents.html</link>
<guid>http://scienceindex.com/stories/3123791/Polyphenols_A_Diverse_Class_of_MultiTarget_AntiHIV1_Agents.html</guid><description><![CDATA[Polyphenols are a versatile class of compounds that represent secondary metabolites from higher plants and which are abundantly present in the human diet. Epidemiological data suggest protective ef...]]></description>
<pubDate>Sun, 19 May 2013 11:44:03 +0100</pubDate>
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<title>Metabolism of Dietary Flavonoids in Liver Microsomes</title>
<link>http://scienceindex.com/stories/3123790/Metabolism_of_Dietary_Flavonoids_in_Liver_Microsomes.html</link>
<guid>http://scienceindex.com/stories/3123790/Metabolism_of_Dietary_Flavonoids_in_Liver_Microsomes.html</guid><description><![CDATA[Flavonoids undergo substantial hepatic metabolism and the metabolites might significantly contribute to the effects of these dietary constituents. The metabolites of flavonoids in liver can be summ...]]></description>
<pubDate>Sun, 19 May 2013 11:44:01 +0100</pubDate>
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<title>Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems</title>
<link>http://scienceindex.com/stories/3123789/Disposition_of_Pharmacologically_Active_Dietary_Isoflavones_in_Biological_Systems.html</link>
<guid>http://scienceindex.com/stories/3123789/Disposition_of_Pharmacologically_Active_Dietary_Isoflavones_in_Biological_Systems.html</guid><description><![CDATA[Dietary isoflavones, popularly known as phytoestrogens, represent one of the most biologically active classes of flavonoids. Numerous in vitro and in vivo studies provide convincing evidence regard...]]></description>
<pubDate>Sun, 19 May 2013 11:44:00 +0100</pubDate>
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<title>The efficacy of preoperative pregabalin on reduction of the incidence and severity of postdural puncture headache after spinal anesthesia</title>
<link>http://scienceindex.com/stories/3123746/The_efficacy_of_preoperative_pregabalin_on_reduction_of_the_incidence_and_severity_of_postdural_puncture_headache_after_spinal_anesthesia.html</link>
<guid>http://scienceindex.com/stories/3123746/The_efficacy_of_preoperative_pregabalin_on_reduction_of_the_incidence_and_severity_of_postdural_puncture_headache_after_spinal_anesthesia.html</guid><description><![CDATA[The aim of this study was to evaluate the efficacy of prophylactic pregabalin on postdural puncture headache incidence and severity after spinal anesthesia. 86 ASA I-II male and female patients age...]]></description>
<pubDate>Sun, 19 May 2013 10:05:07 +0100</pubDate>
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<title>Conditional pharmacology/toxicology V: ambivalent effects of thiocyanate upon the development and the inhibition of experimental arthritis in rats by aurothiomalate (Myocrysin®) and metallic silver</title>
<link>http://scienceindex.com/stories/3123745/Conditional_pharmacologytoxicology_V_ambivalent_effects_of_thiocyanate_upon_the_development_and_the_inhibition_of_experimental_arthritis_in_rats_by_aurothiomalate_Myocrysin_and_metallic_silver.html</link>
<guid>http://scienceindex.com/stories/3123745/Conditional_pharmacologytoxicology_V_ambivalent_effects_of_thiocyanate_upon_the_development_and_the_inhibition_of_experimental_arthritis_in_rats_by_aurothiomalate_Myocrysin_and_metallic_silver.html</guid><description><![CDATA[This article discusses the bizarre and contrary effects of thiocyanate, the major detoxication product of hydrogen cyanide inhaled from tobacco smoke or liberated from cyanogenic foods, e.g. cassav...]]></description>
<pubDate>Sun, 19 May 2013 10:04:43 +0100</pubDate>
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<title>Benzodiazepine use during buprenorphine treatment for opioid dependen Clinical and safety outcomes</title>
<link>http://scienceindex.com/stories/3123661/Benzodiazepine_use_during_buprenorphine_treatment_for_opioid_dependen_Clinical_and_safety_outcomes.html</link>
<guid>http://scienceindex.com/stories/3123661/Benzodiazepine_use_during_buprenorphine_treatment_for_opioid_dependen_Clinical_and_safety_outcomes.html</guid><description><![CDATA[Prescribing benzodiazepines during buprenorphine treatment is a topic of active discussion. Clinical benefit is unclear. Overdose, accidental injury, and benzodiazepine misuse remain concerns. We e...]]></description>
<pubDate>Sun, 19 May 2013 07:52:29 +0100</pubDate>
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<title>A national study of substance use behaviors among NCAA male athletes who use banned performance enhancing substances</title>
<link>http://scienceindex.com/stories/3123660/A_national_study_of_substance_use_behaviors_among_NCAA_male_athletes_who_use_banned_performance_enhancing_substances.html</link>
<guid>http://scienceindex.com/stories/3123660/A_national_study_of_substance_use_behaviors_among_NCAA_male_athletes_who_use_banned_performance_enhancing_substances.html</guid><description><![CDATA[Reports of illicit substance use by college athletes have become commonplace in recent years, yet comparatively little effort has been put forth by the research community to understand these behavi...]]></description>
<pubDate>Sun, 19 May 2013 07:52:28 +0100</pubDate>
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<title>Inhibitors of the Immunoproteasome: Current Status and Future Directions</title>
<link>http://scienceindex.com/stories/3123600/Inhibitors_of_the_Immunoproteasome_Current_Status_and_Future_Directions.html</link>
<guid>http://scienceindex.com/stories/3123600/Inhibitors_of_the_Immunoproteasome_Current_Status_and_Future_Directions.html</guid><description><![CDATA[The ubiquitin-proteasome system (UPS) plays a vital role in maintaining protein homeostasis and regulating numerous cellular processes. The proteasome, a multi-protease complex, is the key componen...]]></description>
<pubDate>Sun, 19 May 2013 06:19:58 +0100</pubDate>
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<title>Negative Regulation of NEDD8 Conjugation Pathway by Novel Molecules and Agents for Anticancer Therapy</title>
<link>http://scienceindex.com/stories/3123599/Negative_Regulation_of_NEDD8_Conjugation_Pathway_by_Novel_Molecules_and_Agents_for_Anticancer_Therapy.html</link>
<guid>http://scienceindex.com/stories/3123599/Negative_Regulation_of_NEDD8_Conjugation_Pathway_by_Novel_Molecules_and_Agents_for_Anticancer_Therapy.html</guid><description><![CDATA[Tumor cells frequently promote the dysregulation of the cell cycle and escape from apoptotic cell death triggered by a number of cellular stresses. Programmed proteolytic degradation of regulatory ...]]></description>
<pubDate>Sun, 19 May 2013 06:19:56 +0100</pubDate>
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<title>Drug Combinations with Proteasome Inhibitors in Antitumor Therapy</title>
<link>http://scienceindex.com/stories/3123598/Drug_Combinations_with_Proteasome_Inhibitors_in_Antitumor_Therapy.html</link>
<guid>http://scienceindex.com/stories/3123598/Drug_Combinations_with_Proteasome_Inhibitors_in_Antitumor_Therapy.html</guid><description><![CDATA[The proteasome has been regarded as a major target for antitumor therapy in selected tumor types (i.e., multiple myeloma). Available evidence suggests that targeting the proteasome with selective c...]]></description>
<pubDate>Sun, 19 May 2013 06:19:54 +0100</pubDate>
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<title>Targeting the Ubiquitin Proteasome System: Beyond Proteasome Inhibition</title>
<link>http://scienceindex.com/stories/3123597/Targeting_the_Ubiquitin_Proteasome_System_Beyond_Proteasome_Inhibition.html</link>
<guid>http://scienceindex.com/stories/3123597/Targeting_the_Ubiquitin_Proteasome_System_Beyond_Proteasome_Inhibition.html</guid><description><![CDATA[The Ubiquitin-Proteasome System (UPS) has been considered as privileged pharmacological target for drug development due to the tremendous potential for intervention on multiple pathologies includin...]]></description>
<pubDate>Sun, 19 May 2013 06:19:52 +0100</pubDate>
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<title>Deubiquitinating Enzymes as Therapeutic Targets in Cancer</title>
<link>http://scienceindex.com/stories/3123596/Deubiquitinating_Enzymes_as_Therapeutic_Targets_in_Cancer.html</link>
<guid>http://scienceindex.com/stories/3123596/Deubiquitinating_Enzymes_as_Therapeutic_Targets_in_Cancer.html</guid><description><![CDATA[Abnormal regulation of the ubiquitin-proteasome system (UPS) has been known to be involved in the pathogenesis of a variety of human diseases. A number of studies have focused on the identification...]]></description>
<pubDate>Sun, 19 May 2013 06:19:50 +0100</pubDate>
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<title>From Bortezomib to other Inhibitors of the Proteasome and Beyond</title>
<link>http://scienceindex.com/stories/3123595/From_Bortezomib_to_other_Inhibitors_of_the_Proteasome_and_Beyond.html</link>
<guid>http://scienceindex.com/stories/3123595/From_Bortezomib_to_other_Inhibitors_of_the_Proteasome_and_Beyond.html</guid><description><![CDATA[The cancer drug discovery field has placed much emphasis on the identification of novel and cancer-specific molecular targets. A rich source of such targets for the design of novel anti-tumor agent...]]></description>
<pubDate>Sun, 19 May 2013 06:19:48 +0100</pubDate>
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<title>Safety and Efficacy of Bridging with Low Molecular Weight Heparins: A Systematic Review and Partial Meta-Analysis</title>
<link>http://scienceindex.com/stories/3123594/Safety_and_Efficacy_of_Bridging_with_Low_Molecular_Weight_Heparins_A_Systematic_Review_and_Partial_MetaAnalysis.html</link>
<guid>http://scienceindex.com/stories/3123594/Safety_and_Efficacy_of_Bridging_with_Low_Molecular_Weight_Heparins_A_Systematic_Review_and_Partial_MetaAnalysis.html</guid><description><![CDATA[Surgical interventions in patients on long term vitamin K antagonist (VKA) treatment create a dilemma; periprocedural interruption of anticoagulation raises the risk of thrombosis, while continuati...]]></description>
<pubDate>Sun, 19 May 2013 06:19:45 +0100</pubDate>
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<title>Dexmedetomidine: A Review of its Use for the Management of Pain, Agitation, and Delirium in the Intensive Care Unit</title>
<link>http://scienceindex.com/stories/3123593/Dexmedetomidine_A_Review_of_its_Use_for_the_Management_of_Pain_Agitation_and_Delirium_in_the_Intensive_Care_Unit.html</link>
<guid>http://scienceindex.com/stories/3123593/Dexmedetomidine_A_Review_of_its_Use_for_the_Management_of_Pain_Agitation_and_Delirium_in_the_Intensive_Care_Unit.html</guid><description><![CDATA[Management of pain, agitation, and delirium is a complex process requiring a multimodal approach to optimize patient outcomes. Dexmedetomidine is a centrally acting alpha-2 agonist with sedative an...]]></description>
<pubDate>Sun, 19 May 2013 06:19:43 +0100</pubDate>
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<title>Sevoflurane in Intraoperative and Postoperative Cardiac Surgery Patients. Our Experience in Intensive Care Unit with Sevoflurane Sedation</title>
<link>http://scienceindex.com/stories/3123592/Sevoflurane_in_Intraoperative_and_Postoperative_Cardiac_Surgery_Patients_Our_Experience_in_Intensive_Care_Unit_with_Sevoflurane_Sedation.html</link>
<guid>http://scienceindex.com/stories/3123592/Sevoflurane_in_Intraoperative_and_Postoperative_Cardiac_Surgery_Patients_Our_Experience_in_Intensive_Care_Unit_with_Sevoflurane_Sedation.html</guid><description><![CDATA[Recently, many studies have shown a decrease in myocardial damage in patients undergoing coronary artery bypass surgery where the anesthetic agent used was sevoflurane compared with propofol. The b...]]></description>
<pubDate>Sun, 19 May 2013 06:19:41 +0100</pubDate>
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<title>Pharmacologic Methods to Reduce Postoperative Bleeding in Adult Cardiac Surgery. A Mini-review</title>
<link>http://scienceindex.com/stories/3123591/Pharmacologic_Methods_to_Reduce_Postoperative_Bleeding_in_Adult_Cardiac_Surgery_A_Minireview.html</link>
<guid>http://scienceindex.com/stories/3123591/Pharmacologic_Methods_to_Reduce_Postoperative_Bleeding_in_Adult_Cardiac_Surgery_A_Minireview.html</guid><description><![CDATA[Because blood for transfusion is a scarce resource and since allogeneic transfusion may even be harmful, there is a growing awareness among surgeons and anesthesiologists regarding the use of multi...]]></description>
<pubDate>Sun, 19 May 2013 06:19:39 +0100</pubDate>
</item>
<item>
<title>Levosimendan Preoperative</title>
<link>http://scienceindex.com/stories/3123590/Levosimendan_Preoperative.html</link>
<guid>http://scienceindex.com/stories/3123590/Levosimendan_Preoperative.html</guid><description><![CDATA[During the last years an increasing number of patients with high perioperative risk and decreased left ventricular function are referred to cardiac and non-cardiac surgery. In this subgroup of pati...]]></description>
<pubDate>Sun, 19 May 2013 06:19:35 +0100</pubDate>
</item>
<item>
<title>Pharmacologic Treatment of Pulmonary Arterial Hypertension</title>
<link>http://scienceindex.com/stories/3123589/Pharmacologic_Treatment_of_Pulmonary_Arterial_Hypertension.html</link>
<guid>http://scienceindex.com/stories/3123589/Pharmacologic_Treatment_of_Pulmonary_Arterial_Hypertension.html</guid><description><![CDATA[Pulmonary arterial hypertension (PAH) is a rare, incurable disease characterized by adverse remodeling of the pulmonary vasculature, leading to increased pulmonary arterial pressures and right vent...]]></description>
<pubDate>Sun, 19 May 2013 06:19:34 +0100</pubDate>
</item>
<item>
<title>Perioperative B-blockers in Non-cardiac Surgery: Actual Situation</title>
<link>http://scienceindex.com/stories/3123588/Perioperative_Bblockers_in_Noncardiac_Surgery_Actual_Situation.html</link>
<guid>http://scienceindex.com/stories/3123588/Perioperative_Bblockers_in_Noncardiac_Surgery_Actual_Situation.html</guid><description><![CDATA[Cardiac events occur in &amp;#37; to &amp;#37; of patients undergoing non-cardiac surgery. Myocardial ischemia and nonfatal myocardial infarction constitute the most significant risk factors for mortality ...]]></description>
<pubDate>Sun, 19 May 2013 06:19:32 +0100</pubDate>
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<title>Current status of local therapy in malignant gliomas – a clinical review of three selected approaches</title>
<link>http://scienceindex.com/stories/3123548/Current_status_of_local_therapy_in_malignant_gliomas__a_clinical_review_of_three_selected_approaches.html</link>
<guid>http://scienceindex.com/stories/3123548/Current_status_of_local_therapy_in_malignant_gliomas__a_clinical_review_of_three_selected_approaches.html</guid><description><![CDATA[Malignant gliomas are the most frequently occurring, devastating primary brain tumors, and are coupled with a poor survival rate. Despite the fact that complete neurosurgical resection of these tum...]]></description>
<pubDate>Sun, 19 May 2013 05:17:36 +0100</pubDate>
</item>
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<title>Opioid μ-receptors as new target for insulin resistance</title>
<link>http://scienceindex.com/stories/3123549/Opioid_receptors_as_new_target_for_insulin_resistance.html</link>
<guid>http://scienceindex.com/stories/3123549/Opioid_receptors_as_new_target_for_insulin_resistance.html</guid><description><![CDATA[Type-2 diabetes is one of the fastest growing public health problems worldwide resulting from both environmental and genetic factors. Activation of μ-opioid receptor (MOR) could result in reversal...]]></description>
<pubDate>Sun, 19 May 2013 05:17:36 +0100</pubDate>
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