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<language>en-us</language>
<description>Sciences Indexed Since 1998</description>
<title>Oncology - Sciences Indexed Since 1998</title>
<atom:link href="http://scienceindex.com/xmlfeeds.php?cmd=popular&amp;id=54" rel="self" type="application/rss+xml" /><link>http://scienceindex.com/view/54/Oncology/1.html</link>
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<title>Selective Ablation of Tumor-Associated Macrophages (TAMs) Suppresses Metastasis and Angiogenesis</title>
<link>http://scienceindex.com/stories/3131452/Selective_Ablation_of_TumorAssociated_Macrophages_TAMs_Suppresses_Metastasis_and_Angiogenesis.html</link>
<guid>http://scienceindex.com/stories/3131452/Selective_Ablation_of_TumorAssociated_Macrophages_TAMs_Suppresses_Metastasis_and_Angiogenesis.html</guid><description><![CDATA[Tumor-associated macrophages (TAMs) play a critical role in promoting tumor development and metastasis. In this study, we found that legumain, an asparaginyl endopeptidase, was highly expressed on ...]]></description>
<pubDate>Wed, 22 May 2013 17:12:33 +0100</pubDate>
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<title>Statin therapy is not associated with prostate cancer recurrence among patients who underwent radiation therapy</title>
<link>http://scienceindex.com/stories/3131399/Statin_therapy_is_not_associated_with_prostate_cancer_recurrence_among_patients_who_underwent_radiation_therapy.html</link>
<guid>http://scienceindex.com/stories/3131399/Statin_therapy_is_not_associated_with_prostate_cancer_recurrence_among_patients_who_underwent_radiation_therapy.html</guid><description><![CDATA[We investigated whether statin use is associated with reduced risk of recurrence in prostate cancer patients who undergo radiotherapy. A retrospective cohort of 774 patients from a California healt...]]></description>
<pubDate>Wed, 22 May 2013 16:37:47 +0100</pubDate>
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<title>MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2</title>
<link>http://scienceindex.com/stories/3131400/MicroRNA146a_acts_as_a_metastasis_suppressor_in_gastric_cancer_by_targeting_WASF2.html</link>
<guid>http://scienceindex.com/stories/3131400/MicroRNA146a_acts_as_a_metastasis_suppressor_in_gastric_cancer_by_targeting_WASF2.html</guid><description><![CDATA[Previous studies have shown that miR-146a acts as either an oncogene or a tumor suppressor in various cancers. In this study, we investigated the role of miR-146a in gastric cancer cells and its po...]]></description>
<pubDate>Wed, 22 May 2013 16:37:47 +0100</pubDate>
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<title>V600EBRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism</title>
<link>http://scienceindex.com/stories/3131401/V600EBRAF_promotes_invasiveness_of_thyroid_cancer_cells_by_decreasing_Ecadherin_expression_through_a_Snaildependent_mechanism.html</link>
<guid>http://scienceindex.com/stories/3131401/V600EBRAF_promotes_invasiveness_of_thyroid_cancer_cells_by_decreasing_Ecadherin_expression_through_a_Snaildependent_mechanism.html</guid><description><![CDATA[BRAF is a main oncogene in human thyroid cancer. Here, we show that BRAF depletion by siRNA or inhibition of its activity by treatment with BRAF inhibitor PLX4720 decreases migration and invasion i...]]></description>
<pubDate>Wed, 22 May 2013 16:37:47 +0100</pubDate>
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<title>Plasmid-based E6-specific siRNA and co-expression of wild-type p53 suppresses the growth of cervical cancer in vitro and in vivo</title>
<link>http://scienceindex.com/stories/3131402/Plasmidbased_E6specific_siRNA_and_coexpression_of_wildtype_p53_suppresses_the_growth_of_cervical_cancer_in_vitro_and_in_vivo.html</link>
<guid>http://scienceindex.com/stories/3131402/Plasmidbased_E6specific_siRNA_and_coexpression_of_wildtype_p53_suppresses_the_growth_of_cervical_cancer_in_vitro_and_in_vivo.html</guid><description><![CDATA[The E6 protein of the oncogenic HPV-16 functions by interfering with the normal cell cycle control mechanisms, particularly those controlled by p53. In this study, we developed a dual expression pl...]]></description>
<pubDate>Wed, 22 May 2013 16:37:47 +0100</pubDate>
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<title>IGF1R-directed targeted therapy enhances the cytotoxic effect of chemotherapy in endometrial cancer</title>
<link>http://scienceindex.com/stories/3131391/IGF1Rdirected_targeted_therapy_enhances_the_cytotoxic_effect_of_chemotherapy_in_endometrial_cancer.html</link>
<guid>http://scienceindex.com/stories/3131391/IGF1Rdirected_targeted_therapy_enhances_the_cytotoxic_effect_of_chemotherapy_in_endometrial_cancer.html</guid><description><![CDATA[This study evaluated the potential ability of MK-0646 to inhibit IGF1-mediated biological actions and cell signaling events in Type 1 and Type 2 endometrial cancer. We found that MK-0646 treatment ...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>Role of β-Catenin in regulating the balance between TNF-α- and Fas-induced acute liver injury</title>
<link>http://scienceindex.com/stories/3131392/Role_of_Catenin_in_regulating_the_balance_between_TNF_and_Fasinduced_acute_liver_injury.html</link>
<guid>http://scienceindex.com/stories/3131392/Role_of_Catenin_in_regulating_the_balance_between_TNF_and_Fasinduced_acute_liver_injury.html</guid><description><![CDATA[Β-Catenin plays many critical roles during various liver physiological and pathological processes. However, the role of β-Catenin in acute liver failure remains unclear. Using hepatocyte specific...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7</title>
<link>http://scienceindex.com/stories/3131393/MicroRNA25_functions_as_a_potential_tumor_suppressor_in_colon_cancer_by_targeting_Smad7.html</link>
<guid>http://scienceindex.com/stories/3131393/MicroRNA25_functions_as_a_potential_tumor_suppressor_in_colon_cancer_by_targeting_Smad7.html</guid><description><![CDATA[Because it is a member of the miR-106b∼25 cluster, microRNA-25 (miR-25) is known to be dysregulated in human cancers. However, the expression and role of miR-25 in colon cancer remain unclear. In...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment</title>
<link>http://scienceindex.com/stories/3131394/The_inhibition_of_Nek6_function_sensitizes_human_cancer_cells_to_premature_senescence_upon_serum_reduction_or_anticancer_drug_treatment.html</link>
<guid>http://scienceindex.com/stories/3131394/The_inhibition_of_Nek6_function_sensitizes_human_cancer_cells_to_premature_senescence_upon_serum_reduction_or_anticancer_drug_treatment.html</guid><description><![CDATA[The induction of premature senescence in cancer cells was proposed as an effective cancer treatment strategy. In this paper, we show that the inhibition of Nek6 expression by Nek6 siRNA-mediated kn...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>A novel therapeutic strategy using ultrasound mediated microbubbles destruction to treat colon cancer in a mouse model</title>
<link>http://scienceindex.com/stories/3131395/A_novel_therapeutic_strategy_using_ultrasound_mediated_microbubbles_destruction_to_treat_colon_cancer_in_a_mouse_model.html</link>
<guid>http://scienceindex.com/stories/3131395/A_novel_therapeutic_strategy_using_ultrasound_mediated_microbubbles_destruction_to_treat_colon_cancer_in_a_mouse_model.html</guid><description><![CDATA[The goal of this study was to determine whether ultrasound mediated microbubbles destruction (UMMD) could inhibit colon cancer growth in a mouse model. Six-week-old balb/c female nude mice were sub...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>Octa-arginine-modified pegylated liposomal doxorubicin: An effective treatment strategy for non-small cell lung cancer</title>
<link>http://scienceindex.com/stories/3131396/Octaargininemodified_pegylated_liposomal_doxorubicin_An_effective_treatment_strategy_for_nonsmall_cell_lung_cancer.html</link>
<guid>http://scienceindex.com/stories/3131396/Octaargininemodified_pegylated_liposomal_doxorubicin_An_effective_treatment_strategy_for_nonsmall_cell_lung_cancer.html</guid><description><![CDATA[The present study aims to evaluate the efficacy of octa-arginine (R8)-modified pegylated liposomal doxorubicin (R8-PLD) for the treatment of non-small cell lung cancer, for which the primary treatm...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth</title>
<link>http://scienceindex.com/stories/3131397/Exosomes_from_marrow_stromal_cells_expressing_miR146b_inhibit_glioma_growth.html</link>
<guid>http://scienceindex.com/stories/3131397/Exosomes_from_marrow_stromal_cells_expressing_miR146b_inhibit_glioma_growth.html</guid><description><![CDATA[Exosomes are 30–150nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>TGF-β1-induced epithelial–mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in Human A549 lung cancer cells</title>
<link>http://scienceindex.com/stories/3131398/TGF1induced_epithelialmesenchymal_transition_and_acetylation_of_Smad2_and_Smad3_are_negatively_regulated_by_EGCG_in_Human_A549_lung_cancer_cells.html</link>
<guid>http://scienceindex.com/stories/3131398/TGF1induced_epithelialmesenchymal_transition_and_acetylation_of_Smad2_and_Smad3_are_negatively_regulated_by_EGCG_in_Human_A549_lung_cancer_cells.html</guid><description><![CDATA[Transforming growth factor-β1, the key ligand of Smad-dependent signaling pathway, is critical for epithelial–mesenchymal transition during embryo-morphogenesis, fibrotic diseases, and tumor met...]]></description>
<pubDate>Wed, 22 May 2013 16:37:46 +0100</pubDate>
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<title>Imaging integrin αvβ3 positive glioma with a novel RGD dimer probe and the impact of antiangiogenic agent (Endostar) on its tumor uptake</title>
<link>http://scienceindex.com/stories/3131388/Imaging_integrin_v3_positive_glioma_with_a_novel_RGD_dimer_probe_and_the_impact_of_antiangiogenic_agent_Endostar_on_its_tumor_uptake.html</link>
<guid>http://scienceindex.com/stories/3131388/Imaging_integrin_v3_positive_glioma_with_a_novel_RGD_dimer_probe_and_the_impact_of_antiangiogenic_agent_Endostar_on_its_tumor_uptake.html</guid><description><![CDATA[Integrin αvβ3 has been recognized to play an important role in angiogenesis, tumor growth and metastasis. It will be of interest to apply this promising target for tumor imaging and visualization...]]></description>
<pubDate>Wed, 22 May 2013 16:37:45 +0100</pubDate>
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<title>Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres</title>
<link>http://scienceindex.com/stories/3131389/Role_of_MIFCXCL8CXCR2_signaling_in_the_growth_of_nasopharyngeal_carcinoma_tumor_spheres.html</link>
<guid>http://scienceindex.com/stories/3131389/Role_of_MIFCXCL8CXCR2_signaling_in_the_growth_of_nasopharyngeal_carcinoma_tumor_spheres.html</guid><description><![CDATA[Macrophage migration inhibitory factor (MIF) and CXCL8 (also named IL-8) are strongly expressed in the tissues of nasopharyngeal carcinoma (NPC). However, their role in the growth of NPC has not be...]]></description>
<pubDate>Wed, 22 May 2013 16:37:45 +0100</pubDate>
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<title>OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells</title>
<link>http://scienceindex.com/stories/3131390/OPB31121_a_novel_small_molecular_inhibitor_disrupts_the_JAK2STAT3_pathway_and_exhibits_an_antitumor_activity_in_gastric_cancer_cells.html</link>
<guid>http://scienceindex.com/stories/3131390/OPB31121_a_novel_small_molecular_inhibitor_disrupts_the_JAK2STAT3_pathway_and_exhibits_an_antitumor_activity_in_gastric_cancer_cells.html</guid><description><![CDATA[We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression and inhibited JAK2 p...]]></description>
<pubDate>Wed, 22 May 2013 16:37:45 +0100</pubDate>
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<title>PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors</title>
<link>http://scienceindex.com/stories/3131384/PI3KAktmTOR_pathway_inhibitors_in_the_therapy_of_pancreatic_neuroendocrine_tumors.html</link>
<guid>http://scienceindex.com/stories/3131384/PI3KAktmTOR_pathway_inhibitors_in_the_therapy_of_pancreatic_neuroendocrine_tumors.html</guid><description><![CDATA[The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is implicated in the pathogenesis of pancreatic neuroendocrine tumors (pNETs). Activation of this pathway i...]]></description>
<pubDate>Wed, 22 May 2013 16:37:44 +0100</pubDate>
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<title>Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer</title>
<link>http://scienceindex.com/stories/3131385/Phosphatase_PP2A_structural_importance_regulation_and_its_aberrant_expression_in_cancer.html</link>
<guid>http://scienceindex.com/stories/3131385/Phosphatase_PP2A_structural_importance_regulation_and_its_aberrant_expression_in_cancer.html</guid><description><![CDATA[Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules like Akt, p53,...]]></description>
<pubDate>Wed, 22 May 2013 16:37:44 +0100</pubDate>
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<title>Pin1 is required for ultraviolet A-stimulated cyclooxygenase-2 induction in mouse epidermal cells</title>
<link>http://scienceindex.com/stories/3131386/Pin1_is_required_for_ultraviolet_Astimulated_cyclooxygenase2_induction_in_mouse_epidermal_cells.html</link>
<guid>http://scienceindex.com/stories/3131386/Pin1_is_required_for_ultraviolet_Astimulated_cyclooxygenase2_induction_in_mouse_epidermal_cells.html</guid><description><![CDATA[Ultraviolet A (UVA) radiation (320–400nm) is considered a major cause of human skin photoaging and skin cancer. Overexpression of cyclooxygenase-2 (COX-2) leads to prostanoid formation in skin ti...]]></description>
<pubDate>Wed, 22 May 2013 16:37:44 +0100</pubDate>
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<title>Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer</title>
<link>http://scienceindex.com/stories/3131387/Notch_signaling_pathway_targeted_therapy_suppresses_tumor_progression_and_metastatic_spread_in_pancreatic_cancer.html</link>
<guid>http://scienceindex.com/stories/3131387/Notch_signaling_pathway_targeted_therapy_suppresses_tumor_progression_and_metastatic_spread_in_pancreatic_cancer.html</guid><description><![CDATA[Pancreatic ductal adenocarcinoma (PDA) remains a lethal human malignancy with historically limited success in treatment. The role of aberrant Notch signaling, which requires the constitutive activa...]]></description>
<pubDate>Wed, 22 May 2013 16:37:44 +0100</pubDate>
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<title>A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells</title>
<link>http://scienceindex.com/stories/3131118/A_new_assay_for_measuring_chromosome_instability_CIN_and_identification_of_drugs_that_elevate_CIN_in_cancer_cells.html</link>
<guid>http://scienceindex.com/stories/3131118/A_new_assay_for_measuring_chromosome_instability_CIN_and_identification_of_drugs_that_elevate_CIN_in_cancer_cells.html</guid><description><![CDATA[Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer...]]></description>
<pubDate>Wed, 22 May 2013 14:53:49 +0100</pubDate>
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<title>Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer</title>
<link>http://scienceindex.com/stories/3131117/Antioxidantmediated_upregulation_of_OGG1_via_NRF2_induction_is_associated_with_inhibition_of_oxidative_DNA_damage_in_estrogeninduced_breast_cancer.html</link>
<guid>http://scienceindex.com/stories/3131117/Antioxidantmediated_upregulation_of_OGG1_via_NRF2_induction_is_associated_with_inhibition_of_oxidative_DNA_damage_in_estrogeninduced_breast_cancer.html</guid><description><![CDATA[Estrogen metabolism-mediated oxidative stress is suggested to play an important role in estrogen-induced breast carcinogenesis. We have earlier demonstrated that antioxidants, vitamin C (Vit C) and...]]></description>
<pubDate>Wed, 22 May 2013 14:53:48 +0100</pubDate>
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<title>Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: A WECARE Study Report</title>
<link>http://scienceindex.com/stories/3131099/Contralateral_breast_cancer_after_radiotherapy_among_BRCA1_and_BRCA2_mutation_carriers_A_WECARE_Study_Report.html</link>
<guid>http://scienceindex.com/stories/3131099/Contralateral_breast_cancer_after_radiotherapy_among_BRCA1_and_BRCA2_mutation_carriers_A_WECARE_Study_Report.html</guid><description><![CDATA[Women with germline BRCA1 or BRCA2 (BRCA1/BRCA2) mutations are at very high risk of developing breast cancer, including asynchronous contralateral breast cancer (CBC). BRCA1/BRCA2 genes help mainta...]]></description>
<pubDate>Wed, 22 May 2013 14:43:33 +0100</pubDate>
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<title>Role of cardioprotective therapy for prevention of cardiotoxicity with chemotherapy: A systematic review and meta-analysis</title>
<link>http://scienceindex.com/stories/3131098/Role_of_cardioprotective_therapy_for_prevention_of_cardiotoxicity_with_chemotherapy_A_systematic_review_and_metaanalysis.html</link>
<guid>http://scienceindex.com/stories/3131098/Role_of_cardioprotective_therapy_for_prevention_of_cardiotoxicity_with_chemotherapy_A_systematic_review_and_metaanalysis.html</guid><description><![CDATA[Cardiotoxicity is a well-recognised complication of chemotherapy with anthracycline and/or trastuzumab, and its prevention remains an important challenge in cancer survivorship. Several successful ...]]></description>
<pubDate>Wed, 22 May 2013 14:43:33 +0100</pubDate>
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<title>Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer</title>
<link>http://scienceindex.com/stories/3130893/Hyperinsulinemia_promotes_metastasis_to_the_lung_in_a_mouse_model_of_Her2mediated_breast_cancer.html</link>
<guid>http://scienceindex.com/stories/3130893/Hyperinsulinemia_promotes_metastasis_to_the_lung_in_a_mouse_model_of_Her2mediated_breast_cancer.html</guid><description><![CDATA[The Her2 oncogene is expressed in ~25% of human breast cancers and is associated with metastatic progression and poor outcome. Epidemiological studies report that breast cancer incidence and mortal...]]></description>
<pubDate>Wed, 22 May 2013 13:15:00 +0100</pubDate>
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<title>Estrogen receptor beta expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naive prostate cancer and are elevated in castration-resistant disease</title>
<link>http://scienceindex.com/stories/3130894/Estrogen_receptor_beta_expression_and_androgen_receptor_phosphorylation_correlate_with_a_poor_clinical_outcome_in_hormonenaive_prostate_cancer_and_are_elevated_in_castrationresistant_disease.html</link>
<guid>http://scienceindex.com/stories/3130894/Estrogen_receptor_beta_expression_and_androgen_receptor_phosphorylation_correlate_with_a_poor_clinical_outcome_in_hormonenaive_prostate_cancer_and_are_elevated_in_castrationresistant_disease.html</guid><description><![CDATA[Patients with advanced prostate cancer (PC) are usually treated with androgen withdrawal. While this therapy is initially effective, nearly all PCs become refractory to it. As hormone receptors pla...]]></description>
<pubDate>Wed, 22 May 2013 13:15:00 +0100</pubDate>
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<title>PXD101 potentiates hormonal therapy and prevents the onset of castration-resistant phenotype modulating androgen receptor, HSP90, and CRM1 in preclinical models of prostate cancer</title>
<link>http://scienceindex.com/stories/3130888/PXD101_potentiates_hormonal_therapy_and_prevents_the_onset_of_castrationresistant_phenotype_modulating_androgen_receptor_HSP90_and_CRM1_in_preclinical_models_of_prostate_cancer.html</link>
<guid>http://scienceindex.com/stories/3130888/PXD101_potentiates_hormonal_therapy_and_prevents_the_onset_of_castrationresistant_phenotype_modulating_androgen_receptor_HSP90_and_CRM1_in_preclinical_models_of_prostate_cancer.html</guid><description><![CDATA[Aberrant activation or &amp;lsquo;reactivation&amp;rsquo; of androgen receptor (AR) during androgen ablation therapy shows a potential cause for the development of castration-resistant prostate cancer. Thi...]]></description>
<pubDate>Wed, 22 May 2013 13:14:59 +0100</pubDate>
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<title>In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas</title>
<link>http://scienceindex.com/stories/3130889/In_vivo_and_in_vitro_oncogenic_effects_of_HIF2A_mutations_in_pheochromocytomas_and_paragangliomas.html</link>
<guid>http://scienceindex.com/stories/3130889/In_vivo_and_in_vitro_oncogenic_effects_of_HIF2A_mutations_in_pheochromocytomas_and_paragangliomas.html</guid><description><![CDATA[Pheochromocytomas and paragangliomas are highly vascular tumors of the autonomic nervous system. Germline mutations, including those in hypoxia-related genes, occur in one third of the cases, but s...]]></description>
<pubDate>Wed, 22 May 2013 13:14:59 +0100</pubDate>
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<title>TOP2A is overexpressed and is a therapeutic target for adrenocortical carcinoma</title>
<link>http://scienceindex.com/stories/3130890/TOP2A_is_overexpressed_and_is_a_therapeutic_target_for_adrenocortical_carcinoma.html</link>
<guid>http://scienceindex.com/stories/3130890/TOP2A_is_overexpressed_and_is_a_therapeutic_target_for_adrenocortical_carcinoma.html</guid><description><![CDATA[Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy with no effective therapy for patients with unresectable disease. The aim of the current study was i) to evaluate TOP2A expression...]]></description>
<pubDate>Wed, 22 May 2013 13:14:59 +0100</pubDate>
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<title>Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells</title>
<link>http://scienceindex.com/stories/3130891/Mitotane_alters_mitochondrial_respiratory_chain_activity_by_inducing_cytochrome_c_oxidase_defect_in_human_adrenocortical_cells.html</link>
<guid>http://scienceindex.com/stories/3130891/Mitotane_alters_mitochondrial_respiratory_chain_activity_by_inducing_cytochrome_c_oxidase_defect_in_human_adrenocortical_cells.html</guid><description><![CDATA[Mitotane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane is the most effective medical therapy for adrenocortical carcinoma, but its molecular mechanism of action remains poorly understoo...]]></description>
<pubDate>Wed, 22 May 2013 13:14:59 +0100</pubDate>
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<title>A multi-institutional, phase II open-label study of ganitumab (AMG 479) in advanced carcinoid and pancreatic neuroendocrine tumors</title>
<link>http://scienceindex.com/stories/3130892/A_multiinstitutional_phase_II_openlabel_study_of_ganitumab_AMG_479_in_advanced_carcinoid_and_pancreatic_neuroendocrine_tumors.html</link>
<guid>http://scienceindex.com/stories/3130892/A_multiinstitutional_phase_II_openlabel_study_of_ganitumab_AMG_479_in_advanced_carcinoid_and_pancreatic_neuroendocrine_tumors.html</guid><description><![CDATA[The IGF pathway has been implicated in the regulation of neuroendocrine tumor (NET) growth, and preliminary studies suggested that ganitumab (AMG 479), a human MAB against IGF1R, may have antitumor...]]></description>
<pubDate>Wed, 22 May 2013 13:14:59 +0100</pubDate>
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<title>Linking inflammation and neuroendocrine differentiation: the role of macrophage migration inhibitory factor-mediated signaling in prostate cancer</title>
<link>http://scienceindex.com/stories/3130887/Linking_inflammation_and_neuroendocrine_differentiation_the_role_of_macrophage_migration_inhibitory_factormediated_signaling_in_prostate_cancer.html</link>
<guid>http://scienceindex.com/stories/3130887/Linking_inflammation_and_neuroendocrine_differentiation_the_role_of_macrophage_migration_inhibitory_factormediated_signaling_in_prostate_cancer.html</guid><description><![CDATA[A new paper by Tawadros et al. in Endocrine-Related Cancer demonstrates a link between macrophage migration inhibitory factor and neuroendocrine differentiation in prostate cancer. This paper may h...]]></description>
<pubDate>Wed, 22 May 2013 13:14:58 +0100</pubDate>
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<title>Association between GSTP1 Ile105Val polymorphism and oxaliplatin-induced neuropathy: a systematic review and meta-analysis</title>
<link>http://scienceindex.com/stories/3130801/Association_between_GSTP1_Ile105Val_polymorphism_and_oxaliplatininduced_neuropathy_a_systematic_review_and_metaanalysis.html</link>
<guid>http://scienceindex.com/stories/3130801/Association_between_GSTP1_Ile105Val_polymorphism_and_oxaliplatininduced_neuropathy_a_systematic_review_and_metaanalysis.html</guid><description><![CDATA[The association between glutathione-S-transferase P1 (GSTP1) Ile105Val polymorphism and oxaliplatin-induced neuropathy has been investigated in a number of published studies. However, most of these...]]></description>
<pubDate>Wed, 22 May 2013 12:26:58 +0100</pubDate>
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<title>Tumor associated macrophages in relapsed and refractory Hodgkin lymphoma</title>
<link>http://scienceindex.com/stories/3130289/Tumor_associated_macrophages_in_relapsed_and_refractory_Hodgkin_lymphoma.html</link>
<guid>http://scienceindex.com/stories/3130289/Tumor_associated_macrophages_in_relapsed_and_refractory_Hodgkin_lymphoma.html</guid><description><![CDATA[Growing evidence demonstrates that an increased number of CD68 positive tumor-associated macrophages (TAM) is associated with decreased survival in patients with newly diagnosed classic Hodgkin lym...]]></description>
<pubDate>Wed, 22 May 2013 08:33:07 +0100</pubDate>
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<title>Computed tomographic colonography (CTC); colorectal cancer diagnosis with CTC in an Auckland population</title>
<link>http://scienceindex.com/stories/3130282/Computed_tomographic_colonography_CTC_colorectal_cancer_diagnosis_with_CTC_in_an_Auckland_population.html</link>
<guid>http://scienceindex.com/stories/3130282/Computed_tomographic_colonography_CTC_colorectal_cancer_diagnosis_with_CTC_in_an_Auckland_population.html</guid><description><![CDATA[To determine the sensitivity of computed tomographic colonography (CTC) in the detection of colorectal cancer in our population and evaluate the reasons why these lesions may be missed on CTC. All ...]]></description>
<pubDate>Wed, 22 May 2013 08:21:55 +0100</pubDate>
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<title>Nanoparticle albumin-bound paclitaxel for second-line treatment of metastatic urothelial carcinoma: a single group, multicentre, phase 2 study</title>
<link>http://scienceindex.com/stories/3129865/Nanoparticle_albuminbound_paclitaxel_for_secondline_treatment_of_metastatic_urothelial_carcinoma_a_single_group_multicentre_phase_2_study.html</link>
<guid>http://scienceindex.com/stories/3129865/Nanoparticle_albuminbound_paclitaxel_for_secondline_treatment_of_metastatic_urothelial_carcinoma_a_single_group_multicentre_phase_2_study.html</guid><description><![CDATA[No standard treatment exists for patients with platinum-refractory urothelial cancer. Taxanes and vinflunine are commonly used, but response is less than 20% with no survival benefit. In this phase...]]></description>
<pubDate>Wed, 22 May 2013 05:29:30 +0100</pubDate>
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<title>Colorectal cancer screening: are stool and blood based tests good enough?</title>
<link>http://scienceindex.com/stories/3129632/Colorectal_cancer_screening_are_stool_and_blood_based_tests_good_enough.html</link>
<guid>http://scienceindex.com/stories/3129632/Colorectal_cancer_screening_are_stool_and_blood_based_tests_good_enough.html</guid><description><![CDATA[Colorectal cancer (CRC) is the third commonest cancer worldwide. As many CRC patients were identified at advanced stages, screening asymptomatic individuals has substantial clinical benefit. Most C...]]></description>
<pubDate>Wed, 22 May 2013 03:34:08 +0100</pubDate>
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<title>Paradigm of polyendocrine therapy in endocrine responsive breast cancer: the role of fulvestrant</title>
<link>http://scienceindex.com/stories/3129633/Paradigm_of_polyendocrine_therapy_in_endocrine_responsive_breast_cancer_the_role_of_fulvestrant.html</link>
<guid>http://scienceindex.com/stories/3129633/Paradigm_of_polyendocrine_therapy_in_endocrine_responsive_breast_cancer_the_role_of_fulvestrant.html</guid><description><![CDATA[Endocrine therapy is the cornerstone of any treatment plan for endocrine-responsive breast cancer in both the adjuvant and metastatic settings (1). In the metastatic setting in post-menopausal pati...]]></description>
<pubDate>Wed, 22 May 2013 03:34:08 +0100</pubDate>
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<title>Can EGFR mutation status evolve with chemotherapy?</title>
<link>http://scienceindex.com/stories/3129625/Can_EGFR_mutation_status_evolve_with_chemotherapy.html</link>
<guid>http://scienceindex.com/stories/3129625/Can_EGFR_mutation_status_evolve_with_chemotherapy.html</guid><description><![CDATA[Epidermal growth factor receptor (EGFR) inhibition by oral tyrosine kinase inhibitors (TKIs) and platinum-based chemotherapy are important treatment strategies for advanced non-small-cell lung canc...]]></description>
<pubDate>Wed, 22 May 2013 03:34:07 +0100</pubDate>
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<title>EGFR mutation in lung cancer: tumor heterogeneity and the impact of chemotherapy</title>
<link>http://scienceindex.com/stories/3129626/EGFR_mutation_in_lung_cancer_tumor_heterogeneity_and_the_impact_of_chemotherapy.html</link>
<guid>http://scienceindex.com/stories/3129626/EGFR_mutation_in_lung_cancer_tumor_heterogeneity_and_the_impact_of_chemotherapy.html</guid><description><![CDATA[EGFR inhibitors have been examined as treatments for unselected NSCLC patients until the discovery that activating EGFR mutations render the tumors highly sensitive to these drugs (1,2). Since then...]]></description>
<pubDate>Wed, 22 May 2013 03:34:07 +0100</pubDate>
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<title>Drifting EGFR mutation</title>
<link>http://scienceindex.com/stories/3129627/Drifting_EGFR_mutation.html</link>
<guid>http://scienceindex.com/stories/3129627/Drifting_EGFR_mutation.html</guid><description><![CDATA[It is generally accepted that somatic mutation in the EGFR gene can serve as a biomarker for predicting the efficacy of treatment with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibi...]]></description>
<pubDate>Wed, 22 May 2013 03:34:07 +0100</pubDate>
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<title>Prostate carcinoma in transgenic Lewis rats - a tumor model for evaluation of immunological treatments</title>
<link>http://scienceindex.com/stories/3129628/Prostate_carcinoma_in_transgenic_Lewis_rats__a_tumor_model_for_evaluation_of_immunological_treatments.html</link>
<guid>http://scienceindex.com/stories/3129628/Prostate_carcinoma_in_transgenic_Lewis_rats__a_tumor_model_for_evaluation_of_immunological_treatments.html</guid><description><![CDATA[Transgenic rodent models of prostate cancer have served as valuable preclinical models to evaluate novel treatments and understand malignant disease progression. In particular, a transgenic rat aut...]]></description>
<pubDate>Wed, 22 May 2013 03:34:07 +0100</pubDate>
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<title>Molecular therapy for gastric cancer</title>
<link>http://scienceindex.com/stories/3129629/Molecular_therapy_for_gastric_cancer.html</link>
<guid>http://scienceindex.com/stories/3129629/Molecular_therapy_for_gastric_cancer.html</guid><description><![CDATA[Several agents that target specific molecules have been investigated for the treatment of gastric cancer in many preclinical and clinical studies. Anti-HER2 antibody, when combined with classical c...]]></description>
<pubDate>Wed, 22 May 2013 03:34:07 +0100</pubDate>
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<title>Current status and future direction of chemotherapy for pancreatic cancer</title>
<link>http://scienceindex.com/stories/3129630/Current_status_and_future_direction_of_chemotherapy_for_pancreatic_cancer.html</link>
<guid>http://scienceindex.com/stories/3129630/Current_status_and_future_direction_of_chemotherapy_for_pancreatic_cancer.html</guid><description><![CDATA[Pancreatic carcinoma is a disease with a dismal prognosis; the 5-year survival rate of patients diagnosed with this cancer remains less than 5% (1). Since it is difficult to diagnose pancreatic can...]]></description>
<pubDate>Wed, 22 May 2013 03:34:07 +0100</pubDate>
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<title>The B7-H1/PD-1 pathway in cancers associated with infections and inflammation: opportunities for therapeutic intervention</title>
<link>http://scienceindex.com/stories/3129631/The_B7H1PD1_pathway_in_cancers_associated_with_infections_and_inflammation_opportunities_for_therapeutic_intervention.html</link>
<guid>http://scienceindex.com/stories/3129631/The_B7H1PD1_pathway_in_cancers_associated_with_infections_and_inflammation_opportunities_for_therapeutic_intervention.html</guid><description><![CDATA[Almost one fifth of malignancies worldwide and about one quarter in China are associated with viral or bacterial infections, mediating an inflammatory environment in the tumor. Hepatitis viruses (B...]]></description>
<pubDate>Wed, 22 May 2013 03:34:07 +0100</pubDate>
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<title>Single-incision laparoscopic distal gastrectomy for early gastric cancer</title>
<link>http://scienceindex.com/stories/3129542/Singleincision_laparoscopic_distal_gastrectomy_for_early_gastric_cancer.html</link>
<guid>http://scienceindex.com/stories/3129542/Singleincision_laparoscopic_distal_gastrectomy_for_early_gastric_cancer.html</guid><description><![CDATA[Laparoscopic gastrectomy for early gastric cancer has been widely adopted as an alternative treatment option and has been reported to be beneficial for patients, with better early postoperative out...]]></description>
<pubDate>Wed, 22 May 2013 03:33:39 +0100</pubDate>
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<title>Mid-term results after single incision transumbilical laparoscopic sleeve gastrectomy</title>
<link>http://scienceindex.com/stories/3129543/Midterm_results_after_single_incision_transumbilical_laparoscopic_sleeve_gastrectomy.html</link>
<guid>http://scienceindex.com/stories/3129543/Midterm_results_after_single_incision_transumbilical_laparoscopic_sleeve_gastrectomy.html</guid><description><![CDATA[Laparoscopic sleeve gastrectomy (LSG) is gaining large popularity as a stand-alone bariatric procedure. Single incision laparoscopic surgery (SILS) was successfully used in bariatric surgery. In 20...]]></description>
<pubDate>Wed, 22 May 2013 03:33:39 +0100</pubDate>
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<title>Laparoscopy-assisted gastrectomy following neoadjuvant chemotherapy for advanced gastric cancer - strategies for development</title>
<link>http://scienceindex.com/stories/3129544/Laparoscopyassisted_gastrectomy_following_neoadjuvant_chemotherapy_for_advanced_gastric_cancer__strategies_for_development.html</link>
<guid>http://scienceindex.com/stories/3129544/Laparoscopyassisted_gastrectomy_following_neoadjuvant_chemotherapy_for_advanced_gastric_cancer__strategies_for_development.html</guid><description><![CDATA[The established treatment for advanced gastric cancer is open gastrectomy with D2 lymph node dissection and postoperative adjuvant chemotherapy with S-1 or capecitabine plus oxaliplatin. However, t...]]></description>
<pubDate>Wed, 22 May 2013 03:33:39 +0100</pubDate>
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<title>Laparoscopic D2 dissection for locally advanced gastric cancer in China</title>
<link>http://scienceindex.com/stories/3129545/Laparoscopic_D2_dissection_for_locally_advanced_gastric_cancer_in_China.html</link>
<guid>http://scienceindex.com/stories/3129545/Laparoscopic_D2_dissection_for_locally_advanced_gastric_cancer_in_China.html</guid><description><![CDATA[Minimally invasive surgery has become one of the most important concepts during the development of surgery in the 21st century, among which the laparoscopic technique represents a major advancement...]]></description>
<pubDate>Wed, 22 May 2013 03:33:39 +0100</pubDate>
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<title>Perfect-results after laparoscopic surgery for gastroesophageal reflux - are they achievable?</title>
<link>http://scienceindex.com/stories/3129546/Perfectresults_after_laparoscopic_surgery_for_gastroesophageal_reflux__are_they_achievable.html</link>
<guid>http://scienceindex.com/stories/3129546/Perfectresults_after_laparoscopic_surgery_for_gastroesophageal_reflux__are_they_achievable.html</guid><description><![CDATA[In the quest for the perfect outcome following antireflux surgery, Nissen’s original fundoplication has undergone many modifications. The original procedure achieved good reflux control, but this...]]></description>
<pubDate>Wed, 22 May 2013 03:33:39 +0100</pubDate>
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