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Rheumatology

Sustained drug-free remission in rheumatoid arthritis after DAS-driven or non-DAS-driven therapy: a comparison of two cohort studies
submitted by EfraDarien 17 hours ago
To compare the prevalence of and predictors for sustained drug-free remission in two cohorts of patients with recent-onset RA treated with DAS-driven therapy or non-DAS-driven therapy.Methods. Sust...
 


No significant change in arterial stiffness in RA after 6 months and 1 year of rituximab treatment
submitted by onetobilly 17 hours ago
The excess cardiac risk, found in RA has been attributed to biological inflammation. Effective control of inflammation may be of benefit in reducing cardiovascular risk in RA patients. The aim of t...
 
Screening for diabetes in patients with inflammatory rheumatological disease administered long-term prednisolone: a cross-sectional study
submitted by hdmahonkamor 17 hours ago
The aim of the study was to assess the effect of long-term prednisolone on fasting and post-glucose load glucose concentration in patients with inflammatory rheumatological disease. We hypothesized...
 
The sensitivity and specificity of pain diagrams in rheumatic disease referrals
submitted by fenliy 17 hours ago
To determine patterns on pain diagrams and corresponding diagnoses in patients referred to a rheumatology clinic and their sensitivity, specificity, and positive and negative predictive values (PPV...
 


Ten-year follow-up of SpA-related oligoarthritis involving the knee: the presence of psoriasis but not HLA-B27 or baseline MRI bone oedema predicts outcome
submitted by hcannenghom 17 hours ago
Bone marrow oedema (BMO) and HLA-B27 are poor prognostic factors in axial SpA, and psoriasis is a poor prognostic factor in small-joint polyarthropathy. The aim of this study was to investigate the...
 
Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American-European classification criteria for primary Sjogren's syndrome
submitted by FisherEdwi 17 hours ago
To test the diagnostic accuracy of modified American–European classification criteria (AEC) for primary SS (pSS) by replacing sialoscintigraphy (sSC) with ultrasonography of the major salivar...
 
Anatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus
submitted by galdlacke 17 hours ago
The autopsy and clinical information on children dying with anti-SSA/Ro-associated cardiac manifestations of neonatal lupus (cardiac NL) were examined to identify patterns of disease, gain insight ...
 
Inflammatory lesions of the orbit: a single paediatric rheumatology centre experience
submitted by Linda 17 hours ago
To describe the clinical, laboratory, histopathological presentations and final diagnoses for children presenting to a tertiary paediatric rheumatology service with an inflammatory lesion of the or...
 
Differential gene expression of MMP-1, TIMP-1 and HGF in clinically involved and uninvolved skin in South Africans with SSc
submitted by odmerjaga 17 hours ago
To investigate the differential expression of MMP-1, tissue inhibitor of metalloproteinase-1 (TIMP-1) and hepatocyte growth factor (HGF) in clinically involved (affected) and uninvolved (unaffected...
 
The papulopustular lesion/arthritis cluster of Behcet's syndrome also clusters in families
submitted by proteksotyo 17 hours ago
We have previously reported distinct symptom clusters among our patients with Behçet's syndrome (BS). The presence of such clusters suggests that more than one pathogenetic mechanism might b...
 
Evidence for reduced angiogenesis in bone marrow in SSc: immunohistochemistry and multiparametric computerized imaging analysis
submitted by bab2 17 hours ago
Dysfunctional angiogenesis is a pathogenetic marker of SSc. Circulating levels of endothelial progenitor cells are reduced, and mesenchymal stromal cells show a reduced differentiation into endothe...
 
The impact of cardiopulmonary manifestations on the mortality of SSc: a systematic review and meta-analysis of observational studies
submitted by felix4792 17 hours ago
Internal organ involvement reduces the life expectancy of SSc patients. Cardiopulmonary manifestations are currently the primary cause of death. We aimed to perform a systematic review and meta-ana...
 
Loss of metacarpal bone density predicts RA development in recent-onset arthritis
submitted by donphainex 17 hours ago
Serum samples taken before the onset of RA suggest that one of the first features of RA is BMD loss. We determined the ability of radiographic BMD loss to predict RA development and arthritis persi...
 
Higher DEFB4 genomic copy number in SLE and ANCA-associated small vasculitis
submitted by AntwaIsa 17 hours ago
Evidence shows that defensins are involved in the pathogenesis of SLE and ANCA-associated small vasculitis (AASV). The copy number variation of DEFB4 has been proposed to be susceptible to inflamma...
 
IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Ralpha
submitted by vmanivannan 17 hours ago
To study the phenotypic characteristics of and the balance between systemic IL-7 receptor (IL-7R)α+ and IL-7Rα– Tregs in primary SS (pSS) patients as compared with control subject...
 

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