Health

The diagnosis of symptomatic recurrent pulmonary embolism and deep vein thrombosis: guidance from the SSC of the ISTH
This document is intended to give clinical guidance for the diagnosis of symptomatic recurrent pulmonary embolism (PE) and/or deep vein thrombosis (DVT). We define recurrent PE and DVT as those events occurring after an initial course of adequate antithrombotic treatment for a first venous thromb...


Normal Cleavage of von Willebrand Factor by ADAMTS13 in the absence of Factor VIII in Patients with Severe Hemophilia A
Von Willebrand factor (VWF) is required for hemostasis, recruiting platelets from rapidly flowing blood to sites of vessel injury and protecting factor VIII (FVIII) from degradation. The adhesive activity of VWF correlates with its size: large VWF multimers bind more avidly to platelets [1]. VWF ...
Regular smoking is not associated with increased thrombin generation in young adults
We read with interest the recent paper “Cigarette smoking and the risk of venous thromboembolism: the Tromsø Study” by Enga KF identifying smoking as a risk factor for provoked venous thromboembolism (VTE) [1]. However, risk for unprovoked VTE, e.g. without associated comorbidities such as m...
Endometrial Ablation: Is Tubal Ligation a Risk Factor for Hysterectomy
To determine whether tubal ligation is a risk factor for future hysterectomy after second-generation endometrial ablation. Retrospective chart review (Canadian Task Force classification II-3). Resident-run clinic and private office in a community setting. Five hundred eighty-seven patients who un...
Neighborhood socioeconomic characteristics and differences in the availability of healthy food stores and restaurants in Sao Paulo, Brazil
Differential access to healthy foods has been hypothesized to contribute to health disparities, but evidence from low and middle-income countries in scarce. This study examines whether the access of healthy foods varies across store types and neighborhoods of different socioeconomic statuses (SES...
Indigenous Māori perspectives on urban transport patterns linked to health and wellbeing
There is a growing body of research linking urban transport systems to inequities in health. However, there is a lack of research providing evidence of the effect of transport systems on indigenous family wellbeing. We examined the connections between urban transport and the health and wellbeing ...


Comparison of high-resolution MRI with CT angiography and digital subtraction angiography for the evaluation of middle cerebral artery atherosclerotic steno-occlusive disease
Intracranial atherosclerotic disease is increasingly recognized as a major stroke subtype worldwide. Current diagnostic evaluation of atherosclerotic disease of the middle cerebral artery (MCA) relies on detection of stenoses with luminographic imaging studies that do not directly visualize plaqu...
Walking kinematics and kinetics following eccentric exercise-induced muscle damage
The goal of this investigation was to investigate how walking patterns are affected following muscle-damaging exercise by quantifying both lower limb kinematics and kinetics. Fifteen young women conducted a maximal isokinetic eccentric exercise (EE) muscle damage protocol (5×15) of the knee exte...
Efficacy of duloxetine versus alternative oral therapies: an indirect comparison of randomised clinical trials in chronic low back pain
The objective of this study was to obtain parameter estimates for the efficacy of duloxetine versus alternative oral therapies for the treatment of chronic low back pain. Electronic databases were searched to identify randomised, double-blind placebo-controlled trials. Studies reporting pain inte...
Measurement of clinically relevant functional health perceptions in patients with whiplash-associated disorders: the development of the whiplash specific activity and participation list (WAL)
The International Classification of Human Functioning Disability and Health (ICF) provides insight into functional health status in patients with whiplash-associated disorders (WAD). In the assessment of functional limitations in patients with WAD, there are several condition-specific questionnai...
Mise en évidence du blanc périveinulaire, par OCT « en-face », dans le cadre d’une OVCR
Nous rapportons le cas d’un patient ayant présenté une occlusion de la veine centrale de la rétine associée à l’apparition de blanc périveinulaire. La prise en charge par OCT spectral domain en mode « en-face » a permis une mise en évidence précise de ces zones de micro-infarcisse...


Medial Patellofemoral Ligament Reconstruction Using a Modified “Reverse-Loop” Technique
Medial patellofemoral ligament reconstruction is a commonly performed procedure for patellofemoral instability. In recent years the surgery has evolved considerably as the anatomy and goals of reconstruction have become more defined. This has resulted in numerous surgical options involving variou...
Alpha-fetoprotein—a potential biomarker of intestinal regeneration in the infant
We hypothesise that the human infant, whether born prematurely or at term, may have special capacities when mounting a healing response to severe post-natal gastrointestinal injury consequent upon stem cells of endodermal origin, located in the infant gut, persisting beyond the intrauterine perio...
Modern Management of Bladder Exstrophy Repair
The exstrophy–epispadias complex is a rare congenital malformation of the genitourinary system, abdominal wall musculature, and pelvic bones. Historically, surgical outcomes in patients with classic bladder exstrophy, the most common presentation of the exstrophy–epispadias complex, were poor...
Use of Buccal Mucosa in Hypospadias Repair
Hypospadias is an embryological disorder that results in an abnormal ventral positioning of the urethral meatus. Among multiple surgical techniques described to correct this anomaly, the use of buccal mucosa grafts has gained popularity among pediatric urologists, pediatric surgeons and plastic s...