Health

Breastfeeding and lactation research: exploring a tool to measure infant feeding patterns
Infant feeding categories, often referred to as breastfeeding definitions, form the basis to describe infant feeding patterns; especially, breastfeeding duration and degree of breastfeeding exclusivity. Researchers use a variety of algorithms and no validated tool exists to measure feeding patterns for research purposes. The goal of this research project was to develop and test a tool to measur...


Isolated hypertrophy of the basal ventricular septum: Characteristics of patients with and without outflow tract obstruction
Isolated basal septal hypertrophy (IBSH) of the left ventricle (LV) is not a well understood phenomenon, particularly in the presence of concomitant left ventricular outflow tract obstruction (LVOTO). We evaluated the prevalence of IBSH and compared those with and without LVOTO. Retrospective observational study of 4104 consecutive patients undergoing echocardiography at a community cardiology ...
The long-term prognostic value of the ST depression criteria for ischemia recommended in the universal definition of myocardial infarction in 43,661 veterans
The third Universal Definition of Myocardial Infarction (UDMI) includes electrocardiographic criteria for ischemia, specifying horizontal or down-sloping ST depression ≥0.05mV in two contiguous electrocardiogram (ECG) leads. We used the surrogate of cardiovascular (CV) death to evaluate the criteria. We collected computerized ST amplitude measurements, in different lead groupings, from the re...


Prognostic role of stress/rest myocardial perfusion scintigraphy in patients with cardiac syndrome x
The prognostic utility of myocardial perfusion scintigraphy (MPS) in patients with angiographically normal coronary arteries has not been evaluated yet. Our aim was to determine the prognostic role of positive MPS in patients with angina, positive exercise test and smooth coronary arteries (syndrome X). A total of 156 patients with angina, positive exercise test, positive MPS and normal coronar...
15-deoxy-Δ12,14-PGJ2 promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis
Prostaglandins (PGs), lipid autacoids derived from arachidonic acid, play a pivotal role during inflammation. PGD2 synthase is abundantly expressed in heart tissue and PGD2 has recently been found to induce cardiomyocyte apoptosis. PGD2 is an unstable prostanoid metabolite; therefore the objective of the present study was to elucidate whether its final dehydration product, 15-deoxy-Δ12,14-PGJ2...


Endothelial function and cardiovascular events in chronic kidney disease
As patients with chronic kidney disease (CKD) are at high risk of developing coronary artery disease (CAD), it is important to stratify their cardiovascular risk. We investigated whether peripheral endothelial dysfunction is associated with the presence of CAD in patients with CKD and is a predictor of cardiovascular events. We enrolled 383 CKD patients with at least one coronary risk factor. P...
The predictive value of CHADS2 risk score in post myocardial infarction arrhythmias — A Cardiac Arrhythmias and RIsk Stratification after Myocardial infArction (CARISMA) substudy
Previous studies have shown substantially increased risk of cardiac arrhythmias and sudden cardiac death in post-myocardial infarction (MI) patients. However it remains difficult to identify the patients who are at highest risk of arrhythmias in the post-MI setting. The purpose of this study was to investigate if CHADS2 score (congestive heart failure, hypertension, age ≥75years, diabetes and...

Sinoatrial node electrical activity modulates pulmonary vein arrhythmogenesis
Sinoatrial node (SAN) dysfunction increases the occurrences of atrial fibrillation (AF). The pulmonary veins (PVs) play a critical role in the pathophysiology of AF. The purpose of this study was to evaluate whether SAN electrical activity can modulate PV arrhythmogenesis. Conventional microelectrodes and multi-electrode array system were used to simultaneously record the electrical activity an...
Dynamic induction of pro-angiogenic milieu after transplantation of marrow-derived mesenchymal stem cells in experimental myocardial infarction
Cell-based pro-angiogenic therapy by bone marrow mesenchymal stem cells (MSCs) has been touted as a means to reducing the adverse effects of cardiac remodeling after myocardial infarction (MI). Milieu-dependent regulation of pro-angiogenic potential of MSCs after infarction remains to be elucidated. In this study, the effects of marrow-derived MSCs on the kinetics of angiogenesis signaling fact...

Growth differentiation factor-15 in Takotsubo cardiomyopathy: Diagnostic and prognostic value
Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, has emerged as a marker of adverse outcome in various cardiovascular diseases. Since GDF-15 has not been evaluated in patients with Takotsubo cardiomyopathy (C), the present study sought to investigate the diagnostic and prognostic value in this patient cohort. A total of 22 patients presenting with C were matched for age ...
Frequency of cardiovascular diseases and risk factors treated in France according to social deprivation and residence in an overseas territory
The frequencies of treated cardiovascular disease (CVD) and their associated risk factors (CVRF) may vary according to socioeconomic and territorial characteristics. These frequencies have been described for 48million policyholders of the French general health insurance scheme, according to a metropolitan geographical deprivation index in five quintiles (from the least to the most deprived: Q1 ...

Does residual aortic regurgitation after transcatheter aortic valve implantation increase mortality in all patients? The importance of baseline natriuretic peptides
Aortic regurgitation (AR) is an important complication of transcatheter aortic valve implantation (TAVI) and even moderate AR is associated with increased mortality after TAVI. The association with decreased survival is unclear. We aimed to analyse the impact of AR after TAVI as a function of baseline NT-proBNP. We included 236 consecutive patients implanted in our centre with the SAPIEN and SA...
Beta-blockers in older patients with heart failure and preserved ejection fraction: Class, dosage, and outcomes
We examined the clinical effectiveness of beta-blockers considered evidenced-based to heart failure and reduced ejection fraction (HFrEF) and their recommended target doses in older adults with HF and preserved ejection fraction (HFpEF). In OPTIMIZE-HF (2003–2004) linked to Medicare (2003–2008), of the 10,570 older (age≥65 years, mean, 81years) adults with HFpEF (EF≥40%, mean 55%), 8373...
AXL receptor tyrosine kinase is increased in patients with heart failure
Axl is a membrane receptor tyrosine kinase highly expressed in the heart and has a conspicuous role in cardiovascular physiology. The role of axl in heart failure (HF) has not been previously addressed. axl protein was enhanced 6-fold in myocardial biopsies of end-stage HF patients undergoing heart transplantation compared to controls from heart donors (P <0.0001). Next, we performed a t...
Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction
This study tested whether adipose-derived mesenchymal stem cells (ADMSC) embedded in platelet-rich fibrin (PRF) scaffold is superior to direct ADMSC implantation in improving left ventricular (LV) performance and reducing LV remodeling in a rat acute myocardial infarction (AMI) model of left anterior descending coronary artery (LAD) ligation. Twenty-eight male adult Sprague Dawley rats equally ...