Health

Bone Regeneration with Osteogenically Enhanced Mesenchymal Stem Cells and Their Extracellular Matrix Proteins
Although bone has remarkable regenerative capacity, about 10% of long bone fractures and 25-40% of vertebral fusion procedures fail to heal. In such instances, a scaffold is employed to bridge the lesion and accommodate osteoprogenitors. Although synthetic bone scaffolds mimic some of the characteristics of bone matrix, their effectiveness can vary due to biological incompatibility. Herein, we ...


Loss of Runx2 in Committed Osteoblasts Impairs Postnatal Skeletogenesis
The Runx2 transcription factor is critical for commitment to the osteoblast lineage. However, its role in committed osteoblasts and its functions during postnatal skeletogenesis remain unclear. We established a Runx2-floxed line with insertion of loxP sites around exon 8 of the Runx2 gene. Runx2 protein lacking the region encoded by exon 8 is imported into the nucleus and binds target DNA, but ...
The Longitudinal Effects of Physical Activity and Dietary Calcium on Bone Mass Accrual Across Stages of Pubertal Development
Childhood and adolescence are critical periods of bone mineral content (BMC) accrual that may have long-term consequences for osteoporosis in adulthood. Adequate dietary calcium intake and weight-bearing physical activity are important for maximizing BMC accrual. However, the relative effects of physical activity and dietary calcium on BMC accrual throughout the continuum of pubertal developmen...


Comparison of radiological and morphologic assessments of myocardial bridges
In this study we aimed to compare the findings of coronary dual-source computed tomography angiography of myocardial bridges with cadaveric dissections. Forty-one isolated, non-damaged fresh sheep hearts were used in this study. Myocardial bridges of the anterior interventricular branch of the left coronary artery were demonstrated and analyzed by a coronary dual-source computed tomography angi...
Hematoma intramural da aorta: evolução (im)previsível?
O hematoma intramural da aorta (IMH) é uma síndrome aórtica aguda caracterizada pela ocorrência de hemorragia a nível da camada média da parede da aorta, sem evidência de rutura ou flap da íntima. A história natural desta entidade clínica é muito variável e ainda pouco conhecida, pelo que a sua abordagem terapêutica não está completamente estabelecida. Nalguns casos pode ocorrer ...


Efeitos cardiovasculares do receptor tipo 2da angiotensina
O recetor da angiotensina do tipo 2, AT2R, tem vindo a ser descrito como tendo ações opostas ao recetor da angiotensina do tipo 1, AT1R. Apesar do AT2R existir em baixas quantidades no adulto, a sua expressão sobe bastante em situações patológicas. o AT2R tem três grandes vias de sinalização: a ativação fosfátases de serina/treonina (promoção da apoptose celular e efeitos antioxid...
Transitions from hospital to community care: the role of patient–provider language concordance
Cultural and language discordance between patients and providers constitutes a significant challenge to provision of quality healthcare. This study aims to evaluate minority patients’ discharge from hospital to community care, specifically examining the relationship between patient–provider language concordance and the quality of transitional care. This was a multi-method prospective study ...

Predictors of health care use by adults 50 years and over in a rural South African setting
South Africa’s epidemiological transition is characterised by an increasing burden of chronic communicable and non-communicable diseases. However, little is known about predictors of health care use (HCU) for the prevention and control of chronic diseases among older adults. To describe reported health problems and determine predictors of HCU by adults aged 50+ living in a rural sub-district ...
Hydrogen sulphide in human nasal air quantified using thermal desorption and selected ion flow tube mass spectrometry
The discovery that hydrogen sulphide (H 2 S) acts as a gasotransmitter when present at very low concentrations (sub-parts per billion (ppbv)) has resulted in the need to quickly quantify trace amounts of the gas in complex biological samples. Selected ion flow tube mass spectrometry (SIFT-MS) is capable of real-time quantification of H 2 S but many SIFT-MS instruments lack sufficient sensitivit...

The origin of mouth-exhaled ammonia
It is known that the oral cavity is a production site for mouth-exhaled NH 3 . However, the mechanism of NH 3 production in the oral cavity has been unclear. Since bacterial urease in the oral cavity has been found to produce ammonia from oral fluid urea, we hypothesize that oral fluid urea is the origin of mouth-exhaled NH 3 . Our results show that under certain conditions a strong correlation...
Analiza 191 pacjentów z rakiem krtani w oparciu o nową klasyfikację otwartych poziomych laryngektomii częściowych według Europejskiego Towarzystwa Laryngologicznego z 2014 roku
Of study was to present material of open partial horizontal laryngectomies (OPHL) in T1b, T2 and T3 larynx cancer treatment in single tertiary referral institution. Retrospective analysis of operating protocols in patients treated in Poznań ENT University Department between 2000–2012 with glottis (T1b – 185, T2 – 185,T3 – 231) and supraglottis tumors (T1 – 80, T2 – 104, T3 – 206)...

Nerve Proximity During Bicortical Drilling for Subpectoral Biceps Tenodesis: A Cadaveric Study
The long head of the biceps can develop tendonitis and tendinosis, which can lead to pain in the bicipital groove. The use of bicortical button fixation allows for a smaller defect in the humerus compared with tenodesis screws, reducing the risk of fracture. Our objective is to evaluate the exit location of our bicortical button and its relation to relevant posterior nervous structures. We perf...
Rotator Cuff Tear Degeneration and Cell Apoptosis in Smokers Versus Nonsmokers
The purpose of this study was to assess the effect of smoking on supraspinatus tendon degeneration, including cellular alterations, proliferation, and apoptosis of tendon cells. Supraspinatus tendon samples of 10 smokers and 15 nonsmokers with full-thickness tears were compared, focusing on the severity of tendon histopathology including apoptosis (programmed cell death), cellularity, and proli...
Arthroscopic Stabilization for Recurrent Shoulder Instability With Moderate Glenoid Bone Defect in Patients With Moderate to Low Functional Demand
The purpose of this study was to investigate the functional outcomes of arthroscopic Bankart repair for recurrent shoulder instability in the setting of moderate glenoid bone defect ranging from 20% to 30% in patients with moderate to low functional demand. This study included 36 patients with unilateral recurrent instability and glenoid bone defects of 20% to 30% treated with arthroscopic stab...
Effect of Ultrasonographically Guided Axillary Nerve Block Combined With Suprascapular Nerve Block in Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial
The aim of this study was to compare the results of ultrasonographically guided axillary nerve block (ANB) combined with suprascapular nerve block (SSNB) with those of SSNB alone on postoperative pain and satisfaction within the first 48 hours after arthroscopic rotator cuff repair. Forty-two patients with rotator cuff tears who had undergone arthroscopic rotator cuff repair were enrolled in t...