Health

Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2
Therosclerosis is a dise ase characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins, those may lead to acute coronary syndrome (ACS). We investigated the expression level of TLR-4 in ACS, as compared with TLR-2 and patients with stable angina. Fift...


Maximal acetylcholine dose of 200 μg into the left coronary artery as a spasm provocation test: comparison with 100 μg of acetylcholine
As a spasm provocation test of acetylcholine (ACH), incremental dose up (20/50/100 μg) into the left coronary artery (LCA) is recommended in the guidelines established by Japanese Circulation Society. Recently, Ong et al. reported the ACOVA study which maximal ACH dose was 200 μg in the LCA. We compared the angiographic findings between ACH 100 μg and ACH 200 μg in the LCA and also exam...
Multilaboratory Study of Flow-Induced Hemolysis Using the FDA Benchmark Nozzle Model
Multilaboratory in vitro blood damage testing was performed on a simple nozzle model to determine how different flow parameters and blood properties affect device-induced hemolysis and to generate data for comparison with computational fluid dynamics-based predictions of blood damage as part of an FDA initiative for assessing medical device safety. Three independent laboratories evaluated hemol...


Megalopapilla in children: a spectral domain optical coherence tomography analysis
To compare various optic nerve head (ONH) parameters and peripapillary retinal nerve fibre layer (pRNFL) thickness between megalopapilla cases and normal control using spectral domain optical coherence tomography (SD-OCT) in children. Fifty eyes with megalopapilla and 80 normal control eyes of totally 130 children between the ages of 6 and 15 were examined using SD-OCT. Optic nerve head paramet...
Comparison of the efficacy and safety of two starting dosages of prednisolone in early active rheumatoid arthritis (CORRA): study protocol for a randomized controlled trial
Although glucocorticoids are widely used in the treatment of patients with early rheumatoid arthritis, the best dosage for glucocorticoids, related to both, efficacy and safety, is not known. The aim of the study "Comparison of the efficacy and safety of two starting dosages of prednisolone in early active rheumatoid arthritis" (CORRA) is to compare two standard glucocorticoid starting dosages ...


Generalized bone loss in early rheumatoid arthritis patients followed for ten years in the biologic treatment era
Osteoporosis is a well-known extra articular manifestation in rheumatoid arthritis (RA). Biologic disease modifying anti rheumatic drugs (DMARDs) has been shown to be superior to synthetic DMARDs to reduce bone destruction including generalized bone loss in RA. Our aim was to study short- and long term changes in hip and spine bone mineral density (BMD) in early RA patients treated during the f...
Comparative Effectiveness of Risperidone Long-Acting Injectable vs First-Generation Antipsychotic Long-Acting Injectables in Schizophrenia: Results From a Nationwide, Retrospective Inception Cohort Study
To compare in a generalizable sample/setting objective outcomes in patients receiving first-generation antipsychotic long-acting injectables (FGA-LAIs) or risperidone-LAI (RIS-LAI). Nationwide, retrospective inception cohort study of adults with International Classification of Diseases-10 schizophrenia using Danish registers from 1995 to 2009 comparing outcomes between clinician’s/patien...

The Epidemiology and Associated Phenomenology of Formal Thought Disorder: A Systematic Review
Authors of the Diagnostic and Statistical Manual, Fifth Edition (DSM-V) have recommended to "integrate dimensions into clinical practice." The epidemiology and associated phenomenology of formal thought disorder (FTD) have been described but not reviewed. We aimed to carry out a systematic review of FTD to this end. A systematic review of FTD literature, from 1978 to 2013, using Preferred Repor...
Very small embryonic-like stem cells are involved in regeneration of mouse pancreas post-pancreatectomy
Despite numerous research efforts, mechanisms underlying regeneration of pancreas remains controversial. Views are divided whether stem cells are involved during pancreatic regeneration or it involves duplication of pre-existing islets or ductal cells or whether pancreatic islet numbers are fixed by birth or they regenerate throughout life. Pluripotent embryonic stem (ES) and induced pluripoten...

Falling and fall risk factors in adults with haemophilia: an exploratory study
Falls are a particular risk in persons with haemophilia (PWH) because of damaged joints, high risk of bleeding, possible impact on the musculoskeletal system and functioning and costs associated with treatment for these fall-related injuries. In addition, fall risk increases with age and PWH are increasingly entering the over 65 age group. The aim of this study was to determine the occurrence o...
Effectiveness of intervention led by a community pharmacist for improving recognition of sleep apnea in primary care – a cohort study
Despite its high prevalence and major public health ramifications, obstructive sleep apnea syndrome (OSAS) remains underdiagnosed. The aim of this study was to determine whether the involvement of a community pharmacist (CP) in the care pathway of a patient at risk of OSAS, through the implementation of a community pharmacist (CP) intervention, was effective, i.e. increased the use of diagnosti...

Childhood sleeping difficulties and depression in adulthood: the 1970 British Cohort Study
Sleeping difficulties in childhood have been associated with an increased risk of depression in adult life, but existing studies have not accounted for comorbid maternal sleeping difficulties and depression. This study aimed to determine the association between childhood sleeping difficulties and depression in adulthood after adjusting for the potential confounding influences of maternal depres...
Pan-European, open-label dose titration study of fentanyl buccal tablet in patients with breakthrough cancer pain
Fentanyl buccal tablet (FBT), a rapid onset opioid used to treat breakthrough cancer pain, must be titrated to an effective dose that provides adequate analgesia and minimizes undesirable events. This open-label, randomized study compared the percentage of patients achieving an effective dose of FBT when starting titration at 100 or 200 μg. Opioid-tolerant patients with chronic cancer-relate...
Analgesic interaction between ondansetron and acetaminophen after tonsillectomy in children: The Paratron randomized, controlled trial
The mechanism of action of acetaminophen remains unclear. One hypothesis involves an interaction with the serotoninergic system. Antagonists to serotonin (5-HT)3 receptors (setrons) have antiemetic properties. Therefore, co-administration of acetaminophen and a setron could lead to a decrease or a loss of acetaminophen analgesic effects. The aim of this study was to demonstrate such an interact...
Further development in the assessment of psychological flexibility: A shortened Committed Action Questionnaire (CAQ-8)
Committed action is a relatively understudied facet of the psychological flexibility model but a potentially important process of overt behaviour in relation to chronic pain. In this study, we take a previously developed measure of committed action, the Committed Action Questionnaire (CAQ), and validate a shorter version. A total of 664 adults seeking treatment for chronic pain participated in ...