Psychiatry

Pharmacological Inhibition of BACE1 Can Impair Synaptic Plasticity and Specific Cognitive Functions
Bace1 is the rate limiting protease in Aβ production from amyloid precursor protein (APP), hence a promising drug target for the treatment of Alzheimer's disease. As the major β-secretase in vivo with multiple substrates, inhibition of bace1 is likely to have mechanism-based adverse effects. We explored the impact of chronic inhibition of bace1 on dendritic spine dynamics, synaptic functions ...


The prevalence and burden of behavioural and psychological symptoms of dementia in rural Tanzania
Behavioural and psychological symptoms (BPS) in dementia are common in high-income countries, but there are few data from sub-Saharan Africa. Our aim was to estimate the prevalence and pattern of BPS and associated caregiver distress in rural Tanzania. Prevalent cases of dementia (aged 70 and over) were identified during a community-based door-to-door study in six rural villages in Tanzania. Fo...
Cohort study evaluating the risk of hip fracture among patients with dementia in Taiwan
To investigate the incidence and risk of hip fracture among dementia patientsMethodsThis is a retrospective population-based 7-year cohort study using case–control matched analysis database from Taiwan's Longitudinal Health Insurance Database 2005. Patients were diagnosed with codes or International Classification of Diseases-9-CM codes of dementia, between 1 January 2004 and 31 December 2006...


Use and cost of hospitalization in dementia: longitudinal results from a community-based study
The aim of this study is to examine the relative contribution of functional impairment and cognitive deficits on risk of hospitalization and costs. A prospective cohort of Medicare beneficiaries aged 65 and older who participated in the Washington Heights-Inwood Columbia Aging Project (WHICAP) were followed approximately every 18 months for over 10 years (1805 never diagnosed with dementia ...
A 13-year prospective cohort study on the effects of aging and frailty on the depression–pain relationship in older adults
The primary aim of the study is to investigate the effect of age and aging on the association between pain and depression over 13 years. We hypothesized that (1) this association would become stronger with age and frailty and that this association is mainly driven by somatic and psychological factors. Data were derived from the Longitudinal Aging Study Amsterdam, a prospective population-base...


MMPI-2-RF characteristics of individuals with interstitial cystitis
This study aimed to describe the psychological functioning of interstitial cystitis/bladder pain syndrome patients utilizing MMPI-2-RF scoring. The MMPI-2 was administered to 60 individuals who reported a diagnosis of IC. Responses were scored in the MMPI-2-RF format. Fifty-one protocols were deemed valid. Elevations were discovered on scales FBS-r (symptom validity), RC1 (somatic complaints), ...
Beliefs about the ‘shape’ and continuity of healthy sleep as a function of age
Treating insomnia includes challenging unrealistic beliefs that may contribute to anxieties and wakefulness. This study explored beliefs about the shape and continuity of healthy adult sleep at different adult ages. Younger (n =113, M =21.4 (2.4)) and older adults (n =110, M =72.3 (7.7)) depicted their concept of the normal sleep of both a healthy 18 and 65 year olds. Plots were drawn to show s...

Cognitive adaptation theory as a predictor of adjustment to emerging adulthood for youth with and without type 1 diabetes
The purpose of the study was to determine whether resilience, defined by cognitive adaptation theory, predicted emerging adulthood outcomes among youth with and without type 1 diabetes. Youth with (n =118) and without type 1 diabetes (n =122), who were part of a previous longitudinal study during adolescence, completed on-line questionnaires during their senior year of high school and one and t...
Associations between insomnia, sleep duration and poor work ability
The aim of this study was to examine the independent and joint effect of insomnia and objective sleep duration on poor work ability. In this cross-sectional study, a total of 2820 Chinese manufacturing workers were categorized as insomnia patients and individuals with normal sleeping pattern by interview according to DSM-IV criteria. Sleep duration was classified into four categories: ≥7h, 6...

Assessing psychological factors, social aspects and psychiatric co-morbidity associated with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in men — A systematic review
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a chronic pain disease with high prevalence rates and substantial health care costs. An interdisciplinary classification system is commonly used (UPOINT) which includes psychosocial factors. Nevertheless, psychosocial influences on CP/CPPS only recently became a research focus. Therefore, we aimed to synthesize the existing data and ...
C-reactive protein and fibrinogen in non-obstructive coronary artery disease as related to depressive symptoms and anxiety: Findings from the TweeSteden Mild Stenosis Study (TWIST)
The majority of acute coronary syndromes occur in the absence of obstructive coronary artery disease (CAD), and the underlying biobehavioral processes are not well understood. Depressive symptoms and anxiety are predictive of prognosis, and have been associated with markers of inflammation that play a role in atherosclerosis. This study examines whether depressive symptoms and anxiety are assoc...

Do psychosocial resources modify the effects of frailty on functional decline and mortality?
Little is known about factors that may prevent or delay adverse health outcomes in frail older adults. Previous studies have demonstrated beneficial effects of psychosocial resources on health outcomes in older adults. The aim of this study was to investigate whether psychosocial resources modify the effects of frailty on functional decline and mortality. The study sample consisted of 1665 men ...
Metacognitions, anxiety, and distress related to motor fluctuations in Parkinson's disease
This study tested the relationship between metacognitive factors, intolerance of uncertainty, anxiety, and the predictability of, and distress associated with, acute fluctuations in symptoms in idiopathic Parkinson's disease (PD), when controlling for disease parameters. 106 adults with idiopathic PD (30 females; Mage =65.3; 90% white) participated in this study, with 93 of them reported experi...
Clinical and evoked pain, personality traits, and emotional states: Can familial confounding explain the associations?
Pain is a complex phenomenon influenced by context and person-specific factors. Affective dimensions of pain involve both enduring personality traits and fleeting emotional states. We examined how personality traits and emotional states are linked with clinical and evoked pain in a twin sample. 99 female twin pairs were evaluated for clinical and evoked pain using the McGill Pain Questionnaire ...
Challenging the validity of the association between oversleeping and overeating in atypical depression
In this study, we used a strict definition of hypersomnia and tested if the association between overeating–hypersomnia remained positive and significant. Hypersomnia was present if the total sleep time was close to 10h per day or was at least 2h longer than in normothymic periods. Cross-sectional study using the adult general population of California and New York. The sample was composed of 6...