Psychiatry

Determinants of suicidal ideation and suicide attempts: parallel cross-sectional analyses examining geographical location
Suicide death rates in Australia are higher in rural than urban communities however the contributors to this difference remain unclear. Geographical differences in suicidal ideation and attempts were explored using two datasets encompassing urban and rural community residents to examine associations between socioeconomic, demographic and mental health factors. Differing patterns of association ...


Neonatal levels of inflammatory markers and later risk of schizophrenia
There is a long standing interest in investigating the impact of early-life immune abnormalities on later onset of psychosis. The aim of this study was to assess inflammatory marker levels in neonatal dried blood spots and their association with later risk of schizophrenia. This nested case-control study included 995 cases and 980 controls. Cases were identified using the Danish Psychiatric Cen...
Effect of combined cognitive-behavioural therapy and endurance training on cortisol and salivary alpha-amylase in panic disorder
Current data point to an alteration of both the hypothalamo-pituitary-adrenal (HPA)-system and the peripheral transmission of catecholamines in anxiety disorders. There is also some evidence for the effect of several components of cognitive-behavioural interventions such as coping and control and for an effect of exercise training on the neuroendocrine stress response in healthy subjects as wel...


Association between the common functional FKBP5 variant (rs1360780) and brain structure in a non-clinical population
Fk506 binding protein 5 (FKBP5) is induced by stress and regulates glucocorticoid receptor sensitivity. The T allele of the single nucleotide polymorphism (SNP) FKBP5 rs1360780 (C/T) is associated with an increased risk of post-traumatic stress disorder (PTSD) and reduced hippocampal volume in traumatized or depressed subjects. To examine whether this SNP affects brain structures that regulate ...
A specific impairment in cognitive control in individuals with high-functioning autism
Although it is largely demonstrated that Autism Spectrum Disorders (ASDs) are characterized by executive dysfunctions, little is known about the fine-grained levels of this impairment. Here, we investigated the hierarchical architecture of control modules in autism using an experimental paradigm based upon a multistage model of executive functions. This model postulates that executive functions...


Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study
Inflammation is one possible mechanism underlying the associations between mental disorders and cardiovascular diseases (CVD). However, studies on mental disorders and inflammation have yielded inconsistent results and the majority did not adjust for potential confounding factors. We examined the associations of several pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) and high sensitive C-r...
Le débat anti-aliéniste français au xixe siècle : une campagne de presse
À la frontière de l’histoire des idées et de l’histoire de la psychiatrie, cet article étudie la genèse de ce qu’on appellera plus tard l’anti-aliénisme ou l’antipsychiatrie au xix e siècle. La présente étude cherche à déterminer comment se déroule cette période de perturbation dans la profession à l’intérieur même des asiles en prenant comme point de départ le poin...

High stakes lies: police and non-police accuracy in detecting deception
To date, the majority of investigations into accuracy in detecting deception has used low-stakes lies as stimulus materials, and findings from these studies suggest that people are generally poor at detecting deception. The research presented here utilised real-life, high-stakes lies as stimulus materials, to investigate the accuracy of police and non-police observers in detecting deception. It...
Associations between mindfulness and panic symptoms among young adults with asthma
Despite the well-documented associations between panic psychopathology and asthma, there has been a dearth of empirical work examining factors that may reduce the negative effects of panic for individuals with asthma. Thus, the goal of the present study was to examine the role of mindfulness skills (i.e. observe, describe, acting with awareness, nonjudgment, and nonreactivity) in symptoms of pa...

Effects of motives on reactions to safe sun messages
We investigated whether appearance motive for sun exposure, which strongly predicts exposure behaviour, would predict reactions to safe sun messages. In a survey with an embedded experiment, 245 individuals completed measures of motives, read a safe sun message framed by incentive (appearance/health), tone (directive/nondirective) and valence (gain/loss), then completed measures of reactions. F...
Analysis of Genes in Serotonin Pathway with Attention and Executive Function in Patients with Bipolar Affective Disorder
The reason why it is difficult to identify susceptibility genes attributed to bipolar disorder (BPD) is the phenotypic heterogeneity. The use of endophenotypes has been advocated as one possible strategy to discovery cause variants of BPD. A total of 164 patients with BPD and 164matched controls were employed in the present research. 52 single nucleotide polymorphisms (SNPs) within the Genes in...

A Preliminary Investigation of the Long-Term Outcome of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
To conduct a preliminary examination of long-term outcomes on a broad range of affective disorder symptoms treated with a newly developed intervention: The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). Maintenance of treatment gains at long-term follow-up (LTFU) were explored in patients (n =15, mean age=32.27; 60% female) who completed a clinical trial of the UP. ...
Re-Examining Premature Mortality in Anorexia Nervosa: A Meta-Analysis Redux
Anorexia nervosa (AN) is reported to have the highest premature mortality of any psychiatric disorder, but recent meta-analyses may have inflated estimates. We sought to re-estimate mortality after methodological corrections and identify predictors of mortality. We included 41 cohorts from 40 peer-reviewed studies published between 1966-2010. included double data extraction, log-linear regressi...
Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder
Breakpoints of chromosomal abnormalities facilitate identification of novel candidate genes for psychiatric disorders. Genome-wide significant evidence supports the linkage between chromosome 17q25.3 and bipolar disorder (BD). Co-segregation of translocation t(9;17)(q33.2;q25.3) with psychiatric disorders has been reported. We aimed to narrow down these chromosomal breakpoint regions and to inv...
Neuropsychological performance of patients with soft bipolar spectrum disorders
There is much evidence that shows that a substantial number of individuals with DSM-IV-defined unipolar depression (UP) manifest hypomanic sub-syndrome and bipolar diathesis. Other definitions have conceptualized the term soft bipolar spectrum (SBP) for these individuals. Little is known about the cognitive profiles of individuals with SBP. We hypothesized that they are representative of indivi...