Psychiatry

A Spatiotemporal Profile of in vivo Cerebral Blood Flow Changes Following Intranasal Oxytocin in Humans
Animal and human studies highlight the role of oxytocin in social cognition and behaviour and the potential of intranasal oxytocin (IN-OT) to treat social impairment in neuropsychiatric disorders such as autism. However, extensive efforts to evaluate its central actions and therapeutic efficacy may be marred by the absence of data regarding its temporal dynamics and sites of action in the livin...


Effects of Yoga on Patients in an Adolescent Mental Health Hospital and the Relationship Between Those Effects and the Patients' Sensory-Processing Patterns
This study investigated the effects of yoga as a sensory regulation tool in reducing adolescent distress in an acute care psychiatric hospital. This was a descriptive, correlational pre-intervention/post-intervention design conducted in a mental health hospital over 5 months from mid-January to mid-June 2012. The population consisted of a convenience sample of 75 adolescent mental health unit i...
Collaborative Care for Patients With Severe Personality Disorders: Analyzing the Execution Process in a Pilot Study (Part II)
To examine the factors that influence the effective execution of a collaborative care program (CCP) for patients with severe personality disorders. and MethodsA multiple case study using qualitative research methods. FindingsThree factors were identified as influencing the execution process: (a) the context in which the CCP was executed, (b) the patient population, and (c) the individual applic...


Mental Health Nurses' Dispositional Decision-Making for People Presenting to the Emergency Department With Deliberate Self-Harm: An Exploratory Study
There is no clear treatment pathway for people presenting to Australian emergency departments with deliberate self-harm. To explore variations in mental health nurses' disposition decisions for patients following risk assessment for deliberate self-harm. and MethodA survey was distributed to mental health nurses. This survey comprised demographic items and questions in response to nine vignette...
Lessons Learned From the Trial of a Cardiometabolic Health Nurse
This paper examines the findings from an exit interview with a cardiometabolic health nurse (CHN) following a 26-week trial. and MethodsThe CHN participated in a semi-structured exit interview following completion of the 26-week trial. Applied thematic analysis was used to identify themes contained in the resultant transcript. FindingsContrary to the literature, the CHN did not consider additio...


Treatment of Children With Attention-Deficit/Hyperactivity Disorder (ADHD) and Irritability: Results From the Multimodal Treatment Study of Children With ADHD (MTA)
Clinically impairing irritability affects 25-45% of children with attention-deficit/hyperactivity disorder (ADHD). Yet we know little about what interventions are effective in treating children with ADHD and co-occurring irritability. We use data from the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (MTA) study to address three aims: 1) to establish wheth...
The Space of Common Psychiatric Disorders in Adolescents: Comorbidity Structure and Individual Latent Liabilities
To construct a virtual space of common adolescent psychiatric disorders, spanned by factors reflecting major psychopathological dimensions, and locate psychiatric disorders in that space; examine whether the major psychopathological dimensions can be hierarchically organized; and determine the distribution of the latent scores of individuals in the space spanned by those dimensions. Exploratory...

High frequency rTMS; a more effective treatment for auditory verbal hallucinations?
The great majority of studies on repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool for auditory verbal hallucinations (AVH) have used 1-Hz stimulation with inconsistent results. Recently, it has been suggested that 20-Hz rTMS has strong therapeutic effects. It is conceivable that this 20-Hz stimulation is more effective than 1-Hz stimulation. The aim of this preliminary ...
Left frontal lobe hypoperfusion and depressive symptoms in Alzheimer's disease patients taking cholinesterase inhibitors
Depressive symptoms are common in patients with Alzheimer's disease (AD) and increase the caregiver burden. Many studies have reported dorsolateral prefrontal hypometabolism or hypoperfusion in AD patients with depressive symptoms, most of whom did not take acetylcholinesterase inhibitors (AChEI). It is not clear, however, whether a similar condition is present in patients taking AChEI medicati...

Corrected QT Changes During Antipsychotic Treatment of Children and Adolescents: A Systematic Review and Meta-Analysis of Clinical Trials
To evaluate the effect of antipsychotics on the corrected QT interval (QTc) interval in youth. We searched PubMed (http://www.ncbi.nlm.nih.gov/pubmed) for randomized or open clinical trials of antipsychotics in youth <18 years with QTc data, meta-analyzing the results. Meta-regression analyses evaluated the effect of age, sex, dose, and study duration on QTc. Incidence of study-defined Q...
Cognitive and structural neuroimaging characteristics of schizophrenia patients with large, rare copy number deletions
Large (>500kb), rare (frequency <1%) deletions are associated with risk for schizophrenia. The aim of the study was to characterize patients with these deletions using measures of cognition, grey-matter volume and white-matter integrity. Patients with schizophrenia and large, rare deletions (SZ-del) (n=17) were assessed on a test of intelligence, the Wechsler Abbreviated Scale of ...

Psychodynamic psychotherapy with adolescents and young adults: Outcome in routine practice
This naturalistic study examined the outcome of psychodynamic psychotherapy with 218 adolescents and young adults aged 14–24 years. Analysis of variance showed significant improvement of general functioning on Children’s Global Assessment Scale (CGAS) and Global Assessment of Functioning (GAF) and decreased symptom severity on Symptoms Checklist-90 (SCL-90) upon completion of psycho...
Systematic review and assessment of validated case definitions for depression in administrative data
Administrative data are increasingly used to conduct research on depression and inform health services and health policy. Depression surveillance using administrative data is an alternative to surveys, which can be more resource-intensive. The objectives of this study were to: (1) systematically review the literature on validated case definitions to identify depression using International Class...
Blended vs. face-to-face cognitive behavioural treatment for major depression in specialized mental health care: study protocol of a randomized controlled cost-effectiveness trial
Depression is a prevalent disorder, associated with a high disease burden and substantial societal, economic and personal costs. Cognitive behavioural treatment has been shown to provide adequate treatment for depression. By offering this treatment in a blended format, in which online and face-to-face treatment are combined, it might be possible to reduce the number of costly face-to-face sessi...
Anomalous Self-Experience and Childhood Trauma in First-Episode Schizophrenia
Anomalous self-experiences (ASEs) are viewed as core features of schizophrenia. Childhood trauma (CT) has been postulated as a risk factor for developing schizophrenia. To investigate the relationships between CT, depression and ASEs in schizophrenia. ASEs were assessed in 55 patients in the early treated phases of schizophrenia using the Examination of Anomalous Self-Experience (EASE) instrume...