• Popular
• Upcoming

An exploratory study of primary care pharmacist-led epilepsy consultations

submitted by cmontico 20 hours ago

Most epilepsies are managed with anti-epileptic drugs (AEDs), but medication non-adherence has been frequently reported. Satisfying patient information needs has demonstrated improved adherence. Mu...

1 dig(s) Dig it Bury Topic: Pharmacology

Use of the Patient Health Questionnaire-2 to Predict Suicidal Ideations in Patients Taking Varenicline

submitted by shohraaz 20 hours ago

Varenicline, when taken for smoking cessation, has been associated with suicidal ideations (SI), but the incidence and risk factors for SI are largely unknown. The aim of this paper was to describe...

1 dig(s) Dig it Bury Topic: Pharmacology

Crack Users Show High Rates of Antisocial Personality Disorder, Engagement in Illegal Activities and Other Psychosocial Problems

submitted by dalsapan 20 hours ago

The aim of this study was to compare three groups of Brazilian psychoactive substance (PAS) abuse patients (crack cocaine users, cocaine snorters, and non-cocaine PAS users) in terms of psychiatric...

1 dig(s) Dig it Bury Topic: Pharmacology

Dopamine Transporter (DAT1) VNTR Polymorphism and Alcoholism in Two Culturally Different Populations of South India

submitted by nec 20 hours ago

It is well established that the central dopaminergic reward pathway is likely involved in alcohol intake and the progression of alcohol dependence. Dopamine transporter (DAT1) mediates the active r...

1 dig(s) Dig it Bury Topic: Pharmacology

Descriptive Characteristics and Cluster Analysis of Male Veteran Hazardous Drinkers in an Alcohol Moderation Intervention

submitted by krsch 20 hours ago

Current efforts underway to develop the fifth edition of the Diagnostic and Statistical Manual (DSM-5) have reignited discussions for classifying the substance use disorders. This study's aim was t...

1 dig(s) Dig it Bury Topic: Pharmacology

Prenatal Exposure to Testosterone Interacts with Lifetime Physical Abuse to Predict Anger Rumination and Cognitive Flexibility among Incarcerated Methamphetamine Users

submitted by larrindosl 20 hours ago

The present pilot study hypothesized that degree of exposure to prenatal testosterone interacts with a history of lifetime physical abuse (LPA) to predict the cognitive (anger rumination) and behav...

1 dig(s) Dig it Bury Topic: Pharmacology

The Obsessive–Compulsive Cocaine Scale (OCCS): A Pilot Study of a New Questionnaire for Assessing Cocaine Craving

submitted by ilino 20 hours ago

This study aimed to develop a scale (Obsessive–Compulsive Cocaine Scale [OCCS]) for measuring cocaine craving based on the Obsessive Compulsive Drinking Scale (OCDS). We tested the scale on 116 F...

1 dig(s) Dig it Bury Topic: Pharmacology

Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors

submitted by mars1999 1 day ago

In efforts to identify novel small molecules with anti-inflammatory properties, we discovered a unique series of tetracyclic indenoquinoxaline derivatives that inhibited lipopolysaccharide (LPS)-in...

1 dig(s) Dig it Bury Topic: Pharmacology

Thermodynamics and Docking of Agonists to the beta2-Adrenoceptor Determined Using

submitted by ratotorajomo118 1 day ago

G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation after ligand binding so that they can transduce signals from an extracellular ligand to a variety of intr...

1 dig(s) Dig it Bury Topic: Pharmacology

Small-Molecule Targeting of Proliferating Cell Nuclear Antigen Chromatin Association Inhibits Tumor Cell Growth

submitted by JordRod 1 day ago

Proliferating cell nuclear antigen (PCNA), a potential anticancer target, forms a homotrimer and is required for DNA replication and numerous other cellular processes. The purpose of this study was...

1 dig(s) Dig it Bury Topic: Pharmacology

Receptor Conformations Involved in Dopamine D2L Receptor Functional Selectivity Induced by Selected Transmembrane-5 Serine Mutations

submitted by rady963 1 day ago

Although functional selectivity is now widely accepted, the molecular basis is poorly understood. We have studied how aspects of transmembrane region 5 (TM5) of the dopamine D2L receptor interacts ...

1 dig(s) Dig it Bury Topic: Pharmacology

Mode of Peroxisome Proliferator-Activated Receptor gamma Activation by Luteolin

submitted by aktoygarkon 1 day ago

The peroxisome proliferator-activated receptor (PPAR) is a target for treatment of type II diabetes and other conditions. PPAR full agonists, such as thiazolidinediones (TZDs), are effective insuli...

1 dig(s) Dig it Bury Topic: Pharmacology

Differential Expression and Function of Alternative Splicing Variants of Human Liver X Receptor alpha

submitted by togedid 1 day ago

The liver X receptor α (LXRα) is a nuclear receptor that is involved in regulation of lipid metabolism, cellular proliferation and apoptosis, and immunity. In this report, we characteri...

1 dig(s) Dig it Bury Topic: Pharmacology

Nonequilibrium Activation of a G-Protein-Coupled Receptor

submitted by jeddocattan 1 day ago

G-protein-coupled receptor activation is generally analyzed under equilibrium conditions. However, real-life receptor functions are often dependent on very short, transient stimuli that may not all...

1 dig(s) Dig it Bury Topic: Pharmacology

DNA Polymerase {zeta} Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic Agents

submitted by ElmJord 1 day ago

Oxaliplatin, satraplatin, and picoplatin are cisplatin analogs that interact with DNA forming intrastrand and interstrand DNA cross-links (ICLs). Replicative bypass of cisplatin DNA adducts require...

1 dig(s) Dig it Bury Topic: Pharmacology