Pharmacology

Impact of prior chronic statin therapy and high-intensity statin therapy at discharge on circulating endothelial progenitor cell levels in patients with acute myocardial infarction: a prospective observational study
Endothelial progenitor stem cells (EPCs) are mobilized to the peripheral circulation in response to myocardial ischemia, playing a crucial role in vascular repair. Statins have been shown to stimulate EPCs. However, neither the impact of previous statin therapy on EPC response of acute myocardial infarction (AMI) patients nor the effect of post-AMI high-intensity statin therapy on the evolution...


Impact of cytochrome P450 inducers with or without inhibitors on the serum clobazam level in patients with antiepileptic polypharmacy
The aim of this study was to evaluate the effect of cytochrome P450 (CYP) inducers/inhibitors on the pharmacokinetics of clobazam (CLB) in patients receiving antiepileptic polypharmacy. A total of 2,504 samples obtained from 1,280 patients for routine therapeutic drug monitoring were retrospectively reviewed. These samples were grouped according to the antiepileptic drug regimens or age, and th...
Assessment of pharmacist-led patient counseling in randomized controlled trials: a systematic review
Pharmacists’ counseling has improved health-related outcomes in many acute and chronic conditions. Several studies have shown how pharmacists have been contributing to reduce morbidity and mortality related to drug-therapy (MMRDT). However, there still is a lack of reviews that assemble evidence-based clinical pharmacists’ counseling. Equally, there is also a need to understand structure ch...


15-deoxy-Δ12,14-prostaglandin J2 reduces albumin-induced arthritis in temporomandibular joint of rats
The aim of this study was to evaluate the peripheral effect of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) in albumin-induced arthritis in temporomandibular joint (TMJ) of rats. Antigen-induced arthritis (AIA) was generated in rats with methylated bovine serum albumin (mBSA) diluted in complete Freund׳s adjuvant. Pretreatment with an intra-articular injection of 15d-PGJ2 (100ng/TMJ) before mB...
Therapeutic Targeting of Src Kinase in Myofibroblast Differentiation and Pulmonary Fibrosis
Myofibroblasts are effector cells in fibrotic disorders by synthesizing and remodeling the extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in myofibroblast activation in vitro and fibrogenesis in vivo. The pro-fibrotic cytokine, transforming growth factor beta-1 (TGF-β1), induced rapid activation of Src kinase that leads to myofibroblast differentiati...


Algorithm for difficult airway management in pediatrics
To describe a series of activities structured for managing the difficult airway in pediatrics and to suggest an algorithm adapted to the individual child's conditions. Case review of medical literature databases (PubMed, BIREME and MD consult); the search was based on the following.
Different Patterns of Drug Use and Barriers to Continuous HIV Care Post-Incarceration
Individuals with a drug use history often experience drug use relapse when they are released from incarceration. This article explores the processes by which a sample of adults experienced relapse post-incarceration and consequently experienced HIV treatment interruption. Data are from in-depth interviews with 25 formerly incarcerated HIV-positive adults who have a self-reported history of drug...

Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations
The aim of this article was to develop and validate a simple, sensitive, precise and cost effective one level agar diffusion (5+1) bioassay for estimation of potency and bioactivity of Levofloxacin in pharmaceutical preparation which has yet not been reported in any Pharmacopoeia. Among 16 microbial strains, Bacillus pumilus ATCC-14884 was selected as the most significant strain against Levoflo...
Design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach
Although a number of antiviral agents are licensed for treatment of some human herpesvirus (HHV) infections, effective antiviral therapy is not available for all HHVs. Additional complications are associated with approved drugs, such as toxicity and side effects, and rise in drug-resistant strains is a driving force for new drug development. Success in HHV vaccine development is limited with on...

The PIP2-binding Sequence of Transient Receptor Potential Channel Canonical 4alpha is Critical for its Contribution to Cardiomyocyte Hypertrophy
Cardiomyocyte hypertrophy requires a source of Ca2+ distinct from the Ca2+ that regulates contraction. The canonical transient receptor potential channel family (TrpC), a family of cation channels regulated by activation of phospholipase C (PLC), has been implicated in this response. Cardiomyocyte hypertrophy downstream of Gq-coupled receptors is mediated specifically by PLCβ1b that is sca...
Evaluation of the Potential for a Pharmacokinetic Drug–Drug Interaction Between Armodafinil and Ziprasidone in Healthy Adults
Armodafinil has been studied as adjunctive therapy for major depressive episodes associated with bipolar I disorder. This open-label, single-centre, 2-period study evaluated the effect of armodafinil, a moderate inducer of cytochrome-P450 (CYP) isoenzyme CYP3A4, on the pharmacokinetics and safety of ziprasidone, an atypical antipsychotic used to treat bipolar I disorder and metabolized in part ...

Effects of new formulation strategy on life cycle management in the US pharmaceutical industry
This research discusses the role of new formulation strategies on life cycle management in the US pharmaceutical industry and evaluates its effect on the market life of existing drug products. We constructed a method to quantitatively measure the life cycle extension period of new formulation pharmaceuticals, including censored cases, wherein the generic drug has not yet been approved and the i...
European Generic Medicines Association (EGA) vision
Patients are at the heart of the generic and biosimilar medicine industries’ mission. We are committed to supplying them with high-quality medicines, delivering better value and ensuring the sustainability of our European healthcare systems. We are, and will continue pursuing this universal aim of a healthier society through trustworthy partnerships including EU institutions, national reg...
Manejo anestésico del síndrome de Stiff Man
El síndrome de Stiff Man o síndrome de la persona rígida es una enfermedad rara de causa inmunológica. Se caracteriza por la rigidez en la musculatura axial y las extremidades inferiores, y espasmos dolorosos desencadenados por estímulos. Presentamos el caso de un paciente de 44 años con síndrome de la persona rígida al que se le realizó una infiltración del esfínter uretral con toxi...
Single shot spinal anesthesia with very low hyperbaric bupivacaine dose (3.75mg) for hip fracture repair surgery in the elderly. A randomized, double blinded study
Single shot spinal anesthesia is used worldwide for hip fracture repair surgery in the elderly. Arterial hypotension is a frequent adverse effect. We hypothesized that lowering local anesthetics dose could decrease the incidence of arterial hypotension, while maintaining quality of surgical anesthesia. In a randomized double blinded study, 66 patients over the age of 65 years, with hip fracture...