Pathology

Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of two cases with markedly increased urinary podocyte excretion
We report 2 cases of diffuse mesangial sclerosis (DMS) accompanied by severe podocyte excretion in urine. Patient 1 was a 9-day-old girl with a WT1 mutation who developed Wilms’ tumor at 6months of age and was subsequently diagnosed with Denys–Drash syndrome. Patient 2 was a 1-year-old boy without a WT1 abnormality but presenting with heavy proteinuria. In both patients, histological examin...


Low expression of microRNA-146b-5p and microRNA-320d predicts poor outcome of large B-cell lymphoma treated with CHOP
While diffuse large B-cell lymphoma (DLBCL) encompasses a biologically and clinically diverse set of diseases, increasing evidence has pointed to an important role of microRNAs (miRs) in the pathogenesis of DLBCL. We report here that low expression of miR-146b-5p and miR-320d is associated with poor prognosis of DLBCL patients treated with the standard CHOP regimen, and that this is related to ...
Cytoplasmic PAR-3 protein expression is associated with adverse prognostic factors in clear cell renal cell carcinoma and independently impacts survival
Clear cell renal cell carcinomas (ccRCC) represent 70% of renal cancers and several clinical and histolopathological factors are implicated in its prognosis. We recently demonstrated that the overexpression of PAR-3 protein encoded by the PARD3 gene could be implicated in renal oncogenesis. The object of this work was to study the association of intratumoral PAR-3 expression with known prognost...


Multifocal Kaposiform Hemangioendothelioma in Multiple Visceral Organs: An Autopsy of 9-Day-Old Female Baby
Kaposiform hemangioendothelioma is a vascular tumor categorized as intermediate malignancy. We experienced an autopsy of a female baby with kaposiform hemangioendothelioma with Kasabach-Merritt syndrome. She died of systemic bleeding tendency following disseminated intravascular coagulation at the age of 9 days. At autopsy, a huge main tumor, histologically kaposiform hemangioendothelioma, was ...
Vulvo-vaginal Angiomyofibroblastomas: Morphological, Immunohistochemical and Fluorescence in Situ Hybridization Analysis for Deletion of 13q14 Region
Angiomyofibroblastoma (AMFB) is a benign tumor which belongs to the category of the “stromal tumors of the lower female genital tract”, together with cellular angiofibroma and myofibroblastoma. Previous studies have shown overlapping morphological and immunohistochemical features between these tumors and spindle cell lipoma, mammary-type myofibroblastoma, and vulvo-vaginal cellular angiofib...


B-Lymphoblastic Leukemia/Lymphoma: Overexpression of Nuclear DNA Repair Protein PARP-1 Correlates with Anti-Apoptotic Protein Bcl-2 and Complex Chromosomal Abnormalities
Poly(ADP-ribose) polymerase-1 (PARP-1) and Bcl-2 are emerging as therapeutic targets in various cancers. The former is a DNA repair protein associated with genomic stability and apoptosis, whereas the latter is an anti-apoptotic protein having a DNA repair function through inhibition of PARP-Because genomic stability is critical for prognosis in B-lymphoblastic leukemia/lymphoma (B-ALL), we stu...
Enhanced immunohistochemical detection of neural infiltration in primary melanoma: is there clinical value?
Neural infiltration in primary melanoma is a histopathologic feature that has been associated with desmoplastic histopathologic subtype and local recurrence in the literature. We tested the hypothesis that improved detection and characterization of neural infiltration into peritumoral or intratumoral location and perineural or intraneural involvement could have prognostic relevance. We studied ...

Immunoreactivity using anti-ERG monoclonal antibodies in sarcomas is influenced by clone selection
The aim of the present study was to explore ERG immunoreactivity in a series of sarcomas, GIST and malignant rhabdoid tumor (MRT), considering the not fully elucidated specificity and sensitivity of this antibody. Paraffin-embedded tissue microarrays from those tumors were stained with anti-ERG against the C-terminus [(EPR3864] and N-terminus (Clone 9FY). EPR3864 was positive in almost all angi...
Low Expression of Activating Transcription Factor 3 in Human Hepatocellular Carcinoma and its Clinicopathological Significance
To explore the expression and role of Activating Transcription Factor 3 in Human hepatocellular carcinoma. Immunohistochemistry, Western blot assay and Real-time PCR were used to evaluate Activating Transcription Factor 3 protein and gene level in HCC clinical samples. Activating Transcription Factor 3 expression is lowest in HCC, and the protein level is lower in patients with capsule invasion...

MET expression is associated with disease-specific survival in breast cancer patients in the neoadjuvant setting
Met and RON receptor tyrosine kinases play an important role in tumor progression. The aim of this study was to determine the predictive or prognostic impact of met and RON in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Immunohistochemical analyses were performed to retrospectively examine the predictive or prognostic impact of met and RON expression in 129 breast cancer...
In-stent restenosis is associated with neointimal angiogenesis and macrophage infiltrates
Restenosis after stenting occurs secondary to the neointima formation. Neovessels have been found in the neointima within stents. However, there are few studies correlating neointimal angiogenesis and in-stent restenosis in humans. We analyzed 65 post-mortem stented arteries from 33 patients with duration>3 months. Cause of death was determined incidental to the coronary findings in ever...

Notch3 signaling is associated with MUC5AC expression and favorable prognosis in patients with small intestinal adenocarcinomas
Notch signaling plays diverse roles not only in physiologic processes, including development and differentiation but also in tumorigenesis, either as a tumor promoter or suppressor depending on the cellular context, level of expression and cross-talk with other signaling pathways. In this study we investigated the expression of Notch3 and MUC proteins and their clinicopathological significance ...
The association between indirect bilirubin levels and liver fibrosis due to chronic hepatitis C virus infection
We proposed to evaluate the association between serum indirect bilirubin levels and liver fibrosis in patients with chronic hepatitis C (CHC) genotype 1b. Biopsy proven CHC genotype 1b patients’ demographics, clinical and histopathological characteristics were evaluated. Logistic regression analysis was done to evaluate the clinical, laboratory and demographic features of the histologically p...
Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The aim of our study was to evaluate anterior...
M1- and M2-macrophage Polarization in Rat Liver Cirrhosis Induced by Thioacetamide (TAA), Focusing on Iba1 and Galectin-3
Resident and exudate macrophages play an important role in the development of liver cirrhosis. Ionized calcium binding adaptor molecule 1+ (Iba1+) and galectin-3+ (Gal-3+) macrophages regulate liver fibrosis probably through pro-inflammatory and pro-fibrotic factors. Macrophages show polarized functions in liver fibrosis; however, M1-/M2-polarization of Iba1+ and Gal-3+ macrophages remains obsc...