Pathology

Meta-Analysis of Oncological Outcome After Abdominoperineal Resection or Low Anterior Resection for Lower Rectal Cancer
In lower rectal cancer, postoperative outcome is still subject of controversy between the advocates of abdominoperineal resection (APR) and low anterior resection (LAR). Reports suggest that low anterior resection may be oncologically superior to abdominoperineal excision, although no good evidence exists to support this. Publications were identified which assessed the differences comparing 5-y...


Carcinoma Showing Thymus-Like Elements of the Thyroid Gland: Report of Three Cases Including One Case with Breast Cancer History
Carcinoma showing thymus-like elements (CASTLE) is a rare malignant tumor of the thyroid or adjacent neck soft tissues, whose histogenesis is still debated. It may resemble other primary or metastatic poorly differentiated tumors histologically and the differential diagnosis is crucial for CASTLE has a better prognosis. However, CASTLE as a second primary tumor has not been reported in the lite...
Evaluation of Antitumor Activity of Platelet Microbicidal Protein on the Model of Transplanted Breast Cancer in CBRB-Rb(8.17)1Iem Mice
Breast cancer is the most common women’s cancer in the world. There is considerable current interest in developing anticancer agents with a new mode of action because of the development of resistance by cancer cells towards current anticancer drugs. Mamalian cells have been shown to contain small, cationic, microbicidal peptides. Antimicrobial peptides have drawn attention as a promising alte...


Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma—A review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features
Membranous basal cell adenoma (MBCA) is a rare benign salivary gland neoplasm. It is difficult to diagnose MBCA based on fine-needle aspiration (FNA) cytology due to rare reporting of its FNA cytology and overlapping of its FNA cytologic features with some benign and malignant entities. We present a case of MBCA in a 67-year-old female that was originally misinterpreted as adenoid cystic carcin...
A case-cohort study of recurrent salivary adenoid cystic carcinoma after 125I brachytherapy and resection treatment
Recurrent adenoid cystic carcinoma (rAdCC) can be challenging to be treated with brachytherapy, although brachytherapy is safe and effective in treating head and neck cancers. Patients of adenoid cystic carcinoma (AdCC), who underwent resection and 125I radioactive seed implantation, were recruited for this study. Clinical data, surgical details of resection and seed implantation, histological ...


Asynchronous glands in secretory pattern endometrium: clinical associations and immunohistological changes
The significance and pathogenesis of irregular or asynchronous maturation within endometrial glands remains uncertain. This study investigated differences in epithelial hormone receptor immunoreactivity and stromal cell calretinin, CD34 and p16 expression in morphologically normal secretory endometrium and in asynchronous (non-secretory) endometrial glands (AEGs). and ResultsNineteen consecutiv...
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology
High expression of carbonic anhydrase IX (CA IX) has been reported in clear cell renal cell carcinoma (ccRCC); few studies have reported CA IX expression in other tumours with predominantly clear cell morphology. The aim of study was to examine the expression and diagnostic implications of CA IX in these latter tumours. and resultsAn immunohistochemical study was performed of 159 tumours with p...

Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma
Manual counting of the fraction of Ki-67 positive cells (the Ki-67 index) in 1000 tumor cells is considered the “gold standard” to predict prognosis in mantle cell lymphoma (MCL). This time-consuming method is replaced by the faster, but less accurate semiquantitative estimation in routine practice. The aim of this study was to investigate the use of computerized image analysis software for...
Endoscopic biopsies from gastrointestinal carcinomas and their suitability for molecular analysis: a review of the literature and recommendations for clinical practice and research
Endoscopic biopsies (EB) are the gold standard for diagnosing gastrointestinal carcinoma yet no guidelines address EB use for prognostic and predictive molecular testing. This review summarises the reported quantity and quality of EB, their relationship with molecular test failure rates, and result concordance between EB and resection specimens. Studies reporting molecular testing on gastrointe...

Clinicopathological characteristics and rituximab-plus cytotoxic therapies in patients with rheumatoid arthritis and methotrexate-associated large B-lymphoproliferative disorders
To analyse the clinicopathological characteristics and prognosis of 40 rheumatoid arthritis (RA) patients with methotrexate (MTX)-associated large B-cell lymphoproliferative disorders (MTX-BLPD). Materials and resultsSoluble interleukin 2 receptor titres (median 1500 U/ml) in 40 patients with MTX-BLPD were lower than those of 24 RA patients with non-MTX- associated (non-MTX) BLPD (5731 U/ml) an...
CUL4B activates Wnt/β-catenin signaling in hepatocellular carcinoma by repressing Wnt antagonists
Activation of Wnt/β-catenin signaling is frequently observed in many types of cancers including hepatocellular carcinoma (HCC). We recently reported that Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of solid tumors and contributes to epigenetic silencing of tumor suppressors. In this study, we characterized the function o...

Tumour but not stromal expression of β3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer
Although many pre-clinical studies have implicated β3 integrin receptors (αvβ3 and αIIbβ3) in cancer progression, β3 inhibitors have shown only modest efficacy in patients with advanced solid tumours. The limited efficacy of β3 inhibitors in patients could arise from our incomplete understanding of the precise function of β3 integrin and, consequently, inappropriate clinical application...
Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease
Amyloid β peptide (Aβ) immunization of Alzheimer's disease (AD) patients has been reported to induce amyloid plaque removal but with little impact on cognitive decline. We have explored the consequences of Aβ immunotherapy on neurons in post-mortem brain tissue. Eleven immunized (AN1792, Elan Pharmaceuticals) AD patients were compared to 28 non-immunized AD cases. Immunohistochemistry on sec...
Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses
Osteochondrosis arises as a result of focal failure of the blood supply to growth cartilage. The current aim was to examine the pathogenesis of pseudocysts and true cysts in subchondral bone following failure of the blood supply to the articular-epiphyseal cartilage complex in horses. Cases were recruited based on identification of lesions (n = 17) that were considered likely to progress to or ...
Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens, and toxins from the gut lumen into the circulation. The equilibrium between the rate of apoptosis and shedding of senescent epithelial cells at t...