Pathology

Impact of diabetes mellitus on myocardial lipid deposition: an autopsy study
Lipid accumulation in the cardiac parenchyma has historically been known as fatty heart. Myocardial lipotoxicity and cardiac steatosis have been shown to be involved in the pathogenesis of obesity and diabetic mellitus (DM). Mutated adipose triglyceride lipase (ATGL), a key catalytic enzyme of triglyceride, has been found to cause human triglyceride deposit cardiomyovasculopathy (TGCV). Neverth...


An Epidemiological Study Investigating the Relationship between Chorangioma and Infantile Hemangioma
This study aimed to verify whether the infantile hemangioma (IH) incidence in children whose placentas showed a chorangioma is higher than in the general population, thus addressing the hypothesized relationship between chorangioma and IH. All chorangioma diagnoses by the 1st Service of Pathology, University of Padova in 2004-2010, based on the analysis of placentas sent by the Department of Gy...
CD10 is useful to identify gastrointestinal contamination in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) cytology from pancreatic ductal adenocarcinoma
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) cytology is an effective tool to diagnose pancreatic ductal adenocarcinoma (PDA). Standard morphological criteria are usually reliable. When contaminating gastrointestinal (GI) epithelial cells are prevalent among neoplastic cells, these can be highlighted by carcinoembryonic antigen (CEA) staining. CD10 is a cell-surface metallopept...


Mouse Models of Hepatitis B Virus Infection Comprising Host-Virus Immunologic Interactions
Hepatitis B virus (HBV) infection is one of the most prevalent infectious diseases associated with various human liver diseases, including acute, fulminant and chronic hepatitis; liver cirrhosis; and hepatocellular carcinoma. Despite the availability of an HBV vaccine and the development of antiviral therapies, there are still more than 350 million chronically infected people worldwide, approxi...
The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study
The aim of the present study was to establish the role of HIF1A gene polymorphisms in the risk of developing premature coronary artery disease (CAD) in a well-characterized clinical cohort. Three polymorphisms in HIF1A (rs11549465, rs11549467, rs2057482) gene were genotyped in 949 patients with premature CAD, and 676 healthy controls (with negative calcium score by computed tomography). Under a...


Activation of Monocyte-Derived Cells in the Bone Marrow of Myelodysplastic Syndrome
Object: To study the relationship between monocyte/histiocyte activation and myelodysplastic syndrome (MDS). Analyzing ultrastructure and myeloperoxidase reaction of nucleated cells in bone marrow from 59 cases of MDS by transmission electron microscopy. Four groups of MDS were subdivided on the basis of their content of activated inflammatory cells – morbid hematopoiesis with minimal inflamm...
An NRAS mutation in a case of Erdheim Chester disease
Erdheim Chester disease (ECD) is a rare, non-Langerhans’ cell histiocytic neoplastic disorder that usually presents in patients in their fifties. ECD often presents as a multi-system macrophagic infiltration and common sites of involvement are the central nervous system, cardiovascular system, respiratory system, retroperitoneum, and skin. Extra-skeletal involvement is usually responsible for...

The Role of Protein p16INK4a in Glottic Laryngeal Squamous Cell Carcinoma
Head and neck squamous cell cancer (HNSCC) includes tumors of various anatomical sites sharing the common etiological factors. However some differences in pathogenesis and prognosis of HNSCC have been hitherto documented. Laryngeal squamous cell carcinoma (LSCC) is one the most common type of the head and neck cancer. The majority of laryngeal cancers are located in the glottic area. P16 was re...
Caveolin-1 Promotes an Invasive Phenotype and Predicts Poor Prognosis in Large Cell Lung Carcinoma
This study investigated the relationships of caveolin-1 expression with clinical pathologic parameters and the prognosis of patients with large cell lung carcinoma. This study also explored the roles of caveolin-1 in cell invasiveness, matrix metalloproteinase (MMP) expression, and non-small cell lung carcinoma activity in vitro A total of 120 tissue samples were immunohistochemically analyzed ...

Elevated Circulating miR-150 and miR-342-3p in Patients with Irritable Bowel Syndrome
MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression and are thus of interest as diagnostic markers, and as clues to etiology and targets of intervention. This pilot study examined whether circulating miRNAs are differentially expressed in patients with IBS. miRNA microarrays (Nanostring) were run on the whole blood of 43 participants. hsa-miR-150 and hsa-miR-342-3p were...
Matrix Metalloproteinase-12 Immunolocalization in the Degenerating Human Intervertebral Disc and Sand Rat Spine: Biologic Implications
Matrix metalloproteinase-12 (MMP-12; macrophage metalloelastase) degrades a number of extracellular matrix components which are present in the intervertebral disc, including type IV collagen, fibronectin, laminin, chondroitin sulfates, elastin and fibrinogen. MMP-12 has recently discovered relationships with cytokines and chemokines which also relate to disc cell biology. To date, no study has ...

Renin Angiotensin System Modulates mTOR Pathway through AT2R in HIVAN
Mammalian target of rapamycin (mTOR) has been reported to contribute to the development of HIV-associated nephropathy (HIVAN). We hypothesized that HIV may be activating renal tissue mTOR pathway through renin angiotensin system (RAS) via Angiotensin Receptor Type II receptor (AT2R). Renal tissues of Vpr transgenic and Tg26 (HIVAN) mice displayed enhanced phoshphorylation of mTOR and p70S6K. Al...
Kallikrein 3 and vitamin D receptor polymorphisms: potentials environmental risk factors for prostate cancer
To investigate the relationship and interaction of the single nucleotide polymorphisms(SNPs) of KLK3 and VDR and environmental factors with the predisposition to prostate cancer within Chinese population. The comparison between 108 patients and 242 healthy people was carried out by using the TaqMan/MGB Probe Technology to determine the genotypes of KLK3(rs2735839 is located between KLK2 and KLK...
FNAC samples: a good source of material to evaluate biomarkers in breast cancer
We read with interest the article published recently in Histopathology by Stalhammar and coworkers entitled “Low concordance of biomarkers in histopathological and cytological material from breast cancer”The assessment of the classical routine prognostic and predictive biomarkers of breast cancer (ER, PR and HER2) has becoming a relevant issue, especially in metastatic site2, 3. Amir E et ...
Pathological Evaluation of the Staging Axillary Lymph Nodes for breast cancer: A National Survey in the United Kingdom
The handling and examination of sentinel lymph nodes (SLNs) to detect metastasis is critical in the assessment of early breast cancer patients. This survey investigates the variation in practice followed by pathology units across the United Kingdom in the staging evaluation of axillary lymph nodes (ALN). A structured questionnaire, approved by the NHSBSP pathology Big 18 committee, was circulat...