Pathology

Boveri at 100: Theodor Boveri and Genetic Predisposition To Cancer
A hundred years have passed since the publication of Theodore Boveri's Zur Frage der Entstehung maligner Tumoren (‘Concerning the Origin of Malignant Tumours’). This prescient publication created the foundations for much of our understanding of the origins of cancer and in particular the genetic basis of some cancers. In his work, Boveri's suggested that loss of key attributes, now known as...


PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition
Pancreatic adenocarcinoma (PDAC) is a major unmet medical need and a deeper understanding of molecular drivers is needed to advance therapeutic options for patients. We report here that p21-activated kinase 1 (PAK1) is a central node in PDAC cells downstream of multiple growth factor signaling pathways, including hepatocyte growth factor (HGF) and MET receptor tyrosine kinase. PAK1 inhibition b...
Histologische Malignitätsgraduierung des Ovarialkarzinoms
Die Malignitätsgraduierung des Ovarialkarzinoms ist für die Therapieentscheidung wichtig und hat prognostische Bedeutung. Bisher ist jedoch kein einheitliches System zur Graduierung etabliert. Mehrere Gradingsysteme sind in Gebrauch, wie z. B. das FIGO-, WHO- und Silverberg-Grading, die nicht oder nur unzureichend übersetzbar sind. Darüber hinaus lassen sich die einzelnen Gradingsysteme un...


Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2-independent and RACK1-mediated mechanism of HIF-1α stabilization
The growth adaptation of cancer cells to an hypoxic tumor microenvironment is mostly regulated by hypoxia-induced transcription factor HIF-HIF-1 transcriptional activity is strictly controlled by protein levels of the HIF-1α subunit, which is tightly regulated by a well-characterized O2-dependent ubiquitin ligase-proteasomal degradation pathway. The cold-sensitive Ca2+ channel protein TRPM8 ex...
Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases
Liposarcoma are the most frequent soft tissue sarcoma. Well differentiated liposarcoma may progress into dedifferentiated liposarcoma with pleomorphic histology. A minority additionally features myogenic, osteo- or chondrosarcomatous heterologous differentiation. Genomic amplification of the Mouse double minute 2 homolog (MDM2) locus is characteristic for well differentiated and dedifferentiate...


Motor and Memory Function in Rat models of Cyanide Toxicity and Vascular Occlusion Induced Ischemic Injury
Although oxidative stress is characteristic of global vascular occlusion and cyanide toxicity, the pattern of cerebral metabolism reconditioning and rate of progression or reversal of neural tissue damage differ for both forms of ischemia. Thus, it is important to compare cognitive and motor functions in both models of ischemia involving cyanide treatment (CN) and vascular occlusion (VO). Adult...
Protease-Activated Receptor 2 Suppresses Lymphangiogenesis and Subsequent Lymph Node Metastasis in a Murine Pancreatic Cancer Model
Protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that functions as a cell-surface sensor for coagulation factors, and other proteases associated with the tumour microenvironment. Pancreatic cancer cells express high levels of PAR-2 and activation of PAR-2 may induce their proliferation and migration. Interestingly however, PAR-2 expression is increased in stromal rich pancr...

Boveri at 100: The life and times of Theodor Boveri
This Perspective focuses on the life and personality of T. H. Boveri who was one of the leading, creative and visionary scientists of the second half of the 19tth century. Born in Bamberg 1862 he made his scientific career in Munich and Würzburg where he produced his prolific and important research including seminal papers on cytogenetics. Of particular note is his work on chromosomal structur...
Clear Cell Carcinomas of the Ovary. Evaluation of Prognostic Parameters Based On a Clinicopathologic Analysis of 100 Cases
The aim of this study was to evaluate the clinicopathologic features of ovarian clear cell carcinomas to identify which, if any, are prognostically significant and determine whether there is value in grading these tumors. One-hundred tumors with clinical follow-up were reviewed. Features evaluated included age, preoperative/intraoperative rupture, size, architectural pattern(s), presence of oxy...

Multifocal synchronous mucinous adenocarcinomas arising in congenital pulmonary airway malformation: a case report with molecular study
Congenital pulmonary airway malformation (CPAM) is a rare developmental anomaly of the lung. Here, we report a case of mucinous adenocarcinoma arising in CPAM. A 23-month-old boy underwent a thoracoscopic lobectomy of the left upper lobe of the lung based on a presumptive diagnosis of asymptomatic CPAM, found in antenatal sonogram. & ResultsHistologically, the lesion was consistent with CPAM, S...
Novel use for an EGFR mutation-specific antibody in discriminating lung adenocarcinoma from reactive pneumocyte hyperplasia
Pulmonary ground-glass nodules (GGNs) is frequently observed. Histopathologically, their presentation can indicate a wide range of disorders from an inflammatory process to malignancy. An accurate diagnosis based on GGNs can sometimes be challenging on small-sized biopsies. Mutations in the EGFR gene are detected in pulmonary adenocarcinomas (ADCs). Immunohistochemical analysis using antibodies...

Myoepithelioma of Bone with a Novel FUS-POU5F1 Fusion Gene
Myoepithelial tumours of soft tissue are rare lesions with a broad morphological and clinical spectrum. Previous studies have found EWSR1 rearrangements in approximately half of all cases and PBX1, ZNF44 and POU5F1 have been identified as recurrent fusion partners. In bone, only a small number of myoepithelial tumours have been described. We investigated an intraosseous myoepithelioma of the sa...
Liver histology of acute brucellosis caused by Brucella melitensis
As a major organ of the mononuclear phagocytic system, the liver is probably involved in all cases of brucellosis. In this prospective study, liver slides prepared from percutaneous liver biopsy samples of 20 patients with clinical and laboratory evidence of acute brucellosis due to Brucella melitensis were examined for the presence or absence of granulomas by pathologists in Iran and the Unite...
Surgical pathology and the patient: A systematic review evaluating the primary audience of pathology reports
The pathology report is a critical document that helps guide the management of patients with cancer. More and more patients read their reports, intending to participate in decisions about their care. However, a substantial subset of patients may lack the ability to comprehend this often technical and complex document. We hypothesized that most literature on pathology reports discusses reports f...
Prognostic Value of Histologic Grading for Feline Mammary Carcinoma: A Retrospective Survival Analysis
Feline mammary carcinoma is highly malignant and generally associated with a poor prognosis, although studies suggest the range of survival times in affected cats is broad. Histologic grading of these tumors is achieved using the Elston and Ellis system, originally developed for human breast cancer. In cats, however, classification using this method has variable prognostic value. Therefore, obj...