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Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation

submitted by giargis 15 hours ago

Resolvin E1 (RvE1) is a naturally occurring lipid-derived mediator generated during the resolution of inflammation. The anti-inflammatory effects of RvE1 have been demonstrated in a variety of dise...

1 dig(s) Dig it Bury Topic: Pathology

Differential drug-class specific metastatic effects following treatment with a panel of angiogenesis inhibitors

submitted by KaseGaig 15 hours ago

Inhibiting angiogenesis has become an important therapeutic strategy for cancer treatment, but like other current targeted therapies, benefits experienced for late-stage cancers can be curtailed by...

1 dig(s) Dig it Bury Topic: Pathology

Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche

submitted by koangmyot12 15 hours ago

Non-cancerous immune cells can significantly contribute to tumour progression and metastases. Neutrophils associated with tumours can both promote and inhibit tumour progression, but less is known ...

1 dig(s) Dig it Bury Topic: Pathology

Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumor models

submitted by tatabolodo 15 hours ago

Resistance to anti-angiogenic therapy can occur via several potential mechanisms. Unexpectedly, recent studies showed that short-term inhibition of either VEGF or VEGFR enhanced tumor invasiveness ...

1 dig(s) Dig it Bury Topic: Pathology

Cutaneous Pseudolymphoma Following Tattoo Application: Report of Two New Cases of a Potential Lymphoma Mimicker

submitted by dcpad 16 hours ago

The authors report 2 cases of cutaneous pseudolymphoma that occurred in 2 young adult patients who referred for relentlessly growing nodules that appeared within 4 to 5 months after the application...

1 dig(s) Dig it Bury Topic: Pathology

Combined Aldosterone and Cortisol Secretion by Adrenal Incidentaloma

submitted by jissei10 16 hours ago

A 70-year-old woman was referred to the authors’ unit following hospitalization for cardiac failure, high urinary free cortisol concentrations and severe hypokaliemia. A computed tomography s...

1 dig(s) Dig it Bury Topic: Pathology

Abdominal Wall Endometriosis Associated With Ventriculoperitoneal and Lumboperitoneal Shunts: A Report of 2 Cases of an Extremely Rare Phenomenon

submitted by lechin 16 hours ago

Endometriosis is a common condition in women of reproductive age and has a known propensity to involve abdominal wall scars. The authors report 2 cases of endometriosis presenting as mass lesions i...

1 dig(s) Dig it Bury Topic: Pathology

Metaplastic Carcinoma of the Breast With Dominant Squamous and Sebaceous Differentiation in the Primary Tumor and Osteochondroid Metaplasia in a Distant Metastasis: Report of a Case With Review of Sebaceous Differentiation in Breast Tumors

submitted by SidnCase 16 hours ago

Metaplastic breast carcinoma is an uncommon tumor that develops from conventional ductal mammary carcinoma, usually consisting of squamous and/or spindle cell components and/or mesenchymal elements...

1 dig(s) Dig it Bury Topic: Pathology

Embryonal (Undifferentiated) Sarcoma of the Liver With Peripheral Angiosarcoma Differentiation Arising in a Mesenchymal Hamartoma in an Adult Patient

submitted by BraAeda 16 hours ago

Embryonal (undifferentiated) sarcoma of the liver (ESL) is a rare malignant neoplasm composed of undifferentiated sarcomatous tissue. We are presenting a case of a 74-year-old woman diagnosed with ...

1 dig(s) Dig it Bury Topic: Pathology

Adenohibernoma: A Rare Breast Tumor

submitted by NatJor 16 hours ago

Adenohibernoma of the breast is a very rare tumor composed of brown fat tissue and intermingled glandular tissue. There are only 2 case reports in literature. This study reports the third case of a...

1 dig(s) Dig it Bury Topic: Pathology

G-CSF-Producing Malignant Pleural Mesothelioma: An Autopsy Case Report With Literature Review

submitted by jbierzo 16 hours ago

This study reports a 54-year-old man who was a carpenter by occupation. He suffered from left chest and back pain and left pleural effusion. Peripheral blood showed granulocytosis and high serum ti...

1 dig(s) Dig it Bury Topic: Pathology

Primary Extragonadal Germinoma of the Medulla Oblongata

submitted by mizshf 16 hours ago

Extragonadal germ cell tumors rarely arise from the brain stem. In this report, the authors present a rare case of germinoma developing in the medulla oblongata. A 31-year-old woman complained of i...

1 dig(s) Dig it Bury Topic: Pathology

Two Out of Three Required: A Case of Incomplete Carney Triad

submitted by AdrianBro 16 hours ago

A 48-year-old woman presented with chest symptoms. Multiple lesions seen on chest imaging were found to be pulmonary chondromas following surgical resection. Whole body magnetic resonance scan perf...

1 dig(s) Dig it Bury Topic: Pathology

Renal Cell Carcinoma With Extensive Oncocytic Features

submitted by ivintari 16 hours ago

Oncocytic features are a hallmark of renal oncocytoma, but can be seen in other renal tumors such as clear cell renal cell carcinoma with granular cells and eosinophilic variant of chromophobe cell...

1 dig(s) Dig it Bury Topic: Pathology

Use of Fluorescence In Situ Hybridization to Distinguish Metastatic Uveal From Cutaneous Melanoma

submitted by pondo579 16 hours ago

Metastatic lesions of malignant melanoma can on occasion be difficult to classify with regard to the primary site of origin. Given the lack of specificity of light microscopic features, ancillary s...

1 dig(s) Dig it Bury Topic: Pathology