Oncology

Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2 positive metastatic breast cancer patients treated with first-line lapatinib
Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (i.e. PIK3CA mutations and/or phosphatase and tensin homolog (PTEN) loss) has been shown to enhance breast cancer cell survival and confer resistance to chemotherapeutic agents. We studied the prognostic and predictive value of PIK3CA mutations and PTEN low in patients receiving paclitaxel alone or in combination with lapatinib. Immunohi...


Nestin positively regulates the Wnt/ß-catenin pathway and the proliferation, survival, and invasiveness of breast cancer stem cells
We investigated Nestin expression in triple-negative breast cancer and examined how the modulation of Nestin expression affects cell cycle progression, survival, invasion and regulatory signaling in breast cancer stem cells (CSC) in vitro. Nestin expression in 150 triple-negative breast cancer specimens were examined by immunohistochemistry. The role of Nestin expression in tumorigenesis was ex...
A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype
Despite improvements in adjuvant therapy, late systemic recurrences remain a lethal consequence of both early and late stage breast cancer. A delayed recurrence is thought to arise from a state of tumor dormancy, but the mechanisms that govern tumor dormancy remain poorly understood. To address the features of breast tumors associated with late recurrence, but not confounded by variations in sy...


Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression
Expression of indoleamine 2, 3-dioxygenase (IDO) in primary breast cancer increases tumor growth and metastasis. However, clinical significance of stromal IDO and the regulation of stromal IDO are unclear. Metabolomics and enzyme-linked immunosorbent assay (ELISA) were used to study the effect of cyclooxygenase-2 (COX-2)-overexpressing breast cancer cells on IDO expression in co-cultured human ...
MicroRNA and signaling pathways in gastric cancer
MicroRNAs (miRNAs) function as either oncogenes or tumor suppressors by inhibiting the expression of target genes, some of which are either directly or indirectly involved with canonical signaling pathways. The relationship between miRNAs and signaling pathways in gastric cancer is extremely complicated. In this paper, we determined the pathogenic mechanism of gastric cancer related to miRNA ex...


MGr1-Ag/37LRP promotes growth and proliferation of gastric cancer in vitro and in vivo
Gastric carcinoma (GC) is an aggressive cancer with a poor prognosis. We previously reported that MGr1-Ag was involved in multidrug resistance and anti-apoptosis in GC. However, the exact function of MGr1-Ag in GC proliferation is not clear. In this study, we found that MGr1-Ag was highly expressed in GC tissues and four GC cell lines compared with nontumor gastric tissues or gastric epithelial...
Cancers de la prostate en Côte-d’Ivoire : aspects épidémiologiques, cliniques et anatomopathologiques
Le cancer de la prostate pose à l’heure actuelle un problème de santé publique avec une fréquence variable selon les pays. Notre étude avait pour but de décrire les aspects épidémiologiques, cliniques et anatomopathologiques des cancers de la prostate en Côte-d’Ivoire. Il s’agissait d’une étude rétrospective et descriptive portant sur les cancers de la prostate recensés à p...

Cancers urologiques en Algérie : profil histoépidémiologique à propos de 348 cas
Selon les dernières données disponibles de l’Organisation mondiale de la santé, le cancer représentait 21%des causes de mortalité en Algérie et un tiers des décès. Les cancers urologiques, notamment de la vessie et de la prostate, sont en nette augmentation en Algérie, surtout avec la forte consommation du tabac et l’augmentation de l’espérance de vie de la population. Le but de...
Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role in the carcinogenesis process, we aimed to study the possible relationship between HERVs gene expression and Chronic Lymphocytic Leukemia (CLL). We focused on two viral genes: gag and np9, the latter presumably an oncogene. ...

Characterization of long-non coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing
Long noncoding RNA (lncRNA) have proven to play key roles in cell physiology from nuclear organization and epigenetic remodeling to post-transcriptional regulation. Last decade, gene expression based-classifications have been developed in clear-cell renal cell carcinoma (ccRCC) to identify distinct subtypes of disease and predict patient’s outcome. However, there are no current lncRNA compreh...
Interval lung cancers not detected on screening chest x-rays: how are they different?
The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial provides us an opportunity to describe interval lung cancers not detected by screening chest x-ray (CXR) compared to screen-detected cancers. Participants were screened for lung cancer with CXR at baseline and annually for two (never smokers) or three (ever smokers) more years. Screen-detected cancers were those with a positive C...

Successful empirical erlotinib treatment of a mechanically ventilated patient newly diagnosed with metastatic lung adenocarcinoma
Lung cancer is the most common solid tumor in critically ill cancer patients who are admitted to intensive care units (ICUs). An ICU trial consists of unlimited ICU support for a limited time period. We present the case of a 60-year-old woman with newly diagnosed metastatic lung adenocarcinoma who required mechanical ventilation due to respiratory failure. Empirical erlotinib treatment was admi...
HMGN2, a new anti-tumor effector molecule of CD8+ T cells
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells have been implicated as important cells in antitumor responses. Our previous research has shown that high mobility group nucleosomal-binding domain 2 (HMGN2) could be released by IL-2 and PHA stimulated peripheral blood mononuclear cells (PBMCs) and also induced tumor cells apoptosis at low doses. In this study, we isolated and culture...
Precise ex vivo histological validation of heightened cellularity and diffusion-restricted necrosis in regions of dark apparent diffusion coefficient in 7 cases of high-grade glioma
Recent conflicting reports have found both brain tumor hypercellularity and necrosis in regions of restricted diffusion on MRI-derived apparent diffusion coefficient (ADC) images. This study precisely compares ADC and cell density voxel by voxel using postmortem human whole brain samples. Patients with meningioma were evaluated to determine a normative ADC distribution within benign fluid atten...
Novel combination of docetaxel and thymoquinone induces synergistic cytotoxicity and apoptosis in DU-145 human prostate cancer cells by modulating PI3K–AKT pathway
The treatment of castrate-resistant prostate cancer (CRPC) still remains as an important challenge of daily oncology practice. Docetaxel significantly prolongs overall survival in men with CRPC. Thymoquinone (TQ), one of the flavonoid compounds isolated from Nigealla sativa, has been shown to possess cytotoxic activity against a variety of cancer cell lines. The aim of the study was to investig...