Oncology

Fewer complications after laparoscopic nephrectomy as compared to the open procedure with the modified Clavien classification system - a retrospective analysis from Southern China
The objective of the study is to compare complication rates of laparoscopic nephrectomy and open nephrectomy using a standardized classification method We retrospectively included 843 patients from March 2006 to November 2012, of whom 88 had laparoscopic radical nephrectomy (LRN), 526 had open radical nephrectomy (ORN), 42 had laparoscopic partial nephrectomy (LPN), and 187 had open partial nep...


A retrospective study: the prevalence and prognostic value of anemia in patients undergoing radiotherapy for esophageal squamous cell carcinoma
The relationship between anemia and outcomes after radiotherapy has not been systematically addressed. The study aimed to assess the prevalence and prognostic value of anemia in patients receiving primary radiotherapy for esophageal squamous cell carcinoma (ESCC). A total of 103 patients with ESCC were retrospectively reviewed. Anemia was defined as a hemoglobin level ...
Analysis of the predictive role and new proposal for surgical strategies based on the modified Tomita and Tokuhashi scoring systems for spinal metastasis
We sought to identify preoperative factors significantly correlated with survival. We also aimed to evaluate the validity of the prognostic scores in the Tomita and Tokuhashi systems and discuss several aspects to improve the predictive accuracy of these systems. Moreover, we suggest modified criteria for selecting treatment strategies. In total, the outcomes of 112 patients with spinal metasta...


The evolving role of neurological imaging in neuro-oncology
Neuroimaging has played a critical role in the management of patients with neurological disease, since the first ventriculogram was performed in 1918 by Walter Dandy (Mezger et al. Langenbecks Arch Surg 398:501–514, 2013). Over the last century, technology has evolved significantly, and within the last decade, the role of imaging in the management of patients with neuro-oncologic disease has ...
Stem cells and gliomas: past, present, and future
The recognition of stem cells (SC) in the adult CNS and in association with gliomas has spawned an entire field of research and intense investigation. A large body of knowledge is being accumulated to gain insight into the pathobiology of gliomas with the intent of finally improving the grave prognosis that continues to beset patients with high grade gliomas (HGG). In this article, we provide a...


Metastatic meningiomas: an unusual clinical and pathological diagnosis with highly variable outcome
Metastatic meningioma is a rare situation. We conducted a retrospective study from our databases and identified cases of metastatic meningioma. We report three presentations of patients with medical history of surgical removal of meningioma presenting several years later a liver tumor with bone metastasis or multiple lung tumors. These observations highlight the difficulty of the clinical and p...
Olig2 labeling index is correlated with histological and molecular classifications in low-grade diffuse gliomas
Diagnosis of low-grade diffuse gliomas based on morphology is highly subjective and, therefore, is often difficult, with significant intra- and interobserver variability. Here, we investigated WHO grade II diffuse astrocytomas, oligoastrocytomas and oligodendrogliomas for immunohistochemical expression of Olig2, measuring its labeling index (LI), and evaluated the significance of Olig2 LI in th...

LncRNA expression profiles of EGFR exon 19 deletions in lung adenocarcinoma ascertained by using microarray analysis
Studies showed that long chain non-coding RNAs (lncRNAs) involved in the development and progression of lung cancer. However, the mechanisms of EGFR exon 19 deletion in lung adenocarcinoma were unclear. Lung adenocarcinoma was divided into EGFR exon 19 deletion group and EGFR wild-type group. We studied the differential expression profiles of lncRNAs in EGFR exon 19 deletion in lung adenocarcin...
In vitro study of the effect of small interfering RNA on the expression of FOXN1 and BCA1 in thymoma cell lines
To determine the relationship between FOXN1 (a transcription factor) and B cell-attracting chemokine 1 (BCA1, a chemotactic factor), and their influence on thymoma cell proliferation. We initially used immunohistochemical methods to compare the expression levels of FOXN1 and BCA1 in thymoma and nonthymomatous tissue samples. Reverse transcription polymerase chain reaction (RT-PCR) and Western b...

Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention
Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and survival, two processes central in cancer research. Encoded by the SNAI1 gene located on human chromosome 20q13.2, Snail1 is composed of 264 amino acids and usually acts as a transcriptional repr...
Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions
At least 17 genomic regions are established as harbouring melanoma susceptibility variants, in most instances with genome-wide levels of significance and replication in independent samples. Based on genome-wide single nucleotide polymorphism (SNP) data augmented by imputation to the 1000 Genomes reference panel, we have fine-mapped these regions in over 5000 individuals with melanoma (mainly fr...

Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines
HPV-related HNSCC generally have a better prognosis than HPV-negative HNSCC. However, a subgroup of HPV-positive tumors with poor prognosis has been recognized, particularly related to smoking, EGFR overexpression and chromosomal instability. Viral integration into the host genome might contribute to carcinogenesis, as is shown for cervical carcinomas. Therefore, all HPV16-positive HNSCC cell l...
Efficacy of Interventions for Prevention of Chemotherapy-induced alopecia: A Systematic Review and Meta-Analysis
Chemotherapy-induced alopecia (CIA) is a highly distressing event for cancer patients, and hence, we here aimed to assess the efficacy of various interventions in the prevention of CIA. We searched PubMed, EMBASE, and the Cochrane Library, from 20 June 2013 through 31 August 2013. Two of the authors independently reviewed and selected clinical trials that reported the efficacy of any interventi...
Gram Negative Bacteria Increase Non-Small Cell Lung Cancer Metastasis Via Toll-Like Receptor 4 Activation and Mitogen-Activated Protein Kinase Phosphorylation
Surgery is required for the curative treatment of lung cancer but is associated with high rates of post-operative pneumonias predominantly caused by gram negative bacteria. Recent evidence suggests that these severe infectious complications may decrease long term survival after hospital discharge via cancer recurrence, but the mechanism is unclear. Lung cancer cells have recently been demonstra...
Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical challenge. Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a...