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The PI3K/PKC{iota} Pathway Regulates Bcl-x pre-mRNA Splicing

submitted by Jordanfx 16 hours ago

Two splice variants derived from the Bcl-x gene via alternative 5' splice site selection (5'SS) are proapoptotic Bcl-x(s) and antiapoptotic Bcl-x(L). Previously, our laboratory showed that apoptoti...

1 dig(s) Dig it Bury Topic: Oncology

MTORC2 Signaling in NF2

submitted by dibjet 16 hours ago

Inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene results in the development of schwannomas and meningiomas. Using NF2-deficient meningioma cells and tumors, together wi...

1 dig(s) Dig it Bury Topic: Oncology

Eg5 and Checkpoint Abrogation

submitted by tohmod 16 hours ago

The G2 DNA damage checkpoint is activated by genotoxic agents and is particularly important for cancer therapies. Overriding the checkpoint can trigger precocious entry into mitosis, causing cells ...

1 dig(s) Dig it Bury Topic: Oncology

FOXA1 Interacts with AHR to Regulate CCNG2

submitted by dcpad 16 hours ago

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recently, AHR h...

1 dig(s) Dig it Bury Topic: Oncology

Control of Endothelial Cell Apoptosis by p38MAPK Isoforms

submitted by AlvinRaymo 16 hours ago

TGF-β1 and VEGF, both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-β1 induces apoptosis; VEGF induces survival. We have previously shown that TGF-β...

1 dig(s) Dig it Bury Topic: Oncology

Mitotic Degradation of RAP80

submitted by senhtronlom 16 hours ago

Receptor-associated protein 80 (RAP80) is a component of the BRCA1-A complex that recruits BRCA1 to DNA damage sites in the DNA damage–induced ubiquitin signaling pathway. RAP80-depleted cell...

1 dig(s) Dig it Bury Topic: Oncology

Aurora-A Enhances Invasion and MMP-2

submitted by ChadMali 16 hours ago

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers, and metastasis is the principal cause of death in ESCC patients. It has been shown that amplification and overexpres...

1 dig(s) Dig it Bury Topic: Oncology

Heparin-like Polysaccharides Reduce Bone Metastases

submitted by zaleono 16 hours ago

TGF-β regulates several steps in cancer metastasis, including the establishment of bone metastatic lesions. TGF-β is released from bone during osteoclastic bone resorption and it stimulat...

1 dig(s) Dig it Bury Topic: Oncology

STEAP Proteins

submitted by juliewalton 16 hours ago

Potential candidates as biomarkers of several cancers, as well as potential targets for new immunotherapeutic strategies for disease attenuation or treatment. This review brings together the curren...

1 dig(s) Dig it Bury Topic: Oncology

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

submitted by roaino 18 hours ago

Medulloblastomas account for 20% of pediatric brain tumors. With an overall survival of 40%–70%, their treatment is still a challenge. The majority of medulloblastomas lack p53 mutations, but...

1 dig(s) Dig it Bury Topic: Oncology

Ultrasound-guided fine-needle aspiration biopsy of thyroid bed lesions from patients with thyroidectomy for thyroid carcinomas

submitted by sahamplontotean 20 hours ago

To evaluate the efficacy and the limitation of fine-needle aspiration (FNA) biopsy in thyroid bed lesions, a retrospective review was performed of the medical records of thyroid cancer patients who...

1 dig(s) Dig it Bury Topic: Oncology

Cytopathologic evaluation of the in situ margin in patients undergoing hepatectomy

submitted by amor 20 hours ago

Margin status is a predictor of outcome for patients with liver malignancies, although what constitutes a negative margin is controversial. Traditionally, the completeness of resection is estimated...

1 dig(s) Dig it Bury Topic: Oncology

Cytomorphological and molecular genetic findings in pediatric thyroid fine-needle aspiration

submitted by glinn234 20 hours ago

The Bethesda System for Reporting Thyroid Cytopathology is largely based on data from adult studies. Although thyroid nodules in children are rare, the rate of malignancy is high. The authors' aim ...

1 dig(s) Dig it Bury Topic: Oncology

Finnish researchers identified the cause for LGL leukemia

submitted by necak 20 hours ago

Researchers of the University of Helsinki, Helsinki University Central Hospital and Institute for Molecular Medicine Finland, have discovered that a mutation in the STAT3 gene is an underlying caus...

1 dig(s) Dig it Bury Topic: Oncology

Experimental agent may help older people with chronic leukemia

submitted by ovemohlir 20 hours ago

The experimental drug ibrutinib shows great promise for the treatment of elderly patients with chronic lymphocytic leukemia (CLL), according to interim findings from a clinical trial. The findings ...

1 dig(s) Dig it Bury Topic: Oncology