Neurology

Short-term effectiveness of an online behavioral training in migraine self-management: A randomized controlled trial
Behavioral training (BT) is recommended as a supplementary preventive treatment for migraine. Online interventions have been successful in promoting health behavior change, the evidence for online BT in migraine is limited, however. This randomized controlled trial aimed to determine the post-treatment effectiveness of online BT (n=195) compared to a waitlist control group (WLC; n=173) on migra...


Homonymous Visual Field Loss without Structural Lesion on Magnetic Resonance Imaging: Documented with Positron Emission Tomography and Diffusion Tensor Imaging
The authors describe a 35-year-old man suffering from homonymous hemianopia after head trauma 4 years before but with negative magnetic resonance imaging (MRI) findings. Brain fluorine-18 fluorodeoxyglucose positron emission tomography (18FDG-PET) showed hypometabolism at the unilateral occipital lobe and crossed cerebellar hemisphere, and diffusion tensor imaging (DTI) revealed that the ipsila...
Reappraising the relationship between working memory and conscious awareness
Classically, the operation of working memory (WM) has been strongly coupled with conscious states; it is thought that WM operates on conscious input and that we are conscious of the contents and operations of WM. Here, we re-evaluate the relationship between WM and conscious awareness in light of current data and question the views that awareness is mandatory for the operation of WM and that WM...


An organization of visual and auditory fear conditioning in the lateral amygdala
Pavlovian fear conditioning is an evolutionary conserved and extensively studied form of associative learning and memory. In mammals, the lateral amygdala (LA) is an essential locus for Pavlovian fear learning and memory. Despite significant progress unraveling the cellular mechanisms responsible for fear conditioning, very little is known about the anatomical organization of neurons encoding f...
Effects of age on metacognitive efficiency
Humans have a capacity to become aware of thoughts and behaviours known as metacognition. Metacognitive efficiency refers to the relationship between subjective reports and objective behaviour. Understanding how this efficiency changes as we age is important because poor metacognition can lead to negative consequences, such as believing one is a good driver despite a recent spate of accidents. ...


A new look at cerebrospinal fluid movement
Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: "A new look at cerebrospinal circulation", but did not analyze some important available data in sufficient detail. For example, our findings as well as some clinical data and experimental results obtained from different animal species, do not support unidirectional CSF circulation but strongly suggest...
YouTube as a potential learning tool to help distinguish tonic–clonic seizures from nonepileptic attacks
Medical students are increasingly turning to the website YouTube as a learning resource. This study set out to determine whether the videos on YouTube accurately depict the type of seizures that a medical student may search for. Two consultant epileptologists independently assessed the top YouTube videos returned following searches for eight terms relating to different categories of seizures. T...

Validation of the Patient Health Questionnaire-9 (PHQ-9) for depression screening in adults with epilepsy
This study aimed to assess the accuracy and operating characteristics of the Patient Health Questionnaire-9 (PHQ-9) for depression screening in adults with epilepsy. Tertiary epilepsy center patients served as the study population, with 237 agreeing to structured interview using the Mini-International Neuropsychiatric Interview (MINI), a “gold standard” instrument developed for rapid diagno...
Serotonin and sudden death: Differential effects of serotonergic drugs on seizure-induced respiratory arrest in DBA/1 mice
In the DBA/1 mouse model of sudden unexpected death in epilepsy (SUDEP), administration of a selective serotonin (5-HT) reuptake inhibitor (SSRI), fluvoxamine, completely suppressed seizure-induced respiratory arrest (S-IRA) at 30min after administration (i.p.) in a dose-related manner without blocking audiogenic seizures (AGSz), but another SSRI, paroxetine, reduced S-IRA but with a delayed (2...

Nueva mutación en SPG11 en una paciente con paraplejía espástica hereditaria complicada: hallazgos clínicos-electrofisiológicos y moleculares
Las paraplejías espásticas hereditarias complicadas (PEHC) están caracterizadas por presentar síntomas neurológicos acompañantes de la lesión característica de los haces corticoespinales. En las formas asociadas a atrofia de cuerpo calloso, las mutaciones más frecuentes son aquellas vinculadas a SPG11 (espastacsina) y en menor medida a SPG15. Paciente de 39 años de origen italiano, de...
Frecuencia de afección seudobulbar en pacientes con esclerosis lateral amiotrófica, enfermedad de Parkinson, esclerosis múltiple y accidente cerebrovascular
La afección seudobulbar (APB) es la expresión de risa o llanto involuntario e incontrolable. La prevalencia en ELA es del 50%, en EP 11%, en EM 8% y en ACV 18%. No existen datos concluyentes sobre el tipo de APB prevalente en cada afección ni sobre las vías anatómicas involucradas en su génesis. Evaluar la frecuencia y el tipo de APB en dichas enfermedades. Se evaluó a 18 pacientes con E...

Societal cost-of-illness in patients with borderline personality disorder one year before, during and after dialectical behavior therapy in routine outpatient care
Societal cost-of-illness in a German sample of patients with borderline personality disorder (BPD) was calculated for 12 months prior to an outpatient Dialectical Behavior Therapy (DBT) program, during a year of DBT in routine outpatient care and during a follow-up year. We retrospectively assessed resource consumption and productivity loss by means of a structured interview. Direct costs were ...
Treatment of co-occurring PTSD-AUD: Effects of exposure-based and non-trauma focused psychotherapy on alcohol and trauma cue-reactivity
Laboratory studies have shown that exposure to trauma memories increases both craving and salivation responses to alcohol cues among individual with co-occurring posttraumatic stress disorder (PTSD) and alcohol dependence (AD). The purpose of the present study was to examine 1) whether this cue reactivity is dampened following exposure-based treatment for PTSD and 2) how changes in reactivity t...
A randomized controlled trial of an internet-based therapist-assisted indicated preventive intervention for prolonged grief disorder
This trial assessed the feasibility, acceptability, tolerability, and efficacy of an Internet-based therapist-assisted cognitive-behavioral indicated prevention intervention for prolonged grief disorder (PGD) called Healthy Experiences After Loss (HEAL). Eighty-four bereaved individuals at risk for PGD were randomized to either an immediate treatment group (n = 41) or a waitlist control group (...
Bridging the gap: Lessons we have learnt from the merging of psychology and psychiatry for the optimisation of treatments for emotional disorders
In recent years the gap between psychological and psychiatric research and practice has lessened. In turn, greater attention has been paid toward how psychological and pharmacological treatments interact. Unfortunately, the majority of research has indicated no additive effect of anxiolytics and antidepressants when combined with psychological treatments, and in many cases pharmacological treat...