Medicine

Reproductive and biochemical changes in obese and non obese polycystic ovary syndrome women
Reproductive, clinical and laboratory implication varies in polycystic ovary syndrome (PCOS) according to body weight. To compare reproductive, clinical and laboratory data between obese and non obese women with PCOS. A cohort of 180 women with PCOS who attended outpatient clinic of Taibah University from January to September 2012 was included. Studied women were classified according to body ma...


Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells
Isodeoxyelephantopin (IDOE) isolated from Elephantopus scaber L. (Didancao) is used in Chinese medicine for the treatment of some types of cancer. The anti-cancer mechanism of IDOE remains unclear. This study aims to investigate the antiproliferative activity of IDOE on breast carcinoma T47D cells and lung carcinoma A549 cells. The growth inhibitory effects of IDOE on breast carcinoma T47D cell...
Spine Curve Measures Taken in Individuals with Osteoporosis and Osteopenia Using the IONmed Mobile Phone Application Are Highly Consistent with Digital Inclinometer Measures
This study determined the agreement between measures of standing posture in individuals at risk of osteoporotic fracture obtained using the IONmed mobile phone application and a digital inclinometer. Methods. One experienced rater assessed 20 adults, aged 55–88 years, attending an outpatient osteoporosis clinic. A standardized protocol was duplicated to acquire a single measure of spine curva...


Individual and spousal unemployment as predictors of smoking and drinking behavior
The effects of unemployment on health behaviors, and substance use in particular, is still unclear despite substantial existing research. This study aimed to assess the effects of individual and spousal unemployment on smoking and alcohol consumption. The study was based on eight waves of geocoded Framingham Heart Study Offspring Cohort data (US) from 1971 to 2008 that contained social network ...
Cultures of resistance? A Bourdieusian analysis of doctors' antibiotic prescribing
The prospect of an ‘antimicrobial perfect storm’ in the coming decades through the emergence and proliferation of multi-resistant organisms has become an urgent public health concern. With limited drug discovery solutions foreseeable in the immediate future, and with evidence that resistance can be ameliorated by optimisation of prescribing, focus currently centres on antibiotic use. In hos...


Does desire for hastened death change in terminally ill cancer patients?
Understanding why some terminally ill patients may seek a hastened death (a construct referred to as “desire for hastened death” or DHD) is critical to understanding how to optimize quality of life during an individual's final weeks, months or even years of life. Although a number of predictor variables have emerged in past DHD research, there is a dearth of longitudinal research on how DHD...
The geography of chronic obstructive pulmonary disease: A population-based study of Norway
Research on chronic obstructive pulmonary disease (COPD) that includes geographic information is important in order to improve care and appropriate allocation of resources to patients suffering from COPD. The purpose of this study is to investigate the geography of COPD and factors associated with the spatial patterns of COPD prevalence. Particular emphasis is put on the role of the local socio...

Prenatal smoking and genetic risk: Examining the childhood origins of externalizing behavioral problems
An ever-growing body of research has begun to focus closely on the role of prenatal smoke exposure in the development of conduct problems in children. To this point, there appears to be a correlation between prenatal nicotine exposure and behavioral problems. We build on this prior research by examining the coalescence of prenatal smoke exposure and genetic risk factors in the prediction of beh...
Lifetime and current pesticide exposure among Latino farmworkers in comparison to other Latino immigrants
Pesticide exposure poses a health risk for farmworkers. This analysis documents lifetime and current pesticide exposure of North Carolina Latino migrant farmworkers, with comparison to non-farmworker Latino immigrants. During May to October 2012, 235 Latino farmworkers and 212 Latino non-farmworkers completed interviews with items to construct measures of lifetime, current residential and occup...

Worker assessments of organizational practices and psychosocial work environment are associated with musculoskeletal injuries in hospital patient care workers
Hospital patient care (PC) workers have high rates of workplace injuries, particularly musculoskeletal injuries. Despite a wide spectrum of documented health hazards, little is known about the association between psychosocial factors at work and OSHA-recordable musculoskeletal injuries. PC-workers (n = 1,572, 79%) completed surveys assessing a number of organizational, psychosocial and psyc...
Detected health and well-being problems following comprehensive geriatric assessment during a home visit among community-dwelling older people: who benefits most?
Preventive home visits including comprehensive geriatric assessment for potentially frail older people are increasingly implemented in general practice. It remains unclear how to select older people who benefit most from it. To determine which community-dwelling older people benefit most from a comprehensive geriatric assessment by a practice nurse during a home visit in terms of detected probl...

Placebo use in the UK: a qualitative study exploring GPs' views on placebo effects in clinical practice
Surveys show GPs use placebos in clinical practice and reported prevalence rates vary widely. To explore GPs’ perspectives on clinical uses of placebos. and setting. A web-based survey of 783 UK GPs’ use of placebos in clinical practice. Qualitative descriptive analysis of written responses (‘comments’) to three open-ended questions. Comments were classified into three c...
Unraveling human protein interaction networks underlying co-occurrences of diseases and pathological conditions
Human diseases frequently cause complications such as obesity-induced diabetes and share numbers of pathological conditions, such as inflammation, by dysfunctions of common functional modules, such as protein-protein interactions (PPIs). Our developed pipeline, ICod (Interaction analysis for disease Comorbidity), grades similarities between pairs of disease-related PPIs including comorbid disea...
Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory t cells
Autophagy regulates innate and adaptive immune responses to pathogens and tumors. We have reported that autophagosomes derived from tumor cells after proteasome inhibition, DRibbles (Defective ribosomal products in blebs), were excellent sources of antigens for efficient cross priming of tumor-specific CD8+ T cells, which mediated regression of established tumors in mice. But the activity of DR...
Yellow fever, Asia and the East African slave trade
Yellow fever is endemic in parts of sub-Saharan Africa and South America, yet its principal vectors-species of mosquito of the genus Aedes-are found throughout tropical and subtropical latitudes. Phylogenetic analyses indicate that yellow fever originated in Africa and that its spread to the New World coincided with the slave trade, but why yellow fever has never appeared in Asia remains a myst...