Medicine

Sensing Magnetic Directions in Birds: Radical Pair Processes Involving Cryptochrome
Birds can use the geomagnetic field for compass orientation. Behavioral experiments, mostly with migrating passerines, revealed three characteristics of the avian magnetic compass: (1) it works spontaneously only in a narrow functional window around the intensity of the ambient magnetic field, but can adapt to other intensities, it is an “inclination compass”, not based on the polarity of t...


Percutaneous coronary intervention
Percutaneous coronary intervention (PCI) is the dominant method for mechanically improving myocardial perfusion in the treatment of coronary artery disease. The procedure is performed via a small intra-arterial sheath and usually involves a single overnight stay in hospital. Day-case treatment is not infrequent. A balloon is used to dilate the coronary stenosis and a stent is then implanted to ...
Ischaemic heart disease: stable angina
Stable angina is a clinical syndrome reflecting inadequate myocardial perfusion. This is typically, but not always, caused by atherosclerotic coronary artery disease. A detailed history is important to establish the diagnosis, presence of risk factors and unstable symptoms. Stress ECG or stress imaging techniques should ideally be used to determine the presence and extent of myocardial ischaemi...


‘Less like a drug than a drug’: the use of St John's wort among people who self-identify as having depression and/or anxiety symptoms
St John's wort (SJW) is one of the most commonly used complementary medicines (CM) for the self-treatment of depression which can be accessed with or without health professional advice. While there is evidence to support its effectiveness in depression it has potential for serious side effects and interactions with many pharmaceuticals and herbs. Despite the potential risks, we know little abou...
The Effect of Platelet-Rich Plasma on Muscle Contusion Healing in a Rat Model
Current therapy for muscle contusions is usually limited to nonsteroidal anti-inflammatory drugs and/or use of the RICE principle (rest, ice, compression, elevation); thus, other forms of treatment that can potentially accelerate the rate of healing are desirable. A local injection of platelet-rich plasma (PRP) would lead to accelerated healing rates compared with controls; also, delayed admini...


Autologous Chondrocyte Implantation of the Ankle: 2- to 10-Year Results
The treatment of osteochondral lesions of the talus after failed surgery is challenging, with no clear solution. Short-term results using autologous chondrocyte implantation have been promising. To report the long-term outcomes of patients who underwent autologous chondrocyte implantation (ACI) of the talus after failed marrow stimulation techniques for osteochondral lesions of the talus (OLTs)...
Acute Achilles Tendon Ruptures: Incidence of Injury and Surgery in Sweden Between 2001 and 2012
Population-based incidence rates and trends of acute Achilles tendon ruptures are not known. It is also not known whether recent high-quality randomized controlled trials not favoring surgery have had an effect on treatment protocols. To assess the incidence of acute Achilles tendon ruptures in Sweden and to examine the trends in surgical treatment. Descriptive epidemiology study. We conducted ...

Does the Femoral Cam Lesion Regrow After Osteoplasty for Femoroacetabular Impingement?: Two-Year Follow-up
There are currently no studies that have examined the recurrence of the cam lesion after femoral neck osteoplasty for femoroacetabular impingement. Although patient-reported outcome (PRO) scores at midterm follow-up have shown continued success, the maintenance of a normalized alpha angle has not been shown radiographically. To assess the radiographic recurrence of cam deformity at 2-year follo...
Feasibility and Preliminary Effectiveness of a Novel Cognitive–Behavioral Couple Therapy for Provoked Vestibulodynia: A Pilot Study
Provoked vestibulodynia (PVD), a recurrent, localized vulvovaginal pain problem, carries a significant psychosexual burden for afflicted women, who report impoverished sexual function and decreased frequency of sexual activity and pleasure. Interpersonal factors such as partner responses to pain, partner distress, and attachment style are associated with pain outcomes for women and with sexuali...

Undertreatment of Erectile Dysfunction: Claims Analysis of 6.2 Million Patients
Prior research conducted on treatment of erectile dysfunction (ED) has been derived from surveys involving relatively small populations of men. There are needs for large population-based studies in this area. Our study addresses that need. The aim of this study was to characterize ED treatment among a large population of men. Patients ≥30 years in commercial insurance dataset with diagnosis c...
Impact of Cell-Free Fetal DNA Screening on Patients’ Choice of Invasive Procedures after a Positive California Prenatal Screen Result
Until recently, maternal serum analyte levels paired with sonographic fetal nuchal translucency measurement was the most accurate prenatal screen available for Trisomies 18 and 21, (91% and 94% detection and false positive rates of 0.31% and 4.5% respectively). Women with positive California Prenatal Screening Program (CPSP) results have the option of diagnostic testing to determine definitivel...

A 26-Year Experience in Chorionic Villus Sampling Prenatal Genetic Diagnosis
This report describes the trends of chorionic villus sampling (CVS) referred for prenatal genetic diagnosis in the past two and a half decades in a Portuguese Center. Our cohort of 491 CVS was mostly performed by the transcervical method at the 12th gestational week. Data collected within the framework of this study relate to the following: sampling method, referral reason versus abnormality an...
Chromosomal Mosaicism in Human Feto-Placental Development: Implications for Prenatal Diagnosis
Chromosomal mosaicism is one of the primary interpretative issues in prenatal diagnosis. In this review, the mechanisms underlying feto-placental chromosomal mosaicism are presented. Based on the substantial retrospective diagnostic experience with chorionic villi samples (CVS) of a prenatal diagnosis laboratory the following items are discussed: (i) The frequency of the different types of mosa...
The mental health of asbestos-exposed subjects with pleural abnormalities
To examine the effect of knowledge of radiographic abnormalities on the mental health of asbestos-exposed people with and without pleural abnormalities. Subjects were former asbestos mine and mill workers and residents of the mining town who had participated in an annual health review program. Pleural abnormalities (pleural plaques, diffuse pleural thickening and asbestosis) were determined fro...
Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients
The hepatitis C virus (HCV) is an important contributor to morbidity and mortality in patients co-infected with HIV. Co-infection results in increased HCV replication and more rapid rates of liver disease progression. The effect of HIV combination antiretroviral therapy (cART) on HCV replication has not been studied in depth. To address this issue, we enrolled a small cohort of HCV/HIV co-infec...