Medicine

Pluripotent Stem Cells as a Platform for Cardiac Arrhythmia Drug Screening
Since the first demonstrations of the differentiation of pluripotent stem cells to produce functional human cellular models such as cardiomyocytes, the scientific community has been captivated [1, 2 , 3]. In the time since that seminal work, the field has been catapulted forward by the demonstration that adult somatic cells can be reprogrammed to an induced state of pluripotency [4 ], and more ...


Acute Pulmonary Embolus: The Next Frontier in Venous Thromboembolic Interventions
Submassive pulmonary embolism (PE) represents a patient population that is under-recognized and under-treated. Recent clinical trials demonstrated the hemodynamic benefit of IV thrombolytic therapy among these patients; however, it came at the cost of a significantly increased risk of major, particularly intracranial, hemorrhage. Catheter-based treatment modalities have garnered considerable cl...
Management of ST-elevation myocardial infarction
Ischaemic heart disease, and myocardial infarction in particular, remains a common cause of morbidity and mortality worldwide. Acute ST-elevation myocardial infarction (STEMI) usually results from occlusive thrombus formation following coronary plaque rupture. Immediate measures, such as the administration of aspirin and early defibrillation, can be lifesaving in STEMI. Prompt and appropriate r...


Using The Systems Framework For Postural Control To Analyze The Components Of Balance Evaluated In Standardized Balance Measures: A Scoping Review
To identify components of postural control included in standardized balance measures for adult populations. Electronic searches of Medline, Embase, and CINAHL databases using key word combinations of postural balance/ equilibrium, psychometrics/ reproducibility of results/ predictive value of tests/ validation studies, instrument construction/ instrument validation, geriatric assessment/ disabi...
Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling
Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Since inflammation is often associated with an increased generation of reactive oxygen species (ROS), oxidative stress is a mechanistically imperative factor in asthma. Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and ne...


Enhanced Patella-Patellar Tendon Healing Using Combined Magnetic Fields in a Rabbit Model
A combined magnetic field (CMF) is a composite of a dynamic sinusoidal magnetic field and a magnetostatic field. Stimuli from CMFs has proved to be an effective tool for healing problem fractures and spinal fusion procedures. Combined magnetic field technology will enhance healing of bone-tendon junction repair via endochondral ossification for regeneration of the fibrocartilage zone. Controlle...
Comparative Study on Immediate Versus Delayed Meniscus Allograft Transplantation: 4- to 6-Year Follow-up
Meniscus allograft transplantation (MAT) is generally used for patients who sustain symptoms after meniscectomy, which could be called delayed MAT. Meniscus allograft transplantation for patients immediately after meniscectomy has not been reported. Compared with the conventional delayed MAT, immediate MAT might provide better clinical results and reduce joint degeneration. Cohort study; Level ...

Effects of hospital acquired conditions on length of stay for patients with diabetes
In-patients with diabetes have longer length of stays (LOS). Understanding patterns of in-hospital complications between patients with diabetes and others may reveal measures to improve patient welfare and minimise LOS. Evaluate the rates and types of hospital acquired conditions amongst patients with and without diabetes and assess any effects on LOS. 47615 admission episodes from The Northern...
Sticking to minimum standards: implementing antibiotic stewardship in intensive care
In Australia, antimicrobial stewardship programs are a compulsory component of hospital accreditation. Good documentation around antimicrobial prescribing aids communication and can improve prescribing practice in environments with multiple decision-makers. To develop and implement an intervention to improve antimicrobial prescribing practice in a 24-bed intensive care unit in a tertiary referr...

Mortality attributable to rheumatic heart disease in the Kimberley: a data linkage approach
Acute rheumatic fever (ARF) and its sequelae, rheumatic heart disease (RHD) are now uncommon in the general Australian population. However, these preventable and treatable diseases continue to disproportionately affect Aboriginal Australians, especially in remote communities. In the Kimberley region of Western Australia (WA), the prevalence of RHD is approximately 1% among Aboriginal residents....
A Prospective Study of Acute Inpatient Gout Diagnoses and Management in A Tertiary Hospital – the Determinants and Outcome of A Rheumatology Consultation
Despite acute gout frequently complicating hospital admissions, diagnosis and management is variable. Rheumatology input may improve patient outcomes. The aim of this prospective study was to evaluate acute inpatient gout to determine i) factors associated with rheumatology input being sought and ii) the differences in outcomes when rheumatology input occurred. Data collection occurred between ...

Metoclopramide for patients with intractable hiccups: A multi-center, randomized, controlled pilot study
Limited data exist regarding the efficacy of metoclopramide in the treatment of intractable hiccups. This study aimed to assess the feasibility efficacy of metoclopramide in the treatment of patients with intractable hiccups. A total of 36 patients with intractable hiccups were randomly assigned to arm A (n = 18) or arm B (n = 18) in a multi-center, double-blind, randomized, controlled pilot st...
Penile Prostheses and the Litigious Patient: A Legal Database Review
Erectile dysfunction (ED) is a common problem with significant impact on patient quality of life. Penile prosthesis implantation provides an effective treatment for ED but as an invasive procedure carries with it an increased risk of medicolegal liability. To investigate factors associated with malpractice litigation surrounding penile prosthesis implantation. The Westlaw legal database was use...
Optimized MEGA-SPECIAL for in vivo glutamine detection in the rat brain at 14.1 T
Glutamine has multiple roles in brain metabolism and its concentration can be altered in various pathological conditions. An accurate knowledge of its concentration is therefore highly desirable to monitor and study several brain disorders in vivo. However, in recent years, several MRS studies have reported conflicting glutamine concentrations in the human brain. A recent hypothesis for explain...
Antitumor mechanisms of S-allyl mercaptocysteine for breast cancer therapy
Background: S-allyl mercaptocysteine (SAMC), a water-soluble component derived from garlic, has been found to exert multi-antitumor activities. This study was to investigate the responsible molecular mechanisms of SAMC in human breast cancer cell lines. Methods: Sulforhodamine B assay was used to determine cell viability, flow cytometry was applied for the analysis of cell cycle and cell apopto...