Medicine

Single-Organ Gallbladder Vasculitis: Characterization and Distinction From Systemic Vasculitis Involving the Gallbladder. An Analysis of 61 Patients
Systemic vasculitis (SV) involving abdominal structures usually has a poor prognosis. Gallbladder vasculitis (GV) has been reported as part of SV (GB-SV) and focal single-organ vasculitis (GB-SOV). We analyzed clinical and histologic characteristics of patients with GV to identify features that differentiate GB-SOV from the systemic forms of GV. To identify affected patients with GV we used pat...


An Autoimmune Myositis-Overlap Syndrome Associated With Autoantibodies to Nuclear Pore Complexes: Description and Long-Term Follow-up of the Anti-Nup Syndrome
Autoimmune myositis encompasses various myositis-overlap syndromes, each being identified by the presence of serum marker autoantibodies. We describe a novel myositis-overlap syndrome in 4 patients characterized by the presence of a unique immunologic marker, autoantibodies to nuclear pore complexes. The clinical phenotype was characterized by prominent myositis in association with erosive, ant...
Coxiella burnetii Infection in Hemodialysis and Other Vascular Grafts
Prosthetic arteriovenous (AV) graft infection is the principal cause of morbidity related to chronic hemodialysis AV graft fistula. Coxiella burnetii is a known pathogen that causes fever, pneumonia, and intravascular infections with the limitation of negative cultures. Herein, we report the first case of a patient who presented to the emergency department of our hospital with a prosthetic hemo...


Minimal Change Nephrotic Syndrome Associated With Non-Hodgkin Lymphoid Disorders: A Retrospective Study of 18 Cases
Few studies have examined the occurrence of minimal change nephrotic syndrome (MCNS) in patients with non-Hodgkin lymphoma (NHL). We report here a series of 18 patients with MCNS occurring among 13,992 new cases of NHL. We analyzed the clinical and pathologic characteristics of this association, along with the response of patients to treatment, to determine if this association relies on a parti...
Kidney Diseases Associated With Anti-Vascular Endothelial Growth Factor (VEGF): An 8-year Observational Study at a Single Center
Expanded clinical experience with patients taking antiangiogenic compounds has come with increasing recognition of the renal adverse effects. Because renal histology is rarely sought in those patients, the renal consequences are underestimated. Antiangiogenic-treated-cancer patients, who had a renal biopsy for renal adverse effects from 2006 to 2013, were included in the current study. Clinical...


Redefining Dermatomyositis: A Description of New Diagnostic Criteria That Differentiate Pure Dermatomyositis From Overlap Myositis With Dermatomyositis Features
Dermatomyositis (DM) is a major clinical subset of autoimmune myositis (AIM). The characteristic DM rash (Gottron papules, heliotrope rash) and perifascicular atrophy at skeletal muscle biopsy are regarded as specific features for this diagnosis. However, new concepts are challenging the current definition of DM. A modified Bohan and Peter classification of AIM was proposed in which the core co...
Eleanor Roosevelt’s Last Days: A Bioethical Case Study
When Eleanor Roosevelt died in 1962, she was widely regarded as “the greatest woman in the world.” In spite of her celebrity, or more likely because of it, she was forced to endure a protracted period of intense suffering and humiliation before dying. On critical analysis, her end-of-life care violated most of the ethical standards of care for the dying we hold dear today. However, caring f...

The Effect of Optimally Timed Osteopathic Manipulative Treatment on Length of Hospital Stay in Moderate and Late Preterm Infants: Results from a RCT
Little research has been conducted looking at the effects of osteopathic manipulative treatment (OMT) on preterm infants. of the Study. This study hypothesized that osteopathic care is effective in reducing length of hospital stay and that early OMT produces the most pronounced benefit, compared to moderately early and late OMT. A secondary outcome was to estimate hospital cost savings by the u...
Effects of Anethole in Nociception Experimental Models
This study investigated the antinociceptive activity of anethole (anethole 1-methoxy-4-benzene (1-propenyl)), major compound of the essential oil of star anise (Illicium verum), in different experimental models of nociception. The animals were pretreated with anethole (62.5, 125, 250, and 500 mg/kg) one hour before the experiments. To eliminate a possible sedative effect of anethole, the open...

Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats
Aberrant neuronal activity in injured peripheral nerves is believed to be an important factor in the development of neuropathic pain (NPP). Channel protein pCREB of that activity has been shown to mitigate the onset of associated molecular events in the nervous system, and sodium hydrosulfide (NaHS) could inhibit the expression of pCREB. However, whether NaHS could relieve the pain, it needs fu...
Efficacy and Safety of Clearing Heat and Detoxifying Injection in the Treatment of Influenza: A Randomized, Double-Blinded, Placebo-Controlled Trial
To evaluate the efficacy and safety of CHDI in the treatment of influenza infection. Method. A randomized double-blind, double dummy trial was conducted. Influenza patients with a positive influenza A rapid test diagnosis were randomized to receive CHDI or oseltamivir. Primary outcome was assessed by the median fever alleviation time and clearance time, and secondary outcome was total scores of...

Anatomo-Functional Correlation between Head Zones and Acupuncture Channels and Points: A Comparative Analysis from the Perspective of Neural Therapy
Neural therapy and traditional Chinese medicine (TCM) are part of complementary and alternative medicine in western world. Both of them share characteristics in diagnosis and therapeutics in search of changes in tenderness, pain, and skin stiffness related to visceral disease, as well as therapeutic procedures with specific stimuli on the skin that generate local, segmental, or remote reactions...
Determinants of Common Mental Disorder, Alcohol Use Disorder and cognitive morbidity among people coming for HIV testing in Goa, India
To investigate associations between background characteristics (psychosocial adversity, risk behaviours/perception of risk and HIV-related knowledge, perceptions and beliefs) and psychological and cognitive morbidity among people coming for testing for HIV/AIDS in Goa, India. Analysis of cross-sectional baseline data (plus HIV status) from a prospective cohort study. Participants were recruited...
Differential patterns, trends and hotspots of road traffic injuries on different road networks in Vellore district, southern India
To describe spatial and temporal profiles of RTIs on different road networks in Vellore district of southern India. Using the information in the police maintained First Information Reports (FIR), daily time series of RTI counts were created and temporal characteristics were analyzed with respect to the vehicle, road types and time of the day for the period January 2005 to May 2007. Daily incide...
A Historical Report of Plague Outbreak in Northern Kermanshah Province, Western Iran, in 1952
Plague is an infectious disease transmitted from rodents to humans. This disease is considered an endemic disease in western Iran. The last officially reported case of human plague in Iran was in 1965. In the last few decades, human plague has been reported in Iran’ neighboring countries. Also, according to some recent evidence witnessing infected rodents in western Iran, it is probable t...