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Osteoporosis and Bone Health in HIV

submitted by newsguru 2 days ago

Patients with HIV can develop several complications that involve bone including low bone mineral density and osteoporosis, osteonecrosis, and rarely osteomalacia. Low bone mineral density leading t...

1 dig(s) Dig it Bury Topic: Immunology

Efficacy, Safety and Pharmacokinetics of a Novel Subcutaneous Immunoglobulin, Evogam®, in Primary Immunodeficiency

submitted by nabliorajo3119 2 days ago

This phase III, open-label, multi-centre study investigated the efficacy, safety, pharmacokinetics and quality of life impact of Evogam®, a new chromatographically fractionated 16% subcutaneous im...

1 dig(s) Dig it Bury Topic: Immunology

The Spectrum of Disease Manifestations in Patients with Common Variable Immunodeficiency Disorders and Partial Antibody Deficiency in a University Hospital

submitted by felix4792 2 days ago

Common variable immunodeficiency disorders (CVIDs) represents a heterogeneous disease spectrum that includes recurrent infections and complications such as autoimmunity, inflammatory organ disease ...

1 dig(s) Dig it Bury Topic: Immunology

Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling

submitted by felixsch4 2 days ago

Chimeric antigen receptor (CAR) engineered T-cells occupy an increasing niche in cancer immunotherapy. In this context, CAR-mediated CD3ζ signaling is sufficient to elicit cytotoxicity and interfe...

1 dig(s) Dig it Bury Topic: Immunology

Immunological Comorbity in Coeliac Disease: Associations, Risk Factors and Clinical Implications

submitted by alexjohn 2 days ago

Coeliac disease is frequently associated with other immunomediated diseases. Our aim was to identify immunological comorbidities and possible risk factors for their development in coeliac patients....

1 dig(s) Dig it Bury Topic: Immunology

Changes in Proliferation Kinetics of T Cells: A New Predictive Cellular Biomarkers for Early Rheumatoid Arthritis?

submitted by HudsSto 2 days ago

It has been demonstrated that early treatment of rheumatoid arthritis (RA) patients prevents further joint damage and disability, but biomarkers enabling early RA to be distinguished within the und...

1 dig(s) Dig it Bury Topic: Immunology

Calcitriol Decreases Expression of Importin α3 and Attenuates RelA Translocation in Human Bronchial Smooth Muscle Cells

submitted by jiffb 2 days ago

A potent immunomodulatory role of Vitamin D in both innate and adaptive immunity has recently been appreciated. In allergic asthma, activation of NF-кB induces transcription of various cytokines a...

1 dig(s) Dig it Bury Topic: Immunology

Accumulation of Activated Invariant Natural Killer T Cells in the Tumor Microenvironment after α-Galactosylceramide-Pulsed Antigen Presenting Cells

submitted by majtobo 2 days ago

The intravenous administration of α-Galactosylceramide (α-GalCer)-pulsed antigen presenting cells (APCs) is well tolerated and the increased IFN-γ producing cells in the peripheral blood after t...

1 dig(s) Dig it Bury Topic: Immunology

Dual Analysis for Mycobacteria and Propionibacteria in Sarcoidosis BAL

submitted by hrvojeko 2 days ago

Sarcoidosis is a non-caseating granulomatous disease for which a role for infectious antigens continues to strengthen. Recent studies have reported molecular evidence of mycobacteria or propionibac...

1 dig(s) Dig it Bury Topic: Immunology

Selective IgA Deficiency: Clinical and Laboratory Features of 118 Children in Turkey

submitted by darespaazoo 2 days ago

Selective IgA deficiency (IgAD) is considered as the most common primary immunodeficiency. Although the vast majority of affected individuals are asymptomatic, symptomatic patients suffer from recu...

1 dig(s) Dig it Bury Topic: Immunology

Clinical, Functional and Genetic Analysis of Twenty-Four Patients with Chronic Granulomatous Disease – Identification of Eight Novel Mutations in CYBB and NCF2 Genes

submitted by bioagri 2 days ago

Chronic granulomatous disease is an inherited disorder in which phagocytes lack a functional NADPH oxidase and cannot produce superoxide anions. The most common form is caused by mutations in CYBB ...

1 dig(s) Dig it Bury Topic: Immunology

Requirements for Growth and IL-10 Expression of Highly Purified Human T Regulatory Cells

submitted by welcos3221 2 days ago

Human regulatory T cells (TR) cells have potential for the treatment of a variety of immune mediated diseases but the anergic phenotype of these cells makes them difficult to expand in vitro. We ha...

1 dig(s) Dig it Bury Topic: Immunology

Hereditary Autoinflammatory Syndromes: A Brazilian Multicenter Study

submitted by ermo 2 days ago

To evaluate the prevalence of genetic defects in clinically suspected autoinflammatory syndromes (AIS) in a Brazilian multicenter study. The study included 102 patients with a clinical diagnosis of...

1 dig(s) Dig it Bury Topic: Immunology

Laying the foundation for a taxonomic review of Puccinia coronata s.l. in a phylogenetic context

submitted by KimballCallis 2 days ago

Intra-specific classification of Puccinia coronata has been controversial, with previous approaches falling into three major categories: A two-species system, namely P. coronifera and P. coronata; ...

1 dig(s) Dig it Bury Topic: Immunology

In situ extraction of RNA from marine-derived fungi associated with the marine sponge, Haliclona simulans

submitted by amorsolih2 2 days ago

Several different methods were compared to recover a significant quantity of high quality RNA from H. simulans containing RNA of marine-derived fungi. Further processing of the RNA showed that ampl...

1 dig(s) Dig it Bury Topic: Immunology