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N-terminal proB-type natriuretic peptide levels aid the diagnosis of left ventricular dysfunction in patients with severe acute exacerbations of chronic obstructive pulmonary disease and renal dysfunction

submitted by doloresstyron 4 hours ago

At a GlanceNT-proBNP levels were effective for the diagnosis of left ventricular dysfunction in patients with acute exacerbations of COPD. The diagnostic accuracy of NT-pro BNP levels in the settin...

1 dig(s) Dig it Bury Topic: Immunology

Development and validation of a novel tool to estimate peri-operative blood loss

submitted by andybohra 4 hours ago

Surgical blood loss predicts peri-operative outcomes. We have developed and validated Blood Loss Scores to estimate peri-operative blood loss during major abdominal surgery. Surgical blood loss and...

1 dig(s) Dig it Bury Topic: Immunology

The differential effects of recombinant brain natriuretic peptide, nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs

submitted by HoldeJamie 4 hours ago

Brain natriuretic peptide has vasodilatory properties and may thus increase splanchnic perfusion and oxygenation. We compared the effects of recombinant brain natriuretic peptide on gastric mucosal...

1 dig(s) Dig it Bury Topic: Immunology

Lipopolysaccharide interference in erythropoiesis in mice

submitted by DevJos 4 hours ago

Anaemia is a common problem in septic patients. We tested whether lipopolysaccharide suppressed erythropoiesis and interfered with erythropoietin. Male mice (strain C57BL/6, n = 76) were injected...

1 dig(s) Dig it Bury Topic: Immunology

A randomised trial comparing the i-gelTM with the LMA ClassicTM in children

submitted by hindrekm 4 hours ago

We performed a prospective, randomised trial comparing the i-gelTM with the LMA ClassicTM in children undergoing general anaesthesia. Ninety-nine healthy patients were randomly assigned to either t...

1 dig(s) Dig it Bury Topic: Immunology

Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans

submitted by qualitybmarks 4 hours ago

Intravenous lipid emulsion is the recommended treatment for severe local anaesthetic intoxication. Lipid emulsion may entrap lipid soluble drugs by functioning as a ‘lipid sink’, but its effect...

1 dig(s) Dig it Bury Topic: Immunology

The impact of focused transthoracic echocardiography in the pre-operative clinic

submitted by larrindosl 4 hours ago

Patients with suspected or symptomatic cardiac disease, associated with increased peri-operative risk, are often seen by anaesthetists in the pre-assessment clinic. The use of transthoracic echocar...

1 dig(s) Dig it Bury Topic: Immunology

Measurement of forces applied during Macintosh direct laryngoscopy compared with GlideScope® videolaryngoscopy

submitted by SeanJax 4 hours ago

Laryngoscopy can induce stress responses that may be harmful in susceptible patients. We directly measured the force applied to the base of the tongue as a surrogate for the stress response. Force ...

1 dig(s) Dig it Bury Topic: Immunology

Intragraft Gene Expression in Positive Crossmatch Kidney Allografts: Ongoing Inflammation Mediates Chronic Antibody-Mediated Injury

submitted by mortgageleads 5 hours ago

We studied intragraft gene expression profiles of positive crossmatch (+XM) kidney transplant recipients who develop transplant glomerulopathy (TG) and those who do not. Whole genome microarray ana...

1 dig(s) Dig it Bury Topic: Immunology

Hypoalbuminemia and Early Mortality After Lung Transplantation: A Cohort Study

submitted by kkktali 5 hours ago

Hypoalbuminemia predicts disability and mortality in patients with various illnesses and in the elderly. The association between serum albumin concentration at the time of listing for lung transpla...

1 dig(s) Dig it Bury Topic: Immunology

Lack of Standardization in Exception Points for Patients with Primary Sclerosing Cholangitis and Bacterial Cholangitis

submitted by mahonbintar 5 hours ago

For conditions that the Model for End-Stage Liver Disease (MELD) score does not accurately predict waitlist mortality, transplant centers may apply to regional review boards for exception points. F...

1 dig(s) Dig it Bury Topic: Immunology

The Impact of Medicare's Lifetime Immunosuppression Coverage on Racial Disparities in Kidney Graft Survival

submitted by BryCory 5 hours ago

Beginning January 1, 2000, Medicare effectively extended its coverage of immunosuppression medications from 3 years to lifetime for patients eligible for Medicare on the basis of age or disability ...

1 dig(s) Dig it Bury Topic: Immunology

Complications of Living Donor Hepatic Lobectomy–A Comprehensive Report

submitted by mema238 5 hours ago

A wider application of living donor liver transplantation is limited by donor morbidity concerns. An observational cohort of 760 living donors accepted for surgery and enrolled in the Adult-to-Adul...

1 dig(s) Dig it Bury Topic: Immunology

IgG keeps virulent Salmonella from evading dendritic cell uptake

submitted by acintiomlivo 6 hours ago

DCs are phagocytic professional antigen presenting cells that can prime naïve T cells and initiate anti-bacterial immunity. However, several pathogenic bacteria have developed virulence mechanisms...

1 dig(s) Dig it Bury Topic: Immunology

Characterizing the binding motifs of 11 common human HLA-DP and HLA-DQ molecules using NNAlign

submitted by wonnybanny 6 hours ago

Compared with HLA-DR molecules, the specificities of HLA-DP and HLA-DQ molecules have only been studied to a limited extent. The description of the binding motifs has been mostly anecdotal and does...

1 dig(s) Dig it Bury Topic: Immunology

Functional Interferon System Is Required for Clearance of Lassa Virus

submitted by dege2 20 hours ago

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results...

1 dig(s) Dig it Bury Topic: Immunology

HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes

submitted by chakks 20 hours ago

HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two i...

1 dig(s) Dig it Bury Topic: Immunology

Endogenous Lentiviruses in the Ferret Genome

submitted by volintenavedea 20 hours ago

By screening 74 chordate genomes for endogenous lentiviruses using Pol sequences of exogenous lentiviruses as a reference, we identified a novel endogenous lentivirus in the genome of the ferret (M...

1 dig(s) Dig it Bury Topic: Immunology

Luria-Delbruck Estimation of Turnip Mosaic Virus Mutation Rate In Vivo

submitted by KennyJam 20 hours ago

A potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which viruses may generate escape mutations. Using a variation of the ...

1 dig(s) Dig it Bury Topic: Immunology

An RNA Interference Screen Identifies the Deubiquitinase STAMBPL1 as a Critical Regulator of Human T-Cell Leukemia Virus Type 1 Tax Nuclear Export and NF-{kappa}B Activation

submitted by rochde0 20 hours ago

The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein actively shuttles between the nucleus, where it interacts with transcriptional and splicing regulatory proteins, and the cytoplasm, w...

1 dig(s) Dig it Bury Topic: Immunology