Healthcare

Efficacy and safety of transdermal fentanyl for the treatment of oral mucositis pain caused by chemoradiotherapy in patients with esophageal squamous cell carcinoma
Oral mucositis is one of the most painful side effects found in esophageal squamous cell carcinoma (ESCC) patients treated with chemoradiotherapy. The transdermal route of administration is worthy of investigation for patients who suffer from dysphagia due to severe oral mucositis. In this phase 2 study, we investigated the efficacy and safety of transdermal fentanyl (TDF) for mucositis pain ca...


Distance from treating hospital and colorectal cancer survivors’ quality of life: a gendered analysis
Distance from residence to hospital has been associated with clinical outcomes for colorectal cancer patients. However, little is known about the association of remoteness with quality of life (QoL) for colorectal cancer survivors. We examined the relationship between distance from hospital and colorectal cancer survivors’ QoL, with a specific focus on gender. Colorectal cancer survivors in I...
Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study
The comorbidity of depression with anxiety disorders is associated with poorer treatment outcomes, worse quality of life, poorer adherence to treatment, and greater suicide risk in cancer patients. To assess the risk of comorbid anxiety and depressive disorders after the diagnosis of esophageal cancer compared with a matched cohort by using the Taiwan National Health Insurance Research Database...


Identifying Aboriginal-specific AUDIT-C and AUDIT-3 cutoff scores for at-risk, high-risk, and likely dependent drinkers using measures of agreement with the 10-item Alcohol Use Disorders Identification Test
The Alcohol Use Disorders Identification Test (AUDIT) is a 10-item alcohol screener that has been recommended for use in Aboriginal primary health care settings. The time it takes respondents to complete AUDIT, however, has proven to be a barrier to its routine delivery. Two shorter versions, AUDIT-C and AUDIT-3, have been used as screening instruments in primary health care. This paper aims to...
Detection of aneuploidy from single fetal nucleated red blood cells using whole genome sequencing
To detect aneuploidy from single fetal nucleated red blood cells (FNRBCs) from placental villi using whole genome amplification (WGA) and next generation sequencing. Three single FNRBCs per sample were manually picked from villi collected from ten women undergoing elective first trimester termination of pregnancy and one or two cells were picked from each of four aneuploidy chorionic villus sam...


Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy
The most common cause of acute kidney injury (AKI) in hospitalized patients is sepsis. However, the molecular pathways and mechanisms that mediate septic AKI are not well defined. Experiments performed over the past 20 years suggest that there are profound differences in the pathogenesis between septic and ischemic AKI. Septic AKI often occurs independently of hypoperfusion, and is mediated by ...
Evaluation of housing adaptation interventions: integrating the economic perspective into occupational therapy practice
The home environment is a key determinant of health, quality of life, and well-being. Given its relevance for such aspects, the scarcity of evaluations of housing adaptation (HA) interventions aimed at removing environmental barriers and accessibility problems in the homes of people with disabilities is surprising. This article aims to contribute to the development of strategies for economic ev...

A bivariate mixed-effects location-scale model with application to ecological momentary assessment (EMA) data
A bivariate mixed-effects location-scale model is proposed for estimation of means, variances, and covariances of two continuous outcomes measured concurrently in time and repeatedly over subjects. Modeling the two outcomes jointly allows examination of BS and WS association between the outcomes and whether the associations are related to covariates. The variance–covariance matrices of the BS...
The first hours of traumatic brain injury. Evaluation and management in emergency room
The traumatic brain injury is a common disease worldwide and it represents the leading cause of death and disability in different age groups, with an incidence of particular concern in adolescents and young adults. The Glasgow Coma Scale remains the best method for the initial classification of these patients and to define the route of administration. Since many deaths occur within the first tw...

Acute asthma exacerbations: an overview
Asthma is a chronic inflammatory disease of the airways. All patient with asthma are at risk of having exacerbations characterized by worsening symptoms, airflow obstruction, and an increased requirement for rescue bronchodilators. Asthma exacerbations can be classified as mild, moderate, severe, or life threatening. The goals of treatment are correction of severe hypoxemia, rapid reversal of a...
A Compressible Scaffold for Minimally Invasive Delivery Of Large Intact Neuronal Networks
Millimeter to centimeter-sized injectable neural scaffolds based on macroporous cryogels are presented. The polymer-scaffolds are made from alginate and carboxymethyl-cellulose by a novel simple one-pot cryosynthesis. They allow surgical sterility by means of autoclaving, and present native laminin as an attachment motive for neural adhesion and neurite development. They are designed to protect...

Dysphagia Management in Stroke Rehabilitation
Oropharyngeal dysphagia is a frequent occurrence following stroke. The length of acute care hospitalization, however, has decreased over time with many individuals weak and frail upon admission for rehabilitation and possibly with continued dysphagia upon discharge. It is imperative that the swallowing therapist have a thorough understanding of evidence-based compensatory and exercise managemen...
Reported Load Carriage Injuries of the Australian Army Soldier
Many injuries experienced by soldiers can be attributed to the occupational loads they are required to carry. The aim of this study was to determine whether contemporary military load carriage is a source of injuries to Australian Regular Army soldiers and to profile these injuries. The Australian Defence Force ‘Occupational Health, Safety and Compensation Analysis and Reporting’ database w...
Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women
Given the high prevalence of polycystic ovary syndrome (PCOS), and that a lifestyle is recognized effective in development of many diseases, this study aimed to compare lifestyle of women with PCOS and healthy women. Nor are there sufficient studies on the difference between lifestyle of these people with that of healthy people. Furthermore, studies show that changes in lifestyle improve this d...
Low Dose Furazolidone for Eradication of H- pylori Instead of Clarithromycin: A Clinical Trial
Helicobacter pylori infection is a common chronic human bacterial infection. Triple- therapy regimen containing a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole is commonly used as first-line treatment for its eradication. However, it may not provide the acceptable eradication rate. The present study was designed to evaluated efficacy of low dose furazolidone wit...