Healthcare

Activation to Self-Management and Exercise in Overweight and Obese Older Women With Knee Osteoarthritis
Knee osteoarthritis (OA) affects approximately 1 in 10 adults in the United States, with higher prevalence in women, aggravated by increased weight. This quasi-experimental pilot study implemented an online self-management (SM) program for older overweight and obese women with knee OA combined with a two-arm progressive exercise trial (walking and stepping groups). After the 10-week interventio...


Influence of Music on Preoperative Anxiety and Physiologic Parameters in Women Undergoing Gynecologic Surgery
The aim of this study was to determine the influence of music on anxiety levels and physiologic parameters in women undergoing gynecologic surgery. This study employed a pre- and posttest experimental design with nonrandom assignment. Ninety-seven women undergoing gynecologic surgery were included in the study, where 49 were allocated to the control group (nonmusic group) and 48 were assigned t...
Starting a Job as Adjunct Clinical Instructor
This article is the second in a new quarterly series on the roles of adjunct clinical faculty and preceptors, who teach nursing students to apply knowledge in clinical settings. Topics will include the preparation of clinical instructors and preceptors for these roles, the student evaluation process, and overcoming challenges that can come with teaching in the clinical field and with adjunct te...


No Association between Power Lines and Childhood Leukemia Risk
Living close to power lines (regardless of voltage) at the time of birth did not increase the risk of childhood leukemia.
Glucosamine Wasn't Effective for Knee Osteoarthritis
In patients with knee osteoarthritis, glucosamine didn't decrease cartilage degradation or improve bone marrow lesions, compared with placebo.


Active ‘Gaming’ May Help Children Manage their Weight
Overweight children provided with gaming consoles and games that required movement lost more weight and increased their physical activity more than children participating only in a weight-loss program.
JBI's Systematic Reviews: Presenting and Interpreting Findings
This article is the sixth and last in a series on the systematic review from the Joanna Briggs Institute, an international collaborative supporting evidence-based practice in nursing, medicine, and allied health fields. The purpose of the series is to describe how to conduct a systematic review—one step at a time. This article details what should be included when presenting the findings of a ...

Naloxone Now Available for Emergency Home Use
Naloxone, sold under the trade name Evzio, is now available as an autoinjection system to treat known or suspected opioid overdose in children or adults. Following a dose of Evzio, follow-up emergency care is still required to prevent recurrence of opioid-overdose symptoms.
What's in a Name? Biologic, Biosimilar, Bioequivalent, Bioavailable
Biologic products are made from human or animal materials. Biosimilar products are designed to be similar to an already approved biologic product. Bioavailability refers to the absorption phase of pharmacokinetics. Bioequivalent products are pharmaceutically equivalent to and have bioavailability identical to that of an already approved drug.

What a wish to die can mean: reasons, meanings and functions of wishes to die, reported from 30 qualitative case studies of terminally ill cancer patients in palliative care
Despite research efforts over recent decades to deepen our understanding of why some terminally ill patients express a wish to die (WTD), there is broad consensus that we need more detailed knowledge about the factors that might influence such a wish. The objective of this study is to explore the different possible motivations and explanations of patients who express or experience a WTD. Thirty...
The indispensable intermediaries: a qualitative study of informal caregivers' struggle to achieve influence at and after hospital discharge
The care policy and organization of the care sector is shifting to accommodate projected demographic changes and to ensure a sustainable model of health care provision in the future. Adult children and spouses are often the first to assume care giving responsibilities for older adults when declining function results in increased care needs. By introducing policies tailored to enabling family me...

The complexity in the implementation process of empowerment-based chronic kidney care: a case study
This study is part of an interactive improvement intervention aimed to facilitate empowerment-based chronic kidney care using data from persons with CKD and their family members. There are many challenges to implementing empowerment-based care, and it is therefore necessary to study the implementation process. The aim of this study was to generate knowledge regarding the implementation process ...
Modeling and Validating the Cost and Clinical Pathway of Colorectal Cancer
Cancer is a major cause of morbidity and mortality, and colorectal cancer (CRC) is the third most common cancer in the world. The estimated costs of CRC treatment vary considerably, and if CRC costs in a model are based on empirically estimated total costs of stage I, II, III, or IV treatments, then they lack some flexibility to capture future changes in CRC treatment. The purpose was 1) to des...
Application of theory to enhance audit and feedback interventions to increase the uptake of evidence-based transfusion practice: an intervention development protocol
Audits of blood transfusion demonstrate around 20% transfusions are outside national recommendations and guidelines. Audit and feedback is a widely used quality improvement intervention but effects on clinical practice are variable, suggesting potential for enhancement. Behavioural theory, theoretical frameworks of behaviour change and behaviour change techniques provide systematic processes to...
STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCI neuropathic pain rats
Activation of signal transducer and activator of transcription-3 (STAT3) is suggested to be critically involved in the development of chronic pain, but the complex regulation of STAT3-dependent pathway and the functional significance of inhibiting this pathway during the development of neuropathic pain remain elusive. To evaluate the contribution of the JAK2/STAT3 pathway to neuropathic pain an...