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Rectal hypersensitivity as hallmark for irritable bowel syndrome: defining the optimal cutoff

submitted by nerzor 1 day ago

Visceral hypersensitivity is a frequently observed hallmark of irritable bowel syndrome (IBS). Studies have reported differently about the presence of visceral hypersensitivity in IBS resulting fro...

1 dig(s) Dig it Bury Topic: Gastroenterology

Voltage-gated potassium channel (Kv1) autoantibodies in patients with chagasic gut dysmotility and distribution of Kv1 channels in human enteric neuromusculature (autoantibodies in GI dysmotility)

submitted by zhinhi92 1 day ago

Autoantibodies directed against specific neuronal antigens are found in a significant number of patients with gastrointestinal neuromuscular diseases (GINMDs) secondary to neoplasia. This study exa...

1 dig(s) Dig it Bury Topic: Gastroenterology

Recombinant Semliki Forest virus vectors encoding hepatitis B virus small surface and pre-S1 antigens induce broadly reactive neutralizing antibodies

submitted by KendrZio 1 day ago

Most hepatitis B virus (HBV) vaccines consist of viral small surface (S) protein subtype adw2 expressed in yeast cells. In spite of good efficacy, HBV-genotype and subtype differences, escape mutan...

1 dig(s) Dig it Bury Topic: Gastroenterology

Randomised clinical trial: esomeprazole for the prevention of nonsteroidal anti-inflammatory drug-related peptic ulcers in Japanese patients

submitted by Dora 1 day ago

The use of proton pump inhibitors for prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal adverse events is well documented. However, data regarding the efficacy and ...

1 dig(s) Dig it Bury Topic: Gastroenterology

Soluble CD163, a marker of Kupffer cell activation, is related to portal hypertension in patients with liver cirrhosis

submitted by MaddoxRoge 1 day ago

Activation of Kupffer cells may be involved in the pathogenesis of portal hypertension by release of vasoconstrictive substances and fibrosis due to co-activation of hepatic stellate cells.AimTo st...

1 dig(s) Dig it Bury Topic: Gastroenterology

High-dose, ten-day esomeprazole, amoxicillin and metronidazole triple therapy achieves high Helicobacter pylori eradication rates

submitted by caalam2 1 day ago

Strong acid inhibition using esomeprazole increases cure rates with triple therapy and 10-day treatments are more effective than 7-day ones. The combination of amoxicillin plus metronidazole at ful...

1 dig(s) Dig it Bury Topic: Gastroenterology

Detection of Exercise-Induced Pulmonary Arterial Hypertension by Cardiopulmonary Exercise Testing

submitted by yoro 2 days ago

The pulmonary arterial pressure (PAP) response to exercise may provide a tool for the early detection of pulmonary arterial hypertension (PAH). Therefore, an accurate noninvasive method for evaluat...

1 dig(s) Dig it Bury Topic: Gastroenterology

Smoking Status on Outcomes After Percutaneous Coronary Intervention

submitted by monto72 2 days ago

The effect of smoking on prognosis among patients undergoing percutaneous coronary intervention (PCI) is controversial, and data on the importance of smoking cessation or reductions were lacking.Sm...

1 dig(s) Dig it Bury Topic: Gastroenterology

Treatment and Outcomes of Acute Coronary Syndrome in the Cancer Population

submitted by eaon 2 days ago

Randomized trials have established the benefit of medical therapy and revascularization in the treatment of acute myocardial infarction (MI). Cancer and cardiovascular disease are the 2 most common...

1 dig(s) Dig it Bury Topic: Gastroenterology

Genetics of Coronary Artery Disease in the 21st Century

submitted by CamGirlz21 2 days ago

Coronary artery disease (CAD) is still the number-one killer in the world, and clinical trials indicate that it is preventable. Mortality and morbidity can be reduced by at least 30% to 40% by trea...

1 dig(s) Dig it Bury Topic: Gastroenterology

Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines

submitted by mahommod 2 days ago

Activating mutations in the KRAS oncogene are common in colorectal cancer. However, the complete spectrum of KRAS targets that mediate its tumorigenic effect has not yet been fully delineated. We i...

1 dig(s) Dig it Bury Topic: Gastroenterology

Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus

submitted by xaaclimoepti 2 days ago

Motilin and ghrelin are the gastrointestinal (GI) hormones released in a fasting state to stimulate the GI motility of the migrating motor complex (MMC). We focused on coordination of the ghrelin/m...

1 dig(s) Dig it Bury Topic: Gastroenterology

Enteropathogenic Escherichia coli inhibits ileal sodium-dependent bile acid transporter ASBT

submitted by vatez 2 days ago

Apical sodium-dependent bile acid transporter (ASBT) is responsible for the absorption of bile acids from the intestine. A decrease in ASBT function and expression has been implicated in diarrhea a...

1 dig(s) Dig it Bury Topic: Gastroenterology

Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats

submitted by gairgin 2 days ago

Low doses of sorafenib have been shown to decrease portal pressure (PP), portal-systemic shunts, and liver fibrosis in cirrhotic rats. Nonselective beta blockers (NSBB) are the only drugs recommend...

1 dig(s) Dig it Bury Topic: Gastroenterology

Site-specific regulation of ion transport by prolactin in rat colon epithelium

submitted by ciostan 2 days ago

The effect of prolactin (PRL) on ion transport across the rat colon epithelium was investigated using Ussing chamber technique. PRL (1 μg/ml) induced a sustained decrease in short-circuit curren...

1 dig(s) Dig it Bury Topic: Gastroenterology