Gastroenterology

Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?
The WHO classified pancreatic neuroendocrine neoplasms in 2010 as G1, G2, and neuroendocrine carcinoma (NEC), according to the Ki67 labeling index (LI). However, the clinical behavior of NEC is still not fully studied. We aimed to clarify the clinicopathological and molecular characteristics of NECs. We retrospectively evaluated the clinicopathological characteristics, KRAS mutation status, tre...


Biliary adenofibroma with ominous features of imminent malignant changes
Biliary adenofibroma (BAF) is a rare, benign liver tumor. Herein, we report a case of BAF with histological features of imminent malignant changes. Ultrasound and CT revealed a solid 2.5-cm mass in the right liver lobe. The patient was asymptomatic and had no past medical history including liver disease. A general examination that included the abdomen and the laboratory data were normal. Becaus...
Factors that Affect Consultation and Screening for Fecal Incontinence
Fecal incontinence (FI) affects 15% of people age 70 years and older, but only 10%–30% discuss FI with their physicians. We aimed to identify barriers that prevent people from consulting with their physicians, and physicians from screening for FI. We performed structured interviews of 124 individuals with FI (mean 56 years old, 87.9% women) recruited from 6 medical offices at the University o...


The Serotonin Receptor 5-HT4 Agonist YKP10811 Accelerates Intestinal Transit and Improves Bowel Functions in Patients with Functional Constipation
Ykp10811, a selective agonist of the serotonin receptor 5-HT4, increases gastrointestinal (GI) motility. We investigated the safety and effects of YKP10811 on GI and colonic transit and bowel movements (BM) in patients with functional constipation in a randomized, double-blind, placebo-controlled study. Patients with functional constipation, based on the Rome III criteria, were randomly assigne...
Temporal Trends of Non-alcoholic Fatty Liver Disease-related Hepatocellular Carcinoma in the Veteran Affairs Population
Non-alcoholic fatty liver disease (NAFLD) is a risk factor for hepatocellular carcinoma (HCC). However, no systemic studies from the United States have examined temporal trends, HCC surveillance practices, and outcomes of NAFLD-related HCC. We identified a national cohort of 1500 patients who developed HCC from 2005 through 2010 from Veterans Administration (VA) hospitals. We reviewed patientsâ...


Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome
It is not known whether specific characteristics of medication are associated with type of drug-induced liver injury (DILI) or outcome. We examined the relationships among select characteristics of medications and DILI phenotype and outcome. We analyzed 383 cases of DILI caused by a single orally administered prescription agent from the DILI Network Prospective Study with causalities of definit...
Risk of Hepatobiliary Cancer After Solid Organ Transplant in the United States
Studies of liver cancer risk in recipients of solid organ transplants generally have been small, yielding mixed results, and little is known about biliary tract cancers among transplant recipients. We identified incident hepatobiliary cancers among 201,549 US recipients of solid organs, from 1987 through 2008, by linking data from the US transplant registry with 15 cancer registries. We calcula...

Increased Long-term Survival Among Patients With Hepatocellular Carcinoma After Implementation of Model for End-stage Liver Disease Score
Assignment of Model for End-stage Liver Disease (MELD) exception points to patients with hepatocellular carcinoma (HCC) who fall within Milan criteria, which began in 2003, increases their priority on liver transplantation waitlists. However, little is known about how this change affected survival of all patients with HCC (transplant eligible and ineligible). We compared long-term survival of H...
Older Women’s Experience with a Benign Breast Biopsy—A Mixed Methods Study
Little is known about older women’s experience with a benign breast biopsy. To examine the psychological impact and experience of women ≥ 65 years of age with a benign breast biopsy. Prospective cohort study using quantitative and qualitative methods. Three Boston-based breast imaging centers. Ninety-four English-speaking women ≥ 65 years without dementia referred for breast biopsy as a...

Inter-observer agreement in endoscopic scoring systems: Preliminary report of an ongoing study from the Italian Group for Inflammatory Bowel Disease (IG-IBD)
Endoscopic activity has become a therapeutic endpoint in inflammatory bowel disease. of this study was to evaluate inter-observer agreement for endoscopic scores in a real-life setting. 14 gastroenterologists with experience in inflammatory bowel disease care and endoscopic scoring reviewed videos of ulcerative colitis (n =13) and postoperative (n =10) and luminal (n =8) Crohn's disease. The Ma...
Genetics of gastric cancer
Gastric cancer accounts for a notable proportion of cancer mortality around the world. Over the past few decades, advances in technology and high-throughput analysis have improved understanding of the molecular aspects of the pathogenesis of gastric cancer. This Review discusses these genetic aspects of the pathogenesis of gastric cancer.

Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding
Peptic ulcer bleeding (PUB) is a major cause of upper gastrointestinal bleeding. The effect of omeprazole on mucosal repair is unknown. We studied the effect of omeprazole, nonsteroidal anti-inflammatory agents, and smoking on PUB. There were 43 PUB patients who received regular or high dose of omeprazole for 72 h. Biopsies from antrum and corpus were taken before and after treatment. Biopsy s...
Akute Pankreatitis
Eine akute Pankreatitis ist am häufigsten biliärer oder äthyltoxischer Genese, seltener iatrogen (ERCP, Medikamente) oder metabolisch bedingt. Meist kann die Diagnose bei abdominellen Schmerzen und mehr als 3-fach erhöhter Serum-Lipase gestellt werden. Die akute Pankreatitis kann entweder nach einer ödematösen Schwellung schnell ausheilen oder als schwere, nekrotisierende Form verlaufen. ...
Akuter Kiefer-Thorax-Schmerz und Synkope bei einem 41-jährigen Patienten
Ein 41-jähriger sportlich aktiver Patient ohne relevante Vorerkrankungen erlitt ein thorakales Schmerzereignis. Eine im nächstgelegenen Klinikum der Maximalversorgung durchgeführte Computertomographie (CT) des Thorax zeigte eine Ektasie der Aorta ascendens sowie Unregelmäßigkeiten im Bereich der Aortenwand ohne Nachweis einer Dissektion. Trotz fehlender Krankheitseinsicht erfolgte die Übe...
Arzneitherapie solider Tumoren
In den vergangenen Jahren haben sich dramatische Neuerungen im Verständnis und der Behandlung solider Tumoren vollzogen. Basierend auf der Tumorbiologie wurden zielgerichtete Therapeutika entwickelt, die direkten Einfluss auf zugrunde liegende genetische und immunologische Veränderungen nehmen. Signifikante Verbesserungen des Überlebens sind der funktionelle Beweis der Wirksamkeit zielgerich...