Gastroenterology

Determinants of Weight Loss prior to Diagnosis in Inflammatory Bowel Disease: A Retrospective Observational Study
To identify prevalence, severity, and environmental determinants of weight loss in inflammatory bowel disease (IBD) patients just prior to time of formal diagnosis. IBD patients attending outpatient clinic were questioned about weight loss prior to diagnosis and other environmental and demographic variables. The percentage BMI loss was calculated for each subject and factors associated with wei...


Gene mutations in Wilson disease in egyptian children: Report on two novel mutations
Wilson disease (WD) is an autosomal recessive disorder, caused by defects in copper-transporting P-type adenosine triphosphatase (ATPase) encoded by the ATP7B gene, resulting in the deposition of copper in the liver and brain with significant disability or death if left untreated. An available regimen of treatment gives hope to those predisposed to the disease if diagnosed early. The objective ...
Childhood abuse history is associated with the development of dyspepsia: a population-based survey in Japan
Functional dyspepsia (FD) is a heterogeneous disorder, and it is not clear whether childhood abuse influences the severity of dyspeptic symptoms and the type of dyspepsia. Accordingly, we administered a questionnaire survey to evaluate the association of abuse history in the development of dyspepsia. Study subjects were selected from among a panel of volunteers, to make equal distribution of ag...


Should Health Care Providers be Accountable for Patients’ Care Experiences?
Measures of patients’ care experiences are increasingly used as quality measures in accountability initiatives. As the prominence and financial impact of patient experience measures have increased, so too have concerns about the relevance and fairness of including them as indicators of health care quality. Using evidence from the Consumer Assessment of Healthcare Providers and Systems (CAHPSÂ...
Patients Report Better Satisfaction with Part-Time Primary Care Physicians, Despite Less Continuity of Care and Access
The growing number of primary care physicians (PCPs) reducing their clinical work hours has raised concerns about meeting the future demand for services and fulfilling the continuity and access mandates for patient-centered care. However, the patient’s experience of care with part-time physicians is relatively unknown, and may be mediated by continuity and access to care outcomes. We aimed to...


Ethnic Disparities in the Risk of Colorectal Adenomas Associated with Lipid Levels: a Retrospective Multiethnic Study
Although data exists showing that uncontrolled lipid levels in white and black patients is associated with colorectal adenomas, there are currently no studies looking only at the Hispanic population. With the rapid increase in the Hispanic population, we aimed to look at their risk of colorectal adenomas in association with lipid levels. We retrospectively analyzed 1473 patients undergoing colo...
Kruppel-like factor 4 is a radioprotective factor for the intestine following gamma-radiation-induced gut injury in mice
Gut radiation-induced injury is a concern during treatment of cancer patients. Krüppel-like factor 4 (KLF4) is expressed in differentiated villous epithelial cells of the small intestine. We previously showed that KLF4 protects cells from apoptosis following -irradiation in vitro. We sought to determine whether KLF4 mediates the small intestinal response to -irradiation in vivo. Mice with ...

Caspase-11 Attenuates Gastrointestinal Inflammation and Experimental Colitis Pathogenesis
NLR inflammasome formation plays an essential role in modulating immune system homeostasis in the gut. Recently, a caspase-11 non-canonical inflammasome has been characterized and appears to modulate many biological functions that were previously considered to be solely dependent on caspase-1 and the canonical inflammasome. To better elucidate the function of this non-canonical inflammasome dur...
Animal models of ischemia-reperfusion induced intestinal injury: progress and promise for translational research
Research in the field of ischemia-reperfusion injury continues to be plagued by the inability to translate research findings to clinically useful therapies. This may in part relate to the complexity of disease processes that result in intestinal ischemia, but may also result from inappropriate research model selection. Research animal models have been integral to the study of ischemia-reperfusi...

Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice
The role (s) of the epidermal growth factor receptor (EGFR) in hepatocytes is unknown. We generated a murine hepatocyte specific-EGFR knockout model to evaluate how loss of hepatocellular EGFR expression affects processes such as EGF clearance, circulating EGF concentrations, and liver regeneration following 70% resection or CCl4-induced centrilobular injury. We were able to disrupt EGFR expres...
Efficacy of entecavir treatment for up to 96 weeks in nucleoside-naive HBeAg-positive chronic hepatitis B patients with high viral load
To evaluate the antiviral response of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients who had baseline high viral load (HVL), defined as having hepatitis B virus (HBV) DNA>9log 10 copies/mL, after 96weeks of entecavir (ETV) treatment. A total of 99 HBeAg-positive CHB patients (50 with HVL and 49 with non-HVL) were treated with ETV monotherapy for 96weeks. Virolo...

Imbalanced splicing in MAPK signaling sustains Ras-induced transformation
Increasingly, evidence suggests that phosphorylation of the mRNA translation initiation factor eIF4E plays an important role in carcinogenesis, downstream of Ras. The eIF4E factor is phosphorylated by MAPK-interacting protein kinases 1 and 2 (MNK1 and MNK2). Due to alternative splicing, two MNK2 proteins exist (MNK2a and MNK2b). While MNK2a possesses a binding site for the stress-induced p38-MA...
Differentiation of benign and malignant bowel lesions by transabdominal ultrasound using grey-scale and Doppler parameters
The aim of this study was to assess the ability of transabdominal ultrasonographic morphologic features and Doppler flow parameters in differentiating benign from malignant bowel lesions. Sixty patients with sonographically detected gastrointestinal lesions and 30 control subjects were prospectively enrolled. Bowel wall thickness; length of the affected segment; the wall layering pattern; the r...
Lipoma of the small intestine treated with endoscopic resection
We report a case of lipoma of the small intestine that was treated by endoscopic resection. A 79-year-old man who complained of tarry stool was diagnosed as having jejunal tumor at a neighboring clinic. Computed tomography (CT) and enteroscopy demonstrated an ulcerating jejunal mass. Because the tumor was considered to be the source of bleeding, we removed it under double-balloon endoscopy with...
Correlates of Suicide Among Veterans Treated in Primary Care: Case–Control Study of a Nationally Representative Sample
Veterans receiving Veterans Affairs (VA) healthcare have increased suicide risk compared to the general population. Many patients see primary care clinicians prior to suicide. Yet little is known about the correlates of suicide among patients who receive primary care treatment prior to death. Our aim was to describe characteristics of veterans who received VA primary care in the 6 months prior ...