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Gastroenterology

Rectal hypersensitivity as hallmark for irritable bowel syndrome: defining the optimal cutoff
submitted by nerzor 1 day ago
Visceral hypersensitivity is a frequently observed hallmark of irritable bowel syndrome (IBS). Studies have reported differently about the presence of visceral hypersensitivity in IBS resulting fro...
 


Voltage-gated potassium channel (Kv1) autoantibodies in patients with chagasic gut dysmotility and distribution of Kv1 channels in human enteric neuromusculature (autoantibodies in GI dysmotility)
submitted by zhinhi92 1 day ago
Autoantibodies directed against specific neuronal antigens are found in a significant number of patients with gastrointestinal neuromuscular diseases (GINMDs) secondary to neoplasia. This study exa...
 
Recombinant Semliki Forest virus vectors encoding hepatitis B virus small surface and pre-S1 antigens induce broadly reactive neutralizing antibodies
submitted by KendrZio 1 day ago
Most hepatitis B virus (HBV) vaccines consist of viral small surface (S) protein subtype adw2 expressed in yeast cells. In spite of good efficacy, HBV-genotype and subtype differences, escape mutan...
 
Randomised clinical trial: esomeprazole for the prevention of nonsteroidal anti-inflammatory drug-related peptic ulcers in Japanese patients
submitted by Dora 1 day ago
The use of proton pump inhibitors for prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal adverse events is well documented. However, data regarding the efficacy and ...
 


Soluble CD163, a marker of Kupffer cell activation, is related to portal hypertension in patients with liver cirrhosis
submitted by MaddoxRoge 1 day ago
Activation of Kupffer cells may be involved in the pathogenesis of portal hypertension by release of vasoconstrictive substances and fibrosis due to co-activation of hepatic stellate cells.AimTo st...
 
High-dose, ten-day esomeprazole, amoxicillin and metronidazole triple therapy achieves high Helicobacter pylori eradication rates
submitted by caalam2 1 day ago
Strong acid inhibition using esomeprazole increases cure rates with triple therapy and 10-day treatments are more effective than 7-day ones. The combination of amoxicillin plus metronidazole at ful...
 
Detection of Exercise-Induced Pulmonary Arterial Hypertension by Cardiopulmonary Exercise Testing
submitted by yoro 2 days ago
The pulmonary arterial pressure (PAP) response to exercise may provide a tool for the early detection of pulmonary arterial hypertension (PAH). Therefore, an accurate noninvasive method for evaluat...
 
Smoking Status on Outcomes After Percutaneous Coronary Intervention
submitted by monto72 2 days ago
The effect of smoking on prognosis among patients undergoing percutaneous coronary intervention (PCI) is controversial, and data on the importance of smoking cessation or reductions were lacking.Sm...
 
Treatment and Outcomes of Acute Coronary Syndrome in the Cancer Population
submitted by eaon 2 days ago
Randomized trials have established the benefit of medical therapy and revascularization in the treatment of acute myocardial infarction (MI). Cancer and cardiovascular disease are the 2 most common...
 
Genetics of Coronary Artery Disease in the 21st Century
submitted by CamGirlz21 2 days ago
Coronary artery disease (CAD) is still the number-one killer in the world, and clinical trials indicate that it is preventable. Mortality and morbidity can be reduced by at least 30% to 40% by trea...
 
Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines
submitted by mahommod 2 days ago
Activating mutations in the KRAS oncogene are common in colorectal cancer. However, the complete spectrum of KRAS targets that mediate its tumorigenic effect has not yet been fully delineated. We i...
 
Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus
submitted by xaaclimoepti 2 days ago
Motilin and ghrelin are the gastrointestinal (GI) hormones released in a fasting state to stimulate the GI motility of the migrating motor complex (MMC). We focused on coordination of the ghrelin/m...
 
Enteropathogenic Escherichia coli inhibits ileal sodium-dependent bile acid transporter ASBT
submitted by vatez 2 days ago
Apical sodium-dependent bile acid transporter (ASBT) is responsible for the absorption of bile acids from the intestine. A decrease in ASBT function and expression has been implicated in diarrhea a...
 
Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats
submitted by gairgin 2 days ago
Low doses of sorafenib have been shown to decrease portal pressure (PP), portal-systemic shunts, and liver fibrosis in cirrhotic rats. Nonselective beta blockers (NSBB) are the only drugs recommend...
 
Site-specific regulation of ion transport by prolactin in rat colon epithelium
submitted by ciostan 2 days ago
The effect of prolactin (PRL) on ion transport across the rat colon epithelium was investigated using Ussing chamber technique. PRL (1 μg/ml) induced a sustained decrease in short-circuit curren...
 

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