Gastroenterology

Detection of Gastric Precancerous Conditions in Daily Clinical Practice: A Nationwide Survey
The burden of gastric precancerous conditions and factors associated with their detection have not been fully investigated in community-based settings. Little is known about adherence to Sydney system for histopathology of gastric biopsies. We aimed to investigate what really happens in clinical practice with regard to the detection of gastric atrophy and intestinal metaplasia in dyspeptic pati...


Rifabutin-based High-dose Proton-pump Inhibitor and Amoxicillin Triple Regimen as the Rescue treatment for Helicobacter pylori
Rifabutin has been known to be effective in multidrug-resistant Helicobacter pylori-harboring patients undergoing treatment failure for H. pylori infection. To evaluate the efficacy of 7-day treatment regimen consisting rifabutin daily but increasing the dose of amoxicillin and lansoprazole in patients who have failed first and second eradication and to assess the side effect profiles in South...
Helicobacter pylori Induces Vascular Endothelial Growth Factor Production in Gastric Epithelial Cells Through Hypoxia-Inducible Factor-1α-Dependent Pathway
Although Helicobacter pylori have been known to induce vascular endothelial growth factor (VEGF) production in gastric epithelial cells, the precise mechanism for cellular signaling is incompletely understood. In this study, we investigated the role of bacterial virulence factor and host cellular signaling in VEGF production of H. pylori-infected gastric epithelial cells. We evaluated producti...


Morbidity of Loop Ileostomy Closure after Restorative Proctocolectomy for Ulcerative Colitis and Familial Adenomatous Polyposis: a Systematic Review
Temporary loop ileostomy is a routine procedure to reduce the morbidity of restorative proctocolectomy. However, morbidity of ileostomy closure could reduce the benefit of this concept. The objective of this systematic review was to assess the risks of ileostomy closure after restorative proctocolectomy for ulcerative colitis or familial adenomatous polyposis. Publications in English or German ...
Strong YB-1 Expression Predicts Liver Recurrence Following Resection for Colorectal Metastases
The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection. Immunohistochemistry was performed to evaluate YB-1 in 66 ...


Impact of Inflammatory Bowel Disease on Disability
Inflammatory bowel disease can impact individuals at a young age, thus compromising their work productivity. Besides the inability to engage in gainful work, the concept of disability also relates to the patients’ diminished ability to undertake household and social activities. A literature search was performed of recent literature, and all articles containing information about the impact of ...
Investigation into celiac disease in Indian patients with portal hypertension
There is limited data on celiac disease in patients with cryptogenic cirrhosis or idiopathic noncirrhotic intrahepatic portal hypertension (NCIPH). Our objective was to evaluate for celiac disease in patients with portal hypertension in India. Consecutive patients with portal hypertension having cryptogenic chronic liver disease (cases) and hepatitis B- or C-related cirrhosis (controls) were pr...

Challenges with the Medicare Obesity Benefit: Practical Concerns & Proposed Solutions
Obesity and the growing population of older adults are significant public health concerns in the United States. In 2011, the Centers for Medicare and Medicaid Services introduced a Medicare benefit for obesity counselling using Intensive Behavioral Therapy that would reimburse structured visits over a 12-month period. Although we applaud this new benefit that addresses the obesity epidemic in o...
Peroral endoscopic myotomy (POEM) for nutcracker esophagus. Three cases with 12 months follow-up
Peroral endoscopic myotomy (POEM) has been introduced as a new treatment of achalasia, and studies are emerging on POEM treatment of other esophageal motility disorders. The effects of medical treatment, botox injections and dilatations are often limited in patients with severe nutcracker esophagus (NE). We therefore decided to perform POEM in three patients with severe NE. Material and methods...

Challenges to Liver Transplantation and Strategies to Improve Outcomes
Liver transplantation (LT) is a highly successful treatment for many non-malignant and malignant liver diseases. However, there is a worldwide shortage of available organs; many patients deteriorate or die on waiting lists. We review the important clinical challenges to LT and the best use for the scarce organs. We focus on changes in indications for LT and discuss scoring systems to best match...
Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells, and Treatment Algorithms for Inflammatory Bowel Diseases
Increased understanding of the pathogenesis of inflammatory bowel diseases (IBD) has led to new therapeutic strategies. One of these is to target the molecules that regulate interactions between leukocytes and endothelial cells at sites of inflammation (mainly leukocyte integrins and endothelial cell adhesion molecules of the immunoglobulin superfamily). These molecules have been validated as t...

Prucalopride is no More Effective than Placebo for Children with Functional Constipation
Prucalopride is a selective, high-affinity agonist of the 5-hydroxytryptamine (serotonin) receptor 4 that increases the kinetics of the gastrointestinal tract. We performed a multicenter, randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of prucalopride in children (6−18 years old) with functional constipation. Children with functional constipatio...
The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease is an emerging liver disease in Western countries and the most frequent cause of incidental elevation of serum liver enzymes. Dyslipidaemia is frequently observed in patients with non-alcoholic fatty liver disease, and treatment of dyslipidaemia plays a critical role in the overall management of these patients. Moreover, coronary artery disease remains the most...
Immune profile of IgA-dominant diffuse proliferative glomerulonephritis
The diagnosis of IgA-dominant post-infectious glomerulonephritis (PIGN) may be challenging, as it must be differentiated from that of active IgA nephropathy. Predominant clinicopathologic features of IgA-dominant PIGN substantially overlap with those of active IgA nephropathy. Here, we present a case of a 67-year-old woman with rapidly rising serum creatinine, proteinuria and severe hypertensio...
Methotrexate toxicity treated with continuous venovenous hemofiltration, leucovorin and glucarpidase
High-dose methotrexate (MTX) can produce acute kidney injury, impairing MTX elimination. Continuous venovenous hemofiltration (CVVH) may enhance elimination in this setting, although its use is largely unstudied. A 79-year-old man received IV MTX for central nervous system lymphoma, and over a 34-h period his serum creatinine increased from 1.09 to 2.24 mg/dL. His serum MTX concentration (sMTX)...