Endocrinology

Direct effects of recurrent hypoglycaemia on adrenal catecholamine release
In Type 1 and advanced Type 2 diabetes mellitus, elevation of plasma epinephrine plays a key role in normalizing plasma glucose during hypoglycaemia. However, recurrent hypoglycaemia blunts this elevation of plasma epinephrine. To determine whether recurrent hypoglycaemia affects peripheral components of the sympatho-adrenal system responsible for epinephrine release, male rats were administere...


Diabetes and cancer: Epidemiology and potential mechanisms
Type 2 diabetes mellitus is an independent risk factor for cancer such as pancreatic, liver, colorectal and breast cancer. In addition, diabetes decreases the risk of prostate cancer. These associations have been found in numerous epidemiological studies, among them several prospective cohorts. However, such studies do not prove causality of the association and cannot exclude inadequate correct...
Molecular diagnosis of intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinomas (iCCA) are primary intrahepatic malignancies originating from biliary epithelia. While both hepatocellular cancer and iCCA can present as mass lesions within the liver, these cancers are distinct in their morphology, etiology, pathology, natural history and response to therapy. There is a need for accurate and sensitive molecular markers for the diagnosis of iCC...


Parámetros de control glucémico en pacientes con diabetes tipo 2 no insulinizados derivados a consulta de Endocrinología, y grado de implementación del consenso nacional sobre el tratamiento de la hiperglucemia
Evaluar el control glucémico en pacientes con diabetes tipo 2 que son remitidos a Endocrinología desde Atención Primaria (AP) por no estar controlados con antidiabéticos orales sin insulinoterapia; y el grado de implementación del consenso nacional de la Sociedad Española de Diabetes, valorando los sucesivos escalones, primero (Pe), segundo (Se) y tercero (Te), del abordaje terapéutico. ...
Optimal Duration of the Early and Late Recurrence of Pancreatic Cancer after Pancreatectomy Based on the Difference in the Prognosis
The term “early recurrence” of pancreatic cancer has not been well-defined in most previous studies. The clinical records of 86 patients who underwent macroscopic curative pancreatectomy for pancreatic cancer between 2000 and 2009 were retrospectively examined. We divided 55 patients who experienced disease recurrence into two groups, the early and late recurrence groups, using the minimum ...


Effectiveness and safety of basal supported oral therapy with insulin glargine, in Japanese insulin-naïve, type 2 diabetes patients, with or without microvascular complications: subanalysis of the observational, non-interventional, 24-week follow-up Add-o
To evaluate effectiveness and safety of basal supported oral therapy (BOT) using insulin glargine in insulin-naïve Japanese patients, with and without microvascular complications. This sub-group analysis of observational, non-interventional ALOHA study, assessed changes in glycemic parameters and glargine dose, at 24 weeks or at glargine discontinuation. Count of hypoglycemic episodes was base...
Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice
Negative feedback regulation of glucocorticoid (GC) synthesis and secretion occurs through the function of glucocorticoid receptor (GR) at sites in the hypothalamic–pituitary–adrenal (HPA) axis, as well as in brain regions such as the hippocampus, prefrontal cortex, and sympathetic nervous system. This function of GRs in negative feedback coordinates basal glucocorticoid secretion and stres...

Low serum galectin-3 concentrations are associated with insulin resistance in patients with type 2 diabetes mellitus
Galectin-3 is a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation. Galectin-3-deficient mice have been shown to exhibit excess adiposity, hyperglycemia, insulin resistance and systemic inflammation. We investigated the association between serum galectin-3 and insulin resistance in patients with type 2 diabetes using a glucose clamp meth...
Is there any relationship between medication compliance and affective temperaments in patients with type 2 diabetes?
Type 2 diabetes mellitus (DM) is the most common type of diabetes. The number of patients with this disease is expected torise in future. Given the increasing prevalence of diabetes, there is an urgent need for the treatment of diabetes and the associated complications. Glycemic control largely depends on compliance with medication therapies. In fact, the most common problem in patients with di...

Single-operator pancreatoscopy is helpful in the evaluation of suspected intraductal papillary mucinous neoplasms (IPMN)
Even when advanced cross-sectional imaging modalities have been employed, endoscopic evaluation of intraductal papillary mucinous neoplasms (IPMN) is often required in order to assess the final character and extent of lesions. The current study addresses the use of SpyGlass single-operator peroral pancreatoscopy in suspected IPMN. A prospective, non-randomized exploratory cohort study. Single-c...
Are frequency and severity of sleep-disordered breathing in obese children and youth with and without type 2 diabetes mellitus different?
Obstructive sleep apnea (OSA) is a risk factor for insulin resistance and type 2 diabetes mellitus (T2DM) in adults. Data in children are limited. The aim was to study the frequency and severity of OSA and its association with cardiometabolic risk factors in obese children and adolescents with and without T2DM. In this prospective cross-sectional study, obese children and adolescents with and w...

Metformin does not attenuate the acute insulin-sensitizing effect of a single bout of exercise in individuals with insulin resistance
Combining metformin and exercise is recommended for the treatment of insulin resistance. However, it has been suggested that metformin blunts the insulin-sensitizing effects of exercise. We evaluated in a group of insulin-resistant patients the interactions between exercise and their daily dose of metformin. Ten insulin-resistant patients underwent insulin sensitivity assessment using intraveno...
The single-port concept: combining optical glucose measurement with insulin infusion
The aim of this study was to develop a single-port system that combines glucose monitoring and insulin infusion. In a preclinical proof-of-concept trial, the performance of the glucose measurement at the site of insulin infusion was assessed. Glucose levels were clamped from 40 to 250 mg/dL by intravenous glucose infusion and subcutaneous insulin infusion via the glucose sensor. Sensor-glucose...
Factores psicosociales en la diabetes mellitus tipo1 y su relación con el riesgo de desarrollar trastornos alimentarios en la infancia y la adolescencia
El tratamiento de la diabetes tipo1 (DMT1) exige modificaciones de los hábitos alimentarios y estilos de vida que puede conducir a desarrollar trastornos de la conducta alimentaria (TCA). Por lo tanto, se hace necesaria la detección precoz de estos trastornos. Existe escasa evidencia sobre la presencia de TCA y/o su relación con características psicosociales en este tipo de pacientes. Estim...
Endometrial expression of the insulin-like growth factor system during uterine involution in the postpartum dairy cow
Rapid uterine involution in the postpartum period of dairy cows is important to achieve a short interval to conception. Expression patterns for members of the insulin-like growth factor (IGF) family were determined by in situ hybridisation at day 14±0.4 postpartum (n =12 cows) to investigate a potential role for IGFs in modulating uterine involution. Expression in each uterine tissue region wa...