submitted by revypoerm 1 hour ago
In a previous pooled analysis of 19 double-blind clinical studies conducted by Merck, which included data available as of July 2009 on 10,246 patients with type 2 diabetes (T2DM), treatment with sitagliptin was shown to be generally well tolerated compared with treatment with control agents. As t...
submitted by diondro 3 hours ago
HIV associated insulin resistance, lipodistrophy and cardiometabolic syndrome have been extensively studied and continue to be the scope of much research. There is compelling evidence that both the HIV itself and the therapeutical regimes are major contributors to all of these associated comorbid...
submitted by nehetj 4 hours ago
With increasing life expectancy of CF-patients, secondary diabetes becomes more prevalent. It appears to be the most common co-morbidity in persons with cystic fibrosis. Therefore, the objective of our study was to describe characteristics of cystic fibrosis related diabetes (CFRD) compared to ty...
submitted by bollye 4 hours ago
Serum visfatin are associated with cardiovascular risk factors and obesity. Relation of this adipokine with nmetabolic syndrome is unclear. We decide to investigate the association between metabolic syndrome and resistin levels in female obese subjects.SubjectsA sample of 826 female obese subject...
submitted by garydiaa48 4 hours ago
In a pilot study we suggested that benfotiamine, a thiamine prodrug, prevents postprandial endothelial dysfunction in people with Type 2 diabetes mellitus. The aim of this study was to test these effects in a larger population. In a double-blind, placebo-controlled, randomized, crossover study, ...
submitted by AngelAsh 4 hours ago
To examine and assess (1) the internal consistency and validity of a Danish translation of the Diabetes Distress Scale (DDS17) among adults with Type 1 diabetes mellitus, the properties of the brief version of DDS17 and cut points for the DDS17. Cross-sectional survey of 2419 adults with Type 1...
submitted by jaiovirogi 4 hours ago
The second Diabetes Attitudes, Wishes and Needs (DAWN2) study examined the experiences of family members of people with diabetes for benchmarking and identifying unmet needs or areas for improvement to assist family members and those with diabetes to effectively self-manage. In total, 2057 family...
submitted by XzavierNi 6 hours ago
Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic pollutants that affect fertility and cause ...
submitted by ohoih 7 hours ago
Studies on the association between homocysteine levels and depression have shown conflicting results. To examine the association between serum total homocysteine (tHcy) levels and major depressive disorder (MDD) in a large community sample with an extended age range. A total of 3392 men and women...
submitted by sudan 7 hours ago
Little information is available on the steroid hormone profiles in obese children and their changes after weight loss.We compared liquid chromatography-tandem mass spectrometry of serum steroid hormone profiles between obese and normal-weight children and studied the differential effects of weigh...
submitted by papidapi 7 hours ago
Calcium and vitamin D are recommended for bone health, but there are concerns about adverse risks. Some clinical studies suggest that calcium intake may be cardioprotective, whereas others report increased risk associated with calcium supplements. Both low and high serum levels of 25-hydroxyvitam...
submitted by LucianoSam 7 hours ago
Seafood long-chain polyunsaturated omega-3 fatty acids (n-3 PUFAs) improve insulin sensitivity in animal experiments, but findings remain inconsistent in humans. Adiponectin is a robust marker for insulin sensitivity and adipocyte function. Whether n-3 PUFAs affect adiponectin in humans is unknow...
submitted by donphainex 8 hours ago
To determine the prevalence of retinopathy in 517 youth with type 2 diabetes of 2–8 years duration enrolled in the TODAY study. Retinal photographs were graded centrally for retinopathy using established standards. Retinopathy was identified in 13.7% of subjects. Prevalence increased with a...
submitted by BryCory 8 hours ago
Among adolescents with type 2 diabetes, there is limited information regarding incidence and progression of hypertension and microalbuminuria. Hypertension and microalbuminuria assessments made during the TODAY clinical trial were analyzed for effect of treatment, glycemic control, sex, and race/...
submitted by EnriqueTr 8 hours ago
The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial showed superiority of metformin plus rosiglitazone (M+R) over metformin alone (M), with metformin plus lifestyle (M+L) intermediate in maintaining glycemic control. We report here treatment effects on measures of bod...