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Beraprost sodium, a stable prostacyclin analogue, improves insulin resistance in high-fat diet-induced obese mice

submitted by smortyiany 16 hours ago

Obesity induces hypertrophy of adipocyte resulting in production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein 1 (MCP1 (CCL2...

1 dig(s) Dig it Bury Topic: Endocrinology

Food intake in lean and obese mice after peripheral administration of glucagon-like peptide 2

submitted by mobarg 16 hours ago

We investigated the potential anorectic action of peripherally administered glucagon-like peptide 2 (GLP2) in lean and diet-induced obese (DIO) mice. Mice, fasted for 16 h, were injected i.p. with ...

1 dig(s) Dig it Bury Topic: Endocrinology

Dp71 gene disruption alters the composition of the dystrophin-associated protein complex and neuronal nitric oxide synthase expression in the hypothalamic supraoptic and paraventricular nuclei

submitted by 6673 16 hours ago

DP71 is the major cerebral dystrophin isoform and exerts its multiple functions via the dystrophin-associated protein complex (DAPC), also comprised of β-dystroglycan (β-DG) and α1-...

1 dig(s) Dig it Bury Topic: Endocrinology

Role of beta-adrenergic receptors in regulation of hepatic fat accumulation during aging

submitted by JesusAug 16 hours ago

Excessive fat accumulation in liver (hepatic steatosis) predisposes to hepatic functional and structural impairment and overall metabolic risk. Previous studies noted an association between hepatic...

1 dig(s) Dig it Bury Topic: Endocrinology

Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors

submitted by sallinmaan 16 hours ago

3-Iodothyronamine (T1AM) is a novel chemical messenger, structurally related to thyroid hormone, able to interact with G protein-coupled receptors known as trace amine-associated receptors (TAARs)....

1 dig(s) Dig it Bury Topic: Endocrinology

Differentiation capacity of native pituitary folliculostellate cells and brain astrocytes

submitted by kiyg 16 hours ago

Pituitary folliculostellate (FS) cells are characterized by producing S100B protein, as do brain astrocytes. FS cells have some functions in the pituitary gland, i.e. scavenger functions, sustentac...

1 dig(s) Dig it Bury Topic: Endocrinology

The skeletal consequences of thyrotoxicosis

submitted by moty 16 hours ago

Euthyroid status is essential for normal skeletal development and the maintenance of adult bone structure and strength. Established thyrotoxicosis has long been recognised as a cause of high bone t...

1 dig(s) Dig it Bury Topic: Endocrinology

Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady state conditions in type 1 diabetes

submitted by lylomahommid 1 day ago

Insulin degludec (IDeg) is a new-generation basal insulin with an ultra-long duration of action. We compared the pharmacodynamic (PD) variability of IDeg and insulin glargine (IGlar) under steady-s...

1 dig(s) Dig it Bury Topic: Endocrinology

Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARγ-dependent and PPARγ -independent mechanisms

submitted by abdu 1 day ago

Adiponectin is an important adipokine whose levels are decreased in obesity despite increases in adipocyte mass. Studies in animal models implicate adiponectin as an insulin sensitizer in skeletal ...

1 dig(s) Dig it Bury Topic: Endocrinology

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells

submitted by soaram1222 2 days ago

The peptide hormone ghrelin is released from a distinct group of gastrointestinal cells in response to caloric restriction, whereas its levels fall after eating. The mechanisms by which ghrelin sec...

1 dig(s) Dig it Bury Topic: Endocrinology

Macrophage-specific transgenic expression of cholesteryl ester hydrolase attenuates hepatic lipid accumulation and also improves glucose tolerance in ob/ob mice

submitted by czoreno 2 days ago

Cellular cholesterol homeostasis is increasingly being recognized as an important determinant of the inflammatory status of macrophages, and a decrease in cellular cholesterol levels polarizes macr...

1 dig(s) Dig it Bury Topic: Endocrinology

CB1 antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs

submitted by raeivran6966 2 days ago

The endocannabinoid system is highly implicated in the development of insulin resistance associated with obesity. It has been shown that antagonism of the CB1 receptor improves insulin sensitivity ...

1 dig(s) Dig it Bury Topic: Endocrinology

Coordinate regulation of heterogeneous nuclear ribonucleoprotein dynamics by steroid hormones in the human fallopian tube and endometrium in vivo and in vitro

submitted by jasicongos 2 days ago

Heterogeneous nuclear ribonucleoproteins (hnRNPs), which are chromatin-associated RNA-binding proteins, participate in mRNA stability, transport, intracellular localization, and translation by acti...

1 dig(s) Dig it Bury Topic: Endocrinology

Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells

submitted by jaykowo 2 days ago

This study was designed to evaluate the effect of acute (2 h daily) and repeated (2 h daily for 2 or 10 consecutive days) immobilization stress (IMO) on: 1) the steroidogenic machinery homeostasis;...

1 dig(s) Dig it Bury Topic: Endocrinology

TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin

submitted by 992096 2 days ago

Brain-derived neurotrophic factor (BDNF) and TrkB receptor signaling contribute to the central nervous system (CNS) control of energy balance. The role of hindbrain BDNF/TrkB receptor signaling in ...

1 dig(s) Dig it Bury Topic: Endocrinology