Endocrinology

Delaying the oocyte maturation trigger by one day leads to a higher metaphase II oocyte yield in IVF/ICSI: a randomised controlled trial
The negative impact of rising progesterone levels on pregnancy rates is well known, but data on mature oocyte yield are conflicting. We examined whether delaying the oocyte maturation trigger in IVF/ICSI affected the number of mature oocytes and investigated the potential influence of serum progesterone levels in this process. Between January 31, 2011, and December 31, 2011, 262 consecutive pat...


Hypothalamic control of bone metabolism
Bones are structures in vertebrates that provide support to organs, protect soft organs, and give them shape and defined features, functions that are essential for their survival. To perform these functions, bones are constantly renewed throughout life. The process through which bones are renewed is known as bone remodeling, an energy demanding process sensitive to changes in energy homeostasis...
Increased Incorporation of Antiplasmin Into the Fibrin Network in Patients With Type 1 Diabetes
Diabetes is associated with various vascular complications and is suggested to induce a prothrombotic state. In the current study, we characterized antiplasmin incorporation into fibrin in relation to other fibrinolytic compounds in patients with type 1 diabetes. A total of 236 patients with type 1 diabetes and 78 control subjects were investigated. The incorporation of antiplasmin into the fib...


Distribution of C-Peptide and Its Determinants in North American Children at Risk for Type 1 Diabetes
To determine basal and stimulated C-peptide percentiles in North American children and adolescents at risk for type 1 diabetes (T1D) and to examine factors associated with this distribution in the Diabetes Prevention Trial of Type 1 (DPT-1). We included 582 subjects aged 4–18 years at randomization in the DPT-1 trials. A 2-h oral glucose tolerance test (OG) was performed at baseline and e...
Prevention of Recurrent Foot Ulcers With Plantar Pressure-Based In-Shoe Orthoses: The CareFUL Prevention Multicenter Randomized Controlled Trial
To assess the efficacy of in-shoe orthoses designed based on shape and barefoot plantar pressure in reducing the incidence of submetatarsal head plantar ulcers in people with diabetes, peripheral neuropathy, and a history of similar prior ulceration. Single-blinded multicenter randomized controlled trial with subjects randomized to wear shape- and pressure-based orthoses (experimental, n = 66) ...


Complement Factor 3 Is Associated With Insulin Resistance and With Incident Type 2 Diabetes Mellitus Over a 7-Year Follow-up Period: The CODAM Study
Immune dysregulation can affect insulin resistance (IR) and β-cell function and hence contribute to development of type 2 diabetes mellitus (T2DM). The complement system, as a regulator of immune and inflammatory homeostasis, may be a relevant contributor therein. However, longitudinal studies focusing on complement as a determinant of T2DM and IR are scarce. Therefore, we prospectively in...
Vitamin D Supplementation and the Effects on Glucose Metabolism During Pregnancy: A Randomized Controlled Trial
Vitamin D deficiency in pregnancy is associated with an increased risk of gestational diabetes mellitus (GDM) and neonatal vitamin D deficiency. We conducted a double-blind, randomized controlled trial of low-dose (LD) versus high-dose (HD) vitamin D supplementation to investigate the effects of vitamin D supplementation on glucose metabolism during pregnancy. Women with plasma 25-hydroxyvitami...

Automated Quantification of Pancreatic beta-cell Mass
β-cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using conventional histological methods is a time-consuming process. Rapidly evolving virtual slide technology with high-resolution slide scanners and newly developed image analysis tools has a potential to transform β-cell mass mea...
Mice Lacking NOX2 are Hyperphagic and Store Fat Preferentially in the Liver
Chronic low-grade inflammation is an important contributor to the development of insulin resistance, a hallmark of type 2 diabetes mellitus (T2DM). Obesity and high fat feeding lead to infiltration of immune cells into metabolic tissues, promoting inflammation and insulin resistance. We hypothesized that macrophages from mice lacking NOX2 (Cybb), an essential component of the NADPH oxidase comp...

Cortisol increases CXCR4 expression but does not affect CD62L and CCR7 levels on specific T cell subsets in humans
Glucocorticoids are well-known to affect T-cell migration, leading to a redistribution of the cells from blood to the bone marrow, accompanied by a concurrent suppression of lymph node homing. Despite numerous studies in this context with most of them employing synthetic glucocorticoids in rather non-physiological doses, the mechanisms of this redistribution are not well understood. Here, we in...
Acylcarnitines activate pro-inflammatory signaling pathways
Incomplete β-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that plasma concentrations of medium- and long-chain acylcarnitines (by-products of incomplete β-oxidation) are elevated in type 2 diabetes and insulin resistance. In a previous study, we reported that mixed D, L isomers of C12- or C14...

Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance
Using a novel positron emission tomography (PET) method with oral administration of 14(R,S)-[18F]-fluoro-6-thia-heptadecanoic acid (18FTHA), we recently demonstrated that subjects with impaired glucose tolerance (IGT) display an impairment in cardiac function associated with increased myocardial uptake of dietary fatty acids. Here, we determined whether modest weight loss induced by lifestyle c...
A community screening plan for the prevalence of some chronic diseases in specified adult populations in Saudi Arabia: 1- prediabetes and diabetes mellitus
The prevalence of “pre-diabetes” and some associated risk factors among enlisted individuals ≥40-year old in Taif, Saudi Arabia was studied. An instrument together with clinical screening was used. The participants’ median age was 45 years, IQR = 5, mean body mass index (BMI) was 28.9 ± 4.1 kg/m2. Also, 51(43.6 %, N = 117) were overweight, 49(41.8 %) were obese. The mean...
Patients with type 1 diabetes transition from pediatric to adult care in Poland—an example from Silesia
Transition from pediatric to the adult care system is an important issue for diabetes management. The objective was to evaluate the transition of young adults with type 1 diabetes (T1DM) from pediatric to adult diabetes care. Questionnaires were sent to all T1DM patients (166), who left pediatric diabetes care in Katowice, Poland (2003–2007). Analyzed parameters included: date of first visit ...
Low-protein diet in adult male rats has long-term effects on metabolism
Nutritional insults during developmental plasticity have been linked with metabolic diseases such as diabetes in adulthood. We aimed to investigate whether a low-protein (LP) diet at the beginning of adulthood is able to program metabolic disruptions in rats. While control rats ate a normal-protein (23%; NP group) diet, treated rats were fed a LP (4%; LP group) diet from 60 to 90 days of age, a...