Endocrinology

Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study
Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered. Design and Methods. We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a complete hydatidiform mole (HM). All participants completed the study. Before HM evacuation mean hCG was markedly ...


Retrospective Analysis of Cushing’s Disease with or without Hyperprolactinemia
We compared the characteristics of patients with Cushing’s disease alone with those of patients with Cushing’s disease and hyperprolactinemia. Methods. Eighty-four patients were enrolled between 2002 and 2011, in a hospital in China. Clinical, endocrinological, and histopathological data, MRI scans, and surgical outcomes were reviewed throughout the follow-up period. Patients with Cushing...
High expression of metadherin correlates with malignant pathological features and poor prognostic significance in papillary thyroid carcinoma
Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumors, and is closely related to tumor invasion and the poor prognosis. This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of PTC patients. and patientsImmunohistochemistry was used to detect MTDH expression in 156 cases of PT...


Um caso raro de carcinoma medular da tiroide não secretor
O carcinoma medular da tiroide (CMT) é uma forma rara de carcinoma desta glândula (3‐5% dos casos). Caracteriza‐se pela síntese e secreção de calcitonina (Ct). A medição da Ct tem baixa especificidade, mas elevada sensibilidade na deteção de CMT. CMT com Ct normal ou apenas ligeiramente aumentada é um evento raro, com poucos casos descritos na literatura. Um homem de 61 anos foi r...
Metabolic syndrome in premenopausal and postmenopausal women with type 2 diabetes: loss of protective effects of premenopausal status
Diabetes is probably responsible for worsening of metabolic syndrome (MetS)components. The aim of the present study was to compare the components of MetS between premenopausal and postmenopausal women with type 2 diabetes (T2DM). MethodIn this cross sectional study, we studied 639 women with T2DM that were divided in pre-menopausal (n?=?221) and post-menopausal (n?=?418) group. They were select...


Health literacy skills in type 2 diabetes mellitus outpatients from an university-affiliated hospital in Rio de Janeiro, Brazil
Type 2 diabetes mellitus is the most common metabolic disorder and has considerable impact on quality of life. Treatment of DM2 is complex and adherence to treatment requires sophisticated cognition which includes literacy skills. Health literacy skills of a cross-sectional nonrandom sample of 164 DM2 outpatients at the Diabetes Unit of the Hospital Universitario Pedro Ernesto at the State Univ...
Predictors for pregnancy outcomes in Romanian women with Type 1 Diabetes Mellitus: a prospective study
Type 1 diabetes mellitus in pregnant women is associated with an increased risk of congenital malformations, obstetric complications, neonatal morbidity, and mortality. Our aim was to evaluate which factors from the first trimester of pregnancy have a significant impact on the pregnancy outcomes of women with type 1 diabetes. We included 94 pregnant women with type 1 diabetes in this study. In ...

Nutraceuticals and cholesterol-lowering action
Nutraceuticals play an important role in cardiovascular prevention in patients with dyslipidemia. Many scientific studies support use of these substances alone or associated with other drugs in clinical practice. Specifically, monacolines, berberine, policosanol and gamma-oryzanol could significantly reduce cholesterolemia. However, there is still an insufficient number of studies demonstrating...
A randomized, double blind, placebo-controlled pilot trial of the safety and efficacy of atorvastatin in children with elevated low-density lipoprotein cholesterol (LDL-C) and type 1 diabetes
Children with type 1 diabetes (T1D) and elevated LDL-C have an increased risk for cardiovascular disease, a process that can begin in childhood. To assess the safety and efficacy of atorvastatin improving lipid profiles in children with T1D and elevated LDL-C. SubjectsSixty children (31M/29F) with T1D, mean age: 15 ± 0.3 yr, mean diabetes duration: 6.8 ± 0.5 yr, HbA1c: 8.8 ± 0.2%...

The use of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of thyroid lesions
Non-palpable thyroid nodules can be difficult to access by conventional ultrasound-guided fine needle aspiration, particularly when they are intrathoracic. Many of these patients are subject to multiple follow up scans or invasive diagnostic procedures such as mediastinoscopy or surgical resection. We aim to describe the feasibility of endobronchial ultrasound-guided transbronchial needle aspir...
Preventing Diabetes in Primary Care: A Feasibility Cluster Randomized Trial
To determine the feasibility of implementing a large-scale primary care-based diabetes prevention trial. A feasibility cluster randomized controlled trial was conducted in British Columbia, Canada, amongst adults with prediabetes using the Facilitated Lifestyle Intervention Prescription (FLIP) vs. usual care. FLIP included lifestyle advice, a pedometer, and telephone support from a lifestyle fa...

Ceftaroline fosamil for treatment of diabetic foot infections: the CAPTURE study experience
To ascertain which demographic, clinical and microbiological factors might affect clinical outcomes of patients with diabetic foot infections, excluding known osteomyelitis, by analysing CAPTURE registry study data of patients treated with ceftaroline fosamil. At participating study centres, we collected data by randomised selection and chart review, including patient demographics, co-morbiditi...
Impacts of elevated glycemic hemoglobin and disease duration on the sensorimotor control of hands in diabetes patients
To understand the impacts of disease chronicity and hyperglycemia on sensorimotor control of diabetic hands, this study investigated the differences in hand sensation, strength and motor control by applying the pinch-holding-up-activity (PHUA) test for patients with diabetes mellitus (DM) with different levels of glycemic control and disease chronicity. One hundred and fifty-nine patients with ...
Implementación del protocolo hospitalario de insulinización subcutánea para pacientes no críticos en hospitales andaluces de tercer nivel
En 2009, la Sociedad Andaluza de Endocrinología y Nutrición diseñó un protocolo de insulinización subcutánea para pacientes hospitalizados no críticos («Protocolo de insulinización hospitalaria para el paciente no crítico» [PIH]), adoptado dentro del Sistema Sanitario Público Andaluz. Analizar la implementación del PIH en hospitales de tercer nivel del Sistema Sanitario Público An...
A central role for the mammalian target of rapamycin in LPS-induced anorexia in mice
Bacterial lipopolysaccharide (LPS), also known as endotoxin, induces profound anorexia. However, the LPS-provoked pro-inflammatory signaling cascades and the neural mechanisms underlying the development of anorexia are not clear. Mammalian target of rapamycin (mTOR) is a key regulator of metabolism, cell growth, and protein synthesis. This study aimed to determine whether the mTOR pathway is in...