Dermatology

Primary cutaneous T cell lymphomas: photochemotherapy immunomodulation with analysis of the inflammatory-expansive cellular dynamic
Primary cutaneous T cell lymphomas (CTCLs) are characterized by hyperproliferation of malignant CD4+ T cells with primary localization on the skin. The common characteristics are the migration of the malignant mature T-lymphocytes into the epidermis, with hyperproliferation of malignant CD4+ T ce...


Is the step-up therapy of topical 5-aminolevulinic acid photodynamic therapy effective and safe for the patients with recalcitrant facial flat wart?
Facial flat wart, caused by human papilloma virus type 3 and less often, type 10, 27, and 41, often brings many cosmetic problems to children and young adults. Considering the disturbing cosmetic problem, the treatment of facial flat wart is always frustrating and often unsuccessful, although the...
Prevalence and viral DNA loads of three novel human polyomaviruses in skin cancers from Japanese patients
Merkel cell polyomavirus (MCPyV), human polyomaviruses 6 (HPyV6) and 7 (HPyV7) are novel human polyomaviruses. This study investigated their detection rates and DNA loads in various skin cancers from Japanese patients. MCPyV, HPyV6 and HPyV7 were detected in 22.2%, 3.2% and 1.6% of squamous cell ...
Clinical effects of stereotactic radiation surgery in patients with metastatic melanoma
We examined the effectiveness of stereotactic radiation surgery (SRS) in 14 patients with brain metastasis in our hospital. The age of the patients ranged 45–85 years old (mean, 65). Brain metastasis was detected by neurological symptoms in seven patients and by regular imaging examination in ...
The changes in the hair cycle during gestation and the post-partum period
We included 116 women in this study; 28 women at the 24th week of pregnancy, 30 pregnant women at term gestation, 29 women in the 4th post-partum month, and 29 in the first post-partum year. The number of breastfeeding mothers in the post-partum period and the month in which they were examined we...
Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon-induced apoptosis
BCL11B is a Kruppel-like C2H2-type zinc finger transcription factor, which has been associated with several human malignancies. Recent evidence showed that overexpressed BCL11B conferred chemoresistance to malignant T cells and that inhibiting BCL11B led to increased apoptosis, suggesting its pot...


Adverse reactions and alleged allergy to local anesthetics: Analysis of 331 patients
The aim of this study was to determine the prevalence of true local anesthetic (LA) allergy among patients referred for suspected hypersensitivity and to describe the main characteristics of adverse drug reactions (ADR) induced by LA in our population. We retrospectively analyzed the medical file...
Twist1 in tumor cells and α-smooth muscle actin in stromal cells are possible biomarkers for metastatic giant basal cell carcinoma
We previously reported a case of giant basal cell carcinoma (BCC) in a 75-year-old Japanese man, who subsequently developed a pulmonary metastasis. With regard to the pathogenesis of metastasis of BCC, recently, it has been reported that high levels of expression of Twist1 and N-cadherin in prima...
Mustard seed (Sinapis Alba Linn) attenuates imiquimod-induced psoriasiform inflammation of BALB/c mice
Psoriasis is a chronic inflammatory autoimmune disease with undefined etiology. All present treatments are symptomatic. The unsatisfactory outcome in the treatment of psoriasis is partially due to the poor compliance to the present therapies with more or less side-effects. As is known, drug homol...
Régression rapide d’un hémangiome infantile sous propranolol topique à 2 %
Le propranolol par voie orale donne des résultats spectaculaires dans les hémangiomes sévères de l’enfant. Nous rapportons un cas de régression rapide et importante d’un hémangiome infantile chez un nourrisson traité avec du propranolol à 2 % par voie topique. Un nourrisson de sexe f...
Overlap syndrome of type Wong variant dermatomyositis and rheumatoid arthritis
Wong type dermatomyositis describes a small group of patients with dermatomyositis clinically presented with pityriasis rubra pilaris-like eruptions, including diffuse palmoplantar hyperkeratosis and follicular hyperkeratosis. Histopathologic findings include follicular hyperkeratosis and arrecto...


Maladie de Kaposi : un effet secondaire inhabituel des dermocorticoïdes
La maladie de Kaposi (MK) est un processus tumoral angiogénique lié au virus HHV8. Il en existe plusieurs formes cliniques qui peuvent survenir dans diverses circonstances, notamment en rapport avec une immunodépression acquise. Nous rapportons le cas d’une patiente chez qui des lésions nod...
Syphilis neurologique révélée par un tableau évocateur d’artérite temporale et de pseudopolyarthrite rhizomélique
La syphilis est une maladie en résurgence depuis une dizaine d’années. La neurosyphilis peut apparaître à n’importe quel stade d’infection. Son diagnostic est rendu difficile par l’existence de formes trompeuses. Nous en décrivons un exemple. Une femme de 56ans présentait une sympto...
Clinical and histological features of leprosy and human immunodeficiency virus co-infection in Brazil
Both leprosy and human immunodeficiency virus (HIV) are infectious diseases, and are an important global health problem. Patients with leprosy who are co-infected with HIV seem to be at higher risk of developing leprosy reactions. To examine the histological features of leprosy in patients with H...
Effects of briakinumab treatment for moderate to severe psoriasis on health-related quality of life and work productivity and activity impairment: results from a randomized phase III study
Psoriasis is known to have a significant negative impact on a patient's health-related quality of life, including social, recreational and work activities. To evaluate the effects of briakinumab on quality of life and work productivity measures in patients with moderate to severe psoriasis. Patie...