Dermatology

Vascular patterns of nonpigmented tumoral skin lesions: confocal perspectives
The characteristic vascular patterns of nonpigmented skin tumors have been established by dermoscopy. Recently, in vivo reflectance confocal microscopy (RCM) has become an established method for the noninvasive examination of skin tumors. Determination of the value of RCM on the vascularity of nonpigmented skin tumors. One hundred and twenty two tumoral lesions have been evaluated by RCM in ter...


Various peroxisome proliferator-activated receptor (PPAR)-γ agonists differently induce differentiation of cultured human keratinocytes
Peroxisome proliferator-activated receptors (PPARs) are potentially useful for treatment of skin diseases, because they stimulate keratinocyte differentiation, exert anti-inflammatory effects and improve barrier function. We examined five PPAR-γ agonists, including four thiazolidinediones (ciglitazone, troglitazone, rosiglitazone and pioglitazone) and an angiotensin-II receptor blocker (telmis...
Characterization of pigmented dermo-epidermal skin substitutes in a long-term in vivo assay
In our laboratory, we have been using human pigmented dermo-epidermal skin substitutes for short term experiments since several years. Little is known, however, about the long-term biology of such constructs after transplantation. We constructed human, melanocyte-containing dermo-epidermal skin substitutes of different (light and dark) pigmentation types and studied them in a long-term animal e...


Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors
Skin DC express C-type lectin receptors for the recognition of pathogens. Langerhans cells (LC) express the receptor Langerin/CD207, whereas DEC-205/CD205 is mainly expressed by dermal DC, but can also be detected at low levels on LC. In this study we tested an ex vivo approach for targeting DC in situ with monoclonal antibodies (mAb) against Langerin and DEC-205. The targeting mAb were injecte...
DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability
Dopachrome tautomerase (DCT) is involved in the formation of the photoprotective skin pigment eumelanin, and has also been shown to have a role in response to apoptotic stimuli and oxidative stress. The effect of DCT on UVR DNA damage responses and survival pathways in human melanocytic cells was examined by knockdown experiments using melanoma cells, neonatal foreskin melanoblasts (MB) in mono...


Genetic Variants in Fanconi Anemia Pathway Genes BRCA2 and FANCA Predict Melanoma Survival
Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association study, we comprehensively analyzed the associations of 2,339 common single-nucleotide polymorphisms (SNPs) in 14 autosomal FA genes with overall survival (OS) in 858 CM patie...
Innate Lymphoid Cells in the Skin
Innate lymphoid cells (ILCs) are part of a heterogeneous family of innate immune cells with newly identified roles in mediating immunity, tissue homeostasis, and pathologic inflammation. Here, we review recent studies delineating the roles of ILCs in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions. Finally, we address how these studies have informed ...

Peripheral and Local Human Papillomavirus 16–Specific CD8+ T-Cell Expansions Characterize Erosive Oral Lichen Planus
Erosive oral lichen planus (OLP) is a chronic, disabling mucocutaneous dysimmune rare disease characterized by mucosal inflammatory erosive lesions with pathological evidence for a marked CD8+ cytotoxic T-lymphocyte (CTL) infiltration. However, the specificity of lesional CTL in OLP has never been analyzed. To investigate the molecular mechanisms underlying dysregulation of T-cell immun...
Human Mitochondrial NAD(P)+–Dependent Malic Enzyme Participates in Cutaneous Melanoma Progression and Invasion
Cutaneous melanoma is the most life-threatening neoplasm of the skin, accounting for most of the skin cancer deaths. Accumulating evidence suggests that targeting metabolism is an appealing strategy for melanoma therapy. Mitochondrial NAD(P)+–dependent malic enzyme (ME2), an oxidative decarboxylase, was evaluated for its biological significance in cutaneous melanoma progression....

Syk Mediates IL-17-Induced CCL20 Expression by Targeting Act1-Dependent K63-Linked Ubiquitination of TRAF6
IL-17 has an important role in the immunopathogenesis of autoimmune diseases, and spleen tyrosine kinase (Syk) has been implicated as a critical molecule in the signaling pathways of various immunoreceptors. Chemokine (C–C motif) ligand 20 (CCL20) interacts with chemokine (C–C motif) receptor 6 to recruit IL-17-producing cells into the skin to promote progression of psoriasis. H...
Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function
Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands. The X-linked hypohidrotic ectodermal dysplasia (XLHED), resulting from EDA deficiency, can be rescued with lifelong benefits in animal models by stimulation of ectodermal appendage development with EDAR agonists. Treatments initiated later in th...

Cabines de bronzage : étude des motivations et croyances des utilisateurs et non-utilisateurs dans la population lilloise
L’utilisation non contrôlée des cabines de bronzage pose un problème majeur de santé publique. En effet, le rôle des UV dans la cancérogenèse cutanée est bien démontré. L’objectif principal de l’étude était d’évaluer les motivations et les croyances de la population lilloise concernant l’utilisation des cabines UV. Les objectifs secondaires étaient de comparer les connai...
Deux cas de dermatose acantholytique sous vémurafénib
Les dermatoses acantholytiques apparaissant sous inhibiteurs de BRAF sont des manifestations dermatologiques très peu rapportées dans la littérature à ce jour. Nous rapportons deux observations d’une dermatose acantholytique non prurigineuse atteignant le tronc et les zones séborrhéiques, apparue dans les deux cas un mois après l’introduction d’un traitement par vémurafénib. Pour...
Leucémie prolymphocytaire T : un piège diagnostique à connaître
Le syndrome de Sézary est une variété leucémique de lymphome cutané T épidermotrope. Il est caractérisé cliniquement par une érythrodermie et des adénopathies, associées à une population circulante de lymphocytes atypiques. Son diagnostic différentiel comprend les autres causes d’érythrodermie mais aussi la leucémie prolymphocytaire T (LPLT). Nous présentons un cas initialemen...
Prurit sévère révélant un lymphome de Hodgkin chez l’enfant : deux observations
Le prurit chez l’enfant est un motif fréquent de consultation, le plus souvent en rapport avec une dermatose commune. Quand l’examen cutané ne trouve pas de cause dermatologique, une cause générale doit être évoquée. Nous rapportons deux observations d’enfant avec un prurit révélant un lymphome de Hodgkin. Cas no 1 : une jeune fille de 14ans présentait un prurit avec de nombre...