Dermatology

Changes in serum free testosterone, sleep patterns, and 5-alpha-reductase type I activity influence changes in sebum excretion in female subjects
Sebum is thought to play an important role in acne vulgaris and sebum excretion rate (SER) is often used as a marker of efficacy in acne studies. This study explored factors that could induce intra-subject variability in SER. SER was measured twice, 7 days apart, on the forehead of 40 healthy subjects. At each visit, the following parameters were also evaluated: serum androgen levels, 5-alpha-r...


Pro-Survival Role of MITF in Melanoma
Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell survival. Although components of melanoma cytoprotective mechanisms are overexpressed in many types of tumors, some of their regulators are characteristic for melanoma. Several genes mediating pro-survival functions have been identified as direct targets of microphthalmia-associated transcription factor (MITF...
Β2-Adrenoceptor Activation Modulates Skin Wound Healing Processes to Reduce Scarring
During wound healing, excessive inflammation, angiogenesis, and differentiated human dermal fibroblast (HDF ) function contribute to scarring, whereas hyperpigmentation negatively affects scar quality. Over 100 million patients heal with a scar every year. To investigate the role of the beta 2 adrenergic receptor (β2AR) in wound scarring, the ability of beta 2 adrenergic receptor...


Persistence of Anti-Desmoglein 3 IgG+ B-Cell Clones in Pemphigus Patients over Years
Pemphigus vulgaris (PV) is a prototypic tissue-specific autoantibody-mediated disease, in which anti-desmoglein 3 (Dsg3) IgG autoantibodies cause life-threatening blistering. We characterized the autoimmune B-cell response over 14 patient years in two patients with active and relapsing disease, then in one of these patients after long-term remission induced by multiple courses of rituximab (ant...
Comparative Effectiveness of Topical Drugs in Dermatologic Priority Diseases: Geometry of Randomized Trial Networks
Among the 100 initial priority topics for comparative effectiveness research, three concern topical drugs in the following dermatologic diseases: psoriasis, chronic lower-extremity wounds (CLEWs), and acne vulgaris (AV). Our objective was to explore the geometry of the corresponding networks of randomized controlled trials (RCTs). We performed a review of RCTs on topical drugs in psoriasis, CLE...


Treatment of vitiligo with NB-UVB: A systematic review
To assess the effect and safety of NB-UVB for vitiligo using an evidence-based approach. Randomized controlled trials (RCTs) on the treatment of vitiligo with NB-UVB were identified by searching PubMed and the Cochrane Library. The primary outcome was re-pigmentation degree. A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. The methodologica...
The prevalence of Behçet's disease in a city in Central Anatolia in Turkey
The prevalence of Behçet's disease (BD) is much higher in countries along the ancient Silk Route, extending from Japan to Mediterranean countries including Turkey, than in northern Europe and the USA. The present study aimed to investigate the prevalence of BD in Kayseri, a city in Central Anatolia in Turkey. This study investigated cross-sectional prevalences of BD in individuals aged >10 ye...

Clinical and experimental assessment of the effects of a new topical treatment with praziquantel in the management of rosacea
Rosacea is a common, chronic, and inflammatory skin disease. The burden imposed by this condition requires that new topical treatments be sought to enlarge the arsenal of drugs available in order to better manage this disease. This study was conducted to carry out an in vitro/in vivo evaluation of the antimicrobial activity of 3% praziquantel (PZQ) ointment and to determine its efficacy and saf...
Cholestatic hepatic injury associated with vismodegib, aspirin, and naproxen use: a case study and review of vismodegib safety
Vismodegib is a novel hedgehog pathway inhibitor approved to treat advanced and metastatic basal cell carcinoma (BCC) in the United States. Several studies have demonstrated efficacy for treatment of new and existing BCC in both basal cell nevus syndrome (BCNS) and non-BCNS patients. However, severe and numerous adverse events are associated with vismodegib use. Therefore, we have also examined...

Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women
This study was conducted to investigate the prevalence of and risk factors for actinic cheilitis (AC) in Brazilian fishermen and women. A cross-sectional study was carried out in a representative sample (n = 210) of fishermen and women. Data related to age, skin color, cumulative and daily exposure to solar radiation, smoking, sun protection measures, and the presence of AC were collected. A ...
Severe cutaneous adverse reactions in a local hospital setting: a 5-year retrospective study
Severe cutaneous adverse reactions (SCAR) are rare but important causes of morbidity and mortality. Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous drug reactions that can be potentially life threatening. Our study aims to look at the epidemiology of SCAR in the local setting in Singapore an...

Psoriasis and comorbidities in a southern Brazilian population: a case–control study
Psoriasis is a chronic disease with worldwide prevalences of 0.6–4.8%. Its inherent chronic inflammatory component predisposes patients to cardiovascular and metabolic diseases. This study aimed to evaluate the associations of psoriasis with comorbidities and health risk factors such as smoking and alcohol intake, and to examine demographic differences in its occurrence in a southern Brazil p...
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge
Generalized eruptive keratoacanthoma (GEKA) is an extremely rare variant of keratoacanthoma that poses significant diagnostic and therapeutic challenges. The study included three patients presenting with highly pruritic, generalized eruption of numerous small skin and flesh-colored follicular papules. They were mainly distributed on the face, neck, and trunk. Few larger nodules were also presen...
Screening for skin cancer in bank and insurance employees: risk profile and correlation of self and physician's assessment
Self-assessment and knowledge of individual risk factors can be a reasonable strategy to detect cutaneous malignancies in an early curable stage. Bank and insurance employees were voluntarily screened for skin cancer. They had to fill in a questionnaire asking for their skin and hair color, ultraviolet exposure and tanning ability, number and size of typical and atypical nevi, immunosuppression...
Calcinosis, osificaciones y lesiones cartilaginosas cutáneas
Las calcinosis y las osificaciones cutáneas se caracterizan por depósitos dérmicos o subcutáneos de hidroxiapatita. Bajo estos dos términos se agrupan afecciones muy diversas y heterogéneas, sin relación aparente entre ellas. En este artículo se adopta la clasificación de Cribier, basada en los mecanismos fisiopatogénicos conocidos o supuestos: calcinosis relacionadas con trastornos d...