Dermatology

Chondrocutaneous helix rim advancement flap: two classical and two new modifications for very large defects of the ear
The plastic reconstruction of the ear after microscopically controlled tumor surgery is a particular challenge. The chondrocutaneous helix rim advancement flap (CHRAF) is perfectly suited for the repair of different defects of the helix and even defects beyond. Here, we describe two known and two new modifications of the CHRAF that enlarge the scope of application in tumor surgery of the ear. W...


Accuracy of in vivo confocal microscopy for diagnosis of basal cell carcinoma: a comparative study between handheld and wide-probe confocal imaging
Reflectance confocal microscopy (RCM) increases specificity of identification of basal cell carcinoma (BCC). A smaller-diameter handheld RCM (HH-RCM) allows better access to limited anatomic locations. To compare accuracy of HH-RCM in identification of BCC to that of traditional wide-probe RCM (TWP-RCM). Patients presenting at least one lesion clinically and dermoscopically suspicious for BCC, ...
Silencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells
Task-3 (kcnk9 or K2P9.1) channels are thought to promote proliferation and/or survival of malignantly transformed cells, most likely by increasing their hypoxia tolerance. Based on our previous results that suggested mitochondrial expression of TASK-3 channels, we hypothesized that TASK-3 channels have roles in maintaining mitochondrial activity. In the present work we studied the effect of red...


Identification of biomarkers involved in differential profiling of hypertrophic and keloid scars versus normal skin
Among raised dermal scar types, keloid (KS) and hypertrophic scars (HS) are considered to present clinical similarities, but there are no known specific biomarkers that allow both scar types to be easily distinguished. Development and progression of raised dermal scars comprises the activation of several molecular pathways and cell defence mechanisms leading to elevated extracellular matrix com...
Über die alten und zauberischen Geschwäre im 16. bis 18. Jahrhundert
Zu Beginn der Neuzeit spielten bei der schlechten Heilbarkeit der chronischen Beingeschwüre noch die Zauber-, Hexen- und Teufelsmedizin eine große Rolle. Es gab die allgemeinen Anwendungen von Zaubermitteln und lokale Gebräuche. Als Beispiel für die Beeinflussung des ganzen Körpers durch den Teufel galten die Abracadabra-Zettel von Johann Christoph Bitterkraut anno 1677. Die verzauberten S...


Pankreatische Pannikulitis mit multiplen osteolytischen Läsionen
Wir berichten über den Fall einer schweren pankreatischen Pannikulitis, assoziiert mit der akuten Exazerbation einer chronischen Pankreatitis, bei einem männlichen 62-jährigen Patienten mit chronischem Alkoholabusus in seiner Anamnese.
Stellenwert moderner physikalischer Behandlungsverfahren bei infizierten und kolonisierten Wunden in der Dermatologie
In den kommenden Jahren ist eine Zunahme von Patienten mit chronischen Ulkuswunden, aber auch mit Wunden bei Tumorerkrankungen zu erwarten – beides typischerweise Erkrankungen, die eine komplexe Therapie erfordern und zunehmend und über zum Teil lange Strecken ambulant versorgt werden müssen. Damit rücken in den letzten Jahren immer mehr Behandlungsverfahren in den Vordergrund, die nicht n...

Digitale Ulzerationen bei systemischer Sklerodermie
Digitale Ulzerationen (DUs) sind eines der Hauptsymptome der systemischen Sklerodermie und treten bei ungefähr 60 % der Patienten auf. Sie erfordern aufgrund möglicher Komplikationen wie Infektionen, trockene/feuchte Gangrän oder Amputation regelmäßige Kontrollen und eine angepasste Wundbehandlung durch Arzt und Pflegepersonal. Die „European League against Rheumatism“ (EULAR) hat im ...
Localised pityriasis rosea-like eruption during radiotherapy. Report of 2 cases
Pityriasis rosea is a common skin condition that presents acutely with asymptomatic, scaly and oval plaques, usually in a well-recognised distribution over the trunk. Two men developed ovoid, scaly and annular lesions limited to the radiotherapy field during treatment for pelvic malignancies and without a preceding herald patch. Other causes of the eruption were excluded on clinical and patholo...

Cutaneous CD30 positive lymphoproliferative disorders with coexistent epithelial neoplasms: Report of two cases
Primary cutaneous large cell anaplastic lymphoma (C-ALCL) and lymphomatoid papulosis (LyP) are cutaneous CD30+ lymphoproliferative disorders (CD30+ LPD). An association with CD30+ LPD and pseudoepitheliomatous hyperplasia has been recognized. Additionally, rare reports of epithelial neoplasms such as keratoacanthomas and squamous cell carcinomas (SCC) occurring in association with both C-ALCL a...
Nephrogenic systemic fibrosis in a gadolinium-naïve patient: Successful treatment with oral sirolimus
A 52-year old woman with chronic renal failure presented with tender buttock nodules, bilateral non-tender periocular papules and yellow scleral plaques. The patient then developed sclerodermoid changes of the hands, as well as woody induration, oedema and hyperpigmentation of lower limbs. There was no previous exposure to gadolinium contrast. Her histology and clinical features were consistent...

Angiomyxoma of the nasal dorsum treated by Mohs surgery
Cutaneous angiomyxomas are myofibroblastic neoplasms with locally aggressive behaviour and a high risk of recurrence. We describe a case of a solitary cutaneous angiomyxoma presenting on the nasal dorsum of a 28-year-old man, excised with Mohs surgery using permanent section control and repaired with an advancement flap. Histology showed myxoid nests of bland CD34-positive and vimentin-positive...
Clinical and histological features of head and neck melanoma: a population-based study in France
Head and neck melanomas (HNM) account for an increasing proportion of melanomas and have a poor prognosis. Few population-based studies have focused on specific characteristics of these tumors. To compare clinical and histological characteristic of HNM with those of melanomas at other sites (MOS) and identify pertinent clinico-pathological subgroups of HNM. We performed a retrospective populati...
Atrophie Blanche: Is It Associated with Venous Disease or Livedoid Vasculopathy?
The purpose of this learning activity is to provide information about the etiology and treatment of atrophie blanche. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. After participating in this educational activity, the participant should be better able to:Discuss the pathophysiology of atrophie blanche.2. Explore...
A Novel Hand-Shaped Suprathel Simplifies the Treatment of Partial-Thickness Burns
The standard therapy to treat superficial partial-thickness burns of the hand involves the application of skin substitutes such as Suprathel (PolyMedics Innovations GmbH, Denkendorf, Germany), which reduce pain significantly, thus allowing a fast mobilization and leading to a quicker restoration of function. The aim of this study was to simplify the application of Suprathel by using new precut ...