Dermatology

Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas
We present here that heat-shock protein 90 (Hsp90) inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17AAG), when topically applied to mouse skin, inhibits UVR–induced development of cutaneous squamous cell carcinoma (SCC). In these experiments, DMSO:acetone (1:40 v/v) solution of 17AAG (500 nmol) was applied topically to mouse skin in conjunction with each UVR exposure...


Effects of Intravenous Immunoglobulins on Mice with Experimental Epidermolysis Bullosa Acquisita
Although well-designed prospective trials are generally lacking, intravenous immunoglobulins (IVIG) seem an effective adjuvant treatment for autoimmune bullous skin diseases. Here, efficacy of IVIG monotherapy was compared with corticosteroid treatment in mice with immunization-induced experimental epidermolysis bullosa acquisita (EBA), an autoimmune bullous skin disease characterized by autoan...
CD271 Mediates Stem Cells to Early Progeny Transition in Human Epidermis
CD271 is the low-affinity neurotrophin (p75NTR) receptor that belongs to the tumor necrosis factor receptor superfamily. Because in human epidermis, CD271 is predominantly expressed in transit-amplifying (TA) cells, we evaluated the role of this receptor in keratinocyte differentiation and in the transition from keratinocyte stem cells (KSCs) to progeny. Calcium induced an upregulation of CD271...


Therapie hypertropher Narben und Keloide
Keloide treten meist zwischen dem 10. und 30. Lebensjahr auf und wachsen kontinuierlich über die Grenzen der ursprünglichen Narbe hinaus. Neben der kosmetischen Beeinträchtigung führen sie häufig zu Pruritus, Schmerzen, Bewegungseinschränkungen und Verminderung der Lebensqualität. Fortschritte im Verständnis der Genetik und Pathogenese von hypertrophen Narben und Keloiden haben zu neue...
Dermoscopy structures predictors of sentinel lymph node positivity in cutaneous melanoma
Histological features such as Breslow thickness, ulceration and mitosis are the main criteria to guide sentinel lymph-node biopsy (SLNB) in melanoma. Dermoscopy may add complementary information to these criteria. To evaluate the correlation between dermoscopy structures and SLNB positivity. Retrospective analysis of 123 consecutive melanomas with Breslow > 0.75 mm, SLNB performed follow-up and...


Tofacitinib withdrawal and re-treatment in moderate-to-severe chronic plaque psoriasis: a randomised controlled trial
Tofacitinib is an oral Janus kinase inhibitor being investigated for the treatment of moderate to severe plaque psoriasis. To compare outcomes following tofacitinib withdrawal with those of continuation. In this phase 3 study (NCT01186744), patients received tofacitinib 5 (n=331) or 10mg (n=335) twice daily (BID) for 24 weeks. Patients achieving both ≥75% reduction in Psoriasis Area Severity ...
A pilot trial of mobile, patient-performed teledermoscopy
Early detection by skin self-examination (SSE) could improve outcomes from melanoma. Mobile teledermoscopy may aid this process. To establish clinical accuracy of SSE plus mobile teledermoscopy compared to clinical skin examination (CSE) and test whether providing people with detailed SSE instructions improves accuracy. Men and women 50-64 years (n=58) performed SSE plus mobile teledermoscopy i...

Differential expression and functionality of ATP binding cassette transporters in the human hair follicle
Adenosine triphosphate binding cassette (ABC) transporters are involved in the active transport of an extremely diverse range of substrates across biological membranes. These transporters are commonly implicated in the development of multidrug resistance and are also involved in numerous physiological and homeostatic processes, including lipid transport, cell migration and differentiation. Sinc...
Reflectance Confocal Microscopy correlates of dermoscopic patterns of facial lesions helps to discriminate lentigo maligna from pigmented non-melanocytic macules
The clinical recognition of lentigo maligna (LM) and lentigo maligna melanoma can be very challenging due to the overlapping features with other pigmented macules of the skin. Non-invasive diagnostic tools can assist in the differential diagnosis. To identify Reflectance Confocal Microscopy (RCM) clues for LM through the identification of in vivo microscopic substrates of the main dermoscopic f...

Comparing cold-air analgesia, systemically administered analgesia, and scalp nerve blocks for pain management during photodynamic therapy of actinic keratosis of the scalp presenting as field cancerization: a randomized controlled trial
Photodynamic therapy (PDT) using methylaminolaevulinate (MAL) represents an effective treatment modality for extensive actinic keratosis (AK). However, a major side effect of this therapy is pain./MethodsWe investigated whether scalp nerve blocks (group 1) may provide adequate pain relief during MAL-PDT of the scalp and the forehead in 32 bald men. were compared with patients receiving intraven...
Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL-ALK and SQSTM1-ALK gene fusions
Epithelioid cell histiocytoma (ECH) has been recognized as a rare subtype of benign fibrous histiocytoma (FH) (dermatofibroma) in the skin.1 It typically presents a non-descript solitary nodule involving the extremities of young and middle aged patients.2,3 Histologically, ECH is composed of enlarged epithelioid cells in the superficial dermis with frequent Factor XIIIa expression.3 The clinica...

A clinical study of photodynamic therapy for chronic skin ulcers in lower limbs infected with Pseudomonas aeruginosa
The objective of this study is to evaluate the antimicrobial activity and healing-promoting effect of topical photodynamic therapy (ALA-PDT) on chronic skin ulcers infected with Pseudomonas aeruginosa (PA). A total of 26 patients with chronic skin ulcers in lower limbs infected with PA were enrolled. The surface areas of the ulcers were treated with either δ-aminolevulinic acid (ALA)-mediated ...
Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients
Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The present study is to investigate whether FCER1A polymorphisms are associated with...
Association between cobalt allergy and dermatitis caused by leather articles – a questionnaire study
Cobalt is a strong skin sensitizer and a prevalent contact allergen. Recent studies have recognized exposure to leather articles as a potential cause of cobalt allergy. To examine the association between contact allergy to cobalt and a history of dermatitis resulting from exposure to leather. A questionnaire case–control study was performed: the case group consisted of 183 dermatitis patients...
Are gloves sufficiently protective when hairdressers are exposed to permanent hair dyes? An in vivo study
The use of permanent hair dyes exposes hairdressers to contact allergens such as p-phenylenediamine (PPD), and the preventive measures are insufficient. To perform an in vivo test to study the protective effect of gloves commonly used by hairdressers. /materials/methodsSix gloves from Sweden, Italy and Germany were studied: two vinyl, one natural rubber latex, two nitrile, and one polyethylen...