Toxicology

Can Marketing Data Aid Survey Research?: Examining Accuracy and Completeness in Consumer-File Data
Survey research depends crucially on its ability to collect data from a targeted sample and for that sample to mirror the population of interest. Increasingly, survey firms are using data purchased from marketing firms such as Experian and Acxiom (consumer-file marketing data) as a means to improve correspondence between survey respondents and the general public. These data hold tremendous prom...


Gender and Abortion Attitudes: Religiosity as a Suppressor Variable
Despite the interest-group perspective that women should be more likely than men to support legal abortion, much research finds that women and men hold similar views on this issue. This null relationship has puzzled scholars of abortion attitudes. In an attempt to shed light on this relationship, this paper argues that gender differences in religiosity help explain the lack of a gender differen...
2,4,6-Trichlorophenol Cytotoxicity Involves Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis
This study aims to evaluate the cytotoxicity and potential mechanisms of 2,4,6-trichlorophenol (2,4,6-TCP) in mouse embryonic fibroblasts. Our results show that 2,4,6-TCP causes morphological changes and reduces cell viability. The overproduction of reactive oxygen species, the upregulation of nuclear factor-E2-related factor 2 (Nrf2) and heme oxygenase 1 (HMOX1) messenger RNA (mRNA) expression...


Acute 5-(2-Aminopropyl)Benzofuran (5-APB) Intoxication and Fatality: A Case Report with Postmortem Concentrations
A 20-year-old man, a college student, became unresponsive in front of his girlfriend. He was known to consume alcohol and take an unknown drug at some point while in attendance at a local music festival earlier in the day/evening. Upon arrival of emergency personnel, he was noted to be asystolic and apneic. Despite aggressive medical intervention by emergency personnel and at a local hospital e...
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen
The zebrafish embryo (ZFE) is a promising alternative, non-rodent model in toxicology, which has an advantage over the traditionally used models as it contains complete biological complexity, and provides a medium to high-throughput setting. Here, we assess how the ZFE compares to the traditionally used models for liver toxicity testing, i.e., in vivo mouse and rat liver, in vitro mouse and rat...


Dissolution of lipids from mucus: A possible mechanism for prompt disruption of gut barrier function by alcohol
Acute and/or chronic alcohol ingestion has been shown to exacerbate the morbidity and mortality rate associated with acute mechanical and/or thermal trauma. While alcohol ingestion can affect many organs and systems, clinical and preclinical studies indicate that alcohol ingestion can cause a ‘leaky gut’ syndrome which in turn contributes to infection and systemic organ dysfunction. This st...
The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway
Environmental toxin exposure is associated with the development of Parkinson’s disease (PD), and environmental factors can influence the onset of the majority of sporadic PD cases via genetically mediated pathways. Rotenone, a widespread pesticide, induces Parkinsonism and the formation of Lewy bodies in animals; however, the molecular mechanism that underlies α-synuclein aggregation remains...

Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2
This study utilized pharmacological activation of Nrf2 with oleanolic acid (OA, 22.5mg/kg, sc for 4 days) and the genetic alteration of Nrf2 (Nrf2-null, wild-type, and Keap1-HKO mice) to examine the role of Nrf2 in protection against phalloidin hepatotoxicity. Mice were given phalloidin (1.5mg/kg, ip for 8h) to examine liver injury and the expression of toxicity-related genes. Phalloidin increa...
Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum
The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with significant number of complement-related side effects in patients and some agents have been ...

EDCs DataBank: 3D-Structure database of endocrine disrupting chemicals
Endocrine disrupting chemicals (EDCs) are a group of compounds that affect the endocrine system, frequently found in everyday products and epidemiologically associated with several diseases. The purpose of this work was to develop EDCs DataBank, the only database of EDCs with three-dimensional structures. This database was built on MySQL using the EU list of potential endocrine disruptors and T...
Protective role of Nigella sativa oil against reproductive toxicity, hormonal alterations, and oxidative damage induced by chlorpyrifos in male rats
This study is aimed at elucidating the possible protective effects of Nigella sativa oil (NSO) in alleviating the toxicity of chlorpyrifos (CPF) on reproductive performance in male rats. Animals were orally administered with NSO (1 ml/kg/day), CPF (20 mg/kg/day), and NSO + CPF every day for 4 weeks. showed that CPF decreased spermatid number, sperm count, daily sperm production, and sperm motil...

Effects of T-2 mycotoxin on in vitro development and chromatin status of mouse embryos being in preimplantation stages
T-2 toxin is a mycotoxin produced by phytopathogenic fungi of the Fusarium genus and has many well-studied deleterious effects on mammalian cells and reproductive tract. Despite the wide scale studies, the effects on preimplantation stage embryos are lacking. The aim of our study was to investigate the impact of T-2 on the cleavage stage of mouse embryos with regard to development to blastocyst...
The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells
Nickel compounds are an important class of environmental pollutants and carcinogens. Chronic exposure to nickel compounds has been connected with increased risks of numerous cancers, including lung and kidney cancers. But the precise mechanism by which nickel compounds exert their carcinogenic properties is not completely understood. In this study, kidney cancer cells namely human embryonic kid...
Quercetin ameliorates atrazine-induced changes in the testicular function of rats
The protective effect of quercetin (QT) on atrazine (ATZ)-induced testicular damage in rats was investigated. Sexually mature male Wistar rats (weighing 220–250 g) divided into four groups with six animals in each group were given ATZ (120 mg kg–1; 1/16 of the median lethal dose for an oral dose) and/or QT (10 mg kg–1) daily via gavage for 16 days. By the end of day 16, rats g...
Education, Intelligence, And Attitude Extremity
Education and general intelligence both serve to inform opinions, but do they lead to greater attitude extremity? The potential civic returns to education include not only the sophistication of citizen opinions, but also their moderation. We use questions on economic policy, social issues, and environmental issues from the General Social Survey to test the impact of education on attitude extrem...