Organics

Regioselective (Diacetoxyiodo)benzene-Promoted Halocyclization of Unfunctionalized Olefins
A metal-free method for intramolecular halocyclization of unfunctionalized olefins was detailed. (Diacetoxyiodo)benzene (PIDA) was very effective for haloamidation, haloetherification, and halolactonization of unfunctionalized olefins. In the presence of 1.1 equiv of PIDA and suitable halogen sources, a variety of unfunctionalized olefins could be converted to the corresponding 1,2-bifunctional...


First Investigation of the Kinetic Hydrate Inhibitor Performance of Poly(N-alkylglycine)s
We report for the first time the synthesis and kinetic gas hydrate inhibition of a series of pseudo-polypeptides, poly(N-alkylglycine)s, with varying length alkyl side chains. The polymers have similar molecular weights for performance comparison. Tests were carried out in a multi-cell rocking rig at high pressure using a structure-II-forming natural gas blend. The best polymer tested was poly(...
Synergistic Effects of Trace Amounts of Water in the Enantiodiscrimination Processes by Lipodex E: A Spectroscopic and Computational Investigation
Nuclear magnetic resonance (NMR) investigations on mixtures containing octakis(3-O-butanoyl-2,6-di-O-pentyl)-γ-cyclodextrin (Lipodex E) and each enantiomer of methyl-2-chloropropionate (MCP) ascertained the role of trace amounts of water in the enantiodiscrimination processes. Water is deeply included into the cyclodextrin and favors the formation of the inclusion complex with (S)-MCP, whereas...


Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions
In this paper, we propose to review the ways to produce, through photopolymerization, interpenetrating polymer networks (IPN) based, e.g., on acrylate/epoxide or acrylate/vinylether blends and to outline the recent developments that allows a one-step procedure (concomitant radical/cationic polymerization), under air or in laminate, under various irradiation conditions (UV/visible/near IR; high/...
Analysis of Phenolic and Flavonoid Contents, and the Anti-Oxidative Potential and Lipid Peroxidation Inhibitory Activity of Methanolic Extract of Carissa opaca Roots and Its Fractions in Different Solvents
The objective of the present work was to investigate the anti-oxidative potential of methanolic extract of Carissa opaca roots and its fractions in solvents of different polarities. Total phenolic (TPC) and flavonoid (TFC) contents of methanolic extract were 211.95 ± 0.78 μg/mL gallic acid equivalents (GAE) and 8.35 ± 0.21 μg/mL rutin equivalents (RE), respectively. Ethyl acetate contained ...


Investigation of Diastereoselective Acyclic α-Alkoxydithioacetal Substitutions Involving Thiacarbenium Intermediates
Reported herein is an experimental and theoretical study that elucidates why silylated nucleobase additions to acyclic α-alkoxythiacarbenium intermediates proceed with high 1,2-syn stereocontrol (anti-Felkin–Anh), which is opposite to what would be expected with corresponding activated aldehydes. The acyclic thioaminals formed undergo intramolecular cyclizations to provide nucleoside analogu...
Effect of Tea Polyphenols on Lipid Peroxidation and Antioxidant Activity of Litchi (Litchi chinensis Sonn.) Fruit during Cold Storage
To understand the potential of application of tea polyphenols to the shelf life extension and quality maintenance of litchi (Litchi chinensis Sonn.) fruit, the fruits were dipped into a solution of 1% tea phenols for 5 min before cold storage at 4 °C. Changes in browning index, contents of anthocyanins and phenolic compounds, superoxide dismutase (SOD) and peroxidase (POD) activities, O2.− p...

Quality Evaluation of Pharmaceutical Formulations Containing Hydrochlorothiazide
Hydrochlorothiazide is a diuretic used to treat hypertension that belongs to class IV of the Biopharmaceutics Classification System. The drug was evaluated by quality control, thermal characterization tests, and pharmaceutical formulation compatibility studies. It was concluded that the generic drug, Lab 2, was not a pharmaceutical equivalent. The compounded drugs, Lab 5 and Lab 6, produced uns...
Physicochemical and Antioxidant Properties of Black Garlic
Black garlic (BG) is a processed garlic product prepared by heat treatment of whole garlic bulbs (Allium sativum L.) at high temperature under high humidity for several days, resulting in black cloves with a sweet taste. BG has recently been introduced to the Korean market as a product beneficial to health. To clarify how BG changes during the 35 day aging period, the physicochemical characteri...

Transformation of Glycals into α,β,γ,δ-Conjugated Chirons under Metal-Free Conditions
A diastereoselective, metal-free, one-pot domino synthetic strategy was developed for the transformation of glycals into new chiral scaffolds. Optimization of the reaction conditions to exclude normal Ferrier products, characterization of the new entities, and a plausible mechanism were investigated. A diastereoselective, metal-free, one-pot domino synthetic strategy is developed for the transf...
The Ugi–Smiles and Passerini–Smiles Couplings: A Story About Phenols in Isocyanide-Based Multicomponent Reactions
The Ugi–Smiles and Passerini–Smiles couplings are extensions of Ugi and Passerini reactions involving the use of acidic phenols in place of the traditional carboxylic acid partners. A Smiles rearrangement is in each case responsible for the final N-aryl carboxamide formation. All the available data on the mechanisms and the scope of these reactions are presented. To demonstrate the interest...

One-Pot Double Benzylation of 2-Substituted Pyridines using Palladium-Catalyzed Decarboxylative Coupling of sp2 and sp3 Carbons
An efficient and practical decarboxylative double benzylation method for various 2-picolinic acids has been established by using a bimetallic catalytic system of palladium(II) chloride (PdCl2) and silver(I) oxide (Ag2O), which offered a variety of diarylmethane derivatives with moderate to good yields.
Palladium-Catalyzed Cross Addition of Terminal Alkynes to Aryl Ynamides: An Unusual trans-Hydroalkynylation Reaction
A palladium-catalyzed trans-hydroalkynylation of N-sulfonyl ynamides has been achieved for the first time, providing α-alkynylation adducts in high yields with excellent regio- and stereoselectivity. The resulting enyne products can serve as the useful precursors for the elaboration of naphthalene derivatives via a platinum-catalyzed cycloisomerization reaction.
Hydrogen-bonded diketopyrrolopyrrole (DPP) pigments as organic semiconductors
Diketopyrrolopyrroles (DPPs) have recently gained attention as building-blocks for organic semiconducting polymers and small molecules, however the semiconducting properties of their hydrogen-bonded (H-bonded) pigment forms have not been explored. Herein we report on the performance of three archetypical H-bonded DPP pigments, which show ambipolar carrier mobilities in the range 0.01–0.06cm2/...
Silencing of high-mobility group box 2 (HMGB2) modulates cisplatin and 5-fluorouracil sensitivity in head and neck squamous cell carcinoma
Dysregulation of protein expression is associated with most diseases including cancer. Mass spectrometry-based proteomic analysis is widely employed as a tool to study protein dysregulation in cancers. Proteins which are differentially expressed in head and neck squamous cell carcinoma (HNSCC) cell lines compared to the normal oral cell line could serve as biomarkers for patient stratification....