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Physiology

Splenectomy Delays Uterine Natural Killer Cell Recruitment to Implantation Sites and Prolongs Pregnancy in Mice
submitted by 87hony 15 hours ago
Uterine natural killer (uNK) cells are the dominant lymphocytes found in pregnant mammals that develop uterine decidualization. Four stages of mouse uNK cell differentiation are recognized using Do...
 


Fetal Gyrification in Cynomolgus Monkeys: A Concept of Developmental Stages of Gyrification
submitted by kevoncesek 15 hours ago
Our article summarizes a series of studies about fetal gyrification and its relation to cerebral growth in cynomolgus monkeys. Based on the cerebral growth (i.e., brain weight, cerebral volume, and...
 
Factors other than genotype account largely for the phenotypic variation of the pulmonary valve in Syrian hamsters
submitted by rishown 1 day ago
Understanding of the aetiology of congenitally anomalous pulmonary valves remains incomplete. The aim of our study, therefore, was to elucidate the degree to which the phenotypic variation known to...
 
Investigating the potential value of individual parameters of histological grading systems in a sheep model of cartilage damage: the Modified Mankin method
submitted by joemas999 1 day ago
A total histological grade does not necessarily distinguish between different manifestations of cartilage damage or degeneration. An accurate and reliable histological assessment method is required...
 


Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone
submitted by dlob77 1 day ago
Defibrillation efficacy is decreased in infarcted hearts, but the mechanisms by which infarcted hearts are more vulnerable to electric shocks than healthy hearts remain poorly understood. The goal ...
 
Coronary wave intensity during the valsalva manoeuvre in humans reflects altered intramural vessel compression responsible for extravascular resistance
submitted by ovemohlir 1 day ago
Our aim was to investigate the effect of altered coronary-cardiac interaction during the Valsalva manoeuvre (VM) on coronary wave intensity and the response of coronary microvascular resistance (MR...
 
The electroneutral Na+:HCO3− cotransporter NBCn1 is a major pHi regulator in murine duodenum
submitted by eongordnir 1 day ago
PHi control and HCO3− secretion protects the proximal duodenum against damage by gastric acid. The molecular details of duodenocyte pH control are not well understood. A selective duodenal expres...
 
Shortening and intracellular Ca2+ in ventricular myocytes and expression of genes encoding cardiac muscle proteins in early onset type 2 diabetic Goto-Kakizaki rats
submitted by mokali 1 day ago
There has been a spectacular rise in the global prevalence of type 2 diabetes mellitus and cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. Contract...
 
A role for nitric oxide within the nucleus tractus solitarius in the development of muscle mechanoreflex dysfunction in hypertension
submitted by saostowo 1 day ago
Evidence suggests the muscle mechanoreflex, a circulatory reflex that raises blood pressure and heart rate (HR) upon activation of mechanically sensitive afferent fibers in skeletal muscle, is over...
 
Lipopolysaccharide enhances FcɛRI-mediated mast cell degranulation by increasing Ca2+ entry through store-operated Ca2+ channels: implications for LPS exacerbating allergic asthma
submitted by menhctyhoe 1 day ago
Lipopolysaccharide (LPS) can exacerbate asthma. However, the mechanisms are not fully understood. This study investigated the effect of LPS on antigen-stimulated mast cell degranulation and the und...
 
Noxious somatic stimulus diminishes the respiratory-sympathetic coupling by selective resetting of the respiratory rhythm in anaesthetised rat
submitted by bshodi 1 day ago
Noxious somatic stimulation evokes respiratory and autonomic responses. The mechanisms underlying the responses and the manner in which they are coordinated are still unclear. The effects of somati...
 
Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain
submitted by mffrietos 2 days ago
Calmodulin (CaM) binding sites were recently identified on the cytoplasmic loop (CL) of at least three α-subfamily connexins (Cx43, Cx44, Cx50), while Cx40 does not have this putative CaM bin...
 
Effect of insulin and contraction on glycogen synthase phosphorylation and kinetic properties in epitrochlearis muscles from lean and obese Zucker rats
submitted by oenat 2 days ago
In the present study, the effects of insulin and contraction on glycogen synthase (GS) kinetic properties and phosphorylation were investigated in epitrochlearis muscles from lean and obese Zucker ...
 
Mechanical loading induces the expression of a Pol I regulon at the onset of skeletal muscle hypertrophy
submitted by mgonond 2 days ago
The main goal of the present study was to investigate the regulation of ribosomal DNA (rDNA) gene transcription at the onset of skeletal muscle hypertrophy. Mice were subjected to functional overlo...
 
Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2
submitted by prencib5mi 2 days ago
Fetal nicotine exposure causes impaired adrenal catecholamine secretion and increased neonatal mortality during acute hypoxic challenges. Both effects are attributable to upregulation of ATP-sensit...
 

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