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Elephant Transcriptome Provides Insights into the Evolution of Eutherian Placentation

submitted by imko94 18 hours ago

The chorioallantoic placenta connects mother and fetus in eutherian pregnancies. In order to understand the evolution of the placenta and provide further understanding of placenta biology, we seque...

1 dig(s) Dig it Bury Topic: Genetics

Fine-Scale Population Recombination Rates, Hotspots, and Correlates of Recombination in the Medicago truncatula Genome

submitted by IsraeDeo 18 hours ago

Recombination rates vary across the genome and in many species show significant relationships with several genomic features, including distance to the centromere, gene density, and GC content. Stud...

1 dig(s) Dig it Bury Topic: Genetics

Detecting cryptic speciation in the widespread and morphologically conservative carpet chameleon (Furcifer lateralis) of Madagascar

submitted by chakks 1 day ago

Species delimitation within recently evolved groups can be challenging because species may be difficult to distinguish morphologically. Following the General Lineage Concept, we apply a multiple ev...

1 dig(s) Dig it Bury Topic: Genetics

The evolution of alternative developmental pathways: footprints of selection on life-history traits in a butterfly

submitted by laesboptesto2270 1 day ago

Developmental pathways may evolve to optimize alternative phenotypes across environments. However, the maintenance of such adaptive plasticity under relaxed selection has received little study. We ...

1 dig(s) Dig it Bury Topic: Genetics

Colonizing the world in spite of reduced MHC variation

submitted by ogranamest 1 day ago

The major histocompatibility complex (MHC), which harbours the most polymorphic vertebrate genes, plays a critical role in the host–pathogen coevolutionary arms race. However, the extent to which...

1 dig(s) Dig it Bury Topic: Genetics

MHC genotype predicts mate choice in the ring-necked pheasant Phasianus colchicus

submitted by ponniir 1 day ago

Females of several vertebrate species selectively mate with males on the basis of the major histocompatibility complex (MHC) genes. As androgen-mediated maternal effects have long-lasting consequen...

1 dig(s) Dig it Bury Topic: Genetics

Exploring the effect of the Cardinium endosymbiont on spiders

submitted by kvraam32 1 day ago

Spiders have recently emerged as important diversity hot spots for endosymbiotic bacteria, but the consequences of these symbiotic interactions are largely unknown. In this article, we examined the...

1 dig(s) Dig it Bury Topic: Genetics

Expression of Human Endogenous Retrovirus Type K Envelope Protein is a Novel Candidate Prognostic Marker for Human Breast Cancer

submitted by vinadivon 2 days ago

We previously observed that the HERV type K (HERV-K) envelope (env) protein was expressed in the majority of human breast tumors from a U.S. cohort of women from Texas. We also made the preliminary...

1 dig(s) Dig it Bury Topic: Genetics

Loss of Heterozygosity at the Glutathione Peroxidase 1 Locus Is Not an Early Event in Colon Carcinogenesis

submitted by togedid 2 days ago

It has been previously shown that loss of heterozygosity (LOH) at the cytosolic glutathione peroxidase (GPx-1) locus is a common event in the development of several cancer types, including colorect...

1 dig(s) Dig it Bury Topic: Genetics

Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate Cancer Cells

submitted by BrockIsra 2 days ago

The early growth response gene 1, EGR1, is an important transcriptional regulator and acts as the convergent point between a variety of extracellular stimuli and activation of target genes. Unlike ...

1 dig(s) Dig it Bury Topic: Genetics

Exploring Molecular Pathways of Triple-Negative Breast Cancer

submitted by ToddSau 2 days ago

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with a high rate of proliferation and metastasis, as well as poor prognosis for advanced-stage disease. Although TNBC was...

1 dig(s) Dig it Bury Topic: Genetics

HOXC8-Dependent Cadherin 11 Expression Facilitates Breast Cancer Cell Migration through Trio and Rac

submitted by SidnCase 2 days ago

HOXC8 expression is upregulated in diverse cancer types, and a high level of HOXC8 is often associated with the aggressive/metastatic phenotypes. We previously reported that the presence of HOXC8 i...

1 dig(s) Dig it Bury Topic: Genetics

Role of the Cofilin Activity Cycle in Astrocytoma Migration and Invasion

submitted by leahmarie 2 days ago

The cofilin pathway plays a central role in the regulation of actin polymerization and the formation of cell membrane protrusions that are essential for cell migration. Overexpression of cofilin ha...

1 dig(s) Dig it Bury Topic: Genetics

Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides

submitted by larint 2 days ago

An established paradigm in pre-mRNA splicing is the recognition of the 5' splice site (5'ss) by canonical base-pairing to the 5' end of U1 small nuclear RNA (snRNA). We recently reported that a sma...

1 dig(s) Dig it Bury Topic: Genetics

A mechanism for the coordination of proliferation and differentiation by spatial regulation of Fus2p in budding yeast

submitted by rochilt4ak 2 days ago

Yeast cells induce the genes required for mating prior to the completion of mitosis. To ensure proper cell cycle progression prior to mating differentiation, a key cytoplasmic regulator of cell fus...

1 dig(s) Dig it Bury Topic: Genetics