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Mediators of induced pluripotency and their role in cancer cells – current scientific knowledge and future perspectives

submitted by siohioreng 2 days ago

The discovery that overexpression of the transcription factors Oct4, Sox2, Klf4 and c-Myc reprograms differentiated cells into “induced pluripotent stem cells” (iPSCs) has extended our understa...

1 dig(s) Dig it Bury Topic: Biotechnology

Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance

submitted by doneildeoz 2 days ago

Acute myeloid leukemia (AML) is considered to be a disease of stem cells. A rare defective stem cell population is purported to drive tumor growth. Similarly to their normal counterparts, leukemic ...

1 dig(s) Dig it Bury Topic: Biotechnology

Comparative reaction engineering studies for succinic acid production from sucrose by metabolically engineered Escherichia coli in fed-batch operated stirred tank bioreactors

submitted by OrlDevy 2 days ago

This study presents a comparative reaction engineering analysis of metabolically engineered sucrose utilizing Escherichia coli derived from E. coli K12 MG1655 for the anaerobic production of succin...

1 dig(s) Dig it Bury Topic: Biotechnology

Genomics in Eels — Towards Aquaculture and Biology

submitted by NikolaJam 2 days ago

Freshwater eels (genus Anguilla), especially the species inhabiting the temperate areas such as the European, American and Japanese eels, are important aquaculture species. Although artificial repr...

1 dig(s) Dig it Bury Topic: Biotechnology

Treatment with Algae Extracts Promotes Flocculation, and Enhances Growth and Neutral Lipid Content in Nannochloropsis oculata—a Candidate for Biofuel Production

submitted by thimaadei 2 days ago

Marine microalgae represent a potentially valuable feedstock for biofuel production; however, large-scale production is not yet economically viable. Optimisation of productivity and lipid yields is...

1 dig(s) Dig it Bury Topic: Biotechnology

Exploring the Transcriptome of Atlantic Salmon (Salmo salar) Skin, a Major Defense Organ

submitted by drroe 2 days ago

The skin of fish is the first line of defense against pathogens and parasites. The skin transcriptome of the Atlantic salmon is poorly characterized, and currently only 2,089 expressed sequence tag...

1 dig(s) Dig it Bury Topic: Biotechnology

Use of Comparative Genomics to Develop EST-SSRs for Red Drum (Sciaenops ocellatus)

submitted by xaaclimoepti 2 days ago

Microsatellites physically linked to expressed sequence tags (EST-SSRs) are an important resource for linkage mapping and comparative genomics, and data mining in publicly available EST databases i...

1 dig(s) Dig it Bury Topic: Biotechnology

RNA Aptamers Inhibit the Growth of the Fish Pathogen Viral Hemorrhagic Septicemia Virus (VHSV)

submitted by alegonzalezk 2 days ago

Viral hemorrhagic septicemia virus (VHSV) is a serious disease impacting wild and cultured fish worldwide. Hence, an effective therapeutic method against VHSV infection needs to be developed. Aptam...

1 dig(s) Dig it Bury Topic: Biotechnology

Three EST-SSR Markers Associated with QTL for the Growth of the Clam Meretrix meretrix Revealed by Selective Genotyping

submitted by glinn234 2 days ago

The clam Meretrix meretrix is a member of widely cultured, commercially important clams. A marker–trait association analysis was performed using expressed sequence tag (EST) simple sequence repea...

1 dig(s) Dig it Bury Topic: Biotechnology

Genetic Positioning of Centromeres through Half-Tetrad Analysis in Gynogenetic Diploid Families of the Zhikong Scallop (Chlamys farreri)

submitted by lokshmon 2 days ago

Centromere mapping is a powerful tool for improving linkage maps, investigating crossover events, and understanding chiasma interference during meiosis. Ninety microsatellite markers selected acros...

1 dig(s) Dig it Bury Topic: Biotechnology

Biomass and Lipid Production of Dinoflagellates and Raphidophytes in Indoor and Outdoor Photobioreactors

submitted by CalebDeo 2 days ago

The principal fatty acids from the lipid profiles of two autochthonous dinoflagellates (Alexandrium minutum and Karlodinium veneficum) and one raphidophyte (Heterosigma akashiwo) maintained in bubb...

1 dig(s) Dig it Bury Topic: Biotechnology

Construction of an Artificially Randomized IgNAR Phage Display Library: Screening of Variable Regions that Bind to Hen Egg White Lysozyme

submitted by NatTrav 2 days ago

To develop a multi-antigen-specific immunoglobulin new antigen receptor (IgNAR) variable (V) region phage display library, CDR3 in the V region of IgNAR from banded houndshark (Triakis scyllium) wa...

1 dig(s) Dig it Bury Topic: Biotechnology

Both Decrease in ACL1 Gene Expression and Increase in ICL1 Gene Expression in Marine-Derived Yeast Yarrowia lipolytica Expressing INU1 Gene Enhance Citric Acid Production from Inulin

submitted by rosanna 2 days ago

In this study, some of the ATP-citrate lyase genes (ACL1) were deleted and the copy number of the iso-citrate lyase gene (ICL1) was increased in the marine-derived yeast Yarrowia lipolytica SWJ-1b ...

1 dig(s) Dig it Bury Topic: Biotechnology

Establishment of a Genetic Transformation System for the Marine Pennate Diatom Fistulifera sp. Strain JPCC DA0580—A High Triglyceride Producer

submitted by bibi 2 days ago

A genetic transformation system for the marine pennate diatom, Fistulifera sp. JPCC DA0580, was established using microparticle bombardment methods. Strain JPCC DA0580 has been recently identified ...

1 dig(s) Dig it Bury Topic: Biotechnology

Genomic Mining for Novel FADH2-Dependent Halogenases in Marine Sponge-Associated Microbial Consortia

submitted by notaripradacts 2 days ago

Many marine sponges (Porifera) are known to contain large amounts of phylogenetically diverse microorganisms. Sponges are also known for their large arsenal of natural products, many of which are h...

1 dig(s) Dig it Bury Topic: Biotechnology