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'Last resort' antibiotics increasingly used to fight multidrug-resistant bugs

submitted by xaacininycga 20 hours ago

Multidrug-resistant pathogens are becoming more frequent, and the few "last resort" treatments available for infections with these bacteria have also shown an increase in use in recent years, according to a study published May 16 in the open access journal PLoS ONE.

1 dig(s) Dig it Bury Topic: Immunology

Dermatomyositis: Myositis-specific autoantibodies and skin manifestations

submitted by sflonniry2 19 hours ago

Idiopathic inflammatory myopathies including dermatomyositis (DM) and polymyositis (PM) are a heterogeneous group of disorders with varying degrees of muscle disease, cutaneous manifestations and internal organ involvement. Myositis-specific autoantibodies (MSA) are useful tools, as they further ...

1 dig(s) Dig it Bury Topic: Immunology

Inflammation and type one diabetes

submitted by ShannonC 17 hours ago

Type one diabetes (T1D) is a complex T cell-mediated autoimmune disease, the defining feature of which is the destruction of the insulin-secreting beta- (β)- cell. Both genetic and environmental factors combine to precipitate disease, and the outcome of the pathological process is dependent ...

1 dig(s) Dig it Bury Topic: Immunology

Enumeration of human peripheral blood dendritic cells throughout the life

submitted by omolfansad 17 hours ago

Human aging is associated with immunosenescence, a process characterized by alterations in numerical and functional features of immune system components. Dendritic cells (DCs) are the main antigen-presenting cells, playing a pivotal role in adaptive and innate immunity. Therefore, we investigated...

1 dig(s) Dig it Bury Topic: Immunology

IL-2/CD40-driven NK cells install and maintain potency in the anti-mesothelioma effector/memory phase

submitted by JohnaJamie 17 hours ago

Murine and human mesothelioma tumors are susceptible to immunotherapy, particularly when immune adjuvants are delivered locally. We have shown that direct injection of IL-2 plus agonist anti-CD40 antibody induces regression of large mesothelioma tumors. These studies aimed to determine if NK cell...

1 dig(s) Dig it Bury Topic: Immunology

Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development

submitted by RolandJay 17 hours ago

Receptor activator of nuclear factor kappa-B ligand (RANKL) expression was examined during the development of mouse fetal peripheral lymphoid organs. A shift in the expression pattern was detected during the transition from lymphoid tissue inducer (LTi) cells to lymphoid tissue organizer (LTo) ce...

1 dig(s) Dig it Bury Topic: Immunology

Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis

submitted by lechin 17 hours ago

T lymphocytes are key inflammatory cells contributing significantly to the pathogenesis of Rheumatoid arthritis (RA). Biological treatments targeting T lymphocytes may provide an efficient approach for treatment of RA. CTLA4–FasL, a fusion product of extracellular domains of CTLA4 and FasL,...

1 dig(s) Dig it Bury Topic: Immunology

The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells

submitted by ElijaCol 17 hours ago

Marginal zone (MZ) B cells mount rapid T-cell-independent (T-I) immune responses against microbial components such as LPS. While Toll-like receptor 4 (TLR4) is essential for LPS responses, MZ B cells uniquely express high levels of another LPS sensor Radioprotective 105 (RP105). However, little i...

1 dig(s) Dig it Bury Topic: Immunology