This paper (This work is done in the research laboratory of Prof. Dr. Hans-Michael Hanisch at the Martin Luther University in Germany, and it is supported by the Alexander von Humboldt foundation in Germany under the reference TUN1127196STP.) deals with automatic reconfigurations of safe embedded control systems following the component-based International Industrial Standard IEC61499 in which a Function Block (FB) is an event triggered software component owning data and a control application is a network of blocks. We define a new semantics of reconfigurations that allow automatic improvements of system performances at run-time even if there are no hardware faults.
The paper deals with reconfigurable embedded control systems following component-based technologies and/or Architecture Description Languages (ADL). A Control Component is defined as a software unit of the system which is assumed to be a network of components with precedence constraints. We defin...
This paper deals with automatic refinement-based specifications and verifications of component-based embedded control systems in manufacturing industry. To be independent of any technology, we define the concept of control component as a software unit that reads and interprets data from sensors t...
It can be argued that the last true paradigm shift in the bioanalytical (BA) arena was the shift from high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection to HPLC with tandem mass spectrometry (MS/MS) detection after the commercialization of the triple quadrupole mass spe...
This work provides an update of the state-of-the-art on energy security relating to critical infrastructure protection. For this purpose, this survey is based upon the conceptual view of OECD countries, and specifically in accordance with EU Directive 114/08/EC on the identification and designati...
The E-Rate program has been widely applauded for helping American schools achieve almost 100 percent internet connectivity, up from 14 percent in 1996. However, mismanagement and complex administration problems have tainted the program's fame, making it a target for criticism by many commentators...
Monoamine oxidase (MAO) is an enzyme, present in mammals in two isoforms MAO-A and MAO-B. These isoforms have a crucial role in neurotransmitters metabolism, representing an attractive drug target in the therapy of neurodegenerative diseases (MAO-B) and depression (MAO-A). In this context, our wo...
Preclinical characterization of new chemical entities (NCEs) in terms of efficacy, safety and their pharmacokinetic (PK), pharmacodynamic and pharmaceutical properties, is key to advancing appropriate compounds to clinical trials. The use of high throughput synthetic and screening methodologies h...
A series of N1-(4-substituted-benzyl)-pyrimidines were subjected to 2D and 3D QSAR analysis. Statistically significant models were generated and the most robust model for 2D QSAR was obtained using SA- MLR. The physicochemical descriptors viz., SlogP, Estate descriptors like SaaCHE-index and SdsC...
The sensitivity and accuracy of a bioanalytical method is critical in defining the pharmacokinetic (PK) parameters of a potential new chemical entity (NCE). Inhaled therapeutics and low dose NCEs present one of the most significant analytical challenges to the bioanalyst, due to their low systemi...
The Indian pharmaceutical industry is one of the fastest growing industries in the world competing with the global pharmaceutical industries. It is in the front rank of India's science-based industries with a wide range of capabilities in the complex field of drug manufacture and technology.In th...
