Increasing evidence indicates that lymphangiogenesis in cancer is an important factor in promoting tumour progression and metastasis. The discovery of immunohistochemical markers for lymphatic vessels' identification as well as the characterization of lymphatic-specific growth factors and receptors afforded insight into the mechanisms involved in new lymphatic vessel formation and the process of lymphatic-borne metastasis. Quantitative assessment of lymphangiogenesis in malignant tumours has emerged as a promising prognostic indicator, although there are conflicting results on the impact of lymphatic vessel density to predict lymph nodal metastases and overall survival. Solid tumours were recently found to induce new lymphatic vessel growth in.
Lymphangiogenesis and angiogenesis are essential for tumour development and progression. The lymphatic vessel density (LVD) and blood vessel density (BVD) and their relationship to outcome have been studied extensively, however the clinical significance of the location of LVD/BVD in tumour is not...
Transmembrane proteins of the tetraspanin superfamily are implicated in a broad spectrum of cellular processes in many biological systems in both health and disease. Tetraspanins form specialized membrane microdomains on the cell surface which control cell proliferation and migration through vari...
Over 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance of the key lymphangiogenesis growth factors VEGF-C, VEGF-D and the receptor VEGFR-3 proteins in NBs.Methods and results: 93 NBs and 9 gangli...
Integrin-linked kinase 1 (ILK1), a member of the serine/threonine kinases, has been demonstrated to be associated with numerous biological and pathological processes. However, the clinical and functional significance of ILK1 expression has not been characterized previously in human astrocytoma. I...
NGR-hTNF consists of human tumour necrosis factor-alpha (hTNF-I+-) fused to the tumour-homing peptide NGR, a ligand of an aminopeptidase N/CD13 isoform, which is overexpressed on endothelial cells of newly formed tumour blood vessels. NGR-TNF showed a biphasic dose-response curve in preclinical m...
As the prefrontal cortex expanded in human evolution, so too did the capacity for nesting basic biological goals within more complex systems of behavioral organization. This increased ability for abstraction brought with it the challenge of deciding how to interpret the personal significance of a...
The aim of this study was to investigate endothelial lipase (EL, LIPG) and lipoprotein lipase (LPL) mRNA and protein expression in normal human testis and testicular germ cell tumours (GCT). Both EL and LPL were expressed in normal seminiferous tubules and in the interstitial compartment. EL mRNA...
Recent studies have revealed that insulin, the main regulator of the glucose homeostasis in somatic cells, is expressed in human spermatozoa which are also able to secrete it. This study investigated the expression of insulin and insulin receptor beta in pig spermatozoa, at immunohistochemical pr...
submitted by wentupthehill 2 years and 5 months ago
Steroid and xenobiotic receptor (SXR) is a nuclear receptor activated by diverse exogenous and endogenous compounds and has been demonstrated to play a pivotal role in detoxification through its regulation of various metabolizing enzymes and transporters. Recent studies also demonstrated the pote...
Canine Merkel cell tumours are rare neuroendocrine neoplasms that show a relatively benign biological behaviour when compared with their human counterparts. To date, little information is available on their immunohistochemical properties. This report describes the histopathological and immunohist...
