One of the problems encountered when assessing cervical precancerous lesions is intra- and interobserver variability. The aim of this study was to determine the degree of interobserver variation in conventional PAP smears (CPS) and liquid-based cytology (LBC). Material and The diagnostic variability among three pathologists was assessed using 120 smears (67 conventional CPS and 53 LBC). The cases were selected retrospectively from the archives of the Pathology Department among the patients with follow-up, such as biopsy confirmation and/or persistent/ resolving disease in the follow-up smear. The observers examined the slides in a blinded fashion. Diagnostic agreement on the presence or absence of intraepithelial lesions was found in 30 of 51 slides (58.82%) of LBC (kappa=0.42) and in 44 of 67 slides (65.67%) of conventional cytology (kappa=0.50). The agreement was slightly higher in conventional smears. The highest agreement was in the LSIL category with a kappa value of 0.50 in LBC and 0.62 in conventional cytology, while ASCUS was the least reproducible diagnosis. Our results are in agreement with the literature in that the reproducibility of cervical cytology shows low to moderate consistency. The study showed no significant difference between LBC and CPS in the reproducibility of the diagnosis.
Related Content
Absolute myocardial flow quantification with 82Rb PET/CT: comparison of different software packages and methods
In clinical cardiac 82Rb PET, globally impaired coronary flow reserve (CFR) is a relevant marker for predicting short-term cardiovascular events. However, there are limited data on the impact of different software and methods for estimation of myocardial blood flow (MBF) and CFR. Our objective wa...


Interobserver Agreement of Qualitative Analysis and Tumor Delineation of 18F-Fluoromisonidazole and 3'-Deoxy-3'-18F-Fluorothymidine PET Images in Lung Cancer
As the preparation phase of a multicenter clinical trial using 18F-fluoro-2-deoxy-d-glucose (18F-FDG), 18F-fluoromisonidazole (18F-FMISO), and 3'-deoxy-3'-18F-fluorothymidine (18F-FLT) in non–small cell lung cancer (NSCLC) patients, we investigated whether 18 nuclear medicine centers would ...
Intégration des critères métaboliques de la TEP au 18FDG pour le choix des lésions cibles en imagerie onco-hématologique
Le lymphome est une maladie diffuse et hétérogène. L’évaluation de la réponse morphologique au traitement est basée sur le choix initial de lésions cibles, sélectionnées par critère de taille sur le scanner. La TEP/TDM au 18FDG étant utilisée en routine pour le bilan d’extension, ...


Reliability of Estimates of ACL Attachment Locations in 3-Dimensional Knee Reconstruction Based on Routine Clinical MRI in Pediatric Patients
Current techniques of anterior cruciate ligament (ACL) reconstruction focus on the placement of femoral and tibial tunnels at anatomic ACL attachments, which can be difficult to identify intraoperatively. To determine whether the 3-dimensional (3D) center of ACL attachments can be reliably detect...
Interobserver Agreement of Magnetic Resonance Imaging Signs of Osteomyelitis in Pelvic Pressure Ulcers in Patients With Spinal Cord Injury
To examine the interobserver reliability of magnetic resonance imaging (MRI) signs of osteomyelitis in complex chronic pressure ulcers in patients with spinal cord injury (SCI). Retrospective review study. Specialist SCI rehabilitation center. Adult patients with SCI and pressure ulceration inves...

Additional Diagnostic Value of Integrated Analysis of Cardiac CTA and SPECT MPI Using the SMARTVis System in Patients with Suspected Coronary Artery Disease
CT angiography (CTA) and SPECT myocardial perfusion imaging (MPI) are complementary imaging techniques to assess coronary artery disease (CAD). Spatial integration and combined visualization of SPECT MPI and CTA data may facilitate correlation of myocardial perfusion defects and subtending corona...
Évaluation de l’exactitude de latéralisation du foyer épileptogène par la tomographie par émission de positons au 18f-fluorodésoxyglucose dans le bilan préopératoire de l’épilepsie temporale : analyse visuelle simple et par index d’asymétrie inter-hémisph
Chez les patients présentant une épilepsie temporale pharmacorésistante, l’objectif essentiel du bilan préopératoire consiste en la latéralisation avec certitude du lobe temporal incriminé dans l’épileptogenèse. La tomographie par émission de positons (TEP) cérébrale au fluorodés...

Practice variation in defining sentinel lymph nodes on lymphoscintigrams in oral cancer patients
Lymphoscintigraphic imaging and adequate interpretation of the lymphatic drainage pattern is an essential step in the sentinel lymph node biopsy (SLNB) procedure. In oral cancer, identification of the sentinel lymph node (SLN) can be challenging. In this study, interobserver variability in defini...
Functional guidance in intracranial tumor surgery
Navigated transcranial magnetic stimulation (nTMS) is a newly evolving technique. Despite its supposed purpose of preoperative mapping of the central region, little is known about further applications as well as the accuracy compared to more commonly used modalities like direct cortical stimulati...

Value of Semiquantitative Analysis for Clinical Reporting of 123I-2-beta-Carbomethoxy-3beta-(4-Iodophenyl)-N-(3-Fluoropropyl)Nortropane SPECT Studies
Clinical 123I-2-β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane (123I-FP-CIT) SPECT studies are commonly performed and reported using visual evaluation of tracer binding, an inherently subjective method. Increased objectivity can potentially be obtained using semiquantitat...