The relationship between shear rate and FMD is altered by acute exercise
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submitted by cantriros 3 months ago
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Endothelial function is a predictor of cardiovascular health and is improved with exercise training. However, it is not clear how exercise acutely affects endothelial function. Previous studies present conflicting results, resulting from varied exercise protocols and ambiguity in data analysis after exercise. The aims of this study were to compare brachial artery endothelial function at rest and post-exercise in and to compare the data expressed as a percent change and normalized to shear rate. Fifteen young, healthy subjects completed flow-mediated dilation tests at rest and immediately after a continuous 30-minute treadmill exercise session. Flow-mediated dilation was calculated as percent change in diameter and also normalized for shear rate. Flow-mediated dilation was reduced after exercise (8.9% ± 4.3 to 5.8% ± 3.9, p < .05), but normalizing for shear rate nullified this difference (3.6x10-4% ± 1.8x10-4 to 2.7x10-4% ± 2.4x10-4, p = .25). Baseline shear rate was significantly greater after exercise than at rest (224 s−1 ± 72 to 354 s−1 ± 158, p < .05). Baseline diameter, time to peak diameter, and shear rate area under the curve were not different between the two conditions. The relationship between shear rate and flow-mediated dilation was strong at rest (r = .82, p < .001), but weak post-exercise (r = .16, p = .6).The weak relationship in flow-mediated dilation and shear rate after exercise suggests that these data should not be normalized following aerobic exercise. Thus, endothelial function was attenuated after a continuous 30-minute aerobic exercise session.
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