A Validated Stability Indicating Ultra performance Liquid Chromatographic method for Determination of Impurities in Esomeprazole Magnesium Gastro Resistant Tablets

submitted by pitishorp11 1 year and 8 months ago - Topic: Chemistry

A novel gradient reversed-phase ultra performance liquid chromatographic method has been developed for quantitative determination of Esomeprazole magnesium and its seven impurities in pharmaceutical dosage forms. Chromatographic separation has been achieved on an Acquity BEH C18, 5 x 2.1mm, 1.7μm with buffered mobile phase consisting solvent A (.4 molar (M) glycine (pH 9.) buffer) and solvent B (mixture of acetonitrile and Milli-Q water in the ratio 9: 1 (v/v); respectively) delivered at flow rate of .21 mL min−1 and the detection wavelength 35 nm. Resolution of Esomeprazole magnesium and all the seven potential impurities has been achieved greater than 2. Highlights: The Fig. 2 was redrawn. The manuscripts was checked for English (US) language and corrected. No any technical changes were made.

submitted by 72796 1 month ago - Topic: Chemistry

A simple, sensitive, and reproducible ultra-performance liquid chromatography (UPLC) coupled with a photodiode array detector method was developed for the quantitative determination of Ziprasidone Hydrochloride (ZIP) in API and pharmaceutical dosage forms. Chromatographic separation was achieved ...

Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets

submitted by kora 11 months ago - Topic: Chemistry

A simple reversed phase high performance liquid chromatographic method with diode array detector (HPLC-DAD) has been developed and subsequently validated for the determination of fexofenadine hydrochloride (FEX) and its related compounds; keto fexofenadine (Impurity A), meta isomer of fexofenadin...

A single common stability indicating ultra-performance liquid chromatographic method for estimation of impurities in four angiotensin ii receptor blockers

submitted by ratotorajomo118 9 months ago - Topic: Chemistry

A novel single common stability-indicating gradient reverse phase ultra-performance liquid chromatographic (RP-UPLC) method was developed for the determination of purity of four angiotensin II receptor blockers namely valsartan, losartan potassium, irbesartan, and telmisartan from respective fini...

A Novel and Rapid Validated Stability-Indicating UPLC Method of Related Substances for Dorzolamide Hydrochloride and Timolol Maleate in Ophthalmic Dosage Form

submitted by silsay74 7 months ago - Topic: Chemistry

A novel stability-indicating gradient reversed-phase ultra-performance liquid chromatographic (RP-UPLC) method was developed for the determination of purity of dorzolamide hydrochloride and timalol maleate in presence of their impurities, and forced degradation products and placebo. The method wa...

UPLC and LC-MS Studies on Degradation Behavior of Irinotecan Hydrochloride and Development of a Validated Stability-Indicating Ultra-Performance Liquid Chromatographic Method for Determination of Irinotecan Hydrochloride and its Impurities in Pharmaceutic

submitted by motgerl 7 months ago - Topic: Chemistry

The objective of the current investigation was to study the degradation behavior of irinotecan hydrochloride under different International Conference on Harmonization (ICH) recommended stress conditions using ultra-performance liquid chromatography and liquid chromatography–mass spectrometr...

Stability-Indicating TLC-Densitometric Method for Simultaneous Determination of Paracetamol and Chlorzoxazone and their Toxic Impurities

submitted by CalebDeo 4 months ago - Topic: Chemistry

A highly sensitive, selective and accurate thin-layer chromatographic (TLC)–densitometric method has been developed and validated for the simultaneous determination of paracetamol (PAR) and chlorzoxazone (CZ) and their toxic impurities, 4-amino phenol (4AP) and 2-amino-4-chlorophenol (2ACP)...

Development and Validation of Stability-Indicating Assay Method by UPLC for a Fixed Dose Combination of Atorvastatin and Ezetimibe

submitted by DarnKeith 4 months ago - Topic: Chemistry

A stability-indicating ultra-performance liquid chromatography method was developed and validated for the simultaneous determination of a fixed dose combination of atorvastatin and ezetimibe in bulk drugs. The developed method was successfully applied to the simultaneous quantitative analysis of ...

Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Process Related Impurities and Degradation Products of Rasagiline Mesylate in Pharmaceutical Formulation

submitted by CurtiKrist 4 months ago - Topic: Chemistry

A sensitive, stability-indicating gradient reverse phase high-performance liquid chromatography–ultraviolet method has been developed for the quantitative determination of process-related impurities and forced degradation products of rasagiline mesylate in pharmaceutical formulation. Effici...

Validated Chromatographic Methods for Determination of Perindopril and Amlodipine in Pharmaceutical Formulation in the Presence of their Degradation Products

submitted by KendrZio 4 months ago - Topic: Chemistry

Two specific, sensitive, and precise stability-indicating chromatographic methods have been developed, optimized and validated for determination of perindopril arginin (PER) and amlodipine besylate (AML) in their mixtures and in the presence of their degradation products. The first method was bas...

Development and Validation of a Stability-Indicating RP-HPLC Method for the Determination of Febuxostat (a Xanthine Oxidase Inhibitor)

submitted by mgroceo 4 months ago - Topic: Chemistry

Febuxostat is a selective inhibitor of xanthine oxidase that is used for the treatment of hyperuricaemia in patients with gout. An isocratic liquid chromatographic method was developed and validated for the determination of febuxostat. Chromatographic separation was achieved on a C18 column using...