To determine the effect of lipopolysaccharide (LPS) for the prevention of infection by Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss Walbaum) fingerlings. and Rainbow trout fingerlings were fed with mg (= controls), 1·875 mg, 3·75 mg, 7·5 mg and 15 mg of LPS per 1 g of commercial feed for 14 days before experimental challenge with A. hydrophila. The results revealed a reduction in mortalities to 5% in the two lowest doses and 15% in the group, which received 15 mg LPS per 1 g of feed, compared with 45% mortalities in the control. LPS exerted a powerful oxidative burst effect and was a potent mediator of phagocytic, lysozyme, bactericidal and antiprotease activities and total protein. However, whereas there were increases in specific growth rate (SGR), feed conversion ratio (FCR) and protein efficiency ratio (PER) in LPS-treated fish, the data were not significantly (P > ·5) different. LPS was effective at preventing disease caused by A. hydrophila and in stimulating the innate immune response of rainbow trout.Significance and Impact of the Study: The results of this study highlight the role of LPS in fish disease control.
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