Health

Toward high efficiency green phosphorescent organic light-emitting diodes by fine tuning the charge transporting properties of 1,2,4-thiadiazole based hosts
Two novel host materials, from bipolar-type BzCzTHZ (5-(2-(9H-carbazol-9-yl)phenyl)-3-(3-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)-1,2,4-thiadiazole) to electron-type DBzTHZ (3,5-bis(3-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)-1,2,4-thiadiazole), were designed and synthesized utilizing the unsymmetric intermediate of 3-bromo-5-chloro-1,2,4-thiadiazole as the center. Their thermal, photoelectr...


Highly photosensitive thienoacene single crystal microplate transistors via optimized dielectric
High photosensitivity and high photocurrent gain have been obtained based on dielectric optimized dinaphtho[3,4-d:3′,4′-d′]benzo[1,2-b:4,5-b′]dithiophene (Ph5T2) single crystal microplate transistors. In our experiments, the PMMA dielectric device shows the best operational stability without hysteresis effect. Based on such an optimized device, the photoelectric properties of the Ph5T2 ...
Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes
To investigate obstetric outcomes in Danish women with different phenotypes of polycystic ovary syndrome (PCOS) and isolated hyperandrogenism (HA) and describe the risk of adverse obstetric outcomes in women with PCOS and HA compared to controls. Cohort study. Odense University Hospital, Denmark. PopulationWomen with PCOS were identified prospectively since 1997. Singleton pregnancies in women ...


Effects of disability on pregnancy experiences among women with impaired mobility
Little is known about how functional impairments might affect the pregnancies of women with mobility disability. We aimed to explore complications that arise during pregnancy specifically related to physical functional impairments of women with significant mobility disabilities. Qualitative descriptive analysis. Telephone interviews with women from 17 USA states. Sample22 women with significant...
Antibiotics alone instead of percutaneous drainage as initial treatment of large diverticular abscess
There are limited data assessing the effectiveness of antibiotics as sole initial therapy in patients with large diverticular abscess. The aim of our study was to compare outcomes of selected patients treated with initial antibiotics alone versus percutaneous drainage. All patients with diverticular abscess ≥3 cm in diameter treated in our institution in 1994–2012 with percutaneous drainag...


Cryptoccocal meningitis in Yaoundé (Cameroon) HIV infected patients: Diagnosis, frequency and Cryptococcus neoformans isolates susceptibility study to fluconazole
Cryptococcal meningitis is a mycosis encountered especially in patients with Acquired Immunodeficiency Syndrome and is fatal in the absence of treatment. Information on epidemiology, diagnosis and susceptibility profile to antifungal drugs, are scarce in Cameroon. Authors evaluated the diagnosis possibilities of the cryptococcal meningitis in Cameroon, and studied the antifungal susceptibility ...
Jet Length/Velocity Ratio: A New Index for Echocardiographic Evaluation of Chronic Aortic Regurgitation
Management of aortic regurgitation depends on the assessment for severity. Echocardiography remains as the most widely available tool for evaluation of aortic regurgitation. In this manuscript, we describe a novel parameter, jet length/velocity ratio, for the diagnosis of severe aortic regurgitation. and ResultsA total of 30 patients with aortic regurgitation were included to this study. Severi...

Prenatal Diagnosis of a Persistent Fifth Aortic Arch, Pulmonary-to-Systemic type: An Unusual Association with Evolving Aortic Coarctation
Persistent fifth arch (PFA) is a rare anomaly that is often underdiagnosed and missed. Different PFA types that have been reported in the literature are systemic-to-systemic type (most common), systemic-to-pulmonary artery (PA), and PA-to-systemic types. The designations of systemic-to-PA or PA-to-systemic are based on if the PFA is a source of PA or systemic blood flow, respectively, in the se...
Is Real Time Contrast Echocardiography Useful for Assessment of the Right Ventricular Morphology, Function, and Perfusion?
Contrast-enhanced echocardiography (CE) is recommended to assess left ventricular function and perfusion but is rarely used to assess the right ventricle (RV). We used CE to assess RV function and perfusion and evaluated whether RV perfusion defects varied in different patient groups with RV failure due to pressure overload. We studied 17 patients with acute pulmonary embolism (PE), 19 patients...

Left Ventricular Strain Modifications after Maximal Exercise in Athletes: A Speckle Tracking Study
The increase in systolic indexes from rest (R) to exercise is achieved by combination of enhanced heart rate (HR) and stroke volume (SV). of this study was to evaluate left ventricular (LV) longitudinal, circumferential, and torsional components immediately after a maximal intensity exercise (ME) by speckle tracking echocardiography (STE). Twenty-seven male water polo players performed an ME th...
Effects of Bone Marrow Mononuclear Cells Delivered through a Graft Vessel for Patients with Previous Myocardial Infarction and Chronic Heart Failure: An Echocardiographic Study of Left Ventricular Function
The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. The aim of this study was to evaluate the effectiveness of isolated coronary artery bypass graft combined with bone marrow mononuclear cells (BMMNC) delivered through graft vessels to improve left ventricular function of patients with previous myocardial infarction and chronic heart failure using echoca...

Leczenie zespołów mielodysplastycznych wysokiego ryzyka u dorosłych wg rekomendacji European LeukemiaNet
High-risk myelodysplastic syndromes (MDS) are defined by patients who fall into Intermediate-2 or High-risk group categories in the International Prognostic Scoring System or High/Very high in the revised IPSS (R-IPSS). High-risk MDS carry a major risk of progression to acute myeloid leukemia and short survival. Standard therapies include allogeneic stem cell transplantation, induction therapy ...
Direct Economic Burden and Influencing Factors in Patients With Hepatitis B Virus Related Diseases in Jiangsu, China
The purpose of this study was to explore direct economic burden and its influencing factors in patients with hepatitis B virus (HBV) related diseases. Time phasing continuous sampling was used to select patients from August 1, 2012, to December 31, 2012, in 3 county hospitals of 3 model regions in Jiangsu Province, China. A total of 436 outpatients and 196 inpatients were observed. The average ...
Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition
Recent discoveries suggest that N6-methyladenosine (m6A) modification, a prevalent internal modification in eukaryotic RNA, is an essential RNA regulatory mechanism. This modification is post-transcriptionally installed by m6A methyltransferases (MEL3-MEL14-WTAP complex)1,2,3,4 and oxidatively removed by m6A demethylases (FTO and ALKBH5)5, 6....
EGF promotes mammalian cell growth by suppressing cellular senescence
Cellular senescence is a state of irreversible proliferative arrest that is believed to be an important determinant of both cancer development and organismal aging1. Although numerous molecules have been found to promote senescence, little is known about the nature of anti-senescent factors under physiological conditions.