Health

The role of 3D-conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma
To evaluate the response, survival, and safety on 3-dimensional conformal radiotherapy (3D-CRT) for major portal vein tumor thrombosis (PV) combined with hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC). In this retrospective study, 83 advanced HCC patients treated with HAIC who met the following criteria were enrolled; 1) with PV of main trunk or 1st br...


Long-Term, Low-Dose Exposure to Microcystin Toxin does not Increase the Risk of Liver Tumor Development or Growth in Mice
Cyanotoxins are biological toxins produced by cyanobacteria (blue green algae) that have been implicated in the pathogenesis of liver tumors. Based on acute toxicity studies, the World Health Organization (WHO) has designated 1.0 μg/L of cyanotoxin-contaminated drinking water as the safe allowable limit for daily oral consumption. Whether long term exposure to this concentration of cyanotoxins...
Suppression of hepatocellular carcinoma development in hepatitis C patients given interferon-based anti-viral therapy
The advance of antiviral treatment for chronic hepatitis C has brought a high sustained virologic response (SVR) rate. In this review article, the suppressive effect of interferon (IFN)-based therapy on the development of hepatocellular carcinoma (HCC), risk factors for developing HCC, and the characteristics of HCC development after SVR among chronic hepatitis C patients given IFN-based therap...


The Weight-Inclusive versus Weight-Normative Approach to Health: Evaluating the Evidence for Prioritizing Well-Being over Weight Loss
Using an ethical lens, this review evaluates two methods of working within patient care and public health: the weight-normative approach (emphasis on weight and weight loss when defining health and well-being) and the weight-inclusive approach (emphasis on viewing health and well-being as multifaceted while directing efforts toward improving health access and reducing weight stigma). Data revea...
Incremental value of natriuretic peptide measurement in acute decompensated heart failure (ADHF): a systematic review
The aim of this systematic review was to determine whether B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) independently add incremental value for predicting mortality and morbidity in patients with acute decompensated heart failure (ADHF). Medline®, Embase™, AMED, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and CINAHL were sear...


Prediction of clinical outcomes using B-type natriuretic peptides in the general population: a systematic review
The use of B-type natriuretic peptides to predict outcomes in general populations has been investigated in a number of primary studies. A previous systematic review considering natriuretic peptides in cardiovascular disease included a subgroup of general population studies, which suggested an association with a number of clinical outcomes. We electronically searched Medline, Embase, AMED, Cochr...
Aspects médicaux légaux du mésusage du médicament
La notion de bon ou mauvais usage d’un médicament évolue avec la vie du médicament. Quant à la définition du mésusage, deux critères peuvent être retenus. Il peut se définir, d’une part, par le non-respect des recommandations de bonnes pratiques, et d’autre part, le mésusage peut être analysé eu égard aux pratiques des patients. Sur le plan réglementaire, un certain nombre d...

Étude de faisabilité d’un traitement par rTMS dans la fibromyalgie, à propos de 20 patients
La fibromyalgie est un syndrome douloureux chronique fréquent mais dont l’étiopathogénie demeure encore incertaine. De ce fait, faute de thérapeutique spécifique, sa prise en charge relève d’une complexité certaine dont la faible efficacité des thérapies actuellement disponibles n’est pas le seul exemple. La stimulation magnétique transcrânienne répétée (rTMS) sur le cortex ...
Novel Use of the GuideLiner Catheter to Deliver Rotational Atherectomy Burrs in Tortuous Vessels
Rotational atherectomy (RA) for heavily calcified lesions is essential for improved stent delivery and stent expansion. In tortuous vessels it is often difficult to advance the burr without rotation and possible injury to the endothelium of healthy vessel. The GuideLiner catheter, a child in mother catheter, has recently been used to allow for increased support for delivery of stents through to...

Thulium laser resection versus plasmakinetic resection of prostates larger than 80 ml
To compare the safety and efficiency of thulium laser resection of the prostate-tangerine technique (TmLRP-) and plasmakinetic resection of the prostate (PKRP) for aged symptomatic benign prostatic hyperplasia (BPH) patients with large volume prostates (>80 ml) in a prospective randomized trial with an 18-month follow-up. From January 2010 to November 2011, 90 BPH patients with large volume pr...
DNA comparison between operative and biopsy specimens to investigate stage pT0 after radical prostatectomy
The aim was to eliminate, by DNA comparison, any identity mismatch between operative and biopsy specimens and to analyse the determinants of all pT0 prostate cancers occurred in a single institution. All prostate pT0 cases in a single institution over 20 years were investigated. None of the patients had been diagnosed after a transurethral resection of the prostate nor had they received neoadj...

Symptoms, disabilities, and life satisfaction five years after whiplash injuries
Chronic whiplash-associated disorders (WADs) are often associated with social functioning problems and decreased ability to perform previous activities. This may lead to decreased life satisfaction, which is insufficiently studied in the context of whiplash injuries. Symptoms included in chronic WAD are similar to symptoms frequently reported by persons who have sustained mild traumatic brain i...
Caring for a family member with intellectual disability and epilepsy: practical, social and emotional perspectives
To examine the caregiving impact of those who support a family member with intellectual disability and epilepsy. An online, qualitative international survey was conducted via the auspices of the International Bureau of Epilepsy with various stakeholders who support individuals who have intellectual disability and epilepsy. Qualitative comments were analysed from respondents who identified thems...
Interictal ghrelin levels in adult patients with epilepsy
In vitro or in animal models of epilepsy, ghrelin showed a clear anticonvulsant action, whose mechanisms are somewhat obscure. In humans however, a controversial relation exists between ghrelin and epilepsy. Yet most studies investigated just total ghrelin levels, without a proper distinction between acylated (AG) or unacylated ghrelin (UAG). We thus evaluated separately AG and UAG interictal l...
Johns Hopkins Health System agrees to pay $190m to women filmed by doctor during pelvic exams
The Johns Hopkins Health System in Baltimore, Maryland, has agreed to pay $190m (£111m; €141m) to settle a lawsuit brought by thousands of women who were secretly filmed and photographed by a doctor.