Health

Cognitive Safety and Overall Tolerability of Imidafenacin in Clinical Use: A Long-Term, Open-Label, Post-Marketing Surveillance Study
To assess the effect of imidafenacin on cognitive function, including the conversion rate of mild cognitive impairment (MCI) to dementia, in a period of one year. Patients newly administered imidafenacin to treat overactive bladder (OAB), including those who had MCI or dementia, were surveyed across Japan (cognitive safety analysis set [CSAS]), on all of whom we performed the Mini-Mental Stat...


Klinische Ergebnisse einer multifokalen pseudophaken Zusatzlinse
Um auch bei bereits vorbestehender Pseudophakie flexibel auf den Wunsch eines Presbyopieausgleiches reagieren zu können, wurden als Alternative zu multifokalen Intraokularlinsen mit Positionierung im Kapselsack (MIOL) sulcusgestützte Zusatzlinsen entwickelt, die auch eine nachträgliche Versorgung mit multifokalen Optiken ermöglichen. Diese additiven Linsen bieten des Weiteren im Bedarfsfall...
Overall survival after immunotherapy, tyrosine kinase inhibitors and surgery in treatment of metastatic renal cell cancer: outcome of 143 consecutive patients from a single centre
The aim of this study was to evaluate overall survival (OS) after treatment of metastatic renal cell carcinoma (mRCC) following the introduction of tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors. Material and methods. One-hundred and forty-three consecutive mRCC patients were given immunotherapy (n = 59), TKIs (n = 49) or sequential therapy (IMM→TKI grou...


Improving the Oral Health of Residents with Intellectual and Developmental Disabilities: An Oral Health Strategy and Pilot Study
This article presents an oral health (OH) strategy and pilot study focusing on individuals with intellectual and/or developmental disabilities (IDD) living in group homes. The strategy consists of four components: (1) planned action in the form of the behavioral contract and caregiver OH action planning; capacity building through didactic and observation learning training; environmental adaptat...
Rivaroxaban versus low molecular weight heparin for the prevention of venous thromboembolism after hip or knee arthroplasty: A cohort study
Rivaroxaban is increasingly used to prevent venous thromboembolism after hip or knee arthroplasty. Studies evaluating the effectiveness of rivaroxaban compared to low molecular weight heparin after orthopedic surgery in routine practice are scarce. and MethodsWe conducted a retrospective cohort study in 121 hospitals in Ontario, Canada, between 2002 and 2012. We included patients aged 66 years ...


SPLA2-V impairs EPCR-dependent protein C activation and accelerates thrombosis in vivo
The endothelial protein C receptor (EPCR) must be bound to a molecule of phosphatidylcholine (PCh) to be fully functional, i.e. to interact with protein C/activated protein C (APC) properly. PCh can be replaced with other lipids like lysophosphatidylcholine or platelet activating factor by the action of secretory group V phospholipase A2 (sPLA2-V), an enzyme upregulated in a variety of inflamma...
Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells
Extracellular histones exert part of their prothrombotic activity through the stimulation of blood cells. Besides platelets, histones can bind to red blood cells (RBCs), which are important contributors to thrombogenesis, but little is known about the functional consequences of this interaction. To evaluate the effect of histones on the procoagulant potential of human RBCs with particular regar...

Improvement of myocardial fatty acid metabolism by oral nicorandil in hemodialysis patients without coronary artery disease
We investigated the potential of oral nicorandil to improve myocardial fatty acid metabolism assessed by single-photon emission computed tomography (SPECT) using 123I-β-methyliodophenyl pentadecanoic acid (BMIPP) in hemodialysis patients without obstructive coronary artery disease (CAD). This study was based on a cohort study of 155 hemodialysis patients with angiographic absence of obstructiv...
Psychische Gesundheit und Arbeitsbelastung bei Ärztinnen und Ärzten
Vor dem des Effort-Reward-Imbalance- (ERI-)Stressmodells von Siegrist wurden im Rahmen einer prospektiven Längsschnittstudie die Fragebogendaten von 120 befragten Ärztenanalysiert (Befragungszeitpunkt 1). Im Fokus dieser Studie stand die Erfassung des (Un-)Gleichgewichts zwischen Arbeitsaufwand und Anerkennung sowie die Auswirkungen auf die psychische Gesundheit. Alle Ärzte der Medizinische...

Wirkmechanismen von Antibiotika und bakterielle Resistenz
Antibiotika sind unverzichtbar zur Behandlung von bakteriellen Infektionen und zur Prävention und Therapie von Infektionen bei invasiven therapeutischen Verfahren. Sie können das bakterielle Wachstum hemmen oder die Bakterien töten, ohne den Wirt zu schädigen. Die substantiellen Unterschiede in den molekularen Strukturen zwischen Bakterien und Säugetierzellen sind die Ursachen für diese S...
Datengetriebene Ermittlung des ambulanten und stationären Antibiotikaverbrauchs am Beispiel der Stadt Dresden
Antibiotika spielen eine wichtige Rolle in der Gesundheitsversorgung, doch stellen die zunehmenden Antibiotikaresistenzen eine ernst zu nehmende atik dar. In Deutschland wird momentan der humane Antibiotikaverbrauch pro Jahr auf 250–300 t geschätzt, wobei 85 % davon auf Verordnungen im ambulanten Bereich fallen. Ziel im Projekt ANTI-Resist ist es, den ambulanten und stationären Antibioti...

The role of perceived injustice in the prediction of pain and function following total knee arthroplasty
Emerging evidence suggests that the appraisal of pain and disability in terms of justice-related themes contributes to adverse pain outcomes. To date, however, research on the relation between perceived injustice and pain outcomes has focused primarily on individuals with musculoskeletal injuries. The primary aim of this study was to investigate the role of perceived injustice in the prediction...
Association between sensitisation and pain related behaviours in an experimental canine model of osteoarthritis
Evaluation of nociceptive sensitisation in canine osteoarthritis studies has been poorly reported, or even related to other clinical symptoms. In 16 dogs, peak vertical force (PVF), subjective pain assessment using 3 scales, sympathetic stress response with electrodermal activity (EDA) measurement, and behavioural changes with video-analysis and telemetered motor activity were quantified at bas...
Physical, Lifestyle, Psychological and Social Determinants of Pain Intensity, Pain Disability and the Number of Pain Locations in Depressed Older Adults
Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain characteristics of depressed older adults and a non-depressed comparison group ...
Low back pain in children and adolescents: a systematic review and meta-analysis evaluating the effectiveness of conservative interventions
To identify and evaluate the effectiveness of conservative treatment approaches used in children and adolescents to manage and prevent low back pain (LBP). Five electronic databases and the reference lists of systematic reviews were searched for relevant studies. Randomised controlled trials (RCTs) were considered eligible for inclusion if they enrolled a sample of children or adolescents (...