Health

Existence de grade 5 sur pièce de prostatectomie totale : facteur de mauvais pronostic associé à une moindre survie sans récidive biologique
Analyser l’impact de l’existence de grade 5 de Gleason sur l’agressivité tumorale anatomopathologique et sur la survie sans récidive des patients. Trois-cent soixante-douze prostatectomies ont été réalisées entre 1999 et 2011 au sein de notre institution pour adénocarcinome prostatique localisé. Nous avons examiné l’existence du grade 5 sur la pièce opératoire afin de dé...


Dosage du PSA, biopsie, cancer et hypertrophie bénigne de la prostate en France
La fréquence des tests du prostate-specific antigen (PSA) est élevée en France. Cette étude a permis d’estimer leur fréquence et celles de biopsies et de cancer de la prostate (CPr) nouvellement diagnostiqués selon l’existence d’une hypertrophie bénigne (HBP) traitée. Cette étude observationnelle a concerné les hommes de 40ans et plus couverts par le régime général (73 % de ...
Effects of Horizontal vs. Vertical Vaginal Cuff Closure Techniques on Vagina Length after Vaginal Hysterectomy: A Prospective Randomized Study
To compare the effects of horizontal and vertical vaginal cuff closure techniques on vagina length in vaginal hysterectomy. A prospective randomized study (Canadian Task Force Classification I). Teaching and research hospital, a tertiary center. Fifty-two women with POP-Q stage 0 or 1 uterine prolapse were randomized into two groups using vertical (n = 26) or horizontal (n = 26) vaginal cuff cl...


A novel implantation technique for pudendal nerve stimulation for treatment of overactive bladder and urgency incontinence
To report about the laparoscopic implantation of neuroprothesis to the pudendal nerve (PN) for treatment for non-neurogenic bladder overactivity. Case series Classification: Level I Tertiary referral unit specialized in advanced gynaecological surgery and neuropelveology. 14 consecutive male and female patients Laparoscopic implantation of electrode to endopelvic portion of the pudendal nerve (...
Low expression of insulin-like growth factor binding protein 7 associated with poor prognosis in human glioma
To investigate insulin-like growth factor binding protein 7 (IGFBP7) mRNA levels in human glioma and normal brain tissue, and to determine their clinical significance. In this retrospective study, IGFBP7 mRNA was quantified by real-time reverse transcription–polymerase chain reaction in brain tissue samples from patients with glioma and normal control subjects. Kaplan–Meier and Cox ...


Effect of intravenous general anaesthesia with epidural block on the expression of pre-endogenous opioid peptide genes
To measure the plasma concentrations of three endogenous opioid peptides and the levels of preproenkephalin (PPE) and preprodynorphin (PPD) mRNA in peripheral blood lymphocytes of patients during scheduled surgery performed under intravenous general anaesthesia combined with an epidural block. Patients were anaesthetized and arterial blood was collected at 0 (baseline), 20, 40, 60, and 80 min d...
Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy
To determine the association between body mass index (BMI), serum prostate-specific antigen (PSA) level and PSA density (PSAD) in patients with an elevated serum PSA level but a negative prostate biopsy. This retrospective study enrolled men with a negative prostate biopsy but a serum PSA level of 3.0–10 ng/ml. All men underwent anthropometric measurements, serum PSA determination and tra...

Loudness Perception Affected by Early Age Hearing Loss
Tinnitus and hyperacusis, commonly seen in adults, are also reported in children. Although clinical studies found children with tinnitus and hyperacusis often suffered from recurrent otitis media, there is no direct study on how temporary hearing loss in the early age affects the sound loudness perception. In this study, sound loudness changes in rats affected by perforation of the tympanic mem...
Feeling safe in the plane: Neural mechanisms underlying superior action control in airplane pilot trainees—A combined EEG/MRS study
In day-to-day life, we need to apply strategies to cascade different actions for efficient unfolding of behavior. While deficits in action cascading are examined extensively, almost nothing is known about the neuronal mechanisms mediating superior performance above the normal level. To examine this question, we investigate action control in airplane pilot trainees. We use a stop-change paradigm...

Multi-atlas based representations for Alzheimer's disease diagnosis
Brain morphometry based classification from magnetic resonance (MR) acquisitions has been widely investigated in the diagnosis of Alzheimer's disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). In the literature, a morphometric representation of brain structures is obtained by spatial normalization of each image into a common space (i.e., a pre-defined atlas) via non-li...
Eosinophilic Vasculitis: Time for Recognition of a New Entity?
Hypereosinophilia is part of a group of complex disorders with multisystem involvement. A 23 year old male was admitted to our centre with bilateral popliteal artery and venous thrombosis and impending gangrene of the left forefoot along with deep venous thrombosis of the right lower extremity. Investigations revealed marked peripheral blood eosinophilia (27,669/μL). Bone marrow showed increa...

Serum concentrations of HE4 change little during in vitro fertilization
Human epididymal secretory protein 4 (HE4) is a biomarker for ovarian cancer. The effect of follicle stimulating hormone (FSH) stimulation during in vitro fertilization (IVF) on HE4 was evaluated in order to see whether substantial hormonal stimulation of the ovaries affects the serum levels of this marker. Findings were compared to serum concentrations of cancer antigen 125 (CA125), currently ...
Ultrasound-guided Prolotherapy with Polydeoxyribonucleotide Sodium in Ischiofemoral Impingement Syndrome
Ischiofemoral impingement syndrome is an uncommon disorder defined by hip pain caused by the narrowing of the space between the ischial tuberosity and lesser trochanter with associated entrapment of the quadratus femoris muscle. We effectively treated two male patients using ultrasound-guided prolotherapy with polydeoxyribonucleotide sodium mixed with local anesthetics. A 24-year-old male patie...
The Relation Between Patients' NRS Pain Scores and Their Desire for Additional Opioids after Surgery
Postoperative pain is commonly assessed through a numerical rating scale (NRS), an 11-point scale where 0 indicates no pain and 10 indicates the worst imaginable pain. Guidelines advise the administration of analgesics at NRS pain scores above 3 or 4. In clinical practice, not all patients with pain scores above the treatment threshold are willing to accept additional analgesic treatment, espec...
Measuring the Intensity of Chronic Pain: Are the Visual Analogue Scale and the Verbal Rating Scale Interchangeable?
The 0 to 100 mm visual analogue scale (VAS) and the five-category verbal rating scale (VRS) are commonly used for measuring pain intensity. An open question remains as to whether these scales can be used interchangeably to allow comparisons between intensities of pain in the clinical setting or increased statistical power in pain research. Seven hundred and ninety-six patients were requested t...