Health

Trend and seasonality in hospitalizations for pulmonary embolism.A time series analysis
The existence of seasonal variability in patients with acute pulmonary embolism (PE) has been debated for years, with contradictory results. The aim of this study was to identify the trend and possible existence of a seasonal pattern in hospitalizations for PE in Spain. We analyzed the hospital discharge database of the Spanish National Health System from 2001 to 2010. Patients aged >14 years d...


Late termination of pregnancy for lethal fetal anomalies: a national survey of maternal–fetal medicine specialists
The objective was to ascertain the practices and opinions of US maternal–fetal medicine specialists regarding termination of pregnancy as a management option following late diagnosis of lethal fetal anomalies. We conducted a cross-sectional mail survey of all US members of the Society of Maternal Fetal Medicine to ascertain how they manage pregnancies diagnosed with lethal fetal anomalies aft...
Bleeding pattern and cycle control of a low-dose transdermal contraceptive patch compared with a combined oral contraceptive: a randomized study
To investigate the bleeding pattern and cycle control of a contraceptive patch containing 0.55mg ethinyl estradiol (EE) and 2.1mg gestodene (GSD) compared with a combined oral contraceptive (COC) containing 0.02mg EE and 0.1mg levonorgestrel (LNG). In this phase III, randomized, controlled, double-blind, double-dummy, multicenter trial, healthy women aged 18–45 years (smokers aged 18–35 yea...


A comparison of bleeding patterns and cycle control using two transdermal contraceptive systems: a multicenter, open-label, randomized study
To investigate the bleeding pattern and cycle control parameters of a contraceptive patch containing 0.55mg ethinyl estradiol (EE) and 2.1mg gestodene (GSD) compared with a patch containing 0.6mg EE and 6mg norelgestromin (NGMN). In this phase III, open-label, randomized, parallel-group trial, healthy women aged 18–35 years (smokers aged 18–30 years) received either the EE/GSD patch (n =200...
Randomized comparison of bleeding patterns in women using a combined contraceptive vaginal ring or a low-dose combined oral contraceptive on a menstrually-signaled regimen
To compare bleeding patterns for 12months continuous use of a contraceptive ring (CVR) and pill (COC) on a menstrually-signaled regimen and the effectiveness of 4days “treatment withdrawal” to stop bleeding. Women, 66 to each group, were randomized to continuous use of a CVR (15μg ethinyl estradiol/150μg etonogestrel) or a low–dose pill (20μg ethinyl estradiol/100μg levonorgestrel) fo...


Sino-implant (II)® continuation and effect of concomitant tenofovir disoproxil fumarate-emtricitabine use on plasma levonorgestrel concentrations among women in Bondo, Kenya
To assess associations between tenofovir disoproxil fumarate - emtricitabine (TDF-FTC) exposure and levonorgestrel (LNG) concentrations among Kenyan HIV prevention trial participants using Sino-implant (II) LNG implants for contraception. Women were offered implants among other contraceptive methods, were randomized to daily TDF-FTC or placebo, and followed monthly up to 56weeks. Associations b...
It just happens”: A qualitative study exploring low-income women’s perspectives on pregnancy intention and planning
Unintended pregnancy is common and disproportionately occurs among low-income women. We conducted a qualitative study with low-income women to better typologize pregnancy intention, understand the relationship between pregnancy intention and contraceptive use, and identify the contextual factors that shape pregnancy intention and contraceptive behavior. Semi-structured interviews were conducted...

Nitrous oxide for pain management of first trimester surgical abortion – A randomized controlled pilot study
To determine feasibility of a study comparing mean pain scores between women randomized to nitrous oxide/oxygen (NO) versus oxygen+oral analgesics for outpatient first trimester surgical abortion. Pilot randomized controlled trial comparing NO (n=10) versus oxygen+oral analgesics (n=10). Feasibility of subject recruitment, pain and satisfaction scores on a visual analog scale was evaluated. Fif...
Le refus de soins opposé aux bénéficiaires de l’AME et de la CMU par la médecine de ville : l’exemple lyonnais
Répondant au droit fondamental qui garantit à tous la protection de la santé, l’organisation de la Sécurité sociale vise à rendre ce droit effectif. A cet effet, la loi no 98-657 du 29 juillet 1998 d’orientation relative à la lutte contre les exclusions a permis la mise en œuvre des Permanences d’Accès aux Soins de Santé (PASS). Créant une offre de soins hospitalière et ambula...

Subjective well-being in adolescence and teacher connectedness: A health asset analysis
Teacher connectedness is an important factor for young people’s well-being. The aim of this paper was to examine teacher connectedness in detail and its potential association with emotional well-being. More specifically, we set out to analyse whether teacher connectedness acted as a universal asset for boys and girls of different ages and countries as well as across adolescents with diffe...
Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis
This guideline is a revision of the clinical practice guideline, "Diagnosis and Management of Bronchiolitis," published by the American Academy of Pediatrics in 2006. The guideline applies to children from 1 through 23 months of age. Other exclusions are noted. Each key action statement indicates level of evidence, benefit-harm relationship, and level of recommendation. Key action statements ar...

Successful Management of Cryopyrin-Associated Periodic Syndrome With Canakinumab in Infancy
Neonatal onset multisystem inflammatory disease (NOMID)/chronic infantile neurologic cutaneous and articular (CINCA) syndrome is a rare, early-onset autoinflammatory disorder and the most severe form of cryopyrin-associated periodic syndrome, which is associated with overproduction of interleukin (IL)-1β. This is a case report of a 70-day-old boy, who was diagnosed with NOMID/CINCA syndrom...
Successful Use of Plasma Exchange for Profound Hemolysis in a Child With Loxoscelism
We describe a 6-year-old boy who presented with massive hemolysis, shock, disseminated intravascular coagulopathy, and acute renal failure after loxosceles envenomation. In this patient, plasma exchange therapy (PEX) successfully cleared the plasma from an initial hemolytic index of 2000 (equivalent to 2 g/dL hemoglobin, where optimetric laboratory evaluation is impossible) to an index of ...
Ten-Year Follow-Up of a DOCK8-Deficient Child With Features of Systemic Lupus Erythematosus
Dedicator of cytokinesis 8 (DOCK8) deficiency is an innate error of adaptive immunity characterized by recurrent infections with viruses, bacteria, and fungi, typically high serum levels of immunoglobulin E, eosinophilia, and a progressive deterioration of T- and B-cell–mediated immunity. DOCK8 mutations are the second most common cause of hyper–immunoglobulin E syndromes (HIES). We...
Umbilical Cord Blood Transplantation to Treat Pelizaeus-Merzbacher Disease in 2 Young Boys
Pelizaeus-Merzbacher Disease (PMD) is a rare X-linked recessive leukodystrophy caused by mutations in the proteolipid protein 1 gene on the Xq22 chromosome. PMD is a dysmyelinating disorder characterized by variable clinical presentation and course. Symptoms range from mild motor deficits to progressive spasticity and neurologic decline resulting in death at an early age. There is no definitive...