Health

Das medizinisch-ethische Dilemma von Reanimationsentscheidungen bei Notfallpatienten
Trotz etablierter Strukturen klinischer Ethikberatung steht der Notfallmediziner nach wie vor in der Notfallsituation dem gegenüber, medizinisch und ethisch sinnvolle Entscheidungen in kürzester Zeit und oft ohne Kenntnis der Patientenpräferenz treffen zu müssen, da Settings wie klinisches Ethikkomitee, Ethikkonsil oder ethische Fallbesprechung in der Notfallsituation nicht durchführbar si...


Efficacy of daily 800 IU vitamin D supplementation in reaching vitamin D sufficiency in nursing home residents: cross-sectional patient file study
The Dutch Health Council advises a standard daily vitamin D supplementation of 800 IU (20 mcg) for persons aged >= 70 years, with a target 25(OH)D serum concentration of >= 50 nmol/l. This recommendation is in line with advice from the Institute of Medicine (IOM) (2011) and the Expert Working Group on vitamin D (2012). A target 25(OH)D serum concentration of >= 75 nmol/l is also recommended in ...
Screening for markers of frailty and perceived risk of adverse outcomes using the Risk Instrument for Screening in the Community (RISC)
Functional decline and frailty are common in community dwelling older adults, increasing the risk of adverse outcomes. Given this, we investigated the prevalence of frailty-associated risk factors and their distribution according to the severity of perceived risk in a cohort of community dwelling older adults, using the Risk Instrument for Screening in the Community (RISC). A cohort of 803 comm...


The Probability of Iterated Conditionals
Iterated conditionals of the form If p, then if q, r are an important topic in philosophical logic. In recent years, psychologists have gained much knowledge about how people understand simple conditionals, but there are virtually no published psychological studies of iterated conditionals. This paper presents experimental evidence from a study comparing the iterated form, If p, then if q, r wi...
Efficacy and safety of tocilizumab in elderly patients with rheumatoid arthritis
To assess the safety and efficacy of tocilizumab (TCZ) in elderly (≥65years) rheumatoid arthritis (RA) patients treated in daily practice. We conducted a retrospective study of TCZ use in RA patients in five French university hospitals between 2009 and 2012. We considered two age groups, under 65years (<65) and over 65years (≥65). TCZ efficacy was evaluated at 24weeks by the European...


Essential role for CD103+ cells in the pathogenesis of spondyloarthritides
The clinical features of spondyloarthritides include extraarticular manifestations involving the skin, eyes, and gastrointestinal tract. At these sites, a membrane integrin can be acquired by virtue of the presence of CD4+ T cells and specific dendritic cells and correlates with a regulatory behavior of these cells. This membrane integrin conjugates the beta7 subunit and the alphaE subunit, als...
Variable phenotypes of multiple synostosis syndrome in patients with novel NOG mutations
Multiple synostosis syndrome (SYNS) is an autosomal dominant skeletal disorder characterized by facial dysmorphism, progressive fusion of multiple joints, and conductive hearing loss. Currently, three genes, NOG, GDF5, and FGF9, have been identified as causative of SYNS. However, due to the phenotypic and genotypic heterogeneity of SYNS, as well as its extreme rarity, it is difficult to diagnos...

Management of osteoporosis in women after forearm fracture: Data from a French health insurance database
Despite reliable diagnostic methods and effective drugs, the prevention and management of osteoporosis seems insufficient in France. We evaluated bone mineral density (BMD) assessment and prescription of anti-osteoporotic drugs after forearm fracture in women. We used a health insurance database for outpatients from private clinics in a French population of more than 500,000 inhabitants. Medica...
A combination of ascorbic acid and α-tocopherol to test the effectiveness and safety in the fragile X syndrome: study protocol for a phase II, randomized, placebo-controlled trial
Fragile X syndrome (FXS) is an inherited neurodevelopmental condition characterised by behavioural, learning disabilities, phisical and neurological symptoms. In addition, an important degree of comorbidity with autism is also present. Considered a rare disorder affecting both genders, it first becomes apparent during childhood with displays of language delay and behavioural symptoms. Main aim:...

The utility of fully automated real-time three-dimensional echocardiography in the evaluation of left ventricular diastolic function
A novel real-time three-dimensional echocardiography (RT3DE) system allows fully automated quantification of the left ventricular (LV) volume throughout a cardiac cycle. This study aimed to investigate whether an LV time–volume curve, obtained using fully automated RT3DE, is useful in the evaluation of LV diastolic function. First, 15 patients underwent simultaneous standard two-dimensional e...
Long-term outcomes of septal reduction for obstructive hypertrophic cardiomyopathy
Surgical myectomy and alcohol septal ablation (ASA) aim to decrease left ventricular outflow tract (LVOT) gradient in hypertrophic cardiomyopathy (HCM). Outcome of myectomy beyond 10 years has rarely been described. We describe 20 years of follow-up of surgical myectomy and 5 years of follow-up for ASA performed for obstructive HCM. We studied 171 patients who underwent myectomy for symptomatic...

Impact of low level of high-density lipoprotein-cholesterol sampled in overnight fasting state on the clinical outcomes in patients with acute myocardial infarction (difference between ST-segment and non-ST-segment-elevation myocardial infarction)
Despite good treatment, there are residual risks in acute myocardial infarction (AMI) patients, and low level of high-density lipoprotein-cholesterol (HDL) has drawn attention as a possible cause. However, the impact of low HDL on ST-segment-elevation myocardial infarction (STEMI) compared with non-ST-segment-elevation myocardial infarction (NSTEMI) is not clear. Our aim was to evaluate the imp...
Reproducibility of intravascular ultrasound radiofrequency data analysis (virtual histology) with a 45-MHz rotational imaging catheter in ex vivo human coronary arteries
Despite the frequent use of spectral analysis of intravascular ultrasound radiofrequency data (VH® IVUS) in clinical studies, the assessment for reproducibility using this with high frequency IVUS remains unexplored. The aim of this study was to examine the reproducibility of VH IVUS using 45-MHz rotational IVUS in ex vivo human coronary arteries. Data were collected using 45-MHz VH IVUS (Revo...
CD44 is required for spatial memory retention and sensorimotor functions
Cd44 is a transmembrane receptor for the glycosaminoglycan hyaluronan, a component of the extracellular matrix. cd44 is expressed by neural stem/progenitor cells, astrocytes, and some neurons but its function in the central nervous system is unknown. To determine the role of cd44 in brain function, we behaviorally analyzed cd44-null (KO) and wild-type (WT) mice. KO mice showed increased activit...
Place conditioning to apomorphine in rat models of Parkinson's disease: Differences by dose and side-effect expression
One potential complication of treating Parkinson's Disease (PD) with dopaminergic drugs is dopamine dysregulation syndrome, an addiction-like response to the drug therapy. Here, we assessed whether rats given parkinsonian-like symptoms with a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle (6-OHDA-MFB), exhibit similar behavior. To examine this, we injected these rats...