Electronic Absorption Spectra of Linear C6Br and C6Br+ in Neon Matrices
Electronic absorption spectra of linear C6Br+ and C6Br have been recorded in 6 K neon matrices. Two strong absorption systems starting at 555.1 nm and 539.3 nm are assigned to the 1 2Π ← X 2Π electronic transition of C6Br, and 1 3Σ- ← X 3Σ- of C6Br+. Excitation of normal modes along with overtones and combination bands in the excited electronic state are observed. Assignments are based ...

ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein
Systemic amyloidoses result from the secretion and proteotoxic aggregation of destabilized, amyloidogenic serum proteins, such as transthyretin. Chen et al. show that activation of the unfolded protein response transcription factor ATF6 reduces the secretion and extracellular aggregation of disease-associated transthyretin variants.
Molecular Insights into How Ligands Activate or Inactivate LasR
The article by Gerdt and colleagues in this issue of Chemistry Biology provides molecular insights into how nonlactone quorum sensing modulators either activate or deactivate LasR. Interestingly, an antagonist could flip into an agaonist upon mutation of a single residue in the autoinducer binding site.

Enzyme Dynamics and Engineering: One Step at a Time
Although protein dynamics are accepted as being essential for enzyme function, their effects are not fully understood. In this issue of Chemistry and Biology, Gobeil and coworkers describe how engineered changes in the millisecond motions of a mutant TEM-1 β-lactamase do not significantly affect substrate turnover. This mutational robustness has implications for protein engineering and design ...
ACP—AasS You Like It
Acyl carrier proteins (ACPs) are promiscuous small proteins that play essential roles in the biosynthesis of many natural products, but our understanding of how they interact with various enzymes within larger protein complexes is lacking. In this issue of Chemistry and Biology, Beld and coworkers describe an enzymatic labeling method that will allow tracking of ACPs as they interact with their...

HTS for SMFS, Organohalide Respiration, New Epigenetic Mark, and a Decoy Receptor
Each month, Chemistry Biology Select highlights a selection of research reports from the recent literature. These highlights are a snapshot of interesting research done across the field of chemical biology. This month's Select highlights an on-chip platform for high-throughput force microscopy, a structural view of organohalide respiration, evidence that 5-hydroxymethylcytosine is an epigenetic...
Inhibition of AMP Deaminase Activity Does Not Improve Glucose Control in Rodent Models of Insulin Resistance or Diabetes
AMP deaminase (AMPD) was proposed to be a potential antidiabetes drug target given its role in regulating AMPK via AMP elevation. Admyre et al. profile potent AMPD inhibitors and Ampd1-deficient mice and report that neither pharmacologic nor genetic deletion of AMPD function delivered any beneficial metabolic effects.

A Matter of Location: Influence of G-Quadruplexes on Escherichia coli Gene Expression
Holder and Hartig present results of a systematic analysis of the influence of quadruplex sequences in bacterial gene-regulatory regions. The authors observe drastic effects of four-stranded nucleic acid sequences on gene expression within designed and natural genetic contexts in a strand- and position-dependent manner.
Effects of Pharmacological AMP Deaminase Inhibition and Ampd1 Deletion on Nucleotide Levels and AMPK Activation in Contracting Skeletal Muscle
Plaideau et al. show that AMP-deaminase (AMPD) inhibition leads to a substantial enhancement of contraction-induced AMP accumulation in skeletal muscles. However, this does not always lead to the expected potentiation of AMPK activation, suggesting control by factors other than nucleotides.

Identification of a Potent Antiandrogen that Targets the BF3 Site of the Androgen Receptor and Inhibits Enzalutamide-Resistant Prostate Cancer
The androgen receptor (AR) is an intensively studied therapeutic target implicated in the development and progression of prostate cancer (PCa). Munuganti et al. report a small molecule that inhibits AR activity in a unique manner and is very potent in in vitro assays and PCa xenograft models.
A Multiply Functionalized Base-Coordinated GeII Compound and Its Reversible Dimerization to the Digermene
Stable compounds with a GeGe bond are usually prepared under relatively harsh reaction conditions that are incompatible with many functional groups. In particular, unsaturated functionalities are not tolerated owing to their facile reaction with low-coordinate germanium compounds. We now report the synthesis of an imino-functionalized germanium(II) species, stabilized by coordination of an N-he...

A New Era for ab initio Molecular Crystal Lattice Energy Prediction
From first principles: In recent studies the lattice energy of crystalline benzene was predicted with sub-kilojoule per mole accuracy. Fundamental to this success was the combination of a fragment approach with state-of-the-art electronic structure methods.
Controlled Formation of Polymer Nanocapsules with High Diffusion-Barrier Properties and Prediction of Encapsulation Efficiency
Polymer nanocapsules with high diffusion-barrier performance were designed following simple thermodynamic considerations. Hindered diffusion of the enclosed material leads to high encapsulation efficiencies (EEs), which was demonstrated based on the encapsulation of highly volatile compounds of different chemical natures. Low interactions between core and shell materials are key factors to achi...
Perfluorinated Ionomer-Enveloped Sulfur Cathodes for Lithium–Sulfur Batteries
Nafion is known to suppress the polysulfide (PS) shuttle effect, a major obstacle to achieving high capacity and long cycle life for lithium–sulfur batteries. However, elaborate control of the layer’s configuration is required for high performance. In this regard, we designed a Nafion-enveloped sulfur cathode, where the Nafion layer is formed on the skin of the cathode, covering its surface...
Zeolitic Imidazolate Frameworks: Next-Generation Materials for Energy-Efficient Gas Separations
Industrial separation processes comprise approximately 10 % of the global energy demand, driven largely by the utilization of thermal separation methods (e.g., distillation). Significant energy and cost savings can be realized using advanced separation techniques such as membranes and sorbents. One of the major barriers to acceptances of these techniques remains creating materials that are ef...