Chemistry

Hydroarylations of Heterobicyclic Alkenes through Rhodium-Catalyzed Directed CH Functionalizations of S-Aryl Sulfoximines
Rhodium-catalyzed directed CH-functionalizations have been used in hydroarylations of heterobicyclic alkenes with NH-sulfoximines. Unexpectedly, the bicyclic framework is retained, resulting in the formation of addition products being attractive intermediates for functionalized molecules that are difficult to prepare by other means. Rhodium-catalyzed hydroarylations of heterobicyclic alkenes wi...


Luminescence Color Tuning of PtII Complexes and a Kinetic Study of Trimer Formation in the Photoexcited State
We investigated the luminescence properties and color tuning of [Pt(dpb)Cl] (dpbH=1,3-di(2-pyridyl)benzene) and its analogues. An almost blue emission was obtained for the complex [Pt(Fmdpb)CN] (FmdpbH=4-fluoro-1,3-di(4-methyl-2-pyridyl)benzene), modified by the introduction of F and CH3 groups to the dpb ligand and the substitution of Cl by CN. As the concentration of the solution was increase...
Chelation in metal intoxication–principles and paradigms
The present review provides an update of the general principles for the investigation and use of chelating agents in the treatment of intoxications by metals. The clinical use of the old chelators EDTA (ethylenediamine tetraacetate) and BAL (2,3-dimercaptopropanol) is now limited due to the inconvenience of parenteral administration, their own toxicity and tendency to increase the neurotoxicity...


Novel optical selective chromone Schiff base chemosensor for Al3+ ion
A novel Schiff-base fluorescent sensor 7-methoxychromone-3-carbaldehyde-((2′-Benzothiazolylthio)-acetyl) hydrazone (MCAH) was synthesized. The new chemosensor possesses dual PET processes simultaneously introducing by both nitrogen and sulfur donors. Upon binding al3+, a significant fluorescence enhancement with a turn-on ratio over 500-fold was triggered. The detection limit of MCAH for al3+...
Interactions of DNA with graphene and sensing applications of graphene field-effect transistor devices: A review
Graphene field-effect transistors (GFET) have emerged as powerful detection platforms enabled by the advent of chemical vapor deposition (CVD) production of the unique atomically thin 2D material on a large scale. DNA aptamers, short target-specific oligonucleotides, are excellent sensor moieties for GFETs due to their strong affinity to graphene, relatively short chain-length, selectivity, and...


Rapid nucleic acid melting analyses using a microfabricated electrochemical platform
Microfabrication methods have been used to fabricate a new microscale platform that integrates thermal control and multi-electrode components to enable rapid, temperature-dependent electrochemical measurements on small-volume fluid samples. A wide range of biochemical phenomena can be characterized with the device, for example, when monitoring interactions at the working electrode between probe...
Crosslinked plastic scintillators: A new detection system for radioactivity measurement in organic and aggressive media
The measurement of radioactive solutions containing organic or aggressive media may cause stability problems in liquid and plastic scintillation (PS) techniques. In the case of PS this can be overcome by adding a crosslinker to the polymer structure. The objectives of this study are to synthesise a suitable crosslinked plastic scintillator (C-PS) for radioactivity determination in organic and a...

Rolling cycle amplification based single-color quantum dots-ruthenium complex assembling dyads for homogeneous and highly selective detection of DNA
In this work, a new, label-free, homogeneous, highly sensitive and selective fluorescent biosensor for DNA detection is developed by using rolling-circle amplification (RCA) based single-color quantum dots-ruthenium complex (QDs-Ru) assembling dyads. This strategy includes three steps: (1) The target DNA initiates RCA reaction and generates linear RCA products; the complementary DNA hybridize w...
LC–MS quantification of parthenolide and cholinesterase inhibitory potential of selected Tanacetum L. (Emend. Briq.) taxa
The acetonitrile extracts of various Tanacetum L. (Emend. Briq.) taxa from Turkey as well as parthenolide, a sesquiterpene lactone found in Tanacetum species as active substance were investigated for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the key enzymes in pathogenesis of Alzheimer's disease, at 100μgmL−1 using ELISA microplate assay....

Resorcinol and m-guaiacol alkylated derivatives and asymmetrical secondary alcohols in the leaves from Tamarix canariensis
We have discovered that leaves from the halotolerant plant saltcedar (Tamarix canariensis [Willd.]) are a source of resorcinols and guaiacols. Specifically, the waxes of the saltcedar leaves contained high amounts of 5-n-alkylresorcinols (ARs; 17g/kg dry weight), 5-n-alkyl-m-guaiacols (AGs; 14g/kg dw) and secondary alcohols (44g/kg dw). Herein we provide the report of 5-n-alkylresorcinols with ...
Lessons from molecular modeling human α-L-Iduronidase
Human α-L-iduronidase (IDUA) is a member of glycoside hydrolase family and is involved in the catabolism of glycosaminoglycans (GAGs), heparan sulfate (HS) and dermatan sulfate (DS). Mutations in this enzyme are responsible for mucopolysaccharidosis I (MPS I), an inherited lysosomal storage disorder. Despite great interest in determining and studying this enzyme structure, the lack of a high i...

Hierarchical Particle Swarm Optimizer for Minimizing theNon-Convex Potential Energy of Molecular Structure
The stable conformation of a molecule is greatly important to uncover the secret of its properties and functions. Generally, the conformation of a molecule will be the most stable when it is of the minimum potential energy. Accordingly, the determination of the conformation can be solved in the optimization framework. It is, however, not an easy task to achieve the only conformation with the lo...
Growth, structure and properties of (K1−x(NH4)x)9H7(SO4)8·H2O crystals
Single crystals of (K1− х (NH4) x ) m H n (SO4)(m + n)/2·yH2O solid solutions are grown in the K3H(SO4)2–(NH4)3H(SO4)2–H2O system which end members are known to undergo superprotonic phase transitions with essentially different kinetics. Replacements in the cation sublattice and their influence on structural transitions as well as dielectric and optical properties of these crystals are ...
Synthetic derivatives of aromatic abietane diterpenoids and their biological activities
Naturally occurring aromatic abietane diterpenoids (dehydroabietanes) exhibit a wide range of biological activities. A number of synthetic studies aimed at modifying the abietane skeleton in order to obtain new potential chemotherapeutic agents have been reported. In this study, the biological activities of synthetic derivatives of aromatic abietane diterpenoids are reviewed.
Hairpin oligonucleotides forming G-quadruplexes: New aptamers with anti-HIV activity
We describe the facile syntheses of new modified oligonucleotides based on d(TG3AG) that form bimolecular G-quadruplexes and possess a HEG loop as an inversion of polarity site 3′-3′ or 5′-5′ and aromatic residues conjugated to the 5′-end through phosphodiester bonds. The conjugated hairpin G-quadruplexes exhibited parallel orientation, high thermal stability, elevated resistance in h...