submitted by orviswopnel 2 hours ago
Electronic absorption spectra of linear C6Br+ and C6Br have been recorded in 6 K neon matrices. Two strong absorption systems starting at 555.1 nm and 539.3 nm are assigned to the 1 2Π ← X 2Π electronic transition of C6Br, and 1 3Σ- ← X 3Σ- of C6Br+. Excitation of normal modes along with overtones and combination bands in the excited electronic state are observed. Assignments are based ...
ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein
submitted by alexjohn 3 hours ago
Systemic amyloidoses result from the secretion and proteotoxic aggregation of destabilized, amyloidogenic serum proteins, such as transthyretin. Chen et al. show that activation of the unfolded protein response transcription factor ATF6 reduces the secretion and extracellular aggregation of disease-associated transthyretin variants.
submitted by ntrapec 3 hours ago
The article by Gerdt and colleagues in this issue of Chemistry Biology provides molecular insights into how nonlactone quorum sensing modulators either activate or deactivate LasR. Interestingly, an antagonist could flip into an agaonist upon mutation of a single residue in the autoinducer binding site.
submitted by onni 3 hours ago
Although protein dynamics are accepted as being essential for enzyme function, their effects are not fully understood. In this issue of Chemistry and Biology, Gobeil and coworkers describe how engineered changes in the millisecond motions of a mutant TEM-1 β-lactamase do not significantly affect substrate turnover. This mutational robustness has implications for protein engineering and design ...
submitted by FabiRow 3 hours ago
Acyl carrier proteins (ACPs) are promiscuous small proteins that play essential roles in the biosynthesis of many natural products, but our understanding of how they interact with various enzymes within larger protein complexes is lacking. In this issue of Chemistry and Biology, Beld and coworkers describe an enzymatic labeling method that will allow tracking of ACPs as they interact with their...
submitted by esmoil 3 hours ago
Each month, Chemistry Biology Select highlights a selection of research reports from the recent literature. These highlights are a snapshot of interesting research done across the field of chemical biology. This month's Select highlights an on-chip platform for high-throughput force microscopy, a structural view of organohalide respiration, evidence that 5-hydroxymethylcytosine is an epigenetic...
Inhibition of AMP Deaminase Activity Does Not Improve Glucose Control in Rodent Models of Insulin Resistance or Diabetes
submitted by 87hony 3 hours ago
AMP deaminase (AMPD) was proposed to be a potential antidiabetes drug target given its role in regulating AMPK via AMP elevation. Admyre et al. profile potent AMPD inhibitors and Ampd1-deficient mice and report that neither pharmacologic nor genetic deletion of AMPD function delivered any beneficial metabolic effects.
submitted by corlahomilenck 3 hours ago
Holder and Hartig present results of a systematic analysis of the influence of quadruplex sequences in bacterial gene-regulatory regions. The authors observe drastic effects of four-stranded nucleic acid sequences on gene expression within designed and natural genetic contexts in a strand- and position-dependent manner.
Effects of Pharmacological AMP Deaminase Inhibition and Ampd1 Deletion on Nucleotide Levels and AMPK Activation in Contracting Skeletal Muscle
submitted by eyoda86 3 hours ago
Plaideau et al. show that AMP-deaminase (AMPD) inhibition leads to a substantial enhancement of contraction-induced AMP accumulation in skeletal muscles. However, this does not always lead to the expected potentiation of AMPK activation, suggesting control by factors other than nucleotides.
Identification of a Potent Antiandrogen that Targets the BF3 Site of the Androgen Receptor and Inhibits Enzalutamide-Resistant Prostate Cancer
submitted by betes 3 hours ago
The androgen receptor (AR) is an intensively studied therapeutic target implicated in the development and progression of prostate cancer (PCa). Munuganti et al. report a small molecule that inhibits AR activity in a unique manner and is very potent in in vitro assays and PCa xenograft models.
A Multiply Functionalized Base-Coordinated GeII Compound and Its Reversible Dimerization to the Digermene
submitted by onnittiholl 3 hours ago
Stable compounds with a GeGe bond are usually prepared under relatively harsh reaction conditions that are incompatible with many functional groups. In particular, unsaturated functionalities are not tolerated owing to their facile reaction with low-coordinate germanium compounds. We now report the synthesis of an imino-functionalized germanium(II) species, stabilized by coordination of an N-he...
submitted by bobalol 3 hours ago
From first principles: In recent studies the lattice energy of crystalline benzene was predicted with sub-kilojoule per mole accuracy. Fundamental to this success was the combination of a fragment approach with state-of-the-art electronic structure methods.
Controlled Formation of Polymer Nanocapsules with High Diffusion-Barrier Properties and Prediction of Encapsulation Efficiency
submitted by firvoco 3 hours ago
Polymer nanocapsules with high diffusion-barrier performance were designed following simple thermodynamic considerations. Hindered diffusion of the enclosed material leads to high encapsulation efficiencies (EEs), which was demonstrated based on the encapsulation of highly volatile compounds of different chemical natures. Low interactions between core and shell materials are key factors to achi...
submitted by DarMisael 3 hours ago
Nafion is known to suppress the polysulfide (PS) shuttle effect, a major obstacle to achieving high capacity and long cycle life for lithium–sulfur batteries. However, elaborate control of the layer’s configuration is required for high performance. In this regard, we designed a Nafion-enveloped sulfur cathode, where the Nafion layer is formed on the skin of the cathode, covering its surface...
submitted by kosoore 3 hours ago
Industrial separation processes comprise approximately 10 % of the global energy demand, driven largely by the utilization of thermal separation methods (e.g., distillation). Significant energy and cost savings can be realized using advanced separation techniques such as membranes and sorbents. One of the major barriers to acceptances of these techniques remains creating materials that are ef...