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Two new Targeted alleles for the comprehensive analysis of Meis1 functions in the mouse
Meis1 is a highly conserved transcription factor that is activated in a regionally restricted manner from early stages of development. Meis1 belongs to the three amino acid loop extension (TALE) homeodomain family. Together with Pbx1, Meis1 plays a major role as a Hox cofactor and therefore plays an essential role in the development of several embryonic organs and systems, including limbs, hear...


Estimation of cardiac output and pulmonary vascular resistance by contrast echocardiography transit time measurement: a prospective pilot study
Studies with other imaging modalities have demonstrated a relationship between contrast transit and cardiac output (CO) and pulmonary vascular resistance (PVR). We tested the hypothesis that the transit time during contrast echocardiography could accurately estimate both CO and PVR compared to right heart catheterization (RHC). 27 patients scheduled for RHC had 2D-echocardiogram immediately pri...
Quel rôle en nutrition pour le biologiste en dehors de l’évaluation du statut nutritionnel ?
La nutrition est une discipline à composantes cliniques et biologiques visant à apporter de façon optimale l’ensemble des nutriments dont l’organisme a besoin pour croître et assurer ses différentes fonctions. L’apport de la biologie à cette discipline s’est longtemps limité, dans ses applications cliniques, à l’évaluation du statut nutritionnel des patients, au calcul de leu...


Organisation de la prise en charge en nutrition en France : CLAN, UTNC, nutrition à domicile
La prévalence de la dénutrition à l’hôpital est élevée. L’organisation de son dépistage et de sa prise en charge fait appel aux Comités de liaison alimentation-nutrition (CLAN), créés par circulaire en 2002, si possible aidés par des Unités transversales de nutrition clinique (UTNC) dont le développement est encore faible. La poursuite d’une prise en charge nutritionnelle à ...
Nutrition en cancérologie : un axe thérapeutique central
Les anomalies de l’état nutritionnel sont fréquentes chez les patients atteints de cancer. Toute intervention nutritionnelle doit être précédée d’une évaluation de l’état nutritionnel. Le meilleur indicateur clinique de dénutrition reste la cinétique de la perte de poids. Une diminution significative des capacités fonctionnelles et de la survie est observée chez les patients d...


Cytokines et réseau métabolique : un nouveau paradigme de la diabésité
L’épidémie conjointe de diabète et d’obésité actuelle met au premier plan l’impact délétère majeur d’une surcharge pondérale sur l’homéostasie métabolique. Le tissu adipeux a rapidement été désigné comme l’origine du mal mais les mécanismes physiopathologiques impliqués ont longtemps été mal compris et restent encore porteurs de zones d’ombre. De nombreux travau...
Malnutrition et sous-alimentation
La malnutrition est un état pathologique causé par l’excès ou le défaut en un ou plusieurs nutriments ; il peut s’agir d’une carence en vitamines, protéines (marasme et kwashiorkor), sels minéraux ou oligo-éléments. Les principales vitamines déficitaires appartiennent au groupe B (B1, B2, B3, B9 et B12), auxquelles s’ajoutent les vitamines lipophiles (A, D et E) et la vitamine ...

Determining the safety range of electrical pulses for two benthic invertebrates: brown shrimp (Crangon crangon L.) and ragworm (Alitta virens S.)
Pulse trawling is currently the most promising alternative for conventional beam trawls targeting sole and shrimp, meeting both the fisher's aspirations and the need for more environmentally friendly fishing techniques. Before electrotrawling can be further developed and implemented on a wider scale, however, more information is needed about the effects of electrical pulses on marine organisms....
The effects of key parameters on the transition from SI combustion to HCCI combustion in a two-stroke free piston linear engine
An investigation was conducted to examine the effects of key parameters such as intake temperature, equivalence ratio, engine load, intake pressure, spark timing and spring stiffness on the transition from SI combustion to HCCI combustion in a two-stroke free piston linear engine. Operation of the free piston engine was simulated based on the combination of three mathematical models including a...

Wave energy potential assessment in the Caribbean Low Level Jet using wave hindcast information
We investigate the wave energy potential in the Caribbean Sea using a 30-year wave hindcast. Wave energy in enclosed sea basins, such as the Gulf of Mexico and the Caribbean Sea, is commonly associated with lower energy production rates. However, an easterly zonal wind reaching 13m/s, known as the Caribbean Low-Level Jet (CCLJ), is shown to control the wave climatology in the Caribbean Sea. The...
NCCN Working Group Report: Designing Clinical Trials in the Era of Multiple Biomarkers and Targeted Therapies
Defining treatment-susceptible or -resistant populations of patients with cancer through the use of genetically defined biomarkers has revolutionized cancer care in recent years for some disease/patient groups. Research continues to show that histologically defined diseases are diverse in their expression of unique mutations or other genetic alterations, however, which presents opportunities fo...

Where Exactly Does Ponatinib Fit in Chronic Myelogenous Leukemia?
Ponatinib holds a unique place in the spectrum of drugs in use for the treatment of chronic myelogenous leukemia. It is perhaps the most active tyrosine kinase inhibitor (TKI) among those currently licensed; 51% of patients resistant to or intolerant of second-generation TKIs experienced a major cytogenetic response and 70% of patients with the highly resistant T315I BCR-ABL1 mutation experienc...
Chronic Myelogenous Leukemia, Version 1.2015
Chronic myelogenous leukemia (CML) is usually diagnosed in the chronic phase. Untreated chronic phase CML will eventually progress to advanced phase (accelerated or blast phase) CML. Tyrosine kinase inhibitors (TKIs) have been shown to induce favorable response rates in patients with accelerated and blast phase CML. The addition of TKIs to chemotherapy has also been associated with improved out...
Approach to the Management of Incidental Venous Thromboembolic Events in Patients With Cancer
Venous thromboembolism (VTE) is a frequent clinical complication of cancer and its treatment. Although much of the epidemiologic data regarding this complication have been based on symptomatic events, the use of multidetector row CT scanner technology has led to increased identification of VTE on scans ordered primarily for staging or restaging of malignancy. These incidentally discovered VTEs ...
Role of MRI in Primary Brain Tumor Evaluation
The NCCN Clinical Practice Guidelines in Oncology for Central Nervous System Cancers use radiologic presentation in the initial evaluation of patients with primary brain tumors and in the determination of response to therapy. The dominant modality use is MRI because of its superior image resolution, speed of acquisition, and high safety profile for patients. The interpretation of MRI is a criti...