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Spatio-temporal variability of hydro-chemical characteristics of coastal waters of Gulf of Mannar Marine Biosphere Reserve (GoMMBR), South India
The intention of this study was to appraise the spatial and temporal variations in the physico-chemical parameters of coastal waters of Rameswaram Island, Gulf of Mannar Marine Biosphere Reserve, south India, using multivariate statistical techniques, such as cluster analysis, factor analysis and principal component analysis. Spatio-temporal variations among the physico-chemical parameters are ...


Geomorphological analysis and prioritization of sub-watersheds using Snyder’s synthetic unit hydrograph method
The present study makes an attempt to prioritize sub-watersheds based on Snyder’s synthetic unit hydrograph method. Snyder’s method of synthetic unit hydrograph calculates peak discharge and lag time of the unit hydrograph for each sub-watersheds. Compound values of ranking are calculated from assigned rankings to parameters, viz. peak discharge and lag time. Depending on the range of the c...
Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study
The impact of in vitro resistance on initially appropriate antibiotic therapy (IAAT) remains unclear. We elucidated the relationship between non-IAAT and mortality, and between IAAT and multi-drug resistance (MDR) in sepsis due to Gram-negative bacteremia (GNS). We conducted a single-center retrospective cohort study of adult intensive care unit patients with bacteremia and severe sepsis/septic...


Effects of selective ß1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis
Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect of selective ?1-adrenoceptor blockade on cardiac and renal function and cytokine release in ovine hyperdynamic sepsis. Hyperdynamic sepsis was induced by infusion of live E. Coli for 24?...
Fabrication and characterization of curcumin-loaded silk fibroin/P(LLA-CL) nanofibrous scaffold
Curcumin exhibited excellent properties including antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, anticancer, and anticoagulant activities. In this study, curcumin was incorporated into silk fibroin (SF)/poly(L-lactic acid-co-ecaprolactone) (P(LLA-CL)) nanofibrous scaffolds via electrospinning, and changes brought about by raising the curcumin content were observed: SEM im...


Representing qualitative capacities as families of possibility measures
This paper studies the structure of qualitative capacities, that is, monotonic set-functions, when they range on a finite totally ordered scale equipped with an order-reversing map. These set-functions correspond to general representations of uncertainty, as well as importance levels of groups of criteria in multiple-criteria decision-making. We show that any capacity or fuzzy measure ranging o...
Comparative in situ analyses of cell wall matrix polysaccharide dynamics in developing rice and wheat grain
Cell wall polysaccharides of wheat and rice endosperm are an important source of dietary fibre. Monoclonal antibodies specific to cell wall polysaccharides were used to determine polysaccharide dynamics during the development of both wheat and rice grain. Wheat and rice grain present near synchronous developmental processes and significantly different endosperm cell wall compositions, allowing ...

Shoot-derived signals other than auxin are involved in systemic regulation of strigolactone production in roots
Nitrogen and phosphorus fertilization in one side of split-root sorghum plants systemically reduced root contents of strigolactones in both sides of the split roots. Shoot-derived signals other than auxin appeared to be involved in this process. Strigolactones (SLs) are a novel class of plant hormones regulating both shoot and root architectures and suggested to be functioning downstream of aux...
Conformationally-locked N-glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease
Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit an unprecedented specificity as inhibitors of mammalian β-glucosidase. Notably, their inhibitory potency against human β-glucocerebrosidase (GCase) was found to be strongly dependent on the nature of aglycone-type moieties attached at the sulfur atom. In the particular ...

Treatment compliance or medication adherence in children and adolescents on ADHD medication in clinical practice: results from the COMPLY observational study
Although the efficacy and tolerability of ADHD medications have been investigated fairly extensively, there are very few data comparing the different types of medication (e.g. psychostimulants, non-stimulants) in terms of medication adherence. The primary research objective of the COMPLY observational study was to evaluate medication adherence (i.e. compliance) over 1 year in children and adol...
Combustion noise
Combustion noise is becoming increasingly important as a major noise source in aeroengines and ground based gas turbines. This is partially because advances in design have reduced the other noise sources, and partially because next generation combustion modes burn more unsteadily, resulting in increased external noise from the combustion. This review reports recent progress made in understandin...

Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: Prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma
Beclin-1 induces autophagy, which is known to be involved in many physiopathological processes such as cell development, aging, stress response, immune response and cancer. Several studies showed that Beclin-1 expression is associated with several prognostic factors of gastric carcinomas. Recently, the connection between autophagy and the hedgehog (HH) signaling pathway has been studied. Here, ...
Mycorrhizal phenotypes and the Law of the Minimum
Mycorrhizal phenotypes arise from interactions among plant and fungal genotypes and the environment. Differences in the stoichiometry and uptake capacity of fungi and plants make arbuscular mycorrhizal (AM) fungi inherently more nitrogen (N) limited and less phosphorus (P) limited than their host plants. Mutualistic phenotypes are most likely in P-limited systems and commensal or parasitic phen...
Differential evolution of members of the rhomboid gene family with conservative and divergent patterns
Rhomboid proteins are intramembrane serine proteases that are involved in a plethora of biological functions, but the evolutionary history of the rhomboid gene family is not clear. We performed a comprehensive molecular evolutionary analysis of the rhomboid gene family and also investigated the organization and sequence features of plant rhomboids in different subfamilies. Our results showed th...
Do water-limiting conditions predispose Norway spruce to bark beetle attack?
Drought is considered to enhance susceptibility of Norway spruce (Picea abies) to infestations by the Eurasian spruce bark beetle (Ips typographus, Coleoptera: Curculionidae), although empirical evidence is scarce. We studied the impact of experimentally induced drought on tree water status and constitutive resin flow, and how physiological stress affects host acceptance and resistance. We esta...