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Junctional adhesion molecule-A, an epithelial-mesenchymal transition inducer, correlates with metastasis and poor prognosis in human nasopharyngeal cancer
Junctional adhesion molecule-A (JAM-A) is preferentially concentrated at tight junctions and influences epithelial cell morphology and migration. Epithelial-to-mesenchymal transition (EMT) is the conversion process of epithelial cells into mesenchymal cells, and it plays an important role in the invasiveness and metastasis of various cancers. However, the role of JAM-A in regulating the invasiv...


CYP2A6 Reduced Activity Gene Variants Confer Reduction in Lung Cancer Risk in African American Smokers - Findings from Two Independent Populations
We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African American smokers, a high-risk population. Previously, we found that CYP2A6, a nicotine/nitrosamine metabolism gene, was associated with lung cancer risk in European Americans, but smoking habits, lung cancer risk, and CYP2A6 gene variants differ significantly between European and African ancestry populatio...
Interferon treatment of human keratinocytes harboring extrachromosomal, persistent HPV-16 plasmid genomes induces de novo viral integration
Interferons (IFNs) have been used to treat epithelial lesions caused by human papillomavirus (HPV) persistence. Here, we exposed primary human keratinocytes (HFKs) immortalized by persistently replicating HPV-16 plasmid genomes to increasing levels of IFN-. While untreated HFKs retained replicating HPV-16 plasmids for up to 60-120 population doublings, IFN led to rapid HPV-16 plasmid loss. Howe...


Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction
The neuroprotective effects of carnosic acid (CA), a phenolic diterpene isolated from rosemary (Rosmarinus officinalis), have been widely investigated in recent years, however, its protection in in vivo still unclear. In this study, we investigated the behavioral activity and neuroprotective effects of CA in a rat model of Parkinson’s disease (PD) induced by 6-hydroxydopamine (6-OHDA). Rats w...
Down-regulation of aldo-keto reductase AKR1B10 gene expression by a phorbol ester via the ERK/c-Jun signaling pathway
Akr1b10 is a human member of the aldo-keto reductase (AKR) superfamily, and is considered to be a tumor biomarker because its expression is known to be significantly induced in the cells of various cancers such as lung non-small-cell carcinoma and hepatocellular carcinoma. However, the mechanisms underlying the regulation of its gene remain unclear. In the present study, we demonstrated that th...


Insights from exceptionally preserved Cenomanian trocholinids (benthic foraminifera) of northern Cantabria, Spain
Rich and diverse trocholinid assemblages have been recorded from the lower to middle Cenomanian Altamira and Bielba formations of the Bascocantabrian Basin, northern Spain. They occur in bioclastic for-algal grainstones and near-reefal rudstones referred to platform margin environments. This material, partially impregnated by iron-rich solutions, is unusually well-preserved and offers the uniqu...
Development of cutting edge geometries for hard milling operations
Milling of hardened steels is a challenging task for mould and die manufacturing due to the high material strength. One major drawback is the tool wear, which is a result of the high thermo-mechanical stress on the tool. The wear rate can generally be influenced by the tool geometry, coatings and substrates. A further approach is to modify the flank face of the tool, which leads to geometrical ...

Heat Treatment of Cr- and Cr-V ledeburitic tool steels
Cr- and Cr-V ledeburitic cold work tool steels belong to the most important tool materials for large series manufacturing. To enable high production stability, the tools must be heat treated before use. This overview paper brings a comprehensive study on the heat treatment of these materials, starting from the soft annealing and finishing with the tempering. Also, it describes the impact of any...
Inducible expression of noggin selectively expands neural progenitors in the adult SVZ
Multipotent, self-renewing stem cells are present throughout the developing nervous system remaining in discrete regions of the adult brain. In the subventricular zone (SVZ) signaling molecules, including the bone morphogenetic proteins and their secreted inhibitor, noggin appear to play a critical role in controlling neural stem cell (NSC) behavior. To examine the function of this signaling pa...

Minor salivary gland tumors in the Indian population: A series of cases over a ten year period
Minor salivary glands are found in the sino-nasal cavities, oropharynx, larynx and trachea with the majority being found in the oral cavity. 80% or more of minor salivary gland tumors are malignant and they tend to have a great variation in presentation and histology. We sought out to compare the presentation of various minor salivary gland tumors (MSGT's) in the Indian population as compared t...
Long term dento-facial effects of radiotherapy in a treated patient of retinoblastoma
Newer cancer treatment modalities have increased patient survival rate and longevity. Craniofacial and dental abnormalities occurring after radiation therapy and surgery in cancer patients may lead to severe cosmetic or functional sequelae, which may require surgical or orthodontic intervention later on. We, present a case; who was treated for retinoblastoma with enucleation of left eye and ext...

Aggregate dynamics and associated soil organic matter in topsoils of two 2,000-year paddy soil chronosequences
Paddy chronosequence provides a unique way to investigate soil development. This study investigated dynamic profiles of aggregate and soil organic matter in topsoils of two 2,000-year paddy chronosequences. Based on an investigation of paddy soil surveys on the south bank of Hangzhou Bay, the paddy soil chronosequence derived from marine sediments in Shangyu City (5- to 2,000-year (yr) rice cul...
Pilot-scale evaluation of an in situ amendment delivery and mixing device for contaminated sediment remediation applications
In situ sediment treatment technologies can be more economical alternatives than dredging and ex situ treatment; however, their development and application had been hindered due to uncertainties associated with the homogeneity of amendment delivery and mixing and the concern of contaminated sediment resuspension and amendment release into the water column. The purpose of this study was to evalu...
Sorption behaviours and transport potentials for selected pharmaceuticals and triclosan in two sterilised soils
Pharmaceuticals and personal care products (PPCPs) are emerging environmental pollutants, which, in addition to direct deposition processes, can find their way into surface soils through the agricultural application of sewage sludge and irrigation practices using contaminated wastewater. Therefore, it is important to assess the extent to which soils are able to retain PPCPs and to prevent their...
Simple uniform exponential stability conditions for a system of linear delay differential equations
Uniform exponential stability of linear systems with time varying coefficients x ̇ i ( t ) = - ∑ j = 1 m ∑ k = 1 r ij a ij k ( t ) x j ( h ij k ( t ) ) , i = 1 , … , m is studied, where t ⩾ 0 , m and r ij , i , j = 1 , … , m are natural numbers, a ij k : [ 0 , ∞ ) → R and h ij k ...