RSS feed 

View All

Acute pneumonitis consequent on pleurodesis with Viscum album extract: severe chest images but benign clinical course
Chemical pleurodesis is widely recommended in the treatment of pulmonary air leak of different etiologies as well as malignant pleural effusions and chylothorax. Conventional chemical pleurodesis using erythromycin, tetracycline, hydrophilic fumed silica, autologous blood and talc slurry has been standardized, and its complications, including high fever, intractable chest pain, and acute lung i...


Field Testing of Suction Anchors for Mooring Applications
Suction anchors are among the popular type of anchors used for mooring/position keeping of floating vessels in deep waters. It comprises a cylindrical anchor, closed at the top and achieves penetration into the seabed by applying vacuum pressure inside the anchor. In order to arrive at guidelines for design of such anchors, field tests have been conducted on suction anchors with varying diamete...
Gastric and esophageal metastases in renal cell carcinoma: systematic review and management options
Renal cell cancer (RCC) has been rarely reported as a cause of gastric (GM) or esophageal metastases (EM). The aim of this review was to study the clinical characteristics, management, and outcome of GM and EM in RCC. A systematic review of the literature was conducted by searching four major online databases. Sixty-eight cases were identified: 64 with GM, and 6 with EM (2 had coincident GM and...


Influences of nano-chitosan treatment on physical, mechanical properties and bio resistance of wood
Effects of nano-chitosan on physical and mechanical properties as well as bio-resistances of beech and fir wood were investigated in the current research work. nano-chitosan was prepared and used to treat wood due its smaller size and also stability of the solution. Beech and fir wood blocks were treated with chitosan and nano-chitosan as 1 % concentrations to determine their physical and mech...
Mission BION-M1: Results of RIBES/FOAM2 experiment on shape memory polymer foams and composites
Foam2 is an experiment in microgravity conditions which was performed on 20th of April 2013 during the BION-M1 mission of the Soyuz spacecraft. The experiment was carried out by an autonomous device contained in the BIOKON container (by Kayser Italia) which was in turn assembled in a properly designed payload (called RIBES, “Reconfigurable Incubator for Biology Experiments in Space”). The m...


Suboptimal continuous torque attitude maneuvers for underactuated spacecraft
This work provides a suboptimal continuous torque solution for controlling an underactuated spacecraft using two control inputs. A sequential submaneuver strategy is proposed. Classical quadratic penalty approaches for the control lead to jump discontinuities in the resulting control time history that can potentially excite an unwanted flexible body response. To address this operational concern...
Task-Specificity of Bilateral Anticipatory Activation of the Deep Abdominal Muscles in Healthy and Chronic Low Back Pain Populations
Cross-sectional study of lumbopelvic muscle activation during rapid limb movements in chronic low back pain (CLBP) patients and healthy controls. Controversy exists over whether bilateral anticipatory activation of the deep abdominal muscles represents a normal motor control strategy prior to all rapid limb movements, or if this is simply a task-specific strategy appropriate for only certain mo...

CXCL14 is no direct modulator of CXCR4
C-x-c motif chemokine 12/C-X-C chemokine receptor type 4 (CXCL12/CXCR4) signaling is involved in ontogenesis, hematopoiesis, immune function and cancer. Recently, the orphan chemokine CXCL14 was reported to inhibit CXCL12-induced chemotaxis – probably by allosteric modulation of CXCR4. We thus examined the effects of CXCL14 on CXCR4 regulation and function using CXCR4-transfected human embryo...
Ghrelin augments murine T-cell proliferation by activation of the phosphatidylinositol-3-kinase, extracellular signal-regulated kinase and protein kinase C signaling pathways
Thymic atrophy occurs during normal aging, and is accelerated by exposure to chronic stressors that elevate glucocorticoid levelsand impair the naïve T cell output. The orexigenic hormone ghrelin was recently shown to attenuate age-associated thymic atrophy. Here, we report that ghrelin enhances the proliferation of murine CD4+ primary T cells and a CD4+ T-cell line. Ghrelin induced activation...

Epigenetic Regulation of the NR4A Orphan Nuclear Receptor NOR1 By Histone Acetylation
The nuclear receptor NOR1 is an immediate-early response gene implicated in the transcriptional control of proliferation. Since the expression level of NOR1 is rapidly induced through cAMP response element binding (CREB) protein-dependent promoter activation, we investigated the contribution of histone acetylation to this transient induction. We demonstrate that NOR1 transcription is induced by...
Identification of the WNT1 residues required for palmitoylation by Porcupine
The post-translational palmitoylation of WNT morphogens is critical for proper signaling during embryogenesis and adult homeostasis. The addition of palmitoyl groups to WNT proteins is catalyzed by Porcupine (PORCN). However, the Wnt amino acid residues required for recognition and palmitoylation by PORCN have not been fully characterized. We show that WNT1 residues 214–234 are sufficient for...

An engineered dimeric fragment of hepatocyte growth factor is a potent c-MET agonist
Hepatocyte growth factor (HGF), through activation of the c-MET receptor, mediates biological processes critical for tissue regeneration; however, its clinical application is limited by protein instability and poor recombinant expression. We previously engineered a HGF fragment (eNK1) that possesses increased stability and expression yield, and developed a c-MET agonist by coupling eNK1 through...
Glutamine Synthetase Desensitizes Differentiated Adipocytes to Proinflammatory Stimuli by Raising Intracellular Glutamine Levels
The role of glutamine synthetase (GS) during adipocyte differentiation is unclear. Here, we assess the impact of GS on the adipocytic response to a proinflammatory challenge at different differentiation stages. GS expression at the late stages of differentiation desensitized mature adipocytes to bacterial lipopolysaccharide (LPS) by increasing intracellular glutamine levels. Furthermore, LPS-ac...
MiR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3
MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3 protein levels by interacting with the 3′UTR of ATXN3 mRNA. miR-25 also increased cell viability, decreased early apoptosis,...
Reducing Prejudice Across Cultures via Social Tuning
This research examines whether culture influences the extent to which people’s attitudes tune toward others’ egalitarian beliefs. Hong Kong Chinese, but not American, participants were less prejudiced, explicitly and implicitly, toward homosexuals when they interacted with a person who appeared to hold egalitarian views as opposed to neutral views (Experiment 1). In Experiments 2 an...