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Properties of the marginal survival functions for dependent censored data under an assumed Archimedean copula
Given a random sample from a dependent censored variable ( X , δ ) = ( min ( T , C ) , 1 ( T < C ) ) , general formulas are given for possible marginal survival functions of the failure time T and the censoring time C under the assumption that their underlying copula is Archimedean. These formulas are used to establish the relationship between these possible survival func...


Predictors of Co-Occurring Risk Behavior Trajectories Among Economically Disadvantaged African-American Youth: Contextual and Individual Factors
African-American youth, particularly those from low-income backgrounds, evidence high rates of negative outcomes associated with three problem behaviors, conduct problems, risky sexual behavior, and substance use. This study used a contextually tailored version of problem behavior theory (PBT) to examine predictors of the simultaneous development of problem behaviors in this specific cultural g...
Many L-Shaped Polyominoes Have Odd Rectangular Packings
A polyomino is called odd if it can tile a rectangle using an odd number of copies. We give a very general family of odd polyominoes. Specifically, consider an L-shaped polyomino, i.e., a rectangle that has a rectangular piece removed from one corner. For some of these polyominoes, two copies tile a rectangle, called a basic rectangle. We prove that such a polyomino is odd if its basic rectangl...


Predictive value of CHFR and MLH1 methylation in human gastric cancer
Gastric carcinoma (GC) has one of the highest mortality rates of cancer diseases and has a high incidence rate in China. Palliative chemotherapy is the main treatment for advanced gastric cancer. It is necessary to compare the effectiveness and toxicities of different regimens. This study explores the possibility of methylation of DNA damage repair genes serving as a prognostic and chemo-sensit...
Thermal and mechanical stability of a circular porous plate with piezoelectric actuators
In this study, thermal and mechanical stability of solid circular plate which is made of saturated and unsaturated porous material with piezoelectric actuators is investigated. The edge of the plate is clamped, and the plate is assumed to be geometrically perfect. The effect of porosity on mechanical and thermal buckling loads is investigated in this study. The results show that the effect of p...


Modeling and parameter analysis of in-plane dynamics of a suspension bridge with transfer matrix method
In this paper, the model of a suspension bridge is composed of the main cable and beam with many discrete springs, which are used to model columns between the main cable and the deck. Based on Hamilton’s variational principle, the governing equations for the in-plane dynamics of the model are obtained. The static and dynamic configuration of the beam and cable is considered in the derivation ...
Ventriculoperitoneal Shunt Infection Caused by Bifidobacterium breve
Bifidobacterium breve is a rare cause of human infections. Previously, bacteremia and meningitis caused by this organism linked to probiotic use have been reported in a neonate. We report the first case of a ventriculoperitoneal shunt infection caused by B. breve in an adult without a history of probiotic use.

The rough set based approach to generic routing problems: case of reverse logistics supplier selection
In recent years, Reverse Logistics (RL) has been touted as one of the strategies of improving organization performance and generating a competitive advantage. In RL, the generic routing problem has become a focus since it provides a great flexibility in modeling, e.g., selection of suppliers by using a node as a supplier candidate in a network. To date, complicated networks make decision makers...
Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease
Down syndrome (DS) is the most common genetic cause of intellectual disability, due to partial or complete triplication of chromosome 2DS subjects are characterized by a number of abnormalities including premature aging and development of Alzheimer disease (AD) neuropathology after approximately 40 years of age. Several studies show that oxidative stress plays a crucial role in the development ...

Detection of superoxide production in stimulated and unstimulated living cells using new cyclic nitrone spin traps
Reactive oxygen species (ROS), including superoxide anion and hydrogen peroxide (H2O2), have a diverse array of physiological and pathological effects within living cells depending on the extent, timing, and location of their production. For measuring ROS production in cells, the ESR spin trapping technique using cyclic nitrones distinguishes itself from other methods by its specificity for sup...
Kinetics and mechanism of auto- and copper-catalyzed oxidation of 1,4-naphthohydroquinone
Although quinones represent a class of organic compounds that may exert toxic effects both in vitro and in vivo, the molecular mechanisms involved in quinone species toxicity are still largely unknown, especially in the presence of transition metals, which may both induce the transformation of the various quinone species and result in generation of harmful reactive oxygen species. In this study...

Activation of c-Src: A hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling
To study the role of c-Src kinase in pro-oxidant-induced stimulation of Toll-like receptor 4 (TLR4), we used lipopolysaccharide from Escherichia coli K12 (LPS-EK) and monophosphoryl lipid A, as TLR4-specific agonists and positive controls, and SIN-1 and potassium peroxychromate as pro-oxidant sources. We used the HEK-Blue mTLR4 cell line, which is stably transfected with mouse TLR4 and expresse...
Reactive oxygen species are physiological mediators of the noradrenergic signaling pathway in the mouse supraoptic nucleus
Free radicals are essential for the vasopressin (AVP) response to plasmatic hyperosmolarity. Noradrenergic afferents are the major projections on the supraoptic nucleus (SON) of the hypothalamus and stimulate the expression of AVP via a nitric oxide (NO) pathway. In this study, we investigated the mechanisms linking free radicals and noradrenaline (NA)-induced regulation of AVP. Analysis of Tg8...
Proteasome activation delays aging in vitro and in vivo
Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded, or aggregated proteins. In particular, the proteasome is responsible for the removal of normal as well...
Glut4 Expression Defines An Insulin-Sensitive Hypothalamic Neuronal Population
Insulin signaling in the CNS modulates satiety and glucose metabolism, but insulin target neurons are poorly defined. We have previously shown that ablation of insulin receptors (InsR) in Glut4-expressing tissues results in systemic abnormalities of insulin action. We propose that Glut4 neurons constitute an insulin-sensitive neuronal subset. We determined their gene expression profiles using f...