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Transgenerational effects of obesogens and the obesity epidemic
In the last three decades there has been a dramatic, worldwide increase in the incidence of obesity, particularly in Western societies. This trend has required a significant economic investment to treat obesity-related disorders such as type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. There is an urgent need to understand the factors that contribute to this increa...


Targeting metabotropic glutamate receptors (mGluRs) in Parkinson's disease
The interplay between dopamine and glutamate in the basal ganglia regulate critical aspects of motor and cognitive behavior. Metabotropic glutamate (mGlu) receptors are key modulators of glutamatergic dysfunction in Parkinson's disease (PD). Preclinical evidence demonstrate that group I mGlu receptor antagonism and groups II and III mGlu receptor activation improve motor symptomatology of PD an...
Targeting glutamatergic synapses in Parkinson's disease
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons of the substantia nigra and dramatic motor and cognitive impairments. The current knowledge indicates that the strength of glutamatergic signals from the cortex to the striatum is regulated during the progression of the disease. The efficacy of ionotropic glutamate receptors to modulate synaptic transm...


Semiconductor–metal and metal–semiconductor transitions in twisting graphene nanoribbons
The electronic structure and transport properties of twisting graphene nanoribbons (TGNRs) are systematically investigated using the tight-binding model and the non-equilibrium Green’s function method. We show that the energy gap and conductance around the Fermi energy can be reversibly modulated. Armchair TGNRs (ATGNRs) can be either metallic or semiconducting depending on the widths and the...
Vanadium doped barium germanate microrods and photocatalytic properties under solar light
Vanadium doped barium germanate microrods have been prepared by a facile hydrothermal process. The obtained vanadium doped barium germanate microrods are proved to be hexagonal BaGe4O9 and orthorhombic Ba2V2O7 phases by X-ray diffraction. Scanning electron microscopy shows that the vanadium doped barium germanate products consist of microrods with the diameter of microscale size. The diameter o...


Ab initio study of electronic density of state and photoabsorption of Ga1−xMnxAs under pressure
Ab initio calculation based on density functional theory was performed for studying high-pressure effects on the electronic properties and photoabsorption of Ga1−x Mn x As. Mn atom was substituted into the varied GaAs super cells, which observed the Mn concentrations at 3.70%, 8.33% and 12.50%. In zinc blende phase of Ga1−x Mn x As, we found that the effects of Mn on GaAs in the pressure ra...
Pareto optimal allocations and optimal risk sharing for quasiconvex risk measures
The main goal of this paper is to generalize the characterization of Pareto optimal allocations known for convex risk measures (see, among others, Jouini et al., in Math Financ 18:269–292, 2008 and Filipovic and Kupper, in Int J Theor Appl Financ, 11:325–343, 2008) to the wider class of quasiconvex risk measures. Following the approach of Jouini et al., in Math Financ 18:269–292, 2008 for...

Pay for performance under hierarchical contracting
We consider a simple hierarchical contracting problem where the principal contracts the top manager who in turn subcontracts many middle managers. We show that that the top managerial contract is lower-powered and middle managerial contracts are higher-powered in incentives than predicted by the standard agency model. Consequently, at optimum, middle managers work harder, and the CEO (top manag...
Accounting and happiness
This paper begins with the observation that happiness is the primary goal of human endeavour. One critical element of human endeavour is business, leading to the proposition the primary objective of business is to contribute to happiness, with profit being a means towards this end. This central idea linking business and the pursuit of happiness is used to critique the capability of accounting t...

To verify and compare denoising of ECG signal using various denoising algorithms of IIR and FIR filters
Electrocardiogram (ECG) plays an important role in diagnostics of cardiac diseases. In general, ECG signals are affected by noises during data acquisition. For accurate treatment, doctors need noise-free ECG signals. This paper presents a detailed analysis of algorithms for denoising ECG signals using different IIR filters like Butterworth filter, Elliptic Filter, Types I and II Chebyshev, and ...
Using IS/IT to support the delivery of Chinese medicine: a Chinese medicine clinic management system
OECD countries today are focusing on ways to incorporate IS/IT to facilitate superior healthcare delivery. However, studies of IS/IT implementations for Chinese Medicine (CM) practice are very limited. We analyse western medicine (WM) and CM diagnosis and treatment processes and find that these clinical processes share some similarities. Hence, we contend that by implementing IS/IT system solut...

Performance evaluation of immune-inspired support vector machine
Immune-inspired approach designs ensembles of medical images for classification problems using neural network. Immune SVM is a classification algorithm that replaces the traditional SVM by optimising the parameters of SVM. Among the additional attributes provided by the SVM, the immune algorithm invokes automatic control to the population size along the search, improves the convergence speed an...
Analysis of restrictive pulmonary function abnormality using spirometric investigations and QPSO feature selection
Restrictive pulmonary disorders are leading cause of morbidity and mortality worldwide. Spirometric pulmonary function test is the most common method used to assess restrictive disorder. The sub-maximal effort of the patients may often lead to misclassification due to large interdependency among the spirometric parameters. Also, there is requirement that too many parameters are to be analysed b...
Measurement of the viscosity of freeze dried amorphous lactose near the glass transition temperature
In the literature, the value of the viscosity of amorphous lactose at its glass transition point (T g ) has been assumed to be 1012 Pa s, which is the assumed value for glasses at their transition point, but no one has actually measured it. This paper gives the details of a method, based on parallel plate rheometry, used to determine the viscosity of amorphous lactose near its glass transition...
Enhanced spread spectrum aloha demodulator implementation, laboratory tests and satellite validation
This paper describes the implementation of the first enhanced spread spectrum aloha demodulator, based on an innovative architecture which combines software-defined radio with processing via commercial graphics processing units. The validation tests performed both in laboratory conditions and directly on the satellite EUTELSAT 10A are presented. The performance assessment results obtained via s...