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Prevention of head and neck squamous cell carcinoma: Removing the “chemo” from “chemoprevention
The concept of chemoprevention whereby the use of a systemic agent is intended to halt the carcinogenesis process has been an attractive topic in head and neck squamous cell carcinoma (HNSCC). Yet, despite the significant efforts over the past decades and the substantial gain in knowledge of the biology of pre-malignant lesions of the head and neck, no tangible indications for chemoprevention h...


MicroRNA-29b regulates migration in oral squamous cell carcinoma and its clinical significance
MicroRNA (miRNA) machinery regulates cancer cell behavior, and has been implicated in patients’ clinical status and prognosis. We found that microRNA-29b (miR-29b) increased significantly in advanced migratory cells. However, miR-29b controls the migration ability, and its regulatory mechanism in oral squamous cell carcinoma (OSCC) remains unknown. We triggered miR-29b expression in OSCC pati...
Recurrence in regional lymph nodes after total thyroidectomy and neck dissection in patients with papillary thyroid cancer
We investigated the risk factors of the regional lymph node (LN) recurrence in papillary thyroid cancer (PTC) patients underwent thyroidectomy and neck dissection according to the clinicopathologic features, preoperative clinical nodal status and the recurrence in previously dissected or undissected compartment of the neck. A retrospective analysis was performed on 297 patients who underwent to...


PANORMUS-SPH. A new Smoothed Particle Hydrodynamics solver for incompressible flows
A new Smoothed Particle Hydrodynamics (SPH) solver is presented, fully integrated within the PANORMUS package , originally developed as a Finite Volume Method (FVM) solver. The proposed model employs the fully Incompressible SPH approach, where a Fractional Step Method is used to make the numerical solution march in time. The main novelty of the proposed model is the use of a general and highly...
A nonoverlapping heterogeneous domain decomposition method for three-dimensional gravity wave impact problems
A 3D heterogeneous flow model which combines incompressible viscous flow and potential flow both with free-surface boundaries is developed and solved numerically, using finite element method and boundary element method, respectively. The coupled model is solved based on a nonoverlapping domain decomposition method, which reduces the problem to the coupling interface. at the interface, the probl...


An adaptive immersed boundary-lattice Boltzmann method for simulating a flapping foil in ground effect
An adaptive immersed boundary-lattice Boltzmann method (IB-LBM) for simulating two-dimensional moving boundary problems is presented in this work. On one hand, to accurately and efficiently simulate flow field, our recently developed solution-adaptive LBM (Wu and Shu, 2011) is employed. On the other hand, a smoothed discrete delta function (Yang et al., 2009) is utilized to suppress the non-phy...
Influence of synthetic inlet turbulence on the prediction of low Mach number flows
Time-resolved numerical simulations of fluid flows, such as Large Eddy Simulations (LES), have the capability of simulating the unsteady dynamics of large scale energetic structures. However, they are known to be intrinsically sensitive to inflow conditions the modeling of which may become a crucial ingredient of the computational model. The present work reports LES of both reactive and non-rea...

Natural convection flow of viscous fluid over triangular wavy horizontal surface
The purpose of this paper is to conduct a numerical study of natural convection flow along an irregular semi-infinite triangular wavy horizontal surface. Coordinate transformation is introduced to transform the boundary layer equations into a form which is more suitable for numerical integration. Implicit finite difference iterative numerical scheme is employed to produce solutions of the probl...
Prediction of the unsteady turbulent flow in an axial compressor stage. Part 1: Comparison of unsteady RANS and LES with experiments
A better understanding of turbulent unsteady flows is a necessary step towards a breakthrough in the design of modern gas turbine components. With the increase in computing power, LES emerges as a promising method to improve both knowledge of complex physics and reliability of flow solver predictions. However, there is still a lack of evidences in the literature that LES is applicable for turbo...

Optimised active flow control for micromixers and other fluid applications: Sensitivity- vs. adjoint-based strategies
Active flow control to improve performances and efficiencies of technical fluid systems is of significant importance in many engineering applications. In this work, we investigate two optimisation strategies that are commonly used for systems which can be described by partial differential equations, namely the adjoint-based and the sensitivity-based approach. The approaches are reviewed and the...
Prediction of the unsteady turbulent flow in an axial compressor stage. Part 2: Analysis of unsteady RANS and LES data
This paper presents the analysis of URANS and LES database in a stage of an axial subsonic compressor. Details about numerical methods and comparison with experiments can be found in a companion paper. The analysis here focuses on the transition processes that take place in the rotor and stator rows. In the rotor, LES and URANS show that transition develops at mid-chord and is induced by the ad...

A general framework for computing the turbulence structure tensors
Good measures of the turbulence structure are important for turbulence modeling, flow diagnostics and analysis. Structure information is complementary to the componentality anisotropy that the Reynolds stress tensor carries, and because structures extend in space, structure information is inherently non-local. Given access to instantaneous snapshots of a turbulence field or two-point statistica...
Experimental study of hydraulic cylinder leakage and fault feature extraction based on wavelet packet analysis
Hydraulic cylinder is the actuator in hydraulic system, and its failure directly affects the normal operation of the system. The leakage of hydraulic cylinder is a major failure mode usually caused by failure or damage of the seal, and it should be detected as early as possible to avoid worse breakdowns of system. However, the leakage is difficult to be diagnosed in the early stage, so the basi...
Numerical simulation of wave interaction with vertical circular cylinders of different submergences using immersed boundary method
A three-dimensional numerical model has been developed to simulate wave-structure interaction over an uneven bottom. This model is an extension of the earlier multiple-layer σ-coordinate model (Lin, 2006) by including the direct-forcing immersed boundary method to deal with curved body surfaces. The model verification for free surface computation is firstly conducted. One case is regular wave ...
On the sensitivity and accuracy of proper-orthogonal-decomposition-based reduced order models for Burgers equation
Two aspects of proper-orthogonal-decomposition-based reduced order modeling (POD-ROM) of the Burgers equation are examined. The first is the sensitivity of the eigenvalue spectrum and POD modes to round-off errors and errors caused by using a reduced number of snapshots in the POD. For both the direct and the snapshot method of solving the POD problem, solutions obtained using LAPACK’s DGEEV ...