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Osteonecrosis de los maxilares asociada a denosumab en una paciente con osteoporosis: un caso clínico
Desde la comercialización de fármacos que actúan sobre el remodelado óseo se han registrado numerosos casos de osteonecrosis de los maxilares (ONM), pero hasta hace poco solo se habían descrito casos de ONM asociados a la administración de bifosfonatos. Con la introducción de nuevos agentes antirresortivos han aparecido varios casos de ONM asociados a denosumab. Presentamos el caso de un...


Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration
Cigarette smoking is a common and lethal worldwide habit, with considerable mortality stemming from its deleterious effects on heart function. While current theories posit altered blood lipids and fibrinogen metabolism as likely mediators, none have explored the role of the sphingolipid ceramide in exacerbating heart function with smoke exposure. Ceramide production is a consequence of cigarett...
Stable phase post-MI patients have elevated VEGF levels correlated with inflammation markers, but not with atherosclerotic burden
The role of vascular endothelial growth factor (VEGF) in patients in the stable phase after myocardial infarction (MI) has not yet been explored. Therefore, we compared the values of VEGF in post-MI patients with those obtained in healthy controls. Furthermore, we investigated whether the values of VEGF correlate to either inflammation markers or the atherosclerotic burden. 41 male patients (on...


Sonic affinity
Starting with a brief review of the question, this article examines evidence stemming from classical, popular and ethnic music, as well as from the field of language-based taxonomies and other research areas, that seem to prove a strong correlation between aural environment and musical production. To explain these interesting phenomena, we propose the sonic affinity theory, which holds that the...
Cerebellar Continuous Theta Burst Stimulation in Essential Tremor
The pathophysiological mechanisms of essential tremor (ET) are still not entirely clear. In the present study, we aimed to investigate the cerebello-thalamo-cortical connectivity in ET using the cerebellar continuous theta burst stimulation (cTBS) and possible effects on tremor and reaching movements. Sixteen patients with ET and 11 healthy subjects underwent two experimental sessions: (i) cTBS...


Cerebellar Synaptic Plasticity and the Credit Assignment Problem
The mechanism by which a learnt synaptic weight change can contribute to learning or adaptation of brain function is a type of credit assignment problem, which is a key issue for many parts of the brain. In the cerebellum, detailed knowledge not only of the local circuitry connectivity but also of the topography of different sources of afferent/external information makes this problem particular...
Heat transfer enhancement by helical screw tape coupled with rib turbulators
The influence of helical screw tape coupled with rib turbulators (HST-R) on thermohydraulic characteristics in a circular tube has been experimentally investigated. The experiments were performed under constant heat flux condition for Reynolds number between 6,000 and 20,000. The rib-pitch ratio (p/D) was varied from 1.0 to 3.0 while rib-height ratio (e/W) was varied from 0.5 to 1.5. The experi...

Experimental and numerical research on cavitating flows around axisymmetric bodies
We investigated the cavitating flows around different axisymmetric bodies based on experiments and numerical simulation. In the numerical simulation, the multiphase Reynolds averaged Navier Stokes equations (RANS) were solved via the commercial computational fluid dynamics code CFX. The modified k-ω SST turbulence model was used along with the transport equation-based cavitation model. In the ...
Effect of chevron tip count and shape on the subsonic jet mixing noise emitted from hot air lance
To mitigate jet-mixing noise emitted from a Mach 0.85 hot-air lance in iron manufacturing, we examined the effect of chevron tip geometry on large turbulence structure noise and fine-scale turbulence noise. The parametric variables are tip count (0, 4, 8 and 16) and tip shape (original chevron, tetragonal tip and round tip). To determine the tip effect quantitatively, we proposed the corrected ...

The flexible caterpillar based robotic colonoscope actuated by an external motor through a flexible shaft
Previously developed robotic colonoscopes have difficulties in performing diagnostic procedures since they should be performed by experienced endoscopists to control the device efficiently. In the previous study, therefore, we presented a robotic colonoscope adopting an electric motor in the body to rotate elastic caterpillars. However, the installed small motor, due to the limitation of the ro...
Human-robot collision detection under modeling uncertainty using frequency boundary of manipulator dynamics
This paper presents the development and experimental evaluation of a collision detection method for robotic manipulators sharing a workspace with humans. Fast and robust collision detection is important for guaranteeing safety and preventing false alarms. The main cause of a false alarm is modeling error. We use the characteristic of the maximum frequency boundary of the manipulator’s dynamic...

Heat transfer in a turbulent jet impinging on a moving plate considering high plate-to-jet velocity ratios
In this paper, heat transfer characteristics of a turbulent slot jet impinging orthogonally on an isothermal moving hot plate is studied numerically. The governing equations were discretized using the finite volume method and the υ2— f turbulence model was employed for turbulence modeling. The effect of the jet Reynolds number and the plate-to-jet velocity ratio (R) on the Nusselt were inves...
Forming limit diagram of aluminum AA6063 tubes at high temperatures by bulge tests
A free bulge test and ductile fracture criteria were used to obtain the forming limit diagrams (FLD) of aluminum alloy AA6063 tubes at high temperatures. Ductile fracture criteria were calibrated using the results of uniaxial tension tests at various elevated temperatures and different strain rates through adjusting the Zener-Holloman parameter. High temperature free bulge test of tubes was sim...
Design of a novel knee joint for an exoskeleton with good energy efficiency for load-carrying augmentation
When a linear actuator is used for rotation motion by a knee joint of an exoskeleton, the specifications of the joint range of motion (ROM) and joint torque change according to how the linear actuator are attached. Moreover, while the linear actuator generates a constant amount of force, the joint torque generated by the actuator changes according to the joint angle, which causes the torque con...
Comparison of the characteristics of granular propellant movement in interior ballistics based on the interphase drag model
Interior ballistics are completed in tens of milliseconds, as are all gun-firing phenomena. Thus, some data cannot be measured directly through experimentation. Therefore, such complex gun-firing phenomena are traditionally clarified by numerical analysis. In the twophase flow of interior ballistics, interphase drag has a strong effect on propellant particle movement. This drag is a momentum si...