RSS feed 

View All

The structural basis of differential inhibition of human calpain by indole and phenyl α-mercaptoacrylic acids
Excessive activity of neutrophils has been linked to many pathological conditions, including rheumatoid arthritis, cancer and Alzheimer’s disease. Calpain-I is a Ca2+-dependent protease that plays a key role in the extravasation of neutrophils from the blood stream prior to causing damage within affected tissues. Inhibition of calpain-I with small molecule mercaptoacrylic acid derivatives slo...


Quantification of aortic and cutaneous elastin and collagen morphology in Marfan syndrome by multiphoton microscopy
In a mouse model of Marfan syndrome, conventional Verhoeff-Van Gieson staining displays severe fragmentation, disorganization and loss of the aortic elastic fiber integrity. However, this method involves chemical fixatives and staining, which may alter the native morphology of elastin and collagen. Thus far, quantitative analysis of fiber damage in aorta and skin in Marfan syndrome has not yet ...
The Nuclear Receptor NR2F2 Activates Star Expression and Steroidogenesis in Mouse MA-10 and MLTC-1 Leydig Cells
Testosterone production is dependent on cholesterol transport within the mitochondrial matrix, an essential step mediated by a protein complex containing the steroidogenic acute regulatory (STAR) protein. In steroidogenic Leydig cells, Star expression is hormonally regulated and involves several transcription factors. NR2F2 (COUP-TFII) is an orphan nuclear receptor that plays critical roles in ...


Physical and Mental Development of Children after Levonorgestrel Emergency Contraception Exposure: A Follow-Up Prospective Cohort Study
Levonorgestrel (LNG), a dedicated emergency contraception (EC) product, has been available over-the-counter in China for more than 14 yr. Although LNG-EC is considered to have no effects on the developing fetus if the contraceptive fails and pregnancy occurs, there have been a few studies specifically examining this issue. The purpose of this study was to compare the physical and mental develop...
Simultaneous Gene Deletion of Gata4 and Gata6 Leads to Early Disruption of Follicular Development and Germ Cell Loss in the Murine Ovary
Granulosa cell formation and subsequent follicular assembly are important for ovarian development and function. Two members of the GATA family of transcription factors, GATA4 and GATA6, are expressed in ovarian somatic cells early in development, and their importance in adult ovarian function has been recently highlighted. In this study, we demonstrated that the embryonic loss of Gata4 and Gata...


Enrichment of Spermatogonial Stem Cells Using Side Population in Teleost
Spermatogenesis originates from a small population of spermatogonial stem cells; this population can maintain continuous sperm production throughout the life of fish via self-renewal and differentiation. Despite their biological importance, spermatogonial stem cells are not thoroughly characterized because they are difficult to distinguish from their progeny cells that become committed to diffe...
The SMC5/6 Complex Is Involved in Crucial Processes During Human Spermatogenesis
Genome integrity is crucial for safe reproduction. Therefore, chromatin structure and dynamics should be tightly regulated during germ cell development. Chromatin structure and function are in large part determined by the structural maintenance of chromosomes (SMC) protein complexes, of which SMC5/6 recently has been shown to be involved in both spermatogonial differentiation and meiosis during...

Creating a Patient-Centered Health Care Delivery System: A Systematic Review of Health Care Quality From the Patient Perspective
Patient experience is one of key domains of value-based purchasing that can serve as a measure of quality and be used to improve the delivery of health services. The aims of this study are to explore patient perceptions of quality of health care and to understand how perceptions may differ by settings and condition. A systematic review of multiple databases was conducted for studies targeting p...
Mechanical properties, electronic properties and phase stability of Mg under pressure: A first-principles study
Magnesium (Mg) crystal structures are extensively explored using an evolutionary algorithm implemented in the USPEX code. Two structures with simple trigonal and tetragonal symmetries are discovered to possibly exist under high pressure. The stability of these symmetries is determined by elastic constants and phonon spectrum calculations. First-principle calculations are performed to investigat...

Classroom Writing Environments and Children’s Early Writing Skills: An Observational Study in Head Start Classrooms
This study examined the classroom writing environment in 31 Head Start classrooms, and explored the relations between the writing environment, children’s (N = 262) name-writing, and children’s letter knowledge using pathway analysis. Our analyses showed that Head Start classrooms provided opportunities (i.e., writing materials and teachers’ facilitation) for children to develop early wr...
Cultivating Primary Students’ Scientific Thinking Through Sustained Teacher Professional Development
While the United States’ National Research Council (NRC 2012) and Next Generation Science Standards (NGSS 2013) advocate children’s engagement in active science learning, elementary school teachers in the US indicate lack of time to teach science regularly because of (1) school and district pressure to focus on English language arts and mathematics assessment scores in response to the count...

‘Porque Las Raizes No Se Olvidan’: Continuity and Change among Mexican Migrants in New Jersey
This paper examines how, as in the past in their home community in Mexico, Mexican immigrants in the United States use a system of flexible kinship and ritual practices to adapt to new circumstances of living and working in communities with new neighbours, new challenges and new threats. The paper focuses particularly on how the increased presence of women who have not always been a large part ...
Large screens as creative clusters
This paper begins by situating the large screen in Melbourne as part of the industrial cluster development of the Southbank cultural precinct. It examines urban regeneration and cultural policies to map the politics of its spatial geography of agglomeration. It further explores the role of networked screen in the formation of a transnational creative cluster. Using a telematic large screen even...
Marine mammals and ocean noise: Future directions and information needs with respect to science, policy and law in Canada
Marine mammals are ecologically and culturally important species, and various countries have specific legislation to protect the welfare of individual marine mammals and the conservation of their populations. Anthropogenic noise represents a particular challenge for conservation and management. There is a large and growing body of research to support the conclusion that anthropogenic noise can ...
Organotropism of persistent organic pollutants and heavy metals in the Greenland shark Somniosus microcephalus in NE Greenland
The Greenland shark Somniosus microcephalus is an opportunistic feeder, a top predator, and a very long-lived species. The brain, liver, red and white muscle, gonads, fat, skin, pancreas, and spleen of Greenland sharks from NE Greenland fjords were analysed for PCBs, PCDDs/DFs, PBDEs; DDT isomers; HCH isomers; dieldrin; endrin; HCB; Cd, Hg, Pb, and Se. PCBs (2.01–103ng/gwetwt) and PBDEs (7.9...