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Systems biology in 3D space – enter the morphome
Systems-based understanding of living organisms depends on acquiring huge datasets from arrays of genes, transcripts, proteins, and lipids. These data, referred to as ‘omes’, are assembled using ‘omics’ methodologies. Currently a comprehensive, quantitative view of cellular and organellar systems in 3D space at nanoscale/molecular resolution is missing. We introduce here the term ‘mor...


Affective processing in positive schizotypy: Loose control of social-emotional information
Behavioral studies suggested heightened impact of emotionally laden perceptual input in schizophrenia spectrum disorders, in particular in patients with prominent positive symptoms. De-coupling of prefrontal and posterior cortices during stimulus processing, which is related to loosening of control of the prefrontal cortex over incoming affectively laden information, may underlie this abnormali...
The association of physical activity to neural adaptability during visuo-spatial processing in healthy elderly adults: A multiscale entropy analysis
Physical activity has been shown to benefit brain and cognition in late adulthood. However, this effect is still unexplored in terms of brain signal complexity, which reflects the level of neural adaptability and efficiency during cognitive processing that cannot be acquired via averaged neuroelectric signals. Here we employed multiscale entropy analysis (MSE) of electroencephalography (EEG), a...


Responsiveness and functional connectivity of the scene-sensitive retrosplenial complex in 7–11-year-old children
Brain imaging studies have identified two cortical areas, the parahippocampal place area (PPA) and the retrosplenial complex (RSC), that respond preferentially to the viewing of scenes. Contrary to the PPA, little is known about the functional maturation and cognitive control of the RSC. Here we used functional magnetic resonance imaging and tasks that required attention to scene (or face) imag...
Event-related potentials indicate context effect in reading ambiguous words
The aim of the study was a comparison of lexical and contextual factors in understanding ambiguous words in German. First, a sample of native speakers selected 56 words having maximally strong differences between a dominant and a subordinate meaning. After this, another sample from the same population was visually presented with sentences that activated dominant or subordinate meanings of the w...


Visual asymmetry revisited: Mind wandering preferentially disrupts processing in the left visual field
An emerging theory proposes that visual attention operates in parallel at two distinct time scales – a shorter one (<1s) associated with moment-to-moment orienting of selective visuospatial attention, and a longer one (>10s) associated with more global aspects of attention-to-task. Given their parallel nature, here we examined whether these comparatively slower fluctuations in t...
Associative recognition processes are modulated by the semantic unitizability of memoranda
Although memory of episodic associations is generally considered to be recollective in nature, it has been suggested that when stimuli are experienced as a unit, familiarity processes might contribute to their subsequent associative recognition. To investigate the effect of semantic relatedness during episodic encoding on the processes of retrieval of associative information, we had participant...

A Q-methodology study of flare help-seeking behaviours and different experiences of daily life in rheumatoid arthritis
Previous studies have not addressed rheumatoid arthritis (RA) patients' help-seeking behaviours for RA flares, and only one small qualitative study has addressed how patients experience daily life on current treatment regimes. Thus, this study aims to identify clusters of opinion related to RA patients' experiences of daily life on current treatments, and their help-seeking behaviours for RA fl...
Expression of P16 in high-risk human papillomavirus related lesions of the uterine cervix in a government hospital, Malaysia
Cervical cancer is one of the most common cancers affecting women worldwide. It is well established that human papilloma virus (HPV) infection is the prime risk factor in the development of cervical cancer. The current screening and diagnostic tests have limitations in identifying the range of lesions caused by HPV. The current study aims to evaluate the diagnostic value of p16 immunohistochemi...

Prospecting the biodiversity of the fungal family Ustilaginaceae for the production of value-added chemicals
Ustilaginaceae (belonging to the smut fungi) are commonly known for their plant pathogenicity. Although these microbes lead to yield reduction of cereal production, they can also have an economically positive side. Ustilaginaceae naturally produce a versatile range of value-added chemicals with potential applications in the food, pharmaceutical, and chemical industry. :In this study 68 Ustilagi...
The relationship between working condition factors and well-being
Working conditions can exert influence on the physical, mental, and even social health of workers. Well-being is an appropriate index for the evaluation of a person?s overall health. This paper investigated the association between various working conditions and worker?s well-being. Data from 10,019 interviews were collected from the second wave of the Korean Working Conditions Survey (2010) con...

Protocol for a mixed-methods study of supplemental oxygen in pulmonary fibrosis
Little is known about whether or how supplemental oxygen affects patients with pulmonary fibrosis. A mixed-methods study is described. Patients with pulmonary fibrosis, informal caregivers of pulmonary fibrosis patients and practitioners who prescribe supplemental oxygen will be interviewed to gather data on perceptions of how supplemental oxygen impacts patients. In addition, three hundred pul...
Fanconi anemia: young patients at high risk for squamous cell carcinoma
Fanconi anemia is one of the best studied inherited cancer-prone diseases. Greatly improved protocols for hematopoietic stem cell transplantation increasingly save the lives of these young patients. However, in both transplanted and not transplanted patients, the emergence of aggressive squamous cell carcinoma represents a major medical challenge. This mini review summarizes current knowledge a...
Fast sequential multi-element determination of major and minor elements in environmental samples and drinking waters by high-resolution continuum source flame atomic absorption spectrometry
The fast sequential multi-element determination of 11 elements present at different concentration levels in environmental samples and drinking waters has been investigated using high-resolution continuum source flame atomic absorption spectrometry. The main lines for Cu (324.754nm), Zn (213.857nm), Cd (228.802nm), Ni (232.003nm) and Pb (217.001nm), main and secondary absorption lines for Mn (27...
On-chip graphene oxide aptasensor for multiple protein detection
The versatility of an on-chip graphene oxide (GO) aptasensor was successfully confirmed by the detection of three different proteins, namely, thrombin (TB), prostate specific antigen (PSA), and hemagglutinin (HA), simply by changing the aptamers but with the sensor composition remaining the same. The results indicate that both DNA and RNA aptamers immobilized on the GO surface are sufficiently ...