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Macroprudential policy and imbalances in the euro area
Since its creation the euro area suffered from imbalances between its core and peripheral members. This paper checks whether macroprudential policy applied to the peripheral countries could contribute to providing more macroeconomic stability in this region. To this end we build a two-economy macrofinancial model and simulate the effects of macroprudential policy (regulating the loan-to-value r...


Foreign exchange risk and the term-structure of industry costs of equity
This paper makes two contributions to the literature. First, we build on the methodology of Ang, Liu (2004) to model the cost of capital term-structure for firms subject to foreign exchange (FX) risk. We emphasize the role of time-varying parameters such as FX risk and factor loadings. Second, we estimate the term-structure for 39 U. S. industries. We find that: 1) FX exposure changes the posit...
Out-of-sample bond risk premium predictions: A global common factor
This paper investigates the out-of-sample predictability of international bond risk premia. We endogenously construct a global common Cochrane-Piazzesi (2005) factor. We find that the global factor strongly predicts international bond risk premia and delivers economically significant gains relative to the historical average. The forecasting power of the global factor is above and beyond the pre...


Ruptured distal anterior cerebral artery aneurysm presenting as subdural hemorrhage
We report on a 64-year-old man with no history of trauma who went into a deep coma after aneurysmal rupture. The brain computed tomography (CT) scan showed interhemisphere and convexity subdural hemorrhage (SDH) without detectable subarachnoid hemorrhage. The CT angiography confirmed a rare condition of pericallosal aneurysmal rupture. We emphasize that when a patient with an unclear history of...
Citalopram-induced severe hyponatremia
Citalopram-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) causing hyponatremia is well documented; however, severe hyponatremia with small doses has not been previously reported. An 84-year-old woman presented with acute confusion and gait disturbance of 3–4 days' duration and a 2-day history of vomiting but managed to maintain fluid intake. Seven days earlier she wa...


A new strain energy function for the hyperelastic modelling of ligaments and tendons based on fascicle microstructure
A new strain energy function for the hyperelastic modelling of ligaments and tendons based on the geometrical arrangement of their fibrils is derived. The distribution of the crimp angles of the fibrils is used to determine the stress-strain response of a single fascicle, and this stress-strain response is used to determine the form of the strain energy function, the parameters of which can all...
Pregestational Diabetes Induces Fetal Coronary Artery Malformation via Reactive Oxygen Species Signaling
Hypoplastic coronary artery disease is a congenital coronary artery malformation associated with a high risk of sudden cardiac death. However, the etiology and pathogenesis of hypoplastic coronary artery disease remain undefined. Pregestational diabetes increases reactive oxygen species (ROS) levels and the risk of congenital heart defects. Here we show that pregestational diabetes in mice indu...

Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity and insulin resistance
Accumulation evidence links obesity-induced inflammation as an important contributor to the development of insulin resistance which plays a key role in the pathophysiology of obesity-related diseases such as type 2 diabetes mellitus and non- alcoholic fatty liver disease. Cyclooxygenase (COX)-1 and -2 catalyze the first step in prostanoid biosynthesis. Since adult hepatocytes fail to induce COX...
Role of Type 1 diabetes associated SNPs on risk of autoantibody positivity in the TEDDY Study
The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,677 children enrolled from birth, who carry HLA-susceptibility genotypes for development of islet autoantibodies (IA) and type 1 diabetes (T1D). During the median follow-up time of 57 months, 350 children developed at least one persistent IA (GADA, IA-2A or mIAA) and 84 of them progressed to T1D. We ge...

Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes
The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3-9 weeks after onset of type 1 diabetes in 6 adult patients (age 24-35 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunoh...
MAC layer handover mechanism for continuous communication support in healthcare mobile wireless sensor networks
The use of wireless sensor networks (WSNs) is growing up in the last few years. Therefore, new challenges arise every day and one of the emerging challenges in WSNs is the nodes mobility support. This feature increases the application areas of these technologies but also raises new challenges to solve. This paper proposes a new handover mechanism, called Hand4MAC (Handover mechanism for MAC lay...

Shifting Power, Commitment Problems, and Preventive War
Many scholars argue that leaders' expectations about future shifts in the distribution of power can result in preventive war. If a leader expects her adversary to be significantly stronger in the future, the leader may choose to go to war with that adversary rather than bargain with a stronger adversary in the future. However, quantitative evaluations of this argument prove difficult, as they r...
Regardless of the Degree of Glycaemic Control, Linagliptin has Lower Hypoglycaemia Risk Than All Doses of Glimepiride, at All Time Points Over a 2-Year Trial
To evaluate the risk for documented hypoglycaemia with glimepiride versus linagliptin. This was an exploratory analysis of data from a 2-year, randomised, double-blind study of the dipeptidyl peptidase-4 inhibitor linagliptin 5 mg qd (n = 764) versus the sulphonylurea glimepiride 1–4 mg qd (n = 755) in patients uncontrolled by metformin. Patients randomised to glimepiride started ...
Single-dose new insulin glargine 300 U.mL−1 provides prolonged, stable glycaemic control in Japanese and European people with type 1 diabetes
Two single-dose studies were conducted in Japan and Europe to compare pharmacokinetic (PK) and pharmacodynamic (PD) profiles of new insulin glargine 300 U.mL−1 (Gla-300) and insulin glargine 100 U.mL−1 (Gla-100) in people with type 1 diabetes mellitus (T1DM). In two double-blind, randomised, crossover studies, 18 Japanese participants (aged 20–65 years) and 24 European participants (aged ...
Comparison by Magnetic Resonance Phase Contrast Imagingof Pulse-Wave Velocity in Patients With Single Ventricle Who Have Reconstructed Aortas Versus Those Without
Pulse-wave velocity (PWV), a measure of arterial stiffness, is a known independent risk factor for cardiovascular events. Patients with single ventricle who undergo aortic to pulmonary anastomosis (recon) have noncompliant patch material inserted into the neoaorta, possibly increasing vessel stiffness and afterload. The purpose of this study is to determine if PWV in patients with single ventri...