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Mycobacterium marinum Infection in Japanese Forest Green Tree Frogs (Rhacophorus arboreus)
Four Japanese forest green tree frogs (Rhacophorus arboreus) were presented with emaciation, abdominal distention and ulcerative and nodular cutaneous lesions affecting the brisket, limbs, digits and ventral abdomen. Another three frogs had been found dead in the same tank 1 year previously. Necropsy examination of these seven frogs revealed splenomegaly and hepatomegaly, with multiple tan–ye...


Metabolism-mediated drug interaction potential of HS-23, a new herbal drug for the treatment of sepsis in human hepatocytes and liver microsomes
HS-23, an extract of the dried flower buds of Lonicera japonica, is a new botanical drug currently being evaluated in a phase I clinical study in Korea for the treatment of sepsis. The in vitro induction and inhibition potentials of HS-23 on the drug-metabolizing enzymes using human hepatocytes and liver microsomes were assessed to evaluate herb–drug interaction according to botanical drug gu...
Characterization of the physicochemical properties of KRK-701P
KRK-701P is a broad-spectrum antibiotic with methicillin-resistant antibacterial activity. The objective of this preformulation study was to determine the physicochemical properties of KRK-701P. The n-octanol-to-water partition coefficients of KRK-701P were 0.448 at pH 4 and 2.546 at pH 8. One crystal form and one amorphous form of KRK-701P were isolated by recrystallization and characterized b...


Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a′]diisoquinoline derivatives in human breast cancer cells
Evaluation of the cytotoxicity of novel octahydropyrazin[2,1-a:5,4-a′]diisoquinoline derivatives (1a–2c) employing a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and inhibition of [3H]thymidine incorporation into DNA demonstrated that these compounds were more active than etoposide and camptothecin in both MDA-MB-231 and MCF-7 human breast cancer cells. Flow cytometric...
Efficacy and safety of olmesartan medoxomil/amlodipine fixed-dose combination for hypertensive patients uncontrolled with monotherapy
This study aimed to evaluate the efficacy and safety of olmesartan medoxomil (OM)/amlodipine (AML) 20/5 mg fixed-dose combination tablet in Chinese mild to moderately hypertensive patients with inadequate blood pressure (BP) control on monotherapy. Two multicenter, randomized, double-blind, double-dummy, active-controlled, parallel group clinical trials were conducted. After screening and a 2-...


Effects of age increase on hepatic expression and activity of cytochrome P450 in male C57BL/6 mice
Effects of aging on hepatic expression and activity of cytochrome P450 (CYP) isoforms were investigated in male mice aged 2, 6, 18, and 30 months. Microsomal protein, total CYP, cytochrome b5 and NADPH-dependent cytochrome P450 reductase contents in liver were fully expressed in young (2-month-old) mice. Neither Cyp1a1 nor Cyp2c was detected in any aged mice. And Cyp1a2 was maximally expressed...
Individual variation in foraging behavior reveals a trade-off between flexibility and performance of a top predator
There is increasing evidence that behavioral flexibility is associated with the ability to adaptively respond to environmental change. Flexibility can be advantageous in some contexts such as exploiting novel resources, but it may come at a cost of accuracy or performance in ecologically relevant tasks, such as foraging. Such trade-offs may, in part, explain why individuals within a species are...

Environmentally friendly and efficient catalysis of cyclohexane oxidation by iron meso-tetrakis(pentafluorophenyl)porphyrin immobilized on zinc oxide
The use of zinc oxide-promoted catalysis of tetrakis(pentafluorophenyl)porphyrin iron chloride for cyclohexane oxidation was studied. Tetrakis(pentafluorophenyl)porphyrin iron chloride was immobilized onto zinc oxide, generating zinc oxide-supported tetrakis(pentafluorophenyl)porphyrin iron chloride, which was characterized by a variety of spectroscopic techniques and was employed to provide a ...
Charge carriers injection in tandem semiconductors for dyes mineralization
Four mono-component and three tandem structures were prepared by robotic spray pyrolysis deposition using different precursor compositions and deposition temperatures. The structures of the electronic bands and the light generation/injection of the charge carriers trough the tandem layers (Cu x S, CuO, SnO2, ZnO, TiO2) were studied using electrical (J–V, photocurrent) and optical (UV–vis tr...

Origin of carbon in aromatic and olefin products derived from HZSM-5 catalyzed co-pyrolysis of cellulose and plastics via isotopic labeling
Catalytic pyrolysis over HZSM-5 is an effective method for the conversion of biomass to aromatic hydrocarbons, albeit with low yield and short catalyst lifetimes. Addition of co-reactants rich in carbon and hydrogen can enhance yield and possibly increase catalyst lifetimes by reducing coke formation. Particularly, the catalytic co-pyrolysis of plastic and biomass has been shown to enhance conv...
Electrooxidation of some phenolic compounds at Bi-doped PbO2
It has been determined that bismuth content in the oxide grows from 0.49 to 1.81wt% while increasing the Bi3+ ions additive concentration in the solution from 1 to 10mM. It has been found that ionic additives affect the degree of hydroxylation of lead dioxide surface layer and the bond strength of the oxygen-containing particles. High surface hydration was observed for PbO2 doped with Bi3+. It ...

A comprehensive study on Pt/Al2O3 granular catalyst used for sulfuric acid decomposition step in sulfur–iodine thermochemical cycle: Changes in catalyst structure, morphology and metal-support interaction
In continuation with our last communication on granular Fe2O3 catalysts (Banerjee et al., Applied Catalysis B: Environmental 127 (2012) 36–46), we report here a thorough investigations on Pt/Al2O3 catalyst in granular form of 4–6mm diameter for sulfuric acid decomposition reaction in absence of any carrier or diluents gas in a dual tube quartz catalytic reactor, which served as an integrate...
Reactive oxygen species dependent degradation pathway of 4-chlorophenol with Fe@Fe2O3 core–shell nanowires
In this study, an environmentally benign polyaminocarboxylic ligand diethylenetriamine pentacetate (DTPA) was first used to promote the aerobic 4-chlorophenol (4-CP) degradation with Fe@Fe2O3 core–shell nanowires, and then compared with the most used counterpart ethylenediamine tetraacetate (EDTA) of poor biodegradability. Although the 4-CP removal rate in the Fe@Fe2O3/DTPA/Air system was slo...
Hierarchically nanostructured porous group Vb metal oxides from alkoxide precursors and their role in the catalytic remediation of VOCs
This study reveals how the textural properties of hierarchically porous group V b metal oxides, prepared via a spontaneous auto-formation process, can strongly depend upon the pH of the reaction media, with an acidic media increasing the specific surface of Nb2O5 whereas a basic medium results in the highest specific surface for Ta2O5. Catalytic oxidation of toluene over Pd loaded hierarchica...
Self-sustained combustion of carbon monoxide promoted by the Cu-Ce/ZSM-5 catalyst in CO/O2/N2 atmosphere
The Cu/ZSM-5, Ce/ZSM-5 and Cu-Ce/ZSM-5 catalysts were prepared and characterized in this investigation and the catalytic activity of carbon monoxide (CO) combustion under these catalysts was determined by temperature-programmed oxidation. The activity for the CO combustion follows the decreasing order: Cu-Ce/ZSM-5>Cu/ZSM-5>Ce/ZSM-5, indicated by lower ignition, light-off, extincti...