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Survival extrapolation in the presence of cause specific hazards
Health economic evaluations require estimates of expected survival from patients receiving different interventions, often over a lifetime. However, data on the patients of interest are typically only available for a much shorter follow-up time, from randomised trials or cohorts. Previous work showed how to use general population mortality to improve extrapolations of the short-term data, assumi...


Bayesian dose-finding designs for combination of molecularly targeted agents assuming partial stochastic ordering
Molecularly targeted agent (MTA) combination therapy is in the early stages of development. When using a fixed dose of one agent in combinations of MTAs, toxicity and efficacy do not necessarily increase with an increasing dose of the other agent. Thus, in dose-finding trials for combinations of MTAs, interest may lie in identifying the optimal biological dose combinations (OBDCs), defined as t...
QEL7.2 is a pleiotropic QTL for kernel number per row, ear length and ear weight in maize ( Zea mays L.)
In maize (Zea mays L.) breeding, high grain yield is the most important breeding goal. Maize grain yield is strongly correlated with kernel number per ear, kernel weight, ear weight, among other factors. Unveiling the genetic basis of these yield-associated traits is useful for guiding the genetic improvement of maize. In this study, we found that a chromosome segment substitution line, SL17-1,...


Knowledge-rich temporal relation identification and classification in clinical notes
We examine the task of temporal relation classification for the clinical domain. Our approach to this task departs from existing ones in that it is (i) ‘knowledge-rich’, employing sophisticated knowledge derived from discourse relations as well as both domain-independent and domain-dependent semantic relations, and (ii) ‘hybrid’, combining the strengths of rule-based and...
Kin-Driver: a database of driver mutations in protein kinases
Somatic mutations in protein kinases (PKs) are frequent driver events in many human tumors, while germ-line mutations are associated with hereditary diseases. Here we present Kin-driver, the first database that compiles driver mutations in PKs with experimental evidence demonstrating their functional role. Kin-driver is a manual expert-curated database that pays special attention to activating ...


Determination of Tramadol by Dispersive Liquid-Liquid Microextraction Combined with GC-MS
Dispersive liquid–liquid microextraction (DLLME) coupled with gas chromatography–mass spectrometry (GC–MS) has been developed for preconcentration and determination of tramadol, ((±)-cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol–HCl), in aqueous and biological samples (urine, blood). DLLME is a simple, rapid and efficient method for determination o...
Concave 1-norm group selection
Grouping structures arise naturally in many high-dimensional problems. Incorporation of such information can improve model fitting and variable selection. Existing group selection methods, such as the group Lasso, require correct membership. However, in practice it can be difficult to correctly specify group membership of all variables. Thus, it is important to develop group selection methods t...

A feasibility study of application of laccase-based time-temperature indicator to kimchi quality control on fermentation process
Kimchi, in factories or during transportation, is usually stacked on shelves at different heights, which affects temperature and thus kimchi quality. In this study, a time-temperature indicator (I) was used to control such quality variations. A case study was conducted to evaluate the validity of using the I; one group of small packages of young kimchi had the I attached whereas the other group...
Physical modeling of triple near-Earth asteroid (153591) 2001 SN263 from radar and optical light curve observations
We report radar observations (2380-MHz, 13-cm) by the Arecibo Observatory and optical light curves observed from eight different observatories and collected at the Ondřejov Observatory of the triple near-Earth asteroid system (153591) 2001 SN263. The radar observations were obtained over the course of ten nights spanning February 12 - 26, 2008 and the light curve observations were made through...

Pure intracorporeal laparoscopic radical cystectomy with orthotopic “U” shaped ileal neobladder
Radical cystectomy with pelvic lymph node dissection represents the standard treatment for muscle-invasive, and high-risk non-muscle-invasive bladder cancers. of this study was to report our case series of 30 patients undergoing totally laparoscopic radical cystectomy (LRC) with reconstruction of an intracorporeal orthotopic ileal neobladder. Intra- and perioperative results and the functional ...
Trouble déficit d’attention avec ou sans hyperactivité dans les hypersomnies centrales : vulnérabilité commune ou conséquence de la somnolence diurne excessive ?
Les symptômes du trouble déficit d’attention avec ou sans hyperactivité (TDA/H) sont fréquemment observés chez les sujets souffrant d’hypersomnie centrale. Les hypothèses physiopathologiques concernant cette association sont discutées : s’agit-il de conséquences de la somnolence diurne excessive ou le reflet d’une vulnérabilité commune entre les hypersomnies et le TDA/H ? No...

Physical and chemical properties of isobutanol-gasoline blends
Blended fuels were obtained with isobutanol contents of 10, 20, 30, 40, 50, 60, 70, 80, and 90 vol % with pure gasoline fuel. The physical and chemical properties of isobutanol-gasoline blends were investigated using test methods from standards and codes or calculation. No phase separation occurred in isobutanol-gasoline blends at specific temperatures, and isobutanol and gasoline could be blen...
Usage of thermophilic cyanobacterial biomass for bioethanol production
Although the usage of microalgae biomass as a feedstock for bioethanol production has been extensively studied, very little attention has been given to the usage of cyanobacterial biomass for bioethanol production. In this study, a thermophilic cyanobacterial strain namely Phormidium sp. was used for producing bioethanol. Some important parameters for bioethanol production were optimized. When ...
Developing technology introduction strategies based on visualized scenario analysis: Application in energy systems design
Management of emerging technologies may play a significant role in the advancement towards sustainable development. While the development of consistent management policies requires inputs from a wide spectrum of specialists and other stakeholders, current platforms for facilitating their participation are insufficient. In this study, we present a framework for a visualized scenario analysis tha...
Reduction of dissolved organic matter in secondary municipal effluents by enhanced coagulation
Jar test experiments were performed to investigate the reductions of dissolved organic matter (DOM) in secondary municipal effluents by coagulation, as well as the effect of coagulation on the structural and functional properties of DOM fractions. The reductions of 9–58% and 17–71% in dissolved organic carbon (DOC) and the removals of 30–75% and 30–83% in absorbance of ultraviolet light...