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Γ-Unsaturated Aldehydes as Potential Lilial Replacers
A series of Claisen rearrangements was undertaken in order to find a replacement for Lilial (=3-(4-(tert-butyl)phenyl)-2-methylpropanal), a high-tonnage perfumery ingredient with a lily-of-the-valley odour, which is a CMR2 material [1]. 5,7,7-Trimethyl-4-methyleneoctanal , the synthesis of which is described, became the main lead. It possesses an odour which is very close to that of Lilial but ...


Recent Results in the Search for New Molecules with Ambergris Odor
The synthesis of new odorant molecules is still a challenging task for the fragrance chemist, because now as ever it is difficult to predict the odor properties of small organic molecules. Therefore, certain tools, such as, e.g., lead-structure optimization of existing odorants, are helpful techniques. In this article, we describe the synthesis and the odor properties of a new molecule derived ...
The Search for New Amber Ingredients
There is a constant need for developing new fragrance ingredients in the flavor and fragrance industry, as it allows perfumers to create unique and differentiating perfumes for fine as well as functional products. Among all the categories of notes used in perfume creation, amber notes are indispensible and ubiquitous in their presence in all perfumes. Not only amber notes impart high performanc...


From Cassyrane to Cashmeran – The Molecular Parameters of Odorants
This review, including some new experimental results, is the summary of a talk at the ‘flavors & fragrances 2013’ conference in Leipzig, organized jointly by the GDCh, the Liebig-Vereinigung, and the EuCheMS. After times of searching for natural odor principles and serendipitous discoveries by chemical inspiration, directed odorant design today offers the highest hit rates for the discovery...
From Cats and Blackcurrants: Structure and Dynamics of the Sulfur-Containing Cassis Odorant Cat Ketone
Sulfur-containing odorants and flavors play an important role in flavor and food industry, especially when meaty, garlic, onion, and vegetable scents are needed. Still, many S-containing flavors also possess fruity scents and may be used in compositions of perfumes that require a fresh and fruity odor perception. They are naturally abundant in various fruits, essential oils, and food. Most of t...


Oscillation and heat transfer in upward laminar impinging jet flows
Upward, laminar, axisymmetric, pipe-issued, submerged impinging jets, with the water as the working fluid, are numerically investigated. The impingement surface is subjected to heating, which causes the wall jet to prematurely separate from the impingement surface and turns the following region into a dead zone where the heat transfer rate deteriorates. Effects of (1) the inlet-based Reynolds n...
A General and Concise Enantioselective Divergent Approach to 13-Alkyl-Substituted Ionones
A novel enantioselective divergent route to 13-alkyl derivatives of α- and γ-ionone, important components of perfumes and fragrances, is reported. This relatively short and convenient methodology takes advantage of the use of a common intermediate, easily obtained from highly enantiomerically enriched (S)-α-ionone, which avoids the separate installation of the butenone side chain at C for ea...

The Importance of New Molecules in Selective Perfumery
Perfumery can only evolve thanks to new ingredients. We highlight herein some key molecules and their use in ‘Selective Perfumery’: the violet odorant undecavertol, the floral nerolione and coumarone, the gourmand cappuccino levistamel, the sandalwood notes Sandranol® or Bacdanol®, the fruity top note Magnolia Flower oil, and finally the woody ambery Ambrocenide®.
Prenatal Diagnosis of a Fetus with Ring Chromosomal 15 by Two- and Three-Dimensional Ultrasonography
We report on a prenatal diagnosis of ring chromosome 15 in a fetus with left congenital diaphragmatic hernia (CDH) and severe intrauterine growth restriction (IUGR). A 31-year-old woman, gravida 2 para 1, was referred because of increased nuchal translucency at gestational age of 13 weeks. Comprehensive fetal ultrasound examination was performed at 19 weeks revealing an early onset IUGR, left C...

Robust sliding mode control approach for systems affected by unmatched uncertainties using H∞ with pole clustering constraints
In this paper, the problem of sliding mode control for a class of systems with unmatched parametric uncertainties and external perturbations is considered. LMI technique and polytopic models are used in the design of the switching surface. To achieve some performance requirements and good robustness, in the sliding mode, the H∞ norm and the pole clustering method are investigated. Based on th...
Influence of Root Rotation on Delamination Fracture Toughness of Composites
Large deviations have been observed while analysing composite double cantilever beam (DCB) specimens assuming each cracked half as a simple cantilever beam. This paper examines the effect of rotational spring stiffness on the critical fracture energy considering nonzero slope at the crack-tip of the DCB specimen by modelling each cracked half as the spring-hinged cantilever beam. The critical l...

Controlling self-assembly of DNA-polymer conjugates for applications in imaging and drug delivery
Amphiphilic supramolecular structures such as micelles and vesicles can be formed through phase-driven self-assembly of monomer units having discrete hydrophilic and hydrophobic blocks. These structures show great promise for use in medical and biological applications, and incorporating DNA as the hydrophilic block of the amphiphilic monomers enables the creation of assemblies that also take ad...
Faster-is-slower effect in escaping ants revisited: Ants do not behave like humans
In this work we studied the trajectories, velocities and densities of ants when egressing under controlled levels of stress produced by a chemical repellent at different concentrations. We found that, unlike other animals escaping under life-and-death conditions and pedestrian simulations, ants do not produce a higher density zone near the exit door. Instead, ants are uniformly distributed over...
Thrombosis in Continuous-Flow Left Ventricular Assist Devices: Pathophysiology, Prevention, and Pharmacologic Management
Continuous-flow left ventricular assist devices reduce short-term mortality and improve quality of life in patients with end-stage heart failure. Unfortunately, device-related complications remain common, with many patients experiencing adverse events within the first year. New literature suggests that rates of device-related thrombosis may be increasing since 2011, which is particularly troubl...
Optimizing Medication Use with a Pharmacist-Provided Comprehensive Medication Management Service for Patients with Psychiatric Disorders
Our objective was to evaluate a pharmacist-delivered comprehensive medication management (CMM) service provided to patients with psychiatric disorders. We conducted a retrospective review and analysis of medication-related data, and a return on investment cost analysis. The project consisted of 154 patients with psychiatric disorders who were referred to the CMM service by physicians, therapist...