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High expression of metadherin correlates with malignant pathological features and poor prognostic significance in papillary thyroid carcinoma
Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumors, and is closely related to tumor invasion and the poor prognosis. This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of PTC patients. and patientsImmunohistochemistry was used to detect MTDH expression in 156 cases of PT...


Toward a Set of Internationally Applicable Indicators for Measuring University Internationalization Performance
This article emphasizes the urgent demand for measurements of university internationalization and proposes a new approach to develop a set of internationally applicable indicators for measuring university internationalization performance. The article looks into existing instruments developed for assessing university internationalization, particularly focusing on the methodological aspects. By e...
Longitudinal Myocardial Blood Flow Gradient and CAD Detection
Conventional myocardial perfusion scintigraphy with SPECT/CT or with PET/CT has been established as pivotal clinical imaging modality for the identification of hemodynamically obstructive coronary artery disease (CAD) and risk stratification of patients with suspected or known CAD. While the assessment of the relative distribution of radiotracer uptake in the left-ventricular (LV) myocardium du...


Phase II study of gemcitabine and vinorelbine as second- or third-line therapy in patients with primary refractory or platinum-resistant recurrent ovarian and primary peritoneal cancer by the Korean Cancer Study Group (KCSG)_ KCSG GY10-10
The main aim of this study was to evaluate the antitumor activity and safety of vinorelbine and gemcitabine combination chemotherapy in patients with primary refractory or recurrent platinum-resistant epithelial ovarian and primary peritoneal cancer. Patients with platinum-resistant or primary refractory disease were eligible. Patients were allowed one prior chemotherapy for the treatment of pl...
Diagnostic and prognostic value of circulating miR-18a in the plasma of patients with gastric cancer
The aim of this manuscript is to analyze the diagnostic and prognostic value of circulating miR-18a in the plasma of patients with gastric cancer. In this study, 82 patients with gastric cancer and 65 healthy controls were enrolled in the study, and 10 ml of peripheral venous blood was collected for RNA extraction. miR-18a expression was determined using TaqMan quantitative real-time polymeras...


LAPTM4B-35 protein as a potential therapeutic target in gastric cancer
The objective of this study is to investigate lysosome-associated protein transmembrane 4b-35 (LAPTM4B-35) protein expression in gastric cancer and its clinical implications. LAPTM4B-35 protein expression in 652 gastric cancer specimens and matched adjacent non-cancerous tissues was evaluated by immunohistochemical staining. Subsequently, the relationship between LAPTM4B-35 protein expression, ...
Inhibition of prostatic cancer growth by ginsenoside Rh2
Ginsenoside Rh2 (GRh2) has been reported to have therapeutic effects on some types of cancer, but its effect on prostatic cancer has not been extensively evaluated. Here, we show that GRh2 can substantially inhibit the growth of prostatic cancer in vivo and in vitro. Moreover, the inhibition of the tumor growth appeared to result from a combined inhibitory effect on tumor cell proliferation and...

Comparative study of different procedures for the separation of peripheral blood mononuclear cells in cytokine-induced killer cell immunotherapy for hepatocarcinoma
Cytokine-induced killer (CIK) cell immunotherapy exhibits significant advantages in the clinical treatment of tumors. This study was designed to compare the biological characteristics of autologous CIK cells from patients with hepatocarcinoma following different procedures for the separation of peripheral blood mononuclear cells (PBMCs). Forty-four hepatocarcinoma patients were enrolled and dis...
Efficacy and toxicity of adding cetuximab to chemotherapy in the treatment of metastatic colorectal cancer: a meta-analysis from 12 randomized controlled trials
Cetuxiamb, a monoclonal antibody against epidermal growth factor receptor (EGFR), has been used in combination with chemotherapy for patients with metastatic colorectal cancer (mCRC). However, the efficacy of combined therapies of cetuximab and different chemotherapy regimens remains controversial. Therefore, we conducted a meta-analysis to evaluate the efficacy and toxicity of adding cetuximab...

A study of whether video scoring is a reliable option for blinded scoring of the Gross Motor Function Measure-88
To investigate the agreement between live and video scores of the Gross Motor Function Measure-88. Reliability study. Forty children with bilateral spastic cerebral palsy. Fifty evaluations were administered according to the test guidelines, and were videotaped. After a minimum interval of one month, the video recordings were again rated by the same assessor. Two physical therapy students also ...
On the dynamics of a case study of explosive cyclogenesis in the Mediterranean
In this study, a case of explosive cyclogenesis over the central Mediterranean is examined with the aid of the MS Cyclone Detection and Tracking Scheme along with the Vertical Tracing Software and the Parcel Trajectory Software that were developed in Melbourne University, employing a regular 0.5° × 0.5° latitude–longitude grid of the ERA-Interim dataset. It is found that the explosive cy...

An optimal strategy for coronary revascularization in patients with severe renal dysfunction
The optimal strategy for coronary revascularization in patients with renal dysfunction remains undefined. As coronary artery bypass grafting (CABG) may be associated with higher mortality, less invasive percutaneous coronary intervention (PCI) may be preferred. To date, only limited information has been published regarding the effects of severe renal dysfunction on the outcome after CABG and PC...
Fitting Nonlinear Ordinary Differential Equation Models with Random Effects and Unknown Initial Conditions Using the Stochastic Approximation Expectation–Maximization (SAEM) Algorithm
The past decade has evidenced the increased prevalence of irregularly spaced longitudinal data in social sciences. Clearly lacking, however, are modeling tools that allow researchers to fit dynamic models to irregularly spaced data, particularly data that show nonlinearity and heterogeneity in dynamical structures. We consider the issue of fitting multivariate nonlinear differential equation mo...
Formal land rights versus informal land rights: Governance for sustainable urbanization in the Jakarta metropolitan region, Indonesia
Co-existence of informal settlements and gated communities is a common phenomenon in many developing countries. In the Jakarta metropolitan region, one of the high-density Asian urban centers, it is observed that informal settlements are ubiquitous in its central city, while gated communities are prevalently concentrated in the suburbs. This dual process of informal and formal urbanization is a...
The complex relation between Belarusian trade openness and the agricultural sector
Common sense states that greater trade openness is a very important challenge to some economic sectors such as agriculture. We tested this claim by considering a Belarusian time series observed since 1990. Employing cointegration techniques, we concluded that trade openness exerted a positive stimulus on Belarusian agriculture; therefore, the stagnant evolution of Belarusian trade openness coul...