RSS feed 

View All

Δ-Opioid Receptors Up-regulate Excitatory Amino Acid Transporters in Mouse Astrocytes
Astrocytic excitatory amino acid transporters (EAATs) regulate extracellular glutamate concentrations and play a role in preventing neuroexcitotoxicity. Since δ-opioid receptor (DOR) is neuroprotective against excitotoxic injury, we asked if DOR activation upregulates EAAT expression and function. Experimental approachWe measured mRNA and protein expression of EAAT1, EAAT2 and EAAT3 in culture...


Detection of the secondary low affinity β1-adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP
Cgp 12177 inhibits agonist effects mediated through the catecholamine site of the β1-adrenoceptor with high affinity, but also exhibits agonist effects of its own at higher concentrations through a secondary, low affinity β1-adrenoceptor site or conformation. β-blocker affinities for this “cgp 12177” site of the human β1-adrenoceptor have thus far only been characterised in functional s...
Conflicts in teachers’ professional practices and perspectives about inclusion in Icelandic compulsory schools
Inclusive education policy, now the norm in many parts of the world including Iceland, is highly dependent on teachers for its successful implementation. Research on inclusion often attempts to identify teachers’ attitudes of inclusion (against/for). This article takes a different approach. It focuses on teachers’ perspectives of their professional practices; that is, how teachers understan...


Role of nuclear Lamin A/C in cardiomyocyte functions
Lamin A/C is a structural protein of the nuclear envelope and cardiac involvement in Lamin A/C mutations was one of the first phenotypes to be reported in humans, suggesting a crucial role of this protein in the cardiomyocytes function. Mutations in LMNA gene cause a class of pathologies generically named ‘Lamanopathies’ mainly involving heart and skeletal muscles. Moreover, the well known ...
Human RAD23 homolog A is required for the nuclear translocation of apoptosis-inducing factor during induction of cell death
InformationDuring the initiation of cell death, mitochondrial protein, apoptosis-inducing factor (AIF), is transported to the nucleus. The mechanism of AIF nuclear translocation, however, is not clear. After protein synthesis, the AIF is originally targeted to the mitochondria, and the nuclear targeting is a secondary event. Therefore, we hypothesized that the nuclear translocation of AIF could...


Resource development in otolaryngology-head and neck surgery: an analysis on patient education resource development
There is a need for educational tools in the consenting process of otolaryngology-head and neck procedures. A development strategy for the creation of educational tools in otolaryngology-head and neck surgery, particularly pamphlets on the peri-operative period in an adenotonsillectomy, is described. A participatory design approach, which engages key stakeholders in the development of an educat...
Intermittent Brugada syndrome in an anorexic adolescent girl
We report an anorexic adolescent girl with an intermittent Brugada syndrome. A 14-year-old anorexic girl with a body mass index (BMI) of 13.15kg/m2 was admitted in the acute state of the disease with an ST elevation in V1 and V2, suggestive of Brugada syndrome. After 1 month of re-feeding, a control electrograph (ECG) was normal, but after an 8-month follow-up control with a nearly normal BMI, ...

Percutaneous reconstruction of aortic isthmus atresia using coronary total occlusion technique
Aortic isthmus atresia is an extreme form of coarctation presenting in adults and usually calls for surgical correction. In this report, we present our initial experience with the first four cases successfully treated percutaneously using dedicated coronary total occlusion wires and techniques. <Learning objective: This case series shows a technique to cross totally occluded coarctation ...
Transcatheter mitral paravalvular leakage closure: A beautiful last resort
We describe a case of a 54-year-old patient with rheumatic heart valve disease who was treated with double valve replacement (both aortic and mitral) twice. Two months after the second operation she developed a severe mitral paravalvular leakage (PVL) leading to cardiogenic shock for which she was hospitalized in the intensive care unit. Multiple weaning efforts proved to be unsuccessful becaus...

Barriers to evidence-based treatment for children with attention-deficit/hyperactivity disorder
A number of evidence-based treatments are available for attention-deficit/hyperactivity disorder (ADHD), including pharmacological, psychosocial, or a combination of the two treatments. For a significant number of children diagnosed with aDHD, however, these treatments are not utilized or adhered to for the recommended time period. Given that adherence to treatment regimens is necessary for red...
Reproductive and growth strategies of Idotea balthica basteri (Pallas, 1772) population in the Bizerte lagoon (Tunisia, Southern Mediterranean)
We analysed several life history traits of the marine isopod Idotea balthica basteri (Pallas, 1772) from the Bizerte lagoon, Southern Mediterranean Sea. Growth was continuous throughout the life of the animal with a high growth rate in the first life phase, and the growth curve was described according to von Bertalanffy's model. The lowest growth rate (0.23 mm) was recorded in winter (December...

Low Energy Resolvent for the Hodge Laplacian: Applications to Riesz Transform, Sobolev Estimates, and Analytic Torsion
On an asymptotically conic manifold (M,g), we analyze the asymptotics of the integral kernel of the resolvent Rq(k):=(q+k2)–1 of the Hodge Laplacian q on q-forms as the spectral parameter k approaches zero, assuming that 0 is not a resonance. The first application we give is an Lp Sobolev estimate for d+and q. Then we obtain a complete characterization of the range of p>1 for which the Ri...
The Covariance of Almost-Primes in F
We estimate the covariance in counts of almost-primes in $mathbb {F}_q[T]$, weighted by higher-order von Mangoldt functions. The answer takes a pleasant algebraic form. This generalizes recent work of Keating and Rudnick that estimates the variance of primes, and makes use, as theirs, of a recent equidistribution result of Katz. In an Appendix, we prove some related identities for random matrix...
A new manual dispensing system for in meso membrane protein crystallization with using a stepping motor-based dispenser
A reliable and easy to use manual dispensing system has been developed for the in meso membrane protein crystallization method. The system consists of a stepping motor-based dispenser with a new microsyringe system for dispensing, which allows us to deliver any desired volume of highly viscous lipidic mesophase in the range from ~50 to at least ~200 nl. The average, standard deviation, and coe...
European air transport liberalization: Possible ways out of the single European sky gridlock
This article presents the gradual liberalization of European air transport, especially its most recent problems in the case of the Single European Sky (SES). Indeed, after successfully liberalizing airlines and, to a certain extent, airports, the European Commission has embarked on the process of creating an SES. The article describes the process and the main actors. It focuses in particular on...