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Prediction of β-lactamase and its class by Chou’s pseudo-amino acid composition and support vector machine
Β-Lactam class of antibiotics is used as major therapeutic agent against a number of pathogenic microbes. The widespread and indiscriminate use of antibiotics to treat bacterial infection has prompted evolution of several evading mechanisms from the lethal effect of antibiotics. β-Lactamases are endogenously produced enzyme that makes bacteria resistant against β-lactam antibiotics by cleavi...


Neighborhood functions alter unbalanced facilitation on a stress gradient
The stress-gradient hypothesis states that individual and species competitive and facilitative effects change in relative importance or intensity along environmental gradients of stress. The importance of the number of facilitators in the neighborhood of a potential beneficiary has not been explored. Evenly distributed and stress-correlated facilitation and the increase in the intensity of faci...
Next Steps in TeamSTEPPS(R): Creating a Just Culture With Observation and Simulation
The purpose of this article is to propose a strategy for ensuing simulation training following the implementation of a thorough Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS®) training initiative. The strategies include observing Teams in the workplace to facilitate the construction of organization-wide, follow-on simulation training. A review of organizati...


Innovationen in der operativen Therapie des Mammakarzinoms
Die operative Therapie des Mammakarzinoms hat in den letzten Dekaden einen grundlegenden Wandel hin zu signifikant reduzierter Radikalität und Wahrung der onkologischen Sicherheit durchgemacht. In den letzten Jahren setzt sich dieser Trend weiter fort mit Änderungen im axillären Staging im Rahmen der Sentinel-Node-Biopsie (SNB) sowie reduzierter Radikalität im Sinne des Resektionsrandes. Gl...
Sonographische Beurteilung der Einstellung und des Höhenstandes vor vaginal-operativer Entbindung
Eine Sonographie wird mittlerweile in vielen Kreißsälen routinemäßig sub partu durchgeführt. Untersuchungen konnten zeigen, dass der transperineale Ultraschall unter Verwendung des Austreibungswinkels zur Beurteilung des Höhenstandes vor vaginal-operativen Entbindungen das Potenzial hat, die Kaiserschnittrate ohne erhöhte maternale und neonatale Morbidität zu reduzieren. Allerdings konn...


A randomized trial to evaluate primary care clinician training to use the Teachable Moment Communication Process for smoking cessation counseling
To implement and evaluate the impact of a Teachable Moment Communication Process (TMCP) training intervention on clinicians’ smoking cessation counseling behaviors in practice. Using a group randomized trial, 31 community-based, primary care clinicians in Northeast Ohio received either TMCP training or an attention control (2010-2012). TMCP training consisted of two, three-hour sessions invol...
Drug development for tauopathies
Many different approaches to treating tauopathies are currently being explored, with a few compounds already in clinical development (including small molecules such as anti-aggregation compound LMTX and active vaccines AADvac1 and ACI-35). This review aims to summarize the status of the clinical candidates and to highlight the emerging areas of research that hold promise for drug development. T...

Testing and modelling the effects of climate on the incidence of the emergent nut rot agent of chestnut Gnomoniopsis castanea
Gnomoniopsis castanea is an emerging fungal pathogen causing nut rot of Castanea sativa. This study was aimed at testing and modelling the effects of climate on disease incidence. Up to 120 ripe nuts were collected in 2011 from trees in each of 12 sites located in the north-west of Italy. The incidence of G. castanea in each site was expressed as the number of infected nuts on the total number ...
Intraspecific variation in susceptibility to dothistroma needle blight within native Scottish Pinus sylvestris
Dothistroma needle blight (DNB), caused by Dothistroma septosporum, is the most important disease currently affecting pine plantations in Britain. Intraspecific variation in susceptibility to DNB has been observed in several pine species, but it is not clear if similar variation occurs in Pinus sylvestris (Scots pine), Britain's only native pine. In three separate experiments two- and three-yea...

Low genetic variability in Sclerotinia sclerotiorum populations from common bean fields in Minas Gerais State, Brazil, at regional, local and micro scales
Sclerotinia sclerotiorum causal agent of white mold is the most destructive and widely distributed soilborne pathogen of common bean during the fall-winter season in Brazil. Nevertheless, little is known about the genetic structure of the pathogen population. Microsatellite (SSR) markers and mycelial compatibility groups (MCGs) were used to characterize 118 isolates collected from 20 bean field...
Efficacy and safety of open-label ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis
Ixekizumab, an anti-IL-17A monoclonal antibody, demonstrated a high level of efficacy in moderate-to-severe plaque psoriasis (PP) patients. To evaluate the efficacy and safety of open-label ixekizumab in Japanese patients with moderate-to-severe PP, erythrodermic psoriasis (EP) and generalized pustular psoriasis (GPP). Patients received 160-mg subcutaneous ixekizumab injection at Week 0, 80-mg ...

Reflectance confocal microscopy: non-invasive distinction between actinic keratosis and squamous cell carcinoma
Early recognition of squamous cell carcinoma (SCC) is difficult. Non-invasive reflectance confocal microscopic (RCM) imaging of the skin is a promising diagnostic technique. Although several RCM features for SCC and AK have been described, it is not determined whether RCM has the ability to distinguish between SCC and actinic keratosis (AK). To determine in vivo reflectance confocal microscopic...
What is the impact of tumour size on dermoscopic diagnosis of BCC?
The effect of size on diagnostic performance of dermoscopy in basal cell carcinomas (BCCs) is yet to be determined. To investigate the differences in dermoscopic features between small- and large-sized BCCs. A total of 151 BCCs consecutively collected during a 2-year period were analysed. These tumours were evaluated for the presence of various dermoscopic features (colours, structures and vess...
Using social marketing to create communities for our children and adolescents that do not model and encourage drinking
Our children and adolescents are growing up in environments that support, and even, encourage (excessive) drinking. Thus, if we are to address the problem of underage drinking our focus needs to move beyond eliciting behavior change among children and adolescents to changing underlying community attitudes, social norms, and the environment itself. This review sought to examine the evidence base...
Geographic variation of clinically diagnosed mood and anxiety disorders in Christchurch after the 2010/11 earthquakes
The 22nd February 2011 Christchurch earthquake killed 185 people, injured over 8000, damaged over 100,000 buildings and on-going aftershocks maintained high anxiety levels. This paper examines the dose of exposure effect of earthquake damage assessments, earthquake intensity measures, liquefaction and lateral spreading on mood and anxiety disorders in Christchurch after this event. We hypothesi...