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**iddeiback2**23 minutes ago - Topic: MathematicsFragile X syndrome, a common cause of intellectual disability and autism, is due to mutational silencing of the FMR1 gene leading to the absence of its gene product, FMRP. FMRP is a selective RNA-binding protein owing to two central KH domains and a C-terminal RGG box. However, several properties of the FMRP amino terminus are unresolved. It has been documented for over a decade that the amino ...

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**pp92558**23 minutes ago - Topic: MathematicsMutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis and cause Leber congenital amaurosis (LCA), a severe hereditary blindness occurring in early childhood. The pathology is attributed to a combination of 11-cis-retinal deficiency and photoreceptor degeneration. The mistrafficking of cone membrane-associated proteins including cone opsins (M-and S-opsin...

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**tojmohol4**23 minutes ago - Topic: MathematicsInitial results from sequencing studies suggest that there are relatively few low-frequency (...

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**ox451apcndr**23 minutes ago - Topic: MathematicsBlepharophimosis, ptosis, epicanthus-inversus syndrome (BPES) is an autosomal dominant genetic disorder characterized by narrow palpebral fissures and eyelid levator muscle defects. BPES is often associated to premature ovarian insufficiency (BPES type I). FOXL2, a member of the forkhead transcription factor family, is the only gene known to be mutated in BPES. Foxl2 is essential for maintenanc...

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**zhinhi92**23 minutes ago - Topic: MathematicsVacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosomal protein sorting and intracellular trafficking. We recently linked a mutation in VPS35 (p. D620N) to familial parkinsonism. Here we characterize human VPS35 and retromer function in mature murine neuronal cultures and investigate neuron-specific consequences of the p. D620N mutation. We find VPS...

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**dpspiocack**26 minutes ago - Topic: Civil EngineeringWe mainly consider the stability of discrete-time Markovian jump linear systems with state-dependent noise as well as its linear quadratic (LQ) differential games. A necessary and sufficient condition involved with the connection between stochastic -stability of Markovian jump linear systems with state-dependent noise and Lyapunov equation is proposed. And using the theory of stochastic -stabil...

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**omanca**26 minutes ago - Topic: Civil EngineeringTwo modified three-term type conjugate gradient algorithms which satisfy both the descent condition and the Dai-Liao type conjugacy condition are presented for unconstrained optimization. The first algorithm is a modification of the Hager and Zhang type algorithm in such a way that the search direction is descent and satisfies Dai-Liao’s type conjugacy condition. The second simple three-term ...

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**jmgobreil**26 minutes ago - Topic: Civil EngineeringTraining overcomplete dictionary pair is a critical step of the mainstream superresolution methods. For the high time complexity and susceptible to corruption characteristics of training dictionary, an improved method based on lifting wavelet transform and robust principal component analysis is reported. The high-frequency components of example images are estimated through wavelet coefficients ...

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**bole**26 minutes ago - Topic: Civil EngineeringThe bilinear operator and F-expansion method are applied jointly to study-dimensional Kadomtsev-Petviashvili (KP) equation. An exact cusped solitary wave solution is obtained by using the extended single-soliton test function and its mechanical feature which blows up periodically in finite time for cusped solitary wave is investigated. By constructing the extended double-soliton test function, ...

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**minjo96**33 minutes ago - Topic: ChemistryThe pure rotational spectrum of mono-deuterated ethane, CH3CH2D, has been measured up to 1600 GHz and spectroscopic constants have been fit to 984 transitions in the ground state and 422 transitions in the first torsional excited state (ν18). Analyses of the ground state data were performed with the programs SPFIT, ERHAM and XIAM and of the first torsional state with SPFIT and ERHAM to extract...

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**edihioran**39 minutes ago - Topic: ElectronicsSelection of motion vector (MV) has a significant impact on the quality of an encoded, and particularly a transcoded video, in terms of rate-distortion (R-D) performance. The conventional motion estimation process, in most existing video encoders, ignores the rate of residuals by utilizing rate and distortion of motion compensation step. This approach implies that the selected MV depends on the...

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**anawim**44 minutes ago - Topic: FinanceThe short-distance expansion of the tau function of the radial sine-Gordon/Painlevé III equation is given by a convergent series which involves irregular $c=1$ conformal blocks and possesses certain periodicity properties with respect to monodromy data. The long-distance irregular expansion exhibits a similar periodicity with respect to a different pair of coordinates on the monodromy ma...

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**poezdka**44 minutes ago - Topic: FinanceIn [], we show that three of the fourteen hypergeometric monodromy groups associated to Calabi–Yau threefolds are arithmetic. Brav–Thomas (in []) show that seven of the remaining eleven are thin. In this article, we settle the arithmeticity problem for the fourteen monodromy groups, by showing that, the remaining four are arithmetic.

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**rojish**54 minutes ago - Topic: DentistryTo compare the fatigue life and damage modes of zirconia crowns fabricated with and without framework design modification when porcelain veneered using a fast or slow cooling protocol. Composite resin replicas of a first molar full crown preparation were fabricated. Zirconia copings were milled as conventional (0.5mm even thickness, Zr-C, n =20,) or modified (lingual margin of 1.0mm thickness, ...

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**jhn84wllms**56 minutes ago - Topic: GeologyAll living echinoderms have a pentaradial symmetry that is unique within the Bilateria. However, the Cambrian origin of echinoderm radial/pentaradiate symmetry is a long-standing problem. During the Cambrian (542-488 Ma), gogiids were the most common stalked echinoderm characterized by an “irregularly” plated body. Based on recently discovered material from the Balang Formation (Cambrian Se...