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In vivo 1H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder
Inflammation and oxidative stress are important mechanisms that have been implicated in the pathophysiology of major depressive disorder (MDD). Glutathione (GSH) is the most abundant antioxidant in human tissue, and a key index of antioxidant capacity and, hence, of oxidative stress. The aims of this investigation were to examine possible relationships between occipital GSH and dimensional meas...


Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies
Hypocretin (Hcrt) is a neuropeptide synthesized in the lateral hypothalamus (LHT) that plays a key role in maintaining arousal state. In Parkinson's disease (PD), a narcolepsy-like syndrome is commonly seen, and a previous study showed substantial Hcrt neuronal loss in accordance with PD severity. In the present study, we quantitatively examined Hcrt immunoreactivity and α-synuclein and tau pa...
Expression of the JAK/STAT3/SOCS3 signaling pathway in herniated lumbar discs
The inflammatory cytokine interleukin-6 (IL-6) plays an important role in causing symptoms of lumbar disk herniation. The present study clarifies the expression of the signaling pathway of IL-6 in herniated discs. Homogenates prepared from lumbar herniated discs from 10 patients were assessed. The expression of janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), p...


Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is shown to negatively regulate MAPK signaling in various peripheral tissues as well as the central nervous system such as cortex, striatum and hippocampus. In this study, we examined whether MKP-1 regulates MAPK signaling in the mouse hypothalamus. Intraperitoneal injection of TNFα significantly increased MKP-1 mRNA expression in paravent...
Distinct role of tumor necrosis factor receptor subtypes 1 and 2 in the red nucleus in the development of neuropathic pain
Previous studies have demonstrated that tumor necrosis factor-alpha (TNF-α) in the red nucleus (RN) plays a facilitated role in the development of neuropathic pain. Here, the protein levels and roles of two different TNF receptors, p55 type 1 (TNFR1) and p75 type 2 (TNFR2), in the RN of rats with spared nerve injury (SNI) were investigated. Immunohistochemistry demonstrated that both TNFR1 and...


Is the acetabular cup orientation after total hip arthroplasty on a two dimension or three dimension model accurate?
Malposition of the acetabular component in total hip arthroplasty (THA) is a common surgical problem that can lead to hip dislocation, reduced range of motion and may result in early loosening. The aim of this study is to validate the accuracy and reproducibility of a single x-ray image based 2D/3D reconstruction technique in determining cup inclination and anteversion against two different com...
Is there an association between periprosthetic joint infection and low vitamin D levels?
Vitamin D is increasingly being recognized as an important mediator of immune function and may have a preventive role in the pathogenesis of periprosthetic joint infection. To the best of our knowledge, no other study has examined possible associations between periprosthetic joint infection and vitamin D deficiency. We investigated the rate of vitamin D deficiency in patients treated for peripr...

A comparative and retrospective study of three hundred and twenty primary Charnley type hip replacements with a minimum follow up of ten years to assess wether a dual mobility cup has a decreased dislocation risk
Mid- and long-term follow-up of Charnley total hip arthroplasty (THA) demonstrated good functional results with 85 % survivorship at 25-year follow-up. However, dislocation still remains an unsolved problem. Dislocation may occur throughout the patient’s and implant’s life. The aim of this study is to answer the question: does a dual mobility cup (DMC) decrease the dislocation risk?We repo...
Evaluation of Metabolic and Immunological Changes in Streptozotocin-Nicotinamide induced Diabetic Rats
Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic rats as a model of type 2 diabetes. Male rats were induced diabetes using nicot...

Enhanced antitumor immunity is elicited by adenovirus-mediated gene transfer of CCL21 and IL-15 in murine colon carcinomas
The chemokine CCL21 is a potent chemoattractant for T cells and dendritic cells. IL-15 elicits powerful antitumor immune responses through the stimulation of natural killer cells. We constructed a CCL21/IL-15-expressing adenovirus (Ad-CCL21-IL-15) and evaluated its antitumor effects in vitro and in vivo. We found that the intratumoral injection of Ad-CCL21-IL-15 into murine colon carcinomas sig...
A historical perspective on diversity ideologies in the United States: Reflections on human resource management research and practice
We examine diversity ideologies in the United States across four distinct eras: White supremacy/sanctioned exclusion of racioethnic minorities before the 1960s, the equal opportunity–Civil Rights era of the 1960s, the diversity management/multiculturalism era of the 1980s and 90s, and today's inclusion/post-race era. Our examination provides insight into how changes in societal beliefs and at...

A combination of morphological and molecular analyses to distinguish two fungal pathogens causing leaf spots on Cinnamomum burmannii
The leaves of Cinnamomum burmannii in Guangdong Province were severely affected by two distinctly different types of spots. The dark spot was round, surrounded by a thin yellow zone at the interface between healthy and affected regions, and had a distinct dark ring. The yellow spot had an irregular shape and a broad yellow halo. The pathogens from the different diseased leaves were isolated and...
A fluorometric biosensor based on H2O2-sensitive nanoclusters for the detection of acetylcholine
We have constructed a simple, cost-effective, label-free, selective and sensitive biosensor based on the fluorescence quenching of protein-stabilized nanoclusters (NCs) for the detection of acetylcholine (ACh). In this assay, acetylcholineaterase (AChE) catalyzes the hydrolysis of ACh to form choline, which in turn is oxidized by choline oxidase (ChOx) to generate H2O2 which induces the fluores...
Dithiothreitol-capped fluorescent gold nanoclusters: An efficient probe for detection of copper(II) ions in aqueous solution
We report here a Green method for the synthesis of fluorescent gold nanoclusters using dithiothreitol (D) as both a capping agent and reducing agent at 22°C and pH 8. The physical and chemical properties of the synthesized AuNCs@D were studied by TEM and UV–vis absorption, fluorescence, and X-ray photoelectron spectroscopy. AuNCs@D recognizes cupric ions with high selectivity and sensitivity...
Impedimetric DNA-biosensor for the study of anti-cancer action of mitomycin C: Comparison between acid and electroreductive activation
An electrochemical protocol is described for direct monitoring of anti-cancer properties of MMC. Using electrochemical impedance spectroscopy, a pretreated pencil graphite electrode (PGE) modified with multiwall carbon nanotubes (MWCNTs) and poly(diallyldimethylmmonium chloride), PDDA, decorated with ds-DNA was employed in this study to identify DNA damages induced by MMC. The change in charge ...