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Smoking, alcohol consumption, and drug use among adolescents with psychiatric disorders compared with a population based sample
This study investigated frequencies of smoking, alcohol use, and illicit drug use by diagnostic category in 566 adolescent psychiatric patients, comparing this sample with 8173 adolescents from the general population in Norway who completed the Young-HUNT 3 survey. Frequencies of current alcohol use were high in both samples but were lower among psychiatric patients. Compared with adolescents i...


The repair of G-quadruplex-induced DNA damage
G4 DNA motifs, which can form stable secondary structures called G-quadruplexes, are ubiquitous in eukaryotic genomes, and have been shown to cause genomic instability. Specialized helicases that unwind G-quadruplexes in vitro have been identified, and they have been shown to prevent genetic instability in vivo. In the absence of these helicases, G-quadruplexes can persist and cause replication...
JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells
Jmjd2a is a lysine trimethyl-specific histone demethylase that is highly expressed in a variety of tumours. The role of jmjd2a in tumour progression remains unclear. The objectives of this study were to identify jmjd2a-regulated genes and understand the function of jmjd2a in p53-null neuroectodermal stem cells (p53−/− NE-4Cs). We determined the effect of LPS as a model of inflammation in p5...


Dynamics of apelin receptor/G protein coupling in living cells
During our research on Apelin receptor (APJ) signalling in living cells with BRET and FRET, we demonstrated that apelin-13 stimulation can lead to the activation of Gαi2 or Gαi3 through undergoing a molecular rearrangement rather than dissociation in HEK293 cells expressing APJ. Furthermore, Gαo and Gαq also showed involvement in APJ activation through a classical dissociation model. Howeve...
Intrinsic mechanisms underlying the neurotrophic activity of adipose derived stem cells
Adipose derived stem cells (ADSC) can be differentiated into Schwann cell-like cells which enhance nerve function and regeneration. However, the signalling mechanisms underlying the neurotrophic potential of ADSC remain largely unknown. In this study, we hypothesised that ADSC, upon stimulation with a combination of growth factors, could rapidly produce brain derived neurotrophic factor (BDNF) ...


Elaboration and dielectric property of modified PZT/epoxy nanocomposites
Composites of lead zirconate titanate (PZT) 50 nm nanoparticles and epoxy resins have been produced with various PZT contents from 0 to 20 wt%. The morphology and thermal properties of prepared composites were characterized using scanning electron microscopy and differential scanning calorimetry. The PZT nanoparticles were found to be well dispersed in the epoxy resin matrix. The glass transiti...
Electronic spectra and intersystem spin-orbit coupling in 1,2- and 1,3-squaraines
The main photophysical properties of a series of recently synthetized 1,2- and 1,3-squaraines, including absorption electronic spectra, singlet-triplet energy gaps, and spin-orbit matrix elements, have been investigated by means of density functional theory (DFT) and time-dependent DFT approaches. A benchmark of three exchange-correlation functionals has been performed in six different solvent ...

Serum thyroid-stimulating hormone levels are not associated with exercise capacity and lung function parameters in two population-based studies
Thyroid dysfunction has been described to be linked to a variety of cardiovascular morbidities. Through this pathway thyroid function might also be associated with cardiorespiratory function and exercise capacity. So far only few patient-studies with small study populations investigated the association between thyroid dysfunction and exercise capacity. Thus, the aim of our study was to investig...
Live-cell Imaging of Post-Golgi Transport Vesicles in Cultured Hippocampal Neurons
The subcellular localization of neuronal membrane signaling molecules such as receptors and ion channels depends on intracellular trafficking mechanisms. Essentially, vesicular trafficking mechanisms ensure that a large number of membrane proteins are correctly targeted to different subcellular compartments of neurons. In the past two decades, the establishment and advancement of fluorescent pr...

Unilateral Eye Blinking Arising From the Ictal Ipsilateral Occipital Area
We report on an 18-month-old boy with unilateral left eye blinking as a single ictal manifestation without facial twitching. The clinical onset of this phenomenon was first recorded (as an occasional event) at age 3 months, and it was overlooked. By age 6 months, the child’s blinking increased to almost daily occurrence in clusters: during blinking the infant showed intact awareness and o...
The infl uence of thread geometry on biomechanical load transfer to bone: A fi nite element analysis comparing two implant thread designs
The success of dental implants depends on the manner in which stresses aretransferred to the surrounding bone. An important consideration is to design an implant with ageometry that will minimize the peak bone stresses caused by standard loading. The aim of thisstudy was to assess the infl uence of implant thread geometry on biomechanical load transfer andto compare the difference between two d...

Effects of low-intensity laser therapy on the rate of orthodontic tooth movement: A clinical trial
Low-intensity laser therapy (LILT) can be utilized for different treatments in the fi eldof orthodontics and dentofacial orthopedics. The aim of the present study was to evaluate theeffi cacy of LILT on (1) the rate of canine movement during canine retraction phase and evaluatethe radiographic changes occurring during LILT around the irradiated area.: A total of 10 patients of both genders were...
Effect of zinc-defi cient nutrition on craniofacial bone growth in rats
Zinc (Zn) is an essential nutrient that is required in humans and animals for thegrowth, development, and maintenance of healthy bones. The aim of this study is to investigate theeffects of zinc-defi cient nutrition on the dental, mandibular, maxillary, and cranial dimensions of rats.: This experimental study was carried out on 14 male Wistar rats. Therats were randomly divided into two groups....
Antibacterial effect of triantibiotic mixture, chlorhexidine gel, and two natural materials Propolis and Aloe vera against Enterococcus faecalis: An ex vivo study
The aim of this ex vivo study was to compare the antimicrobial effect of triantibioticpaste, 0.2% chlorhexidine gel, Propolis and Aloe vera on Enterococcus faecalis in deep dentin.: Ninety fresh extracted single-rooted teeth were used in a dentin blockmodel. Seventy-fi ve teeth were infected with E. faecalis and divided into four experimental groups (n =15). Experimental groups were treated wit...
Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study
The accelerating effect of plasma rich in growth factors (PRGFs) in the healing ofextraction sockets has been demonstrated by some studies. The aim of the present study was tohistologically and histomorphometrically evaluate whether bone formation would increase by thecombined use of PRGF and demineralized freeze-dried bone allograft (DFDBA).: In four female dogs, the distal root of the second,...