RSS feed 

View All

Cytotoxic and Antimicrobial Compounds from Cinnamomum cebuense Kosterm. (Lauraceae)
The dichloromethane extract of Cinnamomum cebuense afforded α-terpineol (1), 4-allyl-2-methoxyphenol or eugenol (2), humulene (3), 4-hydroxy-3-methoxycinnamaldehyde (4) and a monoterpene (5) which were evaluated for cytotoxicity against colon carcinoma (HCT 116). Compound 4 showed moderate cytotoxicity against this cell line with an IC50 value of 18.8004 μg/mL, while 3 and 5 exhibited slight ...


Cytotoxic Triterpene from Barringtonia asiatica
Triterpenes isolated from the dichloromethane extract of Barringtonia asiatica, namely, a mixture of betulinic acid (1) and 22-O-tigloylcamelliagenin A (2) in a 1 : 2 ratio and a mixture of 3β-olean-18-en-3-yl palmitate (7), 3β-urs-12-en-3-yl palmitate (8) and 3β-olean-12-en-3-yl palmitate (9) in a 4 : 1 : 2 ratio (isolated from the bark), as well as germanicol caffeoyl ester (3), germanicol...
Spectrophotometric Determination of Taurine in Dosage Forms Using Sodium 1,2-Naphthoquinone-4-Sulfonate
A new spectrophotometric method for quantitative determination of taurine in dosage forms was developed and validated. The method was based on measurement of aqueous taurine solution absorption at 470 nm. The proposed method satisfied requirements of the Ukrainian Pharmacopeia for drug quantitative analytical methods and could be recommended for use in laboratories of the State Inspection for Q...


Design and Antimicrobial Evaluation of 1-Methylimidazole Derivatives as New Antifungal and Antibacterial Agents
Azole antifungal agents, which are widely used as antifungal antibiotics, inhibit cytochrome P450 sterol 14α-demethylase (CYP51). In this research, a group of 1-methylimidazole derivatives were synthesized for evaluation as antibacterial and antifungal agents. Antimicrobial evaluation revealed that some of these compounds exhibited significant antimicrobial activities against tested pathogenic...
Abnormal Visual Contrast Acuity in Parkinson's Disease
Low-contrast vision is thought to be reduced in Parkinson's disease (PD). This may have a direct impact on quality of life such as driving, using tools, finding objects, and mobility in low-light condition. Low-contrast letter acuity testing has been successful in assessing low-contrast vision in multiple sclerosis. We report the use of a new iPad application to measure low-contrast acuity in p...


Bring the Subjective Back In: Resource and Husband-to-Wife Physical Assault Among Chinese Couples in Hong Kong
Resource theory constitutes important explanations of spousal violence in culturally diverse societies. This article extends the theory by adding several subjective indicators: husband’s financial strain and the couple’s appraisal of each other’s financial and nonfinancial contributions to family. We examined the role of these subjective dimensions of resource in spousal viole...
STAT3 Regulates Steady-state Expression of Synaptopodin in Cultured Mouse Podocytes
The transcription factor signal transducer and activator of transcription-3 (STAT3) is activated by pro-inflammatory cytokines and circulating factors in many cell types. Synaptopodin (Synpo) is a cytoskeleton regulatory protein expressed in podocyte foot processes that regulates the dynamics of actin filaments and the stability of small GTPases. Here we show that inhibition of STAT3 signaling ...

Engineered Hyperphosphorylation of the beta2-adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization
G-protein-coupled-receptor phosphorylation plays a major role in receptor desensitization and arrestin binding. It is, however, unclear how distinct receptor phosphorylation patterns may influence arrestin binding and subsequent trafficking. Here we engineer phosphorylation sites into the C-terminal tail of the β2-adrenoceptor (β2AR) and demonstrate that this mutant, termed β2ARS...
Novel Mechanism of Voltage-Gated N-type (Cav2.2) Calcium Channel Inhibition Revealed Through alpha-Conotoxin Vc1.1 Activation of the GABAB Receptor
Neuronal voltage-gated N-type (Cav2.2) calcium channels are expressed throughout the nervous system and regulate neurotransmitter release and hence synaptic transmission. They are predominantly modulated via G protein-coupled receptor activated pathways, and the well-characterised Gβ subunits inhibit Cav2.2 currents. Analgesic α-conotoxin Vc1.1, a peptide from predatory marine cone s...

New Population of Steller's Sea Cows
The Kommandorskiye Islands population of Steller's sea cow (Hydrodamalis gigas) was extirpated ca 1768 CE. Until now, Steller's sea cow was thought to be restricted in historic times to Bering and Copper Islands, Russia, with other records in the last millennium from the western Aleutian Islands. However, Steller's sea cow bone has been obtained by the authors from St Lawrence Island, Alaska, w...
Epidemic Trends of Enterovirus Infections From Pediatric Patients in Cheonan, Korea
This study was performed to investigate the epidemiology of enterovirus (EV) infections in children at a single hospital during recent 5 years. This study was preformed from December 2008 to November 2013. We subjected 1,067 cerebrospinal fluid (CSF) specimens from 1,053 patients and 678 stool specimens from 665 patients using real-time reverse-transcription polymerase chain reaction tests that...

Life history and neutral substitutions
Our understanding of molecular evolution is hampered by a lack of quantitative predictions about how life-history (LH) traits should correlate with substitution rates. Comparative studies have shown that neutral substitution rates vary substantially between species, and evidence shows that much of this diversity is associated with variation in LH traits. However, while these studies often agree...
Useful and Fast Method for Blood Lead and Cadmium Determination Using ICP-MS and GF-AAS; Validation Parameters
In case of clinical analysis, especially in blood lead (Pb-B) and cadmium (Cd-B) determination, the accuracy and precision of the method are crucial. The objective of this article is to present a simple and useful method for Pb-B and Cd-B determination using ICP-MS (inductively coupled plasma-mass spectrometry) as well as GF-AAS (graphite furnace-atomic absorption spectrometry). The principle o...
Influence of Body Mass Index on the Activated Clotting Time Under Weight-Based Heparin Dose
Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to reduce the incidence of thrombotic adverse events and hemorrhagic complications. And this investigation was to explore the influence of body mass index (BMI) on ACT in patients re...
A High Frequency of Peripheral Blood IL-22+CD4+ T Cells in Patients With New Onset Type 2 Diabetes Mellitus
This study is aimed at investigating the frequency of different functional IL-22+CD4+ T cells in Chinese patients with type 2 diabetes mellitus (T2DM). The frequency of circulating IFN-γ+IL-17-IL-22-CD4+ (Th1), IFN-γ-IL-17A+IL-22-CD4+ (Th17), and IFN-γ-IL-17A-IL-22+CD4+ (Th22), and other subsets of IL-22+CD4+ T cells in 31 patients with new onset T2DM and 16 healthy controls was characterize...