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A New γ -Pyrone from Ampelocissus artemisiifolia
Phytochemical investigation of Ampelocissus artemisiifolia Planch. led to the isolation of a new γ-pyrone,(E)-2-(2-hydroxypropyl)-6-(4-hydroxystyryl)-4H-pyran-4-one (1), together with eight known compounds (2–9). Their structures were identified on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. All of them were isolated fro...


A New Flavolignan from Nelumbo nucifera Leaves
A new flavolignan, isohydnocarpin A (1), together with three known flavolignans, isohydnocarpin (2), hydnocarpin B (3), and hydnocarpin D (4), was isolated from the leaves of Nelumbo nicifera. The structure of the new compound was determined based on spectroscopic methods including 1D and 2D NMR and MS spectrometry. The stereochemistry was determined by NOESY experiments.
Diels–Alder Reaction of Levopimaric Acid with 2-(2,4-Dioxo-5-Thiazolidinylidene)Acetic Acid
New derivatives of levopimaric acid containing a thiazolidinedione fragment were synthesized by a Diels–Alder reaction of levopimaric acid and 2-(2,4-dioxo-5-thiazolidinylidene)acetic acid. The new compounds were characterized using elemental analysis and NMR spectroscopy.


The significance of hand dominance in hip osteoarthritis
Hip arthroplasty registries, encompassing all-cause end-stage hip degeneration have shown that slightly more right hip replacements are performed than left. Given that greater than 85% of individuals are right handed, we sought to investigate the association between side of hand dominance and side of hip osteoarthritis. This Level III observational study, evaluated exclusively end-stage osteoar...
The role of central sensitization in shoulder pain: A systematic literature review
Hyperexcitability of the central nervous system has been suggested to play an important role in pain experienced by patients with unilateral shoulder pain. A systematic literature review following the PRISMA guidelines was performed to evaluate the existing evidence related to the presence of central sensitization in patients with unilateral shoulder pain of different etiologies including those...


Safety of Disease-Modifying Antirheumatic Drugs and Biologic Agents for Rheumatoid Arthritis Patients in Real Life Conditions
To describe the incidence rate (IR) of adverse drug reactions (ADRs) in daily clinical practice, related to disease-modifying antirheumatic drugs (DMARDs) and biologic agents (BA) in Rheumatoid Arthritis patients (RA), and to analyze factors causing discontinuation due to ADRs. Prospective observational study (October 2010 to October 2011). RA patients attended in our hospital taking DMARDs or ...
Osteogenic ability of Cu-bearing stainless steel
A newly developed copper-bearing stainless steel (Cu-SS) by directly immobilizing proper amount of Cu into a medical stainless steel (317L SS) during the metallurgical process could enable continuous release of trace amount of Cu2+ ions, which play the key role to offer the multi-biofunctions of the stainless steel, including the osteogenic ability in the present study. The results of in vitro ...

Electrospun poly(ε-caprolactone)-based skin substitutes: In vivo evaluation of wound healing and the mechanism of cell proliferation
In the present study, we have fabricated electrospun poly(ε-caprolactone)-based membranes, characterized and studied the in vivo cell migration and proliferation and wound healing activity. Moreover, we did not seed any cells prior to the animal implantation and we could observe excellent fibroblast attachment and cell proliferation. Further full thickness excision wound on guinea pig complete...
Formant frequencies and bandwidths of the vocal tract transfer function are affected by the mechanical impedance of the vocal tract wall
The acoustical properties of the vocal tract, the air-filled cavity between the vocal folds and the mouth opening, are determined by its individual geometry, the physical properties of the air and of its boundaries. In this article, we address the necessity of complex impedance boundary conditions at the mouth opening and at the border of the acoustical domain inside the human vocal tract. Usin...

Randomized, controlled trial of the effect of e-feedback on knowledge about radiotherapy of breast cancer patients in Finland
The growing number of women with breast cancer and their unmet knowledge expectations of radiotherapy pose a challenge to develop effective electronic patient education. Development efforts should be focused on e-feedback on knowledge because of its positive effects. In this study, we evaluated how an e-feedback knowledge intervention (e-Re-Know) before first radiotherapy improves breast cancer...
Gibberellins Affect Tobacco Growth and Development in a Dose Dependent Manner through Genes Involved in Metabolic Processes
Gibberellins (GAs) play an important role in growth control in plants, but little is known regarding their effects on metabolic processes, which can further regulate plant growth. To increase our understanding of the metabolic regulatory mechanism of GAs during plant growth and development, microarray analysis was performed to identify a subgroup of GA-regulated genes by comparing the expressio...

Copulas-Based Drought Evolution Characteristics and Risk Evaluation in a Typical Arid and Semi-Arid Region
The Wei River Basin, a typical arid and semi-arid region, is frequently attacked by droughts, which heavily limits its sustainable development of society and economy. Therefore, the main motivation of this study is to investigate the drought evolution characteristics and risk evaluation in the basin, which is crucial for drought warning, water resources management as well as agricultural develo...
Incremental Value of Live/Real Time Three-Dimensional Transthoracic Echocardiography over Two-Dimensional Echocardiography in Hypertrophic Cardiomyopathy with Mid-Ventricular Obstruction and Apical Aneurysm
We describe a case of hypertrophic cardiomyopathy with mid-left ventricular obstruction and apical aneurysm containing thrombi where live/real time three-dimensional transthoracic echocardiography provided incremental value over two-dimensional echocardiography in assessing the findings.
A novel de novo STXBP1 mutation is associated with mitochondrial complex I deficiency and late-onset juvenile-onset parkinsonism
Mutations in STXBP1 have recently been identified as a cause of infantile epileptic encephalopathy. The underlying mechanism of the disorder remains unclear and, recently, several case reports have described broad and progressive neurological phenotypes in addition to early-onset epilepsy. Herein, we describe a patient with early-onset epilepsy who subsequently developed a progressive neurologi...
The effect of row spacing on alfalfa seed and forage production under irrigated Mediterranean agricultural conditions
We evaluated the effect of row spacing on seed and forage yields in alfalfa (Medicago sativa L.) using combined seed and forage production plots, in an irrigated Mediterranean agricultural environment. We compared three row distances (20, 40 and 60 cm) in two cultivars at a seed rate of 25 kg ha−1 over a period of 4 years. We measured the seed yield and yield components as well as forage p...