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Brain molecular targets of the multifunctional iron chelating drug, M30 in type 2 diabetes mellitus mouse models
Neurodegenerative diseases are now recognized to be multifunctional, whereby heterogeneous set of reactions act independently or cooperatively, leading eventually to the demise of neurons. This has led our group to design and synthesize the multifunctional, nontoxic, brain permeable, iron chelator compound M30 with pluri-pharmacological properties. Considering the diverse beneficial neuroprotec...


1E7-03, a Small Molecule Targeting Host Protein Phosphatase-1, Inhibits HIV-1 Transcription
HIV-1 transcription is activated by the Tat protein which recruits CDK9/cyclin T1 to TAR RNA. We showed that Tat binds to protein phosphatase-1 (PP1) through the Q35VCF38 sequence and translocates PP1 to the nucleus. PP1 dephosphorylates CDK9 and activates HIV-1 transcription. We recently showed that 1H4, a PP1-targeting small molecule, prevents HIV-1 Tat interaction with PP1 and inhibits HIV-1...
Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes
TAM is a prodrug that is metabolically activated by 4-hydroxylation to the potent primary metabolite 4-hydroxytamoxifen (4OHT) or via another primary metabolite N-desmethytamoxifen (NDMTAM) to a biologically active secondary metabolite endoxifen through a cytochrome P450 variant 2D6 system (CYP2D6). We have determined the antioestrogenic efficacy of TAM and its metabolites, including endoxifen,...


Epigenetics in the Perioperative Period
The perioperative period is characterized by profound changes in the body's homoeostatic processes. This review seeks to address whether epigenetic mechanisms may influence an individual's reaction to surgery and anaesthesia. Evidence from animal and human studies suggests that epigenetic mechanisms can explain many facets of susceptibility to acute and chronic pain, making them potential thera...
Endothelial atypical cannabinoid receptor: do we have enough evidence?
Cannabinoids and their synthetic analogs affect a broad range of physiological functions, including cardiovascular variables. Although direct evidence is still missing, the relaxation to cannabinoids of a vast range of vascular beds is believed to involve still unidentified non-CB1, non-CB2 Gi/o protein-coupled receptor Ta located on endothelial cells, so called endothelial cannabinoid receptor...


Selective Na+/Ca2+ exchanger inhibition prevents Ca2+ overload induced triggered arrhythmias
A crucial role for augmented Na+/Ca2+ exchanger (NCX) activity in cardiac arrhythmogenesis is often suggested, however, in related studies the antiarrhythmic efficacy of NCX inhibition was apparently controversial. Feasible explanations could be the unsatisfactory selectivity of NCX inhibitors and/or experimental model dependence of the degree of Ca2+i overload. In the present study, using NCX ...
Dopamine D1 and corticotrophin releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells
Dopamine and corticotrophin releasing hormone (CRH) are key neurotransmitters in the interaction between stress and addiction. Repeated treatment with cocaine potentiates glutamatergic transmission in the rat basolateral amygdala/cortex pathway through a synergistic action of D1-like dopamine receptor and corticotrophin releasing hormone type-2α receptor (CRH2αR). We hypothesized that this ob...

Development and Characterization of a Novel, Antimicrobial, Sterile Hydrogel Dressing for Burn Wounds: Single-Step Production with Gamma Irradiation Creates Silver Nanoparticles and Radical Polymerization
Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na+) hydrogel. Silver nitrate was dissolved in AMPS-Na+ solution and then exposed to gamma irradiation to form SNP-infused hydrogels. The gamma ...
Influence of frontal cyclones evolution on the 2009 (Ekman) and 2010 (Franklin) Loop Current Eddy detachment events
The anticyclonic Loop Current Eddy (LCE) shedding events are strongly associated with the evolution of Loop Current Frontal Eddies (LCFEs) over the eastern Gulf of Mexico (GoM). A numerical simulation, in tandem with in situ measurements and satellite data, was used to investigate the Loop Current (LC) evolution and the surrounding LCFEs formation, structure, growth and migration during the Edd...

Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity
Due to increasing resistance of bacteria to traditional antibiotics, antimicrobial peptides are being investigated as a promising alternative. Tachyplesin, an antimicrobial peptide isolated from horseshoe crab, inhibits the growth of many different types of bacteria with its ability to permeabilize the cell membrane. Starting with a previously reported linear tachyplesin analog lacking cysteine...
Mesoporous Titania Powders: The Role of Precursors, Ligand Addition and Calcination Rate on Their Morphology, Crystalline Structure and Photocatalytic Activity
We evaluate the influence of the use of different titania precursors, calcination rate, and ligand addition on the morphology, texture and phase content of synthesized mesoporous titania samples, parameters which, in turn, can play a key role in titania photocatalytic performances. The powders, obtained through the evaporation-induced self-assembly method, are characterized by means of ex situ ...

Electrochemical Properties of Poly(Anthraquinonyl Sulfide)/Graphene Sheets Composites as Electrode Materials for Electrochemical Capacitors
Poly(anthraquinonyl sulfide) (PAQS)/graphene sheets (GSs) composite was synthesized through in situ polymerization to evaluate its performance as an electrode material for electrochemical capacitors. PAQS was successfully synthesized in the presence of GSs with uniform distribution. PAQS/GSs showed a pair of reversible redox peaks at around 0 V (vs. Ag/AgCl). The specific capacitance of PAQS/GS...
Targets and Timelines for Reducing Salt in Processed Food in the Americas
Reducing dietary salt is one of the most effective interventions to lessen the burden of premature death and disability. In high-income countries and those in nutrition transition, processed foods are a significant if not the main source of dietary salt. Reformulating these products to reduce their salt content is recommended as a best buy to prevent chronic diseases across populations. In the ...
T1 Mapping for Characterization of Intracellular and Extracellular Myocardial Diseases in Heart Failure
Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive m...
Acute coronary syndrome secondary to in-stent plaque rupture occurred at 9 years after deployment of bare metal stent
We report a case with acute coronary syndrome due to in-stent plaque rupture that occurred 9 years after bare metal stent deployment. From the results of intravascular imaging and pathological findings, we diagnosed this case as acute coronary syndrome caused by in-stent plaque rupture. In-stent neoatherosclerosis is an important mechanism of very late stent thrombosis, and the intravascular im...